Abstract:
OBJECTIVE:To define the benefits of a flexible bronchoscopy (FB) service in a Paediatric Intensive Care Unit (PICU). DESIGN:Review of the first 200 FBs undertaken in a large PICU. SETTING:Large cardiac and medical PICU in the United Kingdom, also providing extra-corporeal life support. PATIENTS:129 patients (78 males, 51 females, median age 9.9 months, median weight 4.6 kg) underwent FB from August 1990 to June 2003. INTERVENTIONS:Broncho-alveolar lavage (BAL) as indicated at time of bronchoscopy. MEASUREMENTS:Basic patient parameters were identified, including ventilation modes and diagnoses. FB findings were correlated with microbiology results. MAIN RESULTS:The majority of the FBs were diagnostic (161 of 200). 114 of these were undertaken to exclude underlying airway abnormalities and 47 to aid the diagnosis of pneumonia. Therapeutic procedures including bronchial stenting, directed surfactant instillation and broncho-alveolar toileting were undertaken in 39 cases. 68% of the diagnostic FBs were deemed to be abnormal. 16% had significant extra-luminal airway obstruction. 24% had new findings of airway anomalies. 14.5% of the FBs showed endo-tracheal tube misplacement. Positive microbiological results which altered or confirmed changes in patient management occurred in 46.1% children who had BAL specimens cultured. 80 of the FBs were undertaken whilst the children were receiving extra-corporeal life support. Only one FB procedure was ceased because of patient instability. CONCLUSION:There is a high yield of positive findings from undertaking FB both anatomically and microbiologically. FB should be seen as a routine diagnostic and therapeutic tool in paediatric intensive care.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Davidson MG,Coutts J,Bell Gdoi
10.1002/ppul.20910subject
Has Abstractpub_date
2008-12-01 00:00:00pages
1188-92issue
12eissn
8755-6863issn
1099-0496journal_volume
43pub_type
杂志文章abstract::The goal of the present investigation was to describe the prevalence of and clinical factors associated with sleep-disordered breathing in children and adolescents. Children and adolescents (3,680 in all, 1-18 years old) attending schools in central Greece were surveyed by questionnaires distributed to parents. We fou...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.20002
更新日期:2004-06-01 00:00:00
abstract::Thirteen children with asthma were treated with cumulative doses of terbutaline delivered as a pressurized aerosol and from a new multidose powder inhaler (Turbuhaler) in a randomized cross-over dose-response study. The cumulative dose of terbutaline was 2 mg on each study day. All children used a correct aerosol inha...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ppul.1950070211
更新日期:1989-01-01 00:00:00
abstract:UNLABELLED:The main goal of the study was to assess possible association between transplacental exposure to genotoxic PAH compounds assessed by the cord blood PAH-DNA adducts and fractional exhaled nitric oxide (FeNO) measured in healthy non-asthmatic children at the age of 7 years. The subjects included the subsample ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22570
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:Percutaneous lymphatic intervention (PCL) is a promising new therapy for plastic bronchitis (PB). We characterized bronchoalveolar lavage (BAL) and cast morphology in surgically repaired congenital heart disease (CHD) patients with PB during PCL. We quantified respiratory and bronchoscopic characteristics an...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24161
更新日期:2018-11-01 00:00:00
abstract::To evaluate the long-term effect of prematurity and/or hyaline membrane disease (HMD) on pulmonary function and airway reactivity, we studied 49 prematurely born children aged 10 to 13 years. They were divided into three groups according to birth weight and HMD status: Groups I and II comprised the children weighing l...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950070412
更新日期:1989-01-01 00:00:00
abstract::Respiratory input impedance (Zin) is a potentially informative test of pulmonary function in infants who are unable to perform standard tests commonly performed in children and adults Analysis of Zin in dogs using the six-element model of DuBois et al. (J Appl Physiol 8:587, 1956) provides estimates of airways resista...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0496(199612)22:6<364::AID-PPUL5
更新日期:1996-12-01 00:00:00
abstract::A neonate with severe neonatal asphyxia was treated with therapeutic hypothermia. He developed hypothermia-induced respiratory deterioration, after which congenital tracheal stenosis and pulmonary artery sling were diagnosed. Even low-grade hypothermia is likely to induce bronchial narrowing in neonates, especially in...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23538
更新日期:2017-03-01 00:00:00
abstract:PURPOSE:To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. METHODS:One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 n...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22547
更新日期:2012-11-01 00:00:00
abstract::Pulmonary hemangioma is a rare benign tumor of the lungs. Airway hemangiomas in particular may lead to feeding difficulties, barking cough, stridor, respiratory distress, and even acute airway obstruction. Hence, such hemangiomas usually require early and aggressive treatment; however, the treatment modalities employe...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23008
更新日期:2014-08-01 00:00:00
abstract::Pulmonary sequestration is a rare anomaly and is conventionally treated with surgical excision. This report describes the successful occlusion of a large aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug. ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20882
更新日期:2008-09-01 00:00:00
abstract::Bronchial responsiveness to isocapnic hyperventilation with cold air (CAH) and to inhaled methacholine (MCH) was compared in 17 children with bronchial asthma. The response to cold air was expressed as the percent drop in FEV1 from baseline at 4 min. after the challenge (delta % FEV1 CAH), and the response to methacho...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.1950190603
更新日期:1995-06-01 00:00:00
abstract::SUMMARY. The detection of early airway disease in infants with cystic fibrosis (CF) may lead to earlier intervention and an improved prognosis. We hypothesized that the ratio of maximal expiratory flows while breathing a mixture of helium and oxygen (heliox) and air, referred to as density dependence (DD), would ident...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/1099-0496(200101)31:1<17::aid-ppul1002>3.0
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To report the respiratory function of school-aged children with infantile Pompe disease (IPD) who started enzyme replacement therapy (ERT) in infancy and early childhood. STUDY DESIGN:This is a retrospective chart review of pulmonary function tests of: (a) patients with IPD 5 to 18 years of age, (b) who wer...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24621
