Terbutaline and aminophylline as second-line therapies for status asthmaticus in the pediatric intensive care unit.

Abstract:

OBJECTIVE:Asthma is the most common chronic disease of childhood. Although asthma admissions to the pediatric intensive care unit (PICU) are increasing, there are no evidence-based guidelines on preferred escalation of therapies for patients with status asthmaticus who fail to respond to inhaled bronchodilators and systemic corticosteroids. The purpose of this study was to assess outcomes of PICU patients receiving aminophylline versus terbutaline as second-tier therapies for status asthmaticus. DESIGN:Retrospective cohort study using Pediatric Health Information System from 2016-2019. SETTING:Fifty-three tertiary children's hospitals. SUBJECTS:Children aged 2 to 18 years admitted to the PICU in children's hospitals contributing data to the Pediatric Health Information System with a primary diagnosis of status asthmaticus. INTERVENTIONS:None. MEASUREMENTS AND MAIN RESULTS:Of 11 133 pediatric patients treated for status asthmaticus in the PICU during the study period, 1144 received either terbutaline or aminophylline. There was no difference in intubation and mechanical ventilation between patients who received aminophylline and those who received terbutaline. However, in African American patients, those who received terbutaline had a significantly higher odds of intubation and mechanical ventilation compared to those who received aminophylline (OR, 12.41; 95%CI, 1.61,95). CONCLUSIONS:The use of aminophylline is associated with lower odds of intubation and mechanical ventilation in African American patients with status asthmaticus as compared to terbutaline.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Stulce C,Gouda S,Said SJ,Kane JM

doi

10.1002/ppul.24821

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

1624-1630

issue

7

eissn

8755-6863

issn

1099-0496

journal_volume

55

pub_type

杂志文章
  • Development and validation of a questionnaire to assess asthma control in pediatrics.

    abstract:OBJECTIVE:To develop and validate a questionnaire to assess asthma control in children (CAN). DESIGN:Two versions of the CAN (for carers and children) were developed. Both versions were validated in an observational, prospective, multicenter study performed in 38 hospital outpatient clinics throughout Spain. Four hund...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20929

    authors: Pérez-Yarza EG,Badía X,Badiola C,Cobos N,Garde J,Ibero M,Villa JR,CAN Investigator Group.

    更新日期:2009-01-01 00:00:00

  • Utility and safety of endobronchial ultrasound-guided transbronchial needle aspiration and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration in children with mediastinal pathology.

    abstract:BACKGROUND:Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) and endoscopic ultrasound with an echobronchoscope-guided fine needle aspiration (EUS-B-FNA) are useful modalities in the evaluation of mediastinal pathologies in adults. However, sparse data are available in children. OBJECTIVE:To...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24313

    authors: Gulla KM,Gunathilaka G,Jat KR,Sankar J,Karan M,Lodha R,Kabra SK

    更新日期:2019-06-01 00:00:00

  • Detection of Pseudomonas aeruginosa type III antibodies in children with tracheostomies.

    abstract::Pseudomonas aeruginosa is often cultured from the airways of children with tracheostomies. P. aeruginosa produces exotoxin A (ETA) and type III cytotoxins. This study tested the hypothesis that children with tracheostomies are colonized by P. aeruginosa that express these virulence factors and will have antibodies dir...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20194

    authors: Rao AR,Splaingard MS,Gershan WM,Havens PL,Thill A,Barbieri JT

    更新日期:2005-05-01 00:00:00

  • Acid steatocrit determination is not helpful in cystic fibrosis patients without or with mild steatorrhea.

    abstract:BACKGROUND:Most methods used for the assessment of severe steatorrhea in cystic fibrosis (CF) are sensitive. In fact, the tests show their usefulness in a borderline zone of the results. Yet, the existing data related to acid steatocrit (AS) are still contradictory. Therefore, in the present study we have aimed to asse...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21149

    authors: Walkowiak J,Lisowska A,Blask-Osipa A,Drzymała-Czyz S,Sobkowiak P,Cichy W,Breborowicz A,Herzig KH,Radzikowski A

    更新日期:2010-03-01 00:00:00

  • Complication of mediastinal mass: acquired tracheoesophageal fistula associated with T-cell lymphoblastic lymphoma.

