Effect of smaller droplet size of dornase alfa on lung function in mild cystic fibrosis. Dornase Alfa Nebulizer Group.

Abstract:

:Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in patients with cystic fibrosis (CF). We postulated that if dornase alfa could be delivered more peripherally to small airways in the lung in the form of smaller aerosol droplets in patients with early airway obstruction, the increase in pulmonary function from baseline might be improved. CF patients (n = 749) with mild lung disease (baseline forced vital capacity > or = 70% predicted) were randomly assigned to receive dornase alfa 2.5 mg daily for 2 weeks by one of two nebulizer systems: 1) the Medic-Aid Durable SideStream nebulizer powered by the MobilAire Compressor (SS/MA) producing a droplet size with a mass median aerodynamic diameter (MMAD) of 2.1 microm; or 2) the Hudson T Up-draft nebulizer with a DeVilbiss Pulmo-Aide compressor (HT/PA) with an MMAD of 4.9 microm. Spirometry was performed at baseline and following 14 days of treatment. Dornase alfa delivered by both nebulizer systems produced small but statistically significant improvements in pulmonary function compared with baseline. There was a trend (P = 0.06) toward greater improvement in forced expiratory flow in 1 s in the SS/MA group (4.3%) compared with the HT/PA group (2.5%). These results indicate that the short-term spirometric response to dornase alfa is influenced in part by the physical characteristics of the aerosol in patients with mild lung disease. We speculate that this may be true for other therapeutic aerosols, and it appears that localization of disease in the lung plays a role in the response to inhaled agents.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Geller DE,Eigen H,Fiel SB,Clark A,Lamarre AP,Johnson CA,Konstan MW

doi

10.1002/(sici)1099-0496(199802)25:2<83::aid-ppul2>

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

83-7

issue

2

eissn

8755-6863

issn

1099-0496

pii

10.1002/(SICI)1099-0496(199802)25:2<83::AID-PPUL2>

journal_volume

25

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
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    journal_title:Pediatric pulmonology

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    journal_title:Pediatric pulmonology

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    更新日期:2013-12-01 00:00:00

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    更新日期:1995-05-01 00:00:00

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    更新日期:2020-12-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/ppul.21287

    authors: Ferrero F,Nascimento-Carvalho CM,Cardoso MR,Camargos P,March MF,Berezin E,Ruvinsky R,Sant'Anna C,Feris-Iglesias J,Maggi R,Benguigui Y,CARIBE group.

    更新日期:2010-10-01 00:00:00

  • Connective tissue, mechanical, and morphometric changes in the lungs of weanling rats fed a low protein diet.

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    pub_type: 杂志文章

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    更新日期:1989-01-01 00:00:00

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

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    更新日期:2009-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2017-07-01 00:00:00

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(200002)29:2<103::aid-ppul4

    authors: Thulesen J,Poulsen SS,Nexø E,Raaberg L

    更新日期:2000-02-01 00:00:00

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22595

    authors: Xu Z,Li B,Shen K

    更新日期:2013-03-01 00:00:00

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    abstract::Episodes of respiratory distress with chest retraction and wheezing, sometimes associated with facial edema, were noted after administering the proton pump inhibitors omeprazole and esomeprazole in an infant with gastroesophageal reflux. The disturbances relieved dramatically after withdrawing the proton pump inhibito...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20616

    authors: Baldassarre E,Sagaon MM,Ferrarini A,Bianchetti MG

    更新日期:2007-06-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1002/ppul.1950070412

    authors: Galdès-Sebaldt M,Sheller JR,Grogaard J,Stahlman M

    更新日期:1989-01-01 00:00:00

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    pub_type: 杂志文章

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    authors: Elders BBLJ,Hermelijn SM,Tiddens HAWM,Pullens B,Wielopolski PA,Ciet P

    更新日期:2019-04-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199712)24:6<391::aid-ppul3

    authors: Lødrup Carlsen KC,Stenzler A,Carlsen KH

    更新日期:1997-12-01 00:00:00

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23913

    authors: O'Connor MG,Suthar D,Vera K,Slaughter JC,Maitre NL,Steele S,Beller A,Fike CD,Aschner JL,Moore PE,Austin ED

    更新日期:2018-03-01 00:00:00

  • Conservative management of pediatric tracheal rupture.