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:Forced expiratory volume in 1 second (FEV1) is an important predictor of outcome in cystic fibrosis (CF). This study aimed to describe the change in lung function, nutritional status, and mortality of children with CF at a single center in Cape Town, South Africa, and identify factors associated with poor lu...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24726
更新日期:2020-06-01 00:00:00
abstract::The purpose of this study was to compare the pathogens obtained by oropharyngeal suction (OPS) and bronchoalveolar lavage (BAL) in children with chronic pulmonary infections. Forty-four children (mean age of 6.1 years; range 4 months to 15 years) were included in the study (27 children with recurrent localized lung in...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950200108
更新日期:1995-07-01 00:00:00
abstract::Plastic bronchitis (PB) is an uncommon, potentially fatal disease, marked by endobronchial cast formation causing variable degrees of respiratory distress. Primary and secondary pulmonary lymphatic abnormalities have been identified among the underlying mechanisms of cast formation. We present a case of PB where lymph...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22673
更新日期:2013-05-01 00:00:00
abstract::There is no consensus about reproducibility and reliability of spirometry in young children. We evaluated forced expiratory maneuvers from 98 children aged 3 to 5 years with a variety of respiratory disorders before and after bronchodilator treatment. Forced vital capacity (FVC) and forced expiratory volume in 1 sec (...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950180305
更新日期:1994-09-01 00:00:00
abstract::Multiple breath inert gas washout (MBW) is gaining popularity for measurements of resting lung volume and ventilation inhomogeneity. Test reproducibility is an important determinant of the clinical applicability of diagnostic tests. The between-test reproducibility of variables derived from MBW tests in newborn infant...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21113
更新日期:2010-01-01 00:00:00
abstract::We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume rela...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950120304
更新日期:1992-03-01 00:00:00
abstract::It has been suggested that cystic fibrosis (CF) patients harboring multiresistant (MR) Pseudomonas aeruginosa (PA) should be seen in separate clinics. The aim of this study was to test the feasibility of this by longitudinally studying the consistency of isolates of MRPA in individuals. We analyzed all respiratory tra...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10262
更新日期:2003-04-01 00:00:00
abstract::Antimicrobial proteins are important in lung defense and are potential therapeutic agents in chronic airways infection such as seen in cystic fibrosis (CF). In preparation for future clinical studies, we sought (1) to determine levels of three antimicrobial proteins [lactoferrin, lysozyme, and secretory leukoprotease ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21028
更新日期:2009-04-01 00:00:00
abstract::In 377 children, the commercially available Siregnost FD-5 was used to measure respiratory system resistance (Rrs) by forced oscillation at 10 Hz. The children were between 3 and 18 years of age and, by a detailed questionnaire and conventional pulmonary function testing in 335, they were shown to be representative of...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950100214
更新日期:1991-01-01 00:00:00
abstract::Prenatal cigarette smoke (CS) exposure, in combination with hypoxia and/or hyperthermia can lead to gasping and attenuated recovery from hypoxia in 7 days old rat pups. We studied 95 unanesthetized spontaneously breathing 14 days old rat pups to investigate if the destabilizing effects of increased ambient temperature...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21578
更新日期:2012-05-01 00:00:00
abstract::The optimal duration of therapy for acute exacerbations of cystic fibrosis (CF) has not been defined, and the utility of serial pulmonary function testing in predicting the duration of therapy has yet to be established. In a review of 90 pulmonary exacerbations of 39 patients with CF requiring hospitalization, we foun...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950160404
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:Different modalities of noninvasive respiratory support have been recommended for the management of acute bronchiolitis in the pediatric intensive care unit (PICU). High-flow nasal cannula (HFNC) is among the new modalities that have been widely used in the last decade. METHODS:This is a retrospective study...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24553
更新日期:2020-02-01 00:00:00
abstract::In 1994-1995 a cross-sectional epidemiological study investigating the respiratory health of school children in two Taiwan areas was conducted; one area was located in a region with petrochemical manufacturing complexes (Linyuan), and the other was situated in a reference area with no local industrial emissions (Taihs...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199805)25:5<299::aid-ppul2
更新日期:1998-05-01 00:00:00
abstract::Eight patients with cystic fibrosis [CF] colonized with Pseudomonas aeruginosa (P. aeruginosa) had serial lung function, peripheral blood inflammatory markers, and serum IgG antibodies to Burkholderia cepacia (B. cepacia) lipopolysaccharide measured in the months preceding and following colonisation with B. cepacia. O...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(200001)29:1<8::aid-ppul2>3
更新日期:2000-01-01 00:00:00
abstract::For the last thirty years, oral chloral hydrate has been used for sedation of infants for lung function testing. Recently, however, availability of chloral hydrate became severely limited in the United States after two manufacturers discontinued manufacturing in 2012. Due to these limitations and the recent and ongoin...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23100
更新日期:2015-02-01 00:00:00
abstract::For patients whose asthma remains in poor control necessitating high utilization of medical services, a referral to a specialized "center of excellence" is often considered. A decade ago, we evaluated our pediatric asthma program of long-term hospitalization (median stay of 75 days) and found significant decreases in ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1027
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:Recent advances in medicine have allowed children with chronic life-threatening disorders to survive longer than ever before with the use of complex medical device technology (e.g., mechanical ventilation, dialysis, etc.). The care of children with chronic pulmonary disorders and respiratory-technology depend...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23155
更新日期:2015-12-01 00:00:00