    abstract::The occurrence of a tracheoesophageal fistula (TEF) in the setting of lymphoma has only rarely been reported in the world literature. Most cases reported were associated with radiation therapy vs. chemotherapy alone. This report presents one case illustrating the difficulty encountered managing a TEF that developed wh...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20405

    authors: Moree JS,Bhakta MG,Ledbetter J

    更新日期:2006-07-01 00:00:00

  • Development of the pulmonary airways in the fetal rat and its relation to the prenatal environment.

    abstract::We studied the left lung using multi-focus microphotography in 378 rat fetuses, assessing airway branching from day 13 to day 19 of gestation, and lung growth variables from day 13 to day 21. Longitudinal growth, and monopodial and dichotomous branching brought about a consistent airway pattern with variations within ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199604)21:4<219::AID-PPUL3

    authors: Rotschild A,Massoud EA,Solimano A,Puterman ML,Sekhon HS,Thurlbeck WM

    更新日期:1996-04-01 00:00:00

  • Blood L-arginine levels in early respiratory distress syndrome.

    abstract::L-arginine is the precursor of nitric oxide which plays an important role on pulmonary circulation and pulmonary vascular tone. Our aim was to compare the levels of L-arginine between infants with respiratory distress syndrome and infants without respiratory distress syndrome and to determine the relationship between ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20326

    authors: Canpolat FE,Yurdakök M,Yiğit S,Korkmaz A,Tekinalp G

    更新日期:2005-12-01 00:00:00

  • The lung is involved in juvenile dermatomyositis.

    abstract:BACKGROUND:Juvenile dermatomyositis (JDM) is the main cause of chronic idiopathic inflammatory myopathy of autoimmune origin in children. The aim of this multicenter prospective study was to describe respiratory status and treatment of children followed for JDM. METHODS AND PATIENTS:Clinical manifestations, pulmonary ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.22742

    authors: Pouessel G,Deschildre A,Le Bourgeois M,Cuisset JM,Catteau B,Karila C,Nève V,Thumerelle C,Quartier P,Tillie-Leblond I

    更新日期:2013-10-01 00:00:00

  • Ventilation efficiency to exercise in patients with cystic fibrosis.

    abstract:INTRODUCTION:Exercise ventilation efficiency index in cardiopulmonary exercise testing (CPET) is elevated in patients with heart failure providing useful information on disease progression and prognosis. Few data, however, exist for ventilation efficiency index among cystic fibrosis (CF) patients. AIMS:To assess venti...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24438

    authors: Kampouras A,Hatziagorou E,Avramidou V,Georgopoulou V,Kirvassilis F,Hebestreit H,Tsanakas J

    更新日期:2019-10-01 00:00:00

  • Relief of central airways obstruction following spinal release in a patient with idiopathic scoliosis.

    abstract::SUMMARY. Patients with idiopathic scoliosis are reported to have a restrictive pattern on pulmonary function tests. A case is presented of a teenage girl with juvenile idiopathic scoliosis who had evidence of airways obstruction in addition to restriction on pulmonary function tests (PFT). Examination of flow-volume l...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200101)31:1<86::aid-ppul1012>3.0

    authors: Borowitz D,Armstrong D,Cerny F

    更新日期:2001-01-01 00:00:00

  • Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model.

    abstract::Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate the effects in a surgical model, where the retinoid signaling pathway is not primarily disrupted by the toxic agent. We created DH in fetal ra...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20829

    authors: Gallot D,Coste K,Jani J,Roubliova X,Marceau G,Velemir L,Verheyen A,Lemery D,Sapin V,Deprest J

    更新日期:2008-06-01 00:00:00

  • Value of surrogate tests to predict exercise-induced bronchoconstriction in atopic childhood asthma.

    abstract::Exercise challenge tests are helpful in the diagnosis and management of childhood asthma, but methodology is complex and time-consuming. The aim of this study was to investigate whether exercise-induced bronchoconstriction (EIB) can be predicted by the results of different surrogate tests in a pediatric population. Ei...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20556

    authors: Lex C,Dymek S,Heying R,Kovacevic A,Kramm CM,Schuster A

    更新日期:2007-03-01 00:00:00

  • Impulse oscillometry: a measure for airway obstruction.

