Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis.

abstract：:The structure, distribution, and frequency of neuroendocrine (NE) cells in human fetal lung from early stages of development to term are described. Neuroendocrine cells were studied by electron microscopy and immunostaining for serotonin and bombesin, recently identified markers of these cells in human lung. The diffe...

journal_title：Pediatric pulmonology

authors： Cutz E,Gillan JE,Bryan AC

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Asthma and obstructive sleep apnea (OSA) in children share multiple epidemiological risk factors and the prevalence of snoring is higher in asthmatic children, suggesting that the latter may be at increased risk for OSA. Since both asthma and OSA are inflammatory disorders, we hypothesized that polysomnograp...

journal_title：Pediatric pulmonology

authors： Kheirandish-Gozal L,Dayyat EA,Eid NS,Morton RL,Gozal D

更新日期：2011-09-01 00:00:00

abstract：:Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in patients with cystic fibrosis (CF). We postulated that if dornase alfa could be delivered more peripherally to small airways in the lung in the form of smaller aerosol droplets in patients with ...

journal_title：Pediatric pulmonology

authors： Geller DE,Eigen H,Fiel SB,Clark A,Lamarre AP,Johnson CA,Konstan MW

更新日期：1998-02-01 00:00:00

abstract：:Sleep disordered breathing (SDB) represents a spectrum of breathing disorders, ranging from snoring to obstructive sleep apnea syndrome (OSAS), that disrupt nocturnal respiration and sleep architecture. OSAS is a common disorder in children, with a prevalence of 2-3%. It is associated with neurobehavioral, cognitive, ...

journal_title：Pediatric pulmonology

authors： Goldbart AD,Tal A

更新日期：2008-12-01 00:00:00

abstract：:Previous research has demonstrated the potential benefit derived from the combination of high frequency oscillatory ventilation and volume guarantee mode (HFOV-VG), a procedure that allows us to explore and control very low tidal volumes. We hypothesized that secondary spontaneous change in oscillation pressure amplit...

journal_title：Pediatric pulmonology

authors： Rodríguez Sánchez de la Blanca A,Sánchez Luna M,González Pacheco N,Ramos Navarro C,Santos González M,Tendillo Cortijo F

更新日期：2020-12-01 00:00:00

abstract：:Progressive lung disease in patients with cystic fibrosis (CF) is caused by thick secretions, which cause airway obstruction and subsequent colonization and infection by inhaled pathogenic microorganisms. Recently, recombinant human DNase has been shown to reduce the viscoelasticity of sputum in patients with cystic f...

journal_title：Pediatric pulmonology

authors： Eng PA,Morton J,Douglass JA,Riedler J,Wilson J,Robertson CF

更新日期：1996-02-01 00:00:00

abstract：UNLABELLED:Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others have not. A possible explanation for these in...

journal_title：Pediatric pulmonology

authors： Stevens TP,Dylag A,Panthagani I,Pryhuber G,Halterman J

更新日期：2010-04-01 00:00:00

abstract：:Drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a rare and severe side-effect, mainly described after intake of anticonvulsants, allopurinol, or antibiotics. It usually begins within 2 months after drug introduction. Symptoms include cutaneous rash, hematologic abnormalities, and internal orga...

journal_title：Pediatric pulmonology

authors： Gohy S,Froidure A,Lebecque P

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:There is currently no evidence-based method for defining competency in pediatric flexible bronchoscopy (FB). Based on expert opinion, guidelines using numbers of procedures have been published in defining competency for pediatric FB. The purpose of this study was to formally survey the opinion of USA pediatri...

journal_title：Pediatric pulmonology

authors： Leong AB,Green CG,Kurland G,Wood RE

更新日期：2014-06-01 00:00:00

abstract：BACKGROUND:Gastro-esophageal reflux (GOR) may contribute to lung disease in children with cystic fibrosis (CF). There is conflicting evidence regarding the effect of chest physiotherapy (CPT) in the head-down position on GOR. Furthermore, there is currently no evidence on the impact of physiotherapy on GOR as assessed ...

journal_title：Pediatric pulmonology

authors： Doumit M,Krishnan U,Jaffé A,Belessis Y

更新日期：2012-02-01 00:00:00

abstract：:Lane-Hamilton syndrome refers to the uncommon co-occurrence of idiopathic pulmonary hemosiderosis and celiac disease (CD). Three children aged between 7 and 14 years with IPH were detected to have co-existing non-diarrheal CD. Institution of gluten-free diet in each of the three children resulted in amelioration of th...

