Reproducibility of multiple breath washout indices in the unsedated preterm neonate.

Abstract:

:Multiple breath inert gas washout (MBW) is gaining popularity for measurements of resting lung volume and ventilation inhomogeneity. Test reproducibility is an important determinant of the clinical applicability of diagnostic tests. The between-test reproducibility of variables derived from MBW tests in newborn infants is unknown. We aimed to determine the within-test repeatability and short-term between-test reproducibility of MBW variables in unsedated preterm infants. We hypothesized that measurements obtained within a 3-day interval in clinically stable preterm infants would be reproducible and suitable for use as an objective clinical outcome measurement. In this cross-sectional observational study, clinically stable hospitalized preterm infants whose parents had given informed consent for MBW studies were tested twice within 72 hr during quiet, unsedated sleep. Functional residual capacity (FRC), lung clearance index (LCI), and the first and second to zeroeth moment ratios (M(1):M(0); M(2):M(0)) were computed from MBW traces obtained using a mainstream ultrasonic flowmeter and 4% sulphur hexafluoride (MBW(SF6)). Within-test repeatability and between-test reproducibility were determined. Within-test repeatability (expressed as a coefficient of variability (C(v))) for differences between two and four replicate measurements on the same test occasion, were 9.3% (FRC), 9.0% (LCI), 7.6% (M(1):M(0)), and 15.6% (M(2):M(0)), respectively. The within-test C(v)'s were not statistically different to the between-tests C(v)'s, which were 7.7% (FRC), 10.3% (LCI), 6.1% (M(1):M(0)), and 13.0% (M(2):M(0)), respectively. Among unsedated preterm infants, between-test reproducibility over a 3-day interval was similar to within-test repeatability. The wide limits of agreement may limit the application of these measures to detect a clinically significant change in condition in small preterm infants.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Sinhal S,Galati J,Baldwin DN,Stocks J,Pillow JJ

doi

10.1002/ppul.21113

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

62-70

issue

1

eissn

8755-6863

issn

1099-0496

journal_volume

45

pub_type

杂志文章
  • Survival of an infant with homozygous surfactant protein C (SFTPC) mutation.

    abstract::Lung diseases caused by surfactant protein C (SFTPC) mutations are inherited as autosomal traits with variable penetrance and severity or as sporadic disease caused by a de novo mutation on one allele. Here, we report the case of a child surviving with a homozygous surfactant protein C mutation after aggressive clinic...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22976

    authors: Arıkan-Ayyıldız Z,Caglayan-Sozmen S,Isık S,Deterding R,Dishop MK,Couderc R,Epaud R,Louha M,Uzuner N

    更新日期:2014-03-01 00:00:00

  • Management of empyema in children.

    abstract::The incidence of empyema complicating community-acquired pneumonia is increasing and causes significant childhood morbidity. Pneumococcal infection remains the most common isolated cause in developed countries, with Staphylococcus aureus the predominant pathogen in the developing world. Newer molecular techniques util...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20251

    authors: Jaffé A,Balfour-Lynn IM

    更新日期:2005-08-01 00:00:00

  • Bronchiolitis Score of Sant Joan de Déu: BROSJOD Score, validation and usefulness.

    abstract:OBJECTIVE:To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS:Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed us...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23546

    authors: Balaguer M,Alejandre C,Vila D,Esteban E,Carrasco JL,Cambra FJ,Jordan I

    更新日期:2017-04-01 00:00:00

  • Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS.

    abstract::Our purpose was to identify and further characterize physiologic mechanisms relevant to autoresuscitation from hypoxic apnea in infants dying suddenly and unexpectedly. We studied cardiorespiratory recordings of 24 infants (age range, 0.8-21 months) who died suddenly while being monitored at home. These recordings wer...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10287

    authors: Sridhar R,Thach BT,Kelly DH,Henslee JA

    更新日期:2003-08-01 00:00:00

  • Lung function outcome at school age in very low birth weight children.

    abstract:OBJECTIVE:The aim of this study was to assess pulmonary function and its predictors in very low birth weight (birth weight ≤1,500 g) children (VLBWc) with or without bronchopulmonary dysplasia (BPD), born at gestational age ≤32 weeks at a single tertiary center during 1996-1999, after the introduction of surfactant the...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22676

    authors: Cazzato S,Ridolfi L,Bernardi F,Faldella G,Bertelli L

    更新日期:2013-08-01 00:00:00

  • A correction formula for computing specific airway resistance from a single-step measurement.

