Abstract:
INTRODUCTION:Laryngomalacia is the most prevalent cause of congenital stridor. Flexible laryngobronchoscopy (FLB) is the gold standard for diagnosis. However, FLB requires venous access, deep sedation or general anesthesia, and is associated with patient's and parental discomfort and a considerable cost. Laryngeal ultrasound (LUS) has been shown to provide good evaluation of the normal anatomy and the dynamic motion of laryngeal structures. We investigated the yield of LUS in the diagnosis of laryngomalacia in infants with congenital stridor compared to FLB. METHODS:A prospective blind study of consecutive infants referred for FLB due to congenital stridor with unknown cause. The presence of arytenoids adduction on LUS during inspiration was used to diagnose laryngomalacia. LUS was followed by FLB under anesthesia. The physician performing the FLB was blinded to the LUS results. RESULTS:Twenty-four patients participated in the study (54% males). Median (IQR) age and weight were 3.5 (1-7.7) months and 5.1 (4-8.4) kg, respectively. LUS was well tolerated in all infants. Compared to FLB, LUS correctly diagnosed laryngomalacia in 11/14 (78.6%) infants. In 10 infants FLB ruled out laryngomalacia of whom LUS concurred in 9 infants and one was falsely diagnosed with laryngomalacia. LUS had a sensitivity of 78.5% (CI 52-95%), specificity of 90% (CI 49-94%), NPV of 75%, and PPV of 92%. ROC analysis demonstrated AUC of 0.84 (P < 0.01, 95%CI: 0.67-1.0). CONCLUSION:We suggest that LUS has a role in screening congenital stridor in otherwise healthy infants when laryngomalacia is highly probable.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Friedman S,Sadot E,Gut G,Armoni Domany K,Sivan Ydoi
10.1002/ppul.23964subject
Has Abstractpub_date
2018-06-01 00:00:00pages
772-777issue
6eissn
8755-6863issn
1099-0496journal_volume
53pub_type
杂志文章abstract:BACKGROUND:Decreased lung function is common in preterm-born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm-born children and adults who di...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,meta分析
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更新日期:2019-05-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:2009-08-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 评论,杂志文章
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1994-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1002/ppul.10047
更新日期:2002-06-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-11-01 00:00:00
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更新日期:2016-10-01 00:00:00
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pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
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