Salivary biomarkers of obstructive sleep apnea syndrome in children.

Abstract:

OBJECTIVES:The present pilot study was performed to evaluate the HPA axis and ANS activity by measuring salivary cortisol and α-amylase diurnal trajectory and production, respectively, in mild or moderate-to-severe (MS) OSA-affected, but otherwise healthy, children. Moreover, a correlative analysis was performed between the salivary biomarker concentrations and the PSG variables characterizing the OSA severity. METHODS:We studied 27 consecutive OSA patients (13 mild OSA; 14 MS OSA) and seven healthy children who were enrolled as controls by collecting salivary samples and measuring cortisol and α-amylase levels using enzyme-linked bioassays. RESULTS:Compared with controls, both mild and MS OSA children showed: (1) increased salivary cortisol diurnal production, (2) maintenance of the physiological circadian activity of the HPA axis, and (3) no changes in α-amylase diurnal trajectory and production. In addition, morning salivary cortisol concentrations was negatively associated with the disease severity in the MS OSA group. CONCLUSIONS:OSA is associated with dysregulation of the HPA axis activity in children, the latter potentially underlying some of the adverse consequences of the disease.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Patacchioli FR,Tabarrini A,Ghiciuc CM,Dima-Cozma LC,Prete A,Bianchini C,Nicoletti F,Gozal D,Villa MP

doi

10.1002/ppul.22972

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

1145-52

issue

11

eissn

8755-6863

issn

1099-0496

journal_volume

49

pub_type

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