    abstract::Specific airway resistance (SRaw) is conventionally determined by multiplying the plethysmographically measured values of airway resistance and functional residual capacity (FRC). An alternative single-step method, which avoids the need for airway occlusion during determination of FRC, has been described by Dab and Al...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950060212

    authors: Haluszka J,Willim G,Cutrera R,Ronchetti R,Filtcher S

    更新日期:1989-01-01 00:00:00

  • A scoring system for lung function tests in infants.

    abstract::Measurements of thoracic gas volume (TGV), airway resistance (Raw), and airway conductance (Gaw) were calculated in a group of 42 normal infants using a whole-body plethysmograph. Maximum expiratory flow at functional residual capacity was measured in a separate group of 108 normal infants. Using data obtained from th...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950140303

    authors: Hampton F,Beardsmore CS,Morgan W,Williams A,Taussig L,Thompson JR

    更新日期:1992-11-01 00:00:00

  • Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

    abstract:BACKGROUND:We hypothesized airway inflammation can be detected non-invasively by induced sputum (IS) or peripheral blood eosinophilia, and IS can detect bacterial and viral infection in preschool children with airway disease, with results comparable to broncho-alveolar lavage (BAL). METHODS:Preschool children with cys...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23366

    authors: Jochmann A,Artusio L,Robson K,Nagakumar P,Collins N,Fleming L,Bush A,Saglani S

    更新日期:2016-08-01 00:00:00

  • Clearance of initial mucoid Pseudomonas aeruginosa in patients with cystic fibrosis.

    abstract:BACKGROUND:Accelerated lung function decline in cystic fibrosis (CF) is associated with mucoid Pseudomonas aeruginosa infection. Recent data suggest that mucoid P. aeruginosa may amenable to elimination from the airway. We aim to determine whether the initiation of an aggressive antibiotic eradication regimen upon init...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22543

    authors: Troxler RB,Hoover WC,Britton LJ,Gerwin AM,Rowe SM

    更新日期:2012-11-01 00:00:00

  • Use of nebulized bronchodilators in infants under 1 year of age: analysis of four forms of therapy.

    abstract::The main purpose of this study was to evaluate four different forms of treatment in young infants admitted for acute wheezing (AW). Seventy-nine infants less than one year of age were randomly assigned to one of five groups. Group 1 received nebulized fenoterol plus ipratropium bromide, group 2 fenoterol, group 3 feno...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/ppul.1950030504

    authors: Mallol J,Barrueto L,Girardi G,Muñoz R,Puppo H,Ulloa V,Toro O,Quevedo F

    更新日期:1987-09-01 00:00:00

  • Respiratory syncytial virus infections in SR Croatia, Yugoslavia.

    abstract::The prevalence of respiratory syncytial virus (RSV) infection was studied during three consecutive annual outbreaks (1983-1986) in SR Croatia, Yugoslavia. A total of 1,238 subjects were examined, using RSV isolation and immunofluorescent (DTFA) methods, with 1,042 showing the signs of respiratory infection and 207 of ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030505

    authors: Mlinarić-Galinović G,Ugrcić I,Bozikov J

    更新日期:1987-09-01 00:00:00

  • Lung ultrasound scoring in invasive mechanically ventilated children with severe bronchiolitis.

    abstract:OBJECTIVE:Lung ultrasound (LUS) is an emerging tool that may be used in the diagnosis and follow-up of children with viral bronchiolitis. In this study, we describe LUS abnormalities in children receiving invasive mechanical ventilation (IMV) for severe bronchiolitis in the pediatric intensive care unit (PICU). Our aim...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24974

    authors: Ingelse SA,Pisani L,Westdorp MHA,Almakdase M,Schultz MJ,van Woensel JBM,Bem RA

    更新日期:2020-10-01 00:00:00

  • Epidermal growth factor and lung development in the offspring of the diabetic rat.

    abstract::Fetuses of diabetic mothers who were exposed to excessive glucose show delayed maturation. Under these conditions, altered growth factor expression or signaling may have important regulatory influences. We examined the role of epidermal growth factor (EGF) in lung development and maternal diabetes in the rat. In order...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(200002)29:2<103::aid-ppul4

    authors: Thulesen J,Poulsen SS,Nexø E,Raaberg L

    更新日期:2000-02-01 00:00:00

  • Greater length of stay and hospital charges for severe asthma in children with depression or anxiety.

