Effects of betamethasone on peripheral arterial development in term fetal rabbit.

Abstract:

:Glucocorticoids are given antenatally to promote pulmonary epithelial maturation and prevent respiratory distress syndrome in premature newborns. In contrast to airway changes, effects on vessels are less documented. We hypothesized that antenatal betamethasone (BM) administration promotes vascular development. Does received either a course of BM = 0.05 mg/kg/day (18 does, 70 fetuses), BM = 0.1 mg/kg/day (20 does, 75 fetuses), or saline (11 does, 92 fetuses) starting on d25, 26 (canalicular stage), d27, d28 (saccular stage), and d29 (alveolar stage) of gestation. In total 236 fetuses from 49 does were examined at term (d31) in terms of vascular development. Lung specimens were weighed and formalin fixed for morphometry. We determined differences in fetal body, liver and lung weight, proportionate medial thickness, muscularization of intra-acinar vessels, number of vessels under 100 microm, as well as immunoreactivity to Flk-1 in vascular smooth muscle and endothelial cells. A dose-dependent reduction in neonatal body and organ weight was observed in fetuses exposed to BM at d25. In contrast, term liver weight increased after late administration of BM (d28, 29). There was a dose- and time-dependent thinning of the pulmonary arterial media, which coincided with a decreased proportion of intra- and pre-acinar muscularized arteries (ED

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Roubliova XI,Lewi PJ,Vaast P,Jani JC,Verbeken EK,Tibboel D,Deprest JA

doi

10.1002/ppul.20870

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

795-805

issue

8

eissn

8755-6863

issn

1099-0496

journal_volume

43

pub_type

杂志文章
  • Chiari I malformation presenting as chronic cough.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20912

    authors: Amos LB,Quintero DR

    更新日期:2008-10-01 00:00:00

  • Treatment effect of idebenone on inspiratory function in patients with Duchenne muscular dystrophy.

    abstract::Assessment of dynamic inspiratory function may provide valuable information about the degree and progression of pulmonary involvement in patients with Duchenne muscular dystrophy (DMD). The aims of this study were to characterize inspiratory function and to assess the efficacy of idebenone on this pulmonary function o...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ppul.23547

    authors: Buyse GM,Voit T,Schara U,Straathof CS,D'Angelo MG,Bernert G,Cuisset JM,Finkel RS,Goemans N,Rummey C,Leinonen M,Mayer OH,Spagnolo P,Meier T,McDonald CM,DELOS Study Group.

    更新日期:2017-04-01 00:00:00

  • Irreversible airway obstruction in childhood asthma? A clinician's viewpoint.

    abstract::Even though childhood asthma is assumed to comprise reversible airway obstruction, some children develop irreversible airway obstruction (not reversed by a bronchodilator or corticosteroids); this may be due to inflammation that has caused remodeling. Lately, it has been claimed that in the absence of treatment with i...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10090

    authors: König P

    更新日期:2002-04-01 00:00:00

  • Small airway involvement in cystic fibrosis lung disease: routine spirometry as an early and sensitive marker.

    abstract:BACKGROUND:In young children with cystic fibrosis (CF) the forced expiratory volume in 1 second (FEV1 ) is often normal and a more sensitive measure to detect early obstructive lung disease is needed. AIM:To evaluate the progression of selected spirometry parameters with age in a cohort of CF patients and healthy chil...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22777

    authors: Bakker EM,Borsboom GJ,van der Wiel-Kooij EC,Caudri D,Rosenfeld M,Tiddens HA

    更新日期:2013-11-01 00:00:00

  • 15-Year trends in respiratory care of extremely preterm infants: Contributing factors and consequences on health and growth during hospitalization.

    abstract:OBJECTIVES:To review 15-year trends in respiratory care of extremely preterm infants managed in a tertiary perinatal center; to identify the factors contributing to their evolution; and to determine whether these changes had an impact on infant mortality, severe morbidity, and growth. METHODS:Retrospective cohort stud...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24774

    authors: Habas F,Durand S,Milési C,Mesnage R,Combes C,Gavotto A,Picaud JC,Cambonie G

    更新日期:2020-08-01 00:00:00

  • An infant with a hyperlucent chest mass: An unexpected diagnosis.

    abstract:INTRODUCTION:We report an unusual finding of pneumatocele in an infant. CASE REPORT:A previously well four month old presented with worsening respiratory distress over 6 weeks. He had no antecedent signs or symptoms of respiratory infection. Chest radiograph demonstrated a lucent hemithorax concerning for tension pneu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23257

    authors: Ehsan Z,Nathan JD,Kercsmar CM

    更新日期:2015-12-01 00:00:00

  • Flexible bronchoscopy in pediatric intensive care.

