Abstract:
:Oxygen supplementation may improve exercise tolerance and the physiological response to exercise in cystic fibrosis (CF) patients. Elevated barometric pressure at low altitude is a simple means of increasing the quantity of inspired oxygen. Our objectives were to examine the effect of natural oxygen enrichment (at the Dead Sea, 396 m below sea level) on exercise capacity, and the physiological responses to maximal and submaximal exercise in CF patients. Patients were tested twice: at sea level (barometric pressure, 754 +/- 6 mmHg, mean +/- SD), and at the Dead Sea (barometric pressure, 791 +/- 3 mmHg), in a randomized crossover design. We studied 14 CF patients (6 females, 8 males), aged 15-45 years, with moderate to severe lung disease (mean forced expired volume in 1 sec = 50.0 +/- 11.2% predicted). Tests at each site included resting spirometry, anthropometry, a graded submaximal exercise test, a maximal exercise test on a treadmill, and a 6-min walk test. Tests were performed in identical order at both sites. Tests at the Dead Sea were performed 72 hr after arrival. No differences between sites were observed in lung function at rest. Peak oxygen consumption was significantly improved at the Dead Sea compared with sea level (1.68 +/- 0.73 vs. 1.57 +/- 0.74 l/min, respectively, P = 0.05), along with an improvement in the ventilatory equivalent for oxygen (41.2 +/- 6.3 vs. 46.1 +/- 7.1, respectively, P < 0.05). During submaximal exercise, blood oxygen saturation improved at the Dead Sea compared with sea level at all exercise intensities (P < 0.05). In conclusion, these results suggest that even a brief stay at the Dead Sea area may have physiological benefits for CF patients with moderate to severe lung disease.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Falk B,Nini A,Zigel L,Yahav Y,Aviram M,Rivlin J,Bentur L,Avital A,Dotan R,Blau Hdoi
10.1002/ppul.20342subject
Has Abstractpub_date
2006-03-01 00:00:00pages
234-41issue
3eissn
8755-6863issn
1099-0496journal_volume
41pub_type
杂志文章,随机对照试验abstract:RATIONALE OF THE STUDY:Increased neonatal fraction of exhaled nitric oxide (FeNO) is associated with lung symptoms early in life, while predictors of neonatal FeNO levels are unknown. The objective of this study was to investigate perinatal and genetic predictors of FeNO in healthy at-risk neonates. METHODS:FeNO was m...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22958
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To examine cystic fibrosis (CF) physician adherence to the 2007 CF Foundation (CFF) Pulmonary Guidelines for Chronic Medications. Specifically adherence and barriers to prescribing level A medication recommendations (i.e., inhaled tobramycin and dornase alfa) and level B medication recommendations (i.e., macr...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21573
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abstract::The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relatio...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21024
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20466
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:Newborns exhibit the lowest immediate respiratory morbidity rates when born following 39 completed weeks of gestation. We sought to determine whether early-term delivery (37-38 + 6 weeks' gestation) impacts on long-term pediatric respiratory morbidity. STUDY DESIGN:In this population-based prospective cohort...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23529
更新日期:2017-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25033
更新日期:2020-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:2009-10-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2008-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2020-11-01 00:00:00
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journal_title:Pediatric pulmonology
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doi:10.1002/ppul.22975
更新日期:2014-09-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:1992-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24464
更新日期:2019-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(200004)29:4<317::aid-ppul1
更新日期:2000-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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更新日期:2001-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2006-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199905)27:5<318::aid-ppul4
更新日期:1999-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950170609
更新日期:1994-06-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1994-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2018-03-01 00:00:00