    abstract:RATIONALE:Asthma is one of the most common chronic disorders of childhood and is associated with significant healthcare utilization and costs. Comorbid psychiatric illnesses, specifically depression and anxiety, are more prevalent in patients with asthma and associated with worse asthma control, more emergency departme...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25061

    authors: Munoz FA,Benton LD,Kops SA,Kowalek KA,Seckeler MD

    更新日期:2020-11-01 00:00:00

  • Current understanding of the inflammatory process in cystic fibrosis: onset and etiology.

    abstract::Although airway obstruction and chronic endobronchial infection have long been recognized as major factors in the pathogenesis of lung disease in cystic fibrosis (CF), only recently has it been recognized that the inflammatory process itself may be responsible in a major way for destroying the lungs. The most characte...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199708)24:2<137::aid-ppul1

    authors: Konstan MW,Berger M

    更新日期:1997-08-01 00:00:00

  • A pediatric high-flow nasal cannula protocol standardizes initial flow and expedites weaning.

    abstract:OBJECTIVE:Respiratory illnesses compose the most common diagnoses of patients admitted to pediatric intensive care units. In pediatrics, high-flow nasal cannula (HFNC) therapy is an intermediate level of respiratory support with variability in practice. We conducted a pre-post intervention study of patients placed on H...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25214

    authors: Wiser RK,Smith AC,Khallouq BB,Chen JG

    更新日期:2020-12-09 00:00:00

  • Pneumococcal serogroups and serotypes in severe pneumococcal pneumonia in Belgian children: theoretical coverage of the 7-valent and 9-valent pneumococcal conjugate vaccines.

    abstract:BACKGROUND:Although the causative pneumococcal serotypes of invasive diseases are already extensively studied, few data are available about the pneumococcal serotypes additionally isolated from broncho-alveolar lavage samples in childhood pneumonia. STUDY AIM:To identify the causative pneumococcal serotypes in culture...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20437

    authors: De Schutter I,Malfroot A,Piérard D,Lauwers S

    更新日期:2006-08-01 00:00:00

  • Associations of obesity and asthma with functional exercise capacity in urban minority adolescents.

    abstract:PURPOSE:To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. METHODS:One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 n...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22547

    authors: Rastogi D,Khan UI,Isasi CR,Coupey SM

    更新日期:2012-11-01 00:00:00

  • An infant with a hyperlucent chest mass: An unexpected diagnosis.

    abstract:INTRODUCTION:We report an unusual finding of pneumatocele in an infant. CASE REPORT:A previously well four month old presented with worsening respiratory distress over 6 weeks. He had no antecedent signs or symptoms of respiratory infection. Chest radiograph demonstrated a lucent hemithorax concerning for tension pneu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23257

    authors: Ehsan Z,Nathan JD,Kercsmar CM

    更新日期:2015-12-01 00:00:00

  • Longitudinal assessment of lung function in children with sickle cell disease.

    abstract:OBJECTIVES:To prospectively assess longitudinal lung function in children with sickle cell disease (SCD). WORKING HYPOTHESIS:Lung function in SCD children deteriorates with increasing age and the decline is more marked in younger children who have recently suffered ACS episodes. STUDY DESIGN:Two prospective longitudi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23367

    authors: Lunt A,McGhee E,Sylvester K,Rafferty G,Dick M,Rees D,Height S,Thein SL,Greenough A

    更新日期:2016-07-01 00:00:00

  • Fine needle aspiration biopsy cytology as an adjunct in the diagnosis of childhood sarcoidosis.

    abstract::Fine needle aspiration biopsy cytology performed in three children with sarcoidosis expedited clinical investigation and diagnosis of their disease. Each patient had a different clinical presentation; in two of them lymphoma was part of the initial differential diagnosis. Aspiration cytology in all cases revealed coll...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950130211

    authors: Wakely PE Jr,Silverman JF,Holbrook CT,Fairman RP,Daeschner CW 3rd,Joshi VV

    更新日期:1992-06-01 00:00:00

  • Performance of a tracheostomy removal protocol for pediatric patients in rehabilitation after acquired brain injury: Factors associated with timing and possibility of decannulation.

    abstract:OBJECTIVES:We assessed the performance of a tracheostomy decannulation protocol privileging safety over quickness, in pediatric patients undergoing rehabilitation from severe acquired brain injury. We analyzed factors associated with decannulation timing and possibility and examined cases of failure. HYPOTHESIS:A safe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23832

    authors: Pozzi M,Galbiati S,Locatelli F,Clementi E,Strazzer S

    更新日期:2017-11-01 00:00:00

  • Comparison of different dosing strategies of intratracheally instilled budesonide on meconium injured piglet lungs.