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    pub_type: 杂志文章

    doi:10.1002/ppul.23507

    authors: Sidell DR,Wood RE,Hart CK

    更新日期:2017-01-01 00:00:00

  • Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease.

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    pub_type: 杂志文章

    doi:10.1002/ppul.20393

    authors: Montgomery GS,Sagel SD,Taylor AL,Abman SH

    更新日期:2006-04-01 00:00:00

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    abstract::Asthma has been found related to a higher risk of psychological problems. Inconsistent results have been reported with respect to the quality of life of children with asthma. So there may be a complex relationship between asthma severity, quality of life, and psychological factors. The aim of this study was to examine...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20509

    authors: Goldbeck L,Koffmane K,Lecheler J,Thiessen K,Fegert JM

    更新日期:2007-01-01 00:00:00

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    abstract::Tracheal mucosal damage has been reported in autopsy specimens of cases with proximal esophageal atresia and distal tracheoesophageal fistula (EA-TEF) (Gross classification type C). Such changes have not been reported for isolated EA (Gross classification type A). Our hypothesis is that passage of amniotic fluid (AF) ...

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    pub_type: 杂志文章

    doi:10.1002/ppul.20490

    authors: Ateş O,Hakgüder G,Olguner M,Ozer E,Akgür FM

    更新日期:2006-11-01 00:00:00

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21183

    authors: Brouwer AF,Visser CA,Duiverman EJ,Roorda RJ,Brand PL

    更新日期:2010-04-01 00:00:00

  • Short and long interpregnancy interval and the risk for pediatric obstructive sleep apnea in the offspring.

    abstract:INTRODUCTION:Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI < 6 months) and long IPI (IPI > 60 months) have been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25240

    authors: Rapaport Pasternak H,Sheiner E,Goldbart A,Wainstock T

    更新日期:2020-12-31 00:00:00

  • Pulmonary renal syndrome in childhood: a report of twenty-one cases and a review of the literature.

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    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1099-0496(200005)29:5<382::aid-ppul7

    authors: von Vigier RO,Trummler SA,Laux-End R,Sauvain MJ,Truttmann AC,Bianchetti MG

    更新日期:2000-05-01 00:00:00

  • Ability of new lung function tests to assess methacholine-induced airway obstruction in infants.

    abstract::We assessed the ability of innovative lung function tests to detect bronchial obstruction induced by methacholine bronchial challenge. Fifty-five recurrently wheezy infants (mean age 16 +/- 5.2 months) free of respiratory symptoms underwent baseline lung function tests. Forty-two completed the methacholine challenge. ...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ppul.1950180508

    authors: Benoist MR,Brouard JJ,Rufin P,Delacourt C,Waernessyckle S,Scheinmann P

    更新日期:1994-11-01 00:00:00

  • RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.

    abstract::Short-acting β2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to β2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22723

    authors: Labuda M,Laberge S,Brière J,Bérubé D,Krajinovic M

    更新日期:2013-10-01 00:00:00

  • Pseudomonas aeruginosa and Burkholderia cepacia cannot be detected by PCR in the breath condensate of patients with cystic fibrosis.

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    pub_type: 杂志文章

    doi:10.1002/ppul.10352

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    更新日期:2003-10-01 00:00:00

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    pub_type: 杂志文章,评审

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    doi:10.1002/ppul.1122

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  • Glucocorticoid receptor disruption delays structural maturation in the lungs of newborn mice.

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    pub_type: 杂志文章

    doi:10.1002/ppul.20746

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    更新日期:2008-02-01 00:00:00

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    doi:10.1002/ppul.1950010605

    authors: Berdel D,Kellersmann U

    更新日期:1985-11-01 00:00:00

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    abstract::Corticosteroids continue to be used by many physicians to treat infants with bronchiolitis. The aim of this study was to examine the short-term and long-term efficacy of oral corticosteroid therapy when added to beta2-agonists in infants with mild to moderate bronchiolitis (defined as the first episode of wheezing ass...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1099-0496(199809)26:3<162::aid-ppul2

    authors: Berger I,Argaman Z,Schwartz SB,Segal E,Kiderman A,Branski D,Kerem E

    更新日期:1998-09-01 00:00:00