journal_title：Pediatric pulmonology

authors： Sethi GR,Singhal KK,Puri AS,Mantan M

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND:Social and family factors may influence the probability of achieving asthma control in children. Parents' quality of life has been insufficiently explored as a predictive factor linked to the probability of achieving disease control in asthmatic children. OBJECTIVE:Determine whether the parents' quality of ...

journal_title：Pediatric pulmonology

authors： Cano-Garcinuño A,Mora-Gandarillas I,Bercedo-Sanz A,Callén-Blecua MT,Castillo-Laita JA,Casares-Alonso I,Forns-Serrallonga D,Tauler-Toro E,Alonso-Bernardo LM,García-Merino Á,Moneo-Hernández I,Cortés-Rico O,Carvajal-Urueña I,Morel

更新日期：2016-07-01 00:00:00

abstract：:For patients whose asthma remains in poor control necessitating high utilization of medical services, a referral to a specialized "center of excellence" is often considered. A decade ago, we evaluated our pediatric asthma program of long-term hospitalization (median stay of 75 days) and found significant decreases in ...

journal_title：Pediatric pulmonology

authors： Bratton DL,Price M,Gavin L,Glenn K,Brenner M,Gelfand EW,Klinnert MD

更新日期：2001-03-01 00:00:00

abstract：:Lung scintigraphy has been used to evaluate the degree of pulmonary hypoplasia in infants with congenital diaphragmatic hernia (CDH). However, the relationship between lung scintigraphy and long-term outcome of CDH remains unclear. The aim of this study is to determine whether lung scintigraphy correlates with long-te...

journal_title：Pediatric pulmonology

authors： Okuyama H,Kubota A,Kawahara H,Oue T,Kitayama Y,Yagi M

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:Childhood interstitial lung disease (chILD) is a group of rare chronic and complex disorders of variable pathology. There has been no systematic review of published chILD research. This study aimed to describe chILD classification systems, epidemiology, morbidity, treatments, outcomes, and the impact of chIL...

journal_title：Pediatric pulmonology

authors： Hime NJ,Zurynski Y,Fitzgerald D,Selvadurai H,Phu A,Deverell M,Elliott EJ,Jaffe A

更新日期：2015-12-01 00:00:00

abstract：:We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume rela...

journal_title：Pediatric pulmonology

authors： Silva Neto G,Gerhardt T,Silberberg A,Gerhardt T,Claure N,Duara S,Bancalari E

更新日期：1992-03-01 00:00:00

abstract：:Ten infants with evidence of impending respiratory failure from severe bronchiolitis were successfully treated with continuous positive airway pressure (NCPAP) with double nasal prongs. Their mean (SD) age was 6.7 (3.8) months and mean (SD) body weight was 7.1 (2.1) kg. Respiratory assessments were made immediately be...

journal_title：Pediatric pulmonology

authors： Soong WJ,Hwang B,Tang RB

更新日期：1993-09-01 00:00:00

abstract：:The long-term efficacy and safety of aminoglycoside aerosol therapy for Pseudomonas aeruginosa colonization/infection in cystic fibrosis has not been fully investigated. In the present study, 14 patients with cystic fibrosis, ages 8-19 years (mean: 13.3 years), received tobramycin aerosol therapy for a mean duration o...

journal_title：Pediatric pulmonology

authors： Steinkamp G,Tümmler B,Gappa M,Albus A,Potel J,Döring G,von der Hardt H

更新日期：1989-01-01 00:00:00

abstract：:Inadequate intake and suboptimal growth are common problems for patients with CF and a critical target for intervention. The purpose of this study was to compare the growth outcomes of children with CF who participated in a randomized clinical trial to improve energy intake and weight to children with CF receiving sta...

journal_title：Pediatric pulmonology

authors： Stark LJ,Opipari-Arrigan L,Quittner AL,Bean J,Powers SW

更新日期：2011-01-01 00:00:00

abstract：:Neutrophil elastase is present at high levels in airway fluid of patients with cystic fibrosis (CF), and is responsible for considerable inflammatory damage. Human monocyte/neutrophil elastase inhibitor (MNEI), a 42-kDa serpin protein, is an effective inhibitor of neutrophil elastase, cathepsin G, and proteinase-3, re...

journal_title：Pediatric pulmonology

authors： Woods DE,Cantin A,Cooley J,Kenney DM,Remold-O'Donnell E

更新日期：2005-02-01 00:00:00

abstract：:Our objective was to determine whether postnatal respiratory function, lung growth, and lung structure are affected by preterm birth which did not require neonatal respiratory support. Two groups of preterm (P) lambs were delivered 2 weeks before term, at 133 days of gestational age (GA). Tissue was collected at term ...