    abstract::The impulse oscillometry system (IOS) was introduced as a new technique to assess airflow obstruction in patients who are not able to perform forced breathing maneuvers, e.g., subjects with cerebral palsy or severe mental retardation, and young children. This study evaluates the sensitivity and specificity of IOS para...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10235

    authors: Vink GR,Arets HG,van der Laag J,van der Ent CK

    更新日期:2003-03-01 00:00:00

  • Cheyne-Stokes respiration as an additional risk factor for pulmonary hypertension in a boy with trisomy 21 and atrioventricular septal defect.

    abstract::Central ventilation disorders(1) and airway obstruction(2) with chronic hypoxemia are causally related to cor pulmonale. Pulmonary vascular resistance is often reversible, and hypoxic pulmonary hypertension often responds to treatment with supplemental oxygen. Oxygen therapy during sleep may be useful as a temporary p...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1037

    authors: Hoch B,Barth H

    更新日期:2001-03-01 00:00:00

  • NAVA-synchronized compared to nonsynchronized noninvasive ventilation for apnea, bradycardia, and desaturation events in VLBW infants.

    abstract::Neurally adjusted ventilatory assistance (NAVA) can overcome technical difficulties with synchronizing noninvasive ventilation breaths with the patient, a modality often used in very low birthweight infants (VLBW) with apnea of prematurity (AOP). This study is a retrospective single-center investigation into whether N...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24464

    authors: Tabacaru CR,Moores RR Jr,Khoury J,Rozycki HJ

    更新日期:2019-11-01 00:00:00

  • Horseshoe lung with pseudo-ring-sling complex.

    abstract::We report on a 1-month-old boy who presented with a "horseshoe" lung, complete "O" rings of the trachea, and an unusual course of the left pulmonary artery mimicking a left pulmonary artery sling. Computed tomography, cardiac catheterization, and bronchoscopy were performed to confirm the rare coexistence of these ano...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10172

    authors: Hwang HK,Chen MR,Chen SJ,Kao HA,Lee KS,Shih SL

    更新日期:2002-11-01 00:00:00

  • Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS.

    abstract::Our purpose was to identify and further characterize physiologic mechanisms relevant to autoresuscitation from hypoxic apnea in infants dying suddenly and unexpectedly. We studied cardiorespiratory recordings of 24 infants (age range, 0.8-21 months) who died suddenly while being monitored at home. These recordings wer...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10287

    authors: Sridhar R,Thach BT,Kelly DH,Henslee JA

    更新日期:2003-08-01 00:00:00

  • AMPK and FoxO1 regulate catalase expression in hypoxic pulmonary arterial smooth muscle.

    abstract:BACKGROUND:Hypoxia and reactive oxygen species (ROS) including H(2)O(2) play major roles in triggering and progression of pulmonary vascular remodeling in persistent pulmonary hypertension. Catalase (CAT), the major endogenous enzyme scavenging H(2)O(2), is regulated in a tissue- and context-specific manner. OBJECTIVE...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22919

    authors: Awad H,Nolette N,Hinton M,Dakshinamurti S

    更新日期:2014-09-01 00:00:00

  • Pediatricians' attitudes and costs of bronchiolitis in the emergency department: a prospective multicentre study.

    abstract:BACKGROUND:How pediatricians manage bronchiolitis and the derived total costs (direct and indirect) in the emergency department (ED) have not been fully characterized. The aim of the present study is to calculate those costs in a European country. METHODS:A prospective and observational study, including 10 EDs of tert...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.22906

    authors: Garcia-Marcos L,Valverde-Molina J,Pavlovic-Nesic S,Claret-Teruel G,Peñalba-Citores AC,Nehme-Álvarez D,Korta-Murua J,Sánchez-Etxaniz J,Alonso-Salas MT,Campos-Calleja C,Fernández-Villar A,Rodríguez-Suarez J,BCOST group.

    更新日期:2014-10-01 00:00:00

  • Pneumonectomy: The final cut in a rare incidence of persistent bronchopleural fistula following empyema.

    abstract::The incidence of necrotizing pneumonia and empyema complicated by bronchopleural fistula is rising. We describe the case of a 2-year-old boy who presented with empyema thoracis and necrotizing pneumonia who developed a bronchopleural fistula. At initial thoracotomy for decortication, necrotic lung was found and resect...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22649

    authors: Peters RT,Child F,Long AM,Humphrey GM,Rakoczy G

    更新日期:2013-06-01 00:00:00

  • Care recommendations for the respiratory complications of esophageal atresia-tracheoesophageal fistula.