    abstract:OBJECTIVE:To define the benefits of a flexible bronchoscopy (FB) service in a Paediatric Intensive Care Unit (PICU). DESIGN:Review of the first 200 FBs undertaken in a large PICU. SETTING:Large cardiac and medical PICU in the United Kingdom, also providing extra-corporeal life support. PATIENTS:129 patients (78 male...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20910

    authors: Davidson MG,Coutts J,Bell G

    更新日期:2008-12-01 00:00:00

  • Salivary biomarkers of obstructive sleep apnea syndrome in children.

    abstract:OBJECTIVES:The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed betwee...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22972

    authors: Patacchioli FR,Tabarrini A,Ghiciuc CM,Dima-Cozma LC,Prete A,Bianchini C,Nicoletti F,Gozal D,Villa MP

    更新日期:2014-11-01 00:00:00

  • Respiratory resistance and transcutaneous PO2 during histamine provocation in children with bronchial asthma.

    abstract::Bronchial reactivity was assessed in 66 children with bronchial asthma (aged 8-15 years) by provocation with histamine-HCl during a symptom-free period. A significant bronchial reaction to histamine was defined as a 50% increase in the resistance of the respiratory system (Rrs) determined by the forced oscillation tec...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950150308

    authors: Holmgren D,Engström I,Bjure J,Sixt R,Aberg N

    更新日期:1993-03-01 00:00:00

  • Diagnostic value and pathophysiologic basis of pulsus paradoxus in infants and children with respiratory disease.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200102)31:2<138::aid-ppul1022>3.

    authors: Frey B,Freezer N

    更新日期:2001-02-01 00:00:00

  • Increased interleukin-8 and monocyte chemoattractant protein-1 concentrations in mechanically ventilated preterm infants with pulmonary hemorrhage.

    abstract::Pulmonary hemorrhage (PH) is a serious complication causing acute respiratory distress in the premature infant, and it is associated with significant mortality and morbidity. The role of inflammatory mediators in this condition is largely undefined. Serial tracheal aspirates (TA) were obtained at intervals from 65 mec...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10141

    authors: Baier RJ,Loggins J,Kruger TE

    更新日期:2002-08-01 00:00:00

  • Combination anti-inflammatory and antiviral therapy of influenza in a cotton rat model.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10320

    authors: Ottolini M,Blanco J,Porter D,Peterson L,Curtis S,Prince G

    更新日期:2003-10-01 00:00:00

  • Early elevations in B-type natriuretic peptide levels are associated with poor clinical outcomes in pediatric acute lung injury.

    abstract:OBJECTIVES:To determine B-type natriuretic peptide (BNP) levels in infants and children with acute lung injury (ALI), and to investigate associations between BNP levels and clinical outcome. DESIGN:Prospective observational study. SUBJECTS:After informed consent, plasma was collected from 48 pediatric patients on day...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21111

    authors: Reel B,Oishi PE,Hsu JH,Gildengorin G,Matthay MA,Fineman JR,Flori H

    更新日期:2009-11-01 00:00:00

  • Waist circumference associated with pulmonary function in children.

    abstract::In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulm...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20854

    authors: Chen Y,Rennie D,Cormier Y,Dosman JA

    更新日期:2009-03-01 00:00:00

  • Beclomethasone diproprionate reduced airway inflammation without adrenal suppression in young children with cystic fibrosis: a pilot study.

    abstract::Inhaled corticosteroids are commonly used in cystic fibrosis (CF), but there are few studies evaluating their safety in young children. We, therefore, prospectively administered beclomethasone diproprionate (BDP) to 12 clinically stable young children with CF to examine the safety of this therapy with respect to adren...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1122

    authors: Wojtczak HA,Kerby GS,Wagener JS,Copenhaver SC,Gotlin RW,Riches DW,Accurso FJ

    更新日期:2001-10-01 00:00:00

  • Identifying pediatric lung disease: A comparison of forced oscillation technique outcomes.

    abstract:RATIONALE:Increasing evidence suggests the forced oscillation technique (FOT) has the capacity to provide non-invasive monitoring and diagnosis of respiratory disease in young children. However, which FOT outcomes provide the most pertinent clinical information is currently unknown. The aim of this study was to determi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24286

    authors: Evans DJ,Schultz A,Verheggen M,Hall GL,Simpson SJ

    更新日期:2019-06-01 00:00:00

  • Longitudinal assessment of health-related quality of life in an observational cohort of patients with cystic fibrosis.

    abstract:BACKGROUND:Patient-reported outcomes (PROs) are increasingly used to evaluate the efficacy of new treatments and the progression of chronic diseases. The Cystic Fibrosis Questionnaire-Revised (CFQ-R) is a disease-specific, PRO measure of health-related quality of life (HRQOL). We evaluated associations between changes ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21325

    authors: Sawicki GS,Rasouliyan L,McMullen AH,Wagener JS,McColley SA,Pasta DJ,Quittner AL