journal_title：Pediatric pulmonology

authors： Cock M,Hanna M,Sozo F,Wallace M,Yawno T,Suzuki K,Maritz G,Hooper S,Harding R

更新日期：2005-10-01 00:00:00

abstract：:The aim of our study was to determine the effects of pulmonary vascular engorgement on airways and pulmonary tissues in juvenile animals before and after methacholine (Mch)-induced changes in lung function. Five anesthetized, paralyzed, and thoracotomized piglets were studied before and during pulmonary vascular engor...

journal_title：Pediatric pulmonology

authors： Wildhaber JH,Uhlig T,Sly PD

更新日期：1998-01-01 00:00:00

abstract：RATIONAL:This study aims at describing the use of bilevel positive airway pressure (BiPAP) in infants with severe bronchiolitis. WORKING HYPOTHESIS:The use of BiPAP in infants with bronchiolitis may be associated with a worst outcome. STUDY DESIGN:A single-center retrospective study performed from October 2013 to Apr...

journal_title：Pediatric pulmonology

authors： Delacroix E,Millet A,Pin I,Mortamet G

更新日期：2020-11-01 00:00:00

abstract：:Multiresistance in Stenotrophomonas maltophilia limits the effectiveness of antimicrobial therapy for infections due to this organism. It can be of special concern in cystic fibrosis (CF) patients due to frequent antimicrobial administration. The in vitro activity of 41 antimicrobial agents against 76 epidemiologicall...

journal_title：Pediatric pulmonology

authors： Cantón R,Valdezate S,Vindel A,Sánchez Del Saz B,Maíz L,Baquero F

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Ivacaftor is a significant innovation in the treatment of cystic fibrosis (CF) with gating mutations. A substantial percentage of patients with CF have severe lung involvement, but these patients are usually excluded from phase III clinical trials. Thus, the effectiveness of ivacaftor in this population has ...

journal_title：Pediatric pulmonology

authors： Salvatore D,Carnovale V,Iacotucci P,Braggion C,Castellani C,Cimino G,Colangelo C,Francalanci M,Leonetti G,Lucidi V,Manca A,Vitullo P,Ferrara N

更新日期：2019-09-01 00:00:00

abstract：OBJECTIVE:To examine cystic fibrosis (CF) physician adherence to the 2007 CF Foundation (CFF) Pulmonary Guidelines for Chronic Medications. Specifically adherence and barriers to prescribing level A medication recommendations (i.e., inhaled tobramycin and dornase alfa) and level B medication recommendations (i.e., macr...

journal_title：Pediatric pulmonology

authors： Glauser TA,Nevins PH,Williamson JC,Abdolrasulnia M,Salinas GD,Zhang J,Debonnett L,Riekert KA

更新日期：2012-05-01 00:00:00

abstract：:Pneumogram (PG) recordings were performed in 87 very low birthweight (VLBW) asymptomatic infants just prior to hospital discharge to determine the relationships between: 1) a prior history of apnea of prematurity (AOP) and cardiorespiratory pattern; and 2) cardiorespiratory pattern at hospital discharge and postconcep...

journal_title：Pediatric pulmonology

authors： Hageman JR,Holmes D,Suchy S,Hunt CE

更新日期：1988-01-01 00:00:00

abstract：:Airway inflammation of eosinophilic asthma (EA) attributes to Th2 response, leaving the role of Th17 response unknown. Signal transducer and activator of transcription 3 (STAT3) induce both suppressors of cytokine signaling 3 (SOCS3) and retinoic acid receptor-related orphan nuclear receptor γ (RORγt) to initiate Th17...

journal_title：Pediatric pulmonology

authors： Lin X,Lv J,Ge D,Bai H,Yang Y,Wu J

更新日期：2020-06-01 00:00:00

abstract：:The airway epithelium represents a primary site for the introduction and deposition of potentially pathogenic microorganisms into the body, through inspired air. The epithelial mucosa is an important component of the innate immune system that recognizes conserved structures in microorganisms and initiates appropriate ...

journal_title：Pediatric pulmonology

authors： Gómez MI,Prince A

更新日期：2008-01-01 00:00:00

abstract：:A continuous subcutaneous infusion of terbutaline (CSIT) was used to treat 8 children with chronic severe asthma who continued to experience frequent symptoms, despite treatment with regular oral prednisolone. Five patients experienced a symptomatic improvement from CSIT, leading to a reduction in regular medication. ...

journal_title：Pediatric pulmonology

authors： Payne DN,Balfour-Lynn IM,Biggart EA,Bush A,Rosenthal M

更新日期：2002-05-01 00:00:00