    abstract:BACKGROUND:Severe inflammation plays a vital role in the pathogenesis of meconium aspiration syndrome (MAS). Intratracheal (IT) instillation of corticosteroids may be beneficial for MAS in optimizing local effect and reducing systemic adverse effects, but the optimum dosing course remains open to question. METHODS:Thi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23697

    authors: Lin CH,Jeng MJ,Yang YC,Hsiao YH,Kou YR

    更新日期:2017-07-01 00:00:00

  • Effect of eosinophil peroxidase on airway epithelial permeability in the guinea pig.

    abstract::Increased numbers of eosinophils and increased concentrations of plasma proteins have been found in the airways of patients with mild asthma. We used an intact guinea pig trachea model to investigate the role of eosinophil peroxidase (EPO) in altering the function of the airway epithelial barrier. EPO in the presence ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199603)21:3<159::AID-PPUL2

    authors: Brottman GM,Regelmann WE,Slungaard A,Wangensteen OD

    更新日期:1996-03-01 00:00:00

  • Efficacy of fiberoptic bronchoscopy and bronchoalveolar lavage in childhood-onset, complicated plastic bronchitis.

    abstract:BACKGROUND:Plastic bronchitis (PB) is a rare, variable, and potentially fatal disease. This study aimed to assess the efficacy of fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in treating children with PB. METHODS:In total, 15 children with PB, between 2012 and 2020, were enrolled in our study. Within...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25016

    authors: Wang L,Wang W,Sun JM,Ni SW,Ding JL,Zhu YL,Ding SG

    更新日期:2020-11-01 00:00:00

  • Effectivenesss of ivacaftor in severe cystic fibrosis patients and non-G551D gating mutations.

    abstract:BACKGROUND:Ivacaftor is a significant innovation in the treatment of cystic fibrosis (CF) with gating mutations. A substantial percentage of patients with CF have severe lung involvement, but these patients are usually excluded from phase III clinical trials. Thus, the effectiveness of ivacaftor in this population has ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24424

    authors: Salvatore D,Carnovale V,Iacotucci P,Braggion C,Castellani C,Cimino G,Colangelo C,Francalanci M,Leonetti G,Lucidi V,Manca A,Vitullo P,Ferrara N

    更新日期:2019-09-01 00:00:00

  • Tuberculosis of the endothoracic fascia.

    abstract::A 13-year-old boy presented with a history of respiratory infection that had progressed for 3 months. A chest X-ray showed pathological findings that suggested endothoracic fascia compromise (Skarby sign). The thorax computerized axial tomography scan revealed multiple opacities in the fascia. A biopsy was performed, ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20379

    authors: Broglia B,Bisero E,Sclavo L,Andreozzi P

    更新日期:2006-05-01 00:00:00

  • Recruitment of intercostal muscle activity during hypercapnia in kittens.

    abstract::Little is known about the respiratory behavior of the intercostal muscles within a neonatal and developmental context. We, therefore, examined intercostal muscle electromyographic (EMG) activity in kittens (1 month old, n = 8; 2 months old, n = 7) during eupnea and heightened respiratory drive induced by hypercapnia. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050407

    authors: Watchko JF,Klesh KW,O'Day TL,Guthrie RD

    更新日期:1988-01-01 00:00:00

  • Pulmonary complications after bone marrow transplantation in children: twenty-four years of experience in a single pediatric center.

    abstract::In children, pulmonary sequelae contribute to early and late morbidity after bone marrow transplantation (BMT). Between 1975-1999, we performed 152 BMTs in 138 pediatric patients with malignant and nonmalignant diseases. Allogenic bone marrow was used from 99 HLA identical siblings and from 23 other related or unrelat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200011)30:5<393::aid-ppul5>3.0.c

    authors: Griese M,Rampf U,Hofmann D,Führer M,Reinhardt D,Bender-Götze C

    更新日期:2000-11-01 00:00:00

  • Descriptive analysis of central sleep apnea in childhood at a single center.

    abstract:UNLABELLED:Data on central sleep apnea (CSA) and its significance in children are limited. Our objectives were to describe the polysomnogram (PSG) characteristics and clinical features of children with significant CSA at a single pediatric sleep center. STUDY DESIGN AND METHODS:A retrospective chart review of children...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21469

    authors: Kritzinger FE,Al-Saleh S,Narang I

    更新日期:2011-10-01 00:00:00