    更新日期:2011-01-01 00:00:00

  • Relief of central airways obstruction following spinal release in a patient with idiopathic scoliosis.

    abstract::SUMMARY. Patients with idiopathic scoliosis are reported to have a restrictive pattern on pulmonary function tests. A case is presented of a teenage girl with juvenile idiopathic scoliosis who had evidence of airways obstruction in addition to restriction on pulmonary function tests (PFT). Examination of flow-volume l...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200101)31:1<86::aid-ppul1012>3.0

    authors: Borowitz D,Armstrong D,Cerny F

    更新日期:2001-01-01 00:00:00

  • Modifiable lifestyle factors impact airway health in non-asthmatic prepubescent boys but not girls.

    abstract:INTRODUCTION:The prevalence of both childhood obesity and childhood asthma has increased dramatically over the past few decades. Little is known concerning the role of body composition and lifestyle influences on airway health in children. PURPOSE:To determine whether body composition, fruit and vegetable intake (FV) ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21393

    authors: Rosenkranz SK,Swain KE,Rosenkranz RR,Beckman B,Harms CA

    更新日期:2011-05-01 00:00:00

  • Comparing the clinical evolution of cystic fibrosis screened neonatally to that of cystic fibrosis diagnosed from clinical symptoms: a 10-year retrospective study in a French region (Brittany).

    abstract::Until the year 2000, systematic cystic fibrosis (CF) neonatal screening was only performed in a few regions of France. The Brittany region began in 1989, but not the neighboring region of Loire-Atlantique. The present study compares the clinical evolution of both affected populations 10 years after screening was start...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10259

    authors: Siret D,Bretaudeau G,Branger B,Dabadie A,Dagorne M,David V,de Braekeleer M,Moisan-Petit V,Picherot G,Rault G,Storni V,Roussey M

    更新日期:2003-05-01 00:00:00

  • Pulmonary outcome measures in long-term survivors of infantile Pompe disease on enzyme replacement therapy: A case series.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24621

    authors: ElMallah MK,Desai AK,Nading EB,DeArmey S,Kravitz RM,Kishnani PS

    更新日期:2020-03-01 00:00:00

  • Family history of atopy and clinical course of RSV infection in ambulatory and hospitalized infants.

    abstract::Respiratory syncytial virus (RSV) infection can be severe in pediatric patients. Risk factors for severe disease include age less than 6 months, prematurity, preexisting heart or lung disease or malformations, gastroesophageal reflux, and immunodeficiency. The aim of the present study was to investigate the influence ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200010)30:4<302::aid-ppul5>3.0.c

    authors: Trefny P,Stricker T,Baerlocher C,Sennhauser FH

    更新日期:2000-10-01 00:00:00

  • Sensitivity and specificity of oropharyngeal suction versus bronchoalveolar lavage in identifying respiratory tract pathogens in children with chronic pulmonary infection.

    abstract::The purpose of this study was to compare the pathogens obtained by oropharyngeal suction (OPS) and bronchoalveolar lavage (BAL) in children with chronic pulmonary infections. Forty-four children (mean age of 6.1 years; range 4 months to 15 years) were included in the study (27 children with recurrent localized lung in...

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    pub_type: 杂志文章

    doi:10.1002/ppul.1950200108

    authors: Avital A,Uwyyed K,Picard E,Godfrey S,Springer C

    更新日期:1995-07-01 00:00:00

  • Cell phone intervention to improve adherence: cystic fibrosis care team, patient, and parent perspectives.

    abstract:BACKGROUND:Treatment regimens for patients with cystic fibrosis (CF) are time-consuming and complex, resulting in consistently low adherence rates. To date, few studies have evaluated innovative technologies to improve adherence in this population. Current infection control guidelines for patients with CF seek to minim...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21164

    authors: Marciel KK,Saiman L,Quittell LM,Dawkins K,Quittner AL

    更新日期:2010-02-01 00:00:00

  • Accurate lung volume measurements in vitro using a novel inert gas washout method suitable for infants.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23348

    authors: Shawcross A,Murray CS,Goddard N,Gupta R,Watson S,Horsley A

    更新日期:2016-05-01 00:00:00

  • Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

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    更新日期:2016-08-01 00:00:00

  • Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis.

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    更新日期:2017-12-01 00:00:00

  • Influence of jacket tightness and pressure on raised lung volume forced expiratory maneuvers in infants.

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    pub_type: 杂志文章

    doi:10.1002/ppul.10170

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    pub_type: 杂志文章

    doi:10.1002/ppul.1950060207

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    更新日期:1989-01-01 00:00:00