    abstract::Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24982

    authors: Koumbourlis AC,Belessis Y,Cataletto M,Cutrera R,DeBoer E,Kazachkov M,Laberge S,Popler J,Porcaro F,Kovesi T

    更新日期:2020-10-01 00:00:00

  • The highs and lows of wheezing: A review of the most popular adventitious lung sound.

    abstract::Wheezing is the most widely reported adventitious lung sound in the English language. It is recognized by health professionals as well as by lay people, although often with a different meaning. Wheezing is an indicator of airway obstruction and therefore of interest particularly for the assessment of young children an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23930

    authors: Pasterkamp H

    更新日期:2018-02-01 00:00:00

  • Severe systemic adverse reaction to proton pump inhibitors in an infant.

    abstract::Episodes of respiratory distress with chest retraction and wheezing, sometimes associated with facial edema, were noted after administering the proton pump inhibitors omeprazole and esomeprazole in an infant with gastroesophageal reflux. The disturbances relieved dramatically after withdrawing the proton pump inhibito...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20616

    authors: Baldassarre E,Sagaon MM,Ferrarini A,Bianchetti MG

    更新日期:2007-06-01 00:00:00

  • Exercise-induced stridor due to abnormal movement of the arytenoid area: videoendoscopic diagnosis and characterization of the "at risk" group.

    abstract::We evaluated 4 patients who developed severe, symptomatic stridor during maximal cardiopulmonary exercise testing, all referred due to exercise-related dyspnea. All underwent resting, unsedated transnasal fiberoptic laryngoscopy and had normal findings. Four patients performed repeat maximal exercise testing with fibe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20076

    authors: Fahey JT,Bryant NJ,Karas D,Goldberg B,Destefano R,Gracco LC

    更新日期:2005-01-01 00:00:00

  • Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease.

    abstract::Cystic fibrosis (CF) patients with advanced lung disease are at risk for developing pulmonary vascular disease and pulmonary hypertension, characterized by progressive exercise intolerance beyond the exercise-limiting effects of airways disease in CF. We report on a patient with severe CF lung disease who experienced ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20393

    authors: Montgomery GS,Sagel SD,Taylor AL,Abman SH

    更新日期:2006-04-01 00:00:00

  • Hering-Breuer reflex in young asthmatic children.

    abstract::The aim of this study was to assess if the Hering-Breuer reflex could be provoked in young children. Thirty asthmatic children with a mean age of 5.3 years and 18 healthy children with a mean age of 7.0 years were studied. The presence of the reflex was indicated by prolongation of the spontaneous expiratory time foll...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950110412

    authors: Greenough A,Pool J

    更新日期:1991-01-01 00:00:00

  • Bone mineral content and body composition in children and young adults with cystic fibrosis.

    abstract::With dual energy X-ray absorptiometry (DEXA), it is possible to quantitate important aspects of growth in children with cystic fibrosis (CF), supplementing the usual measures of height and weight. Of particular concern during growth is the accumulation of bone mineral, since osteoporosis and fractures are well-recogni...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199902)27:2<80::aid-ppul3>

    authors: Henderson RC,Madsen CD

    更新日期:1999-02-01 00:00:00

  • Waist circumference associated with pulmonary function in children.

    abstract::In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulm...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20854

    authors: Chen Y,Rennie D,Cormier Y,Dosman JA

    更新日期:2009-03-01 00:00:00

  • Effect of low altitude at the Dead Sea on exercise capacity and cardiopulmonary response to exercise in cystic fibrosis patients with moderate to severe lung disease.

    abstract::Oxygen supplementation may improve exercise tolerance and the physiological response to exercise in cystic fibrosis (CF) patients. Elevated barometric pressure at low altitude is a simple means of increasing the quantity of inspired oxygen. Our objectives were to examine the effect of natural oxygen enrichment (at the...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.20342

    authors: Falk B,Nini A,Zigel L,Yahav Y,Aviram M,Rivlin J,Bentur L,Avital A,Dotan R,Blau H

    更新日期:2006-03-01 00:00:00

  • Increased serum interleukin-5 and vascular endothelial growth factor in children with acute mycoplasma pneumonia and wheeze.

    abstract::Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, G...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20961

    authors: Choi IS,Byeon JH,Yoo Y,Lee KC,Choung JT

    更新日期:2009-05-01 00:00:00