Prematurity is associated with abnormal airway function in childhood.

Abstract:

:To evaluate the long-term effect of prematurity and/or hyaline membrane disease (HMD) on pulmonary function and airway reactivity, we studied 49 prematurely born children aged 10 to 13 years. They were divided into three groups according to birth weight and HMD status: Groups I and II comprised the children weighing less than 1,500 g at birth, and Group III those whose birth weight exceeded 1,500 g. Children without HMD at birth were classified as Group I and those with HMD as Group II or III. We performed both pulmonary function tests and methacholine (MCh) challenges and compared the results with those of 27 age-matched controls born at term. We found that FEV1 and RV/TLC ratios were significantly different from control values in the groups with birth weights less than 1,500 g, regardless of their HMD status (Groups I and II). In Group I, results for FEF25-75%, Vmax50%, and DLCO were lower than those of controls. Airway reactivity was significantly increased in Groups I and II. A 20% drop in FEV1 after MCh challenge was found in 88%, 62%, 53%, and 36% of children in Groups I, II, and III and controls, respectively, and a 35% drop in SGaw occurred in 87%, 88%, 53%, and 59%. We conclude that prematurity and not HMD per se leads to long-term pulmonary abnormalities and to an increase in nonspecific airway reactivity.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Galdès-Sebaldt M,Sheller JR,Grogaard J,Stahlman M

doi

10.1002/ppul.1950070412

subject

Has Abstract

pub_date

1989-01-01 00:00:00

pages

259-64

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

7

pub_type

杂志文章
  • Dynamics of nasopharyngeal pneumococcal carriage during the course of viral bronchiolitis.

    abstract::The effect of viral infection on nasopharyngeal carriage of Streptococcus pneumoniae during childhood is not well known. We studied dynamics of pneumococcal colonization by quantitative PCR during the natural course of viral bronchiolitis. At time of admission, 47 (47%) of 100 patients with bronchiolitis carried pneum...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23390

    authors: Faber TE,Schuurs TA,Veeger NJ,Hennus MP,Bont LJ

    更新日期:2016-08-01 00:00:00

  • Standardized procedure for measurement of nasal potential difference: an outcome measure in multicenter cystic fibrosis clinical trials.

    abstract::Patients with cystic fibrosis (CF) can be discriminated from healthy subjects by measurement of the nasal potential difference, which has become a useful outcome measure for therapies directed toward correcting defective electrolyte transport in CF. A standard operating procedure was developed by a CF Foundation clini...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.10448

    authors: Standaert TA,Boitano L,Emerson J,Milgram LJ,Konstan MW,Hunter J,Berclaz PY,Brass L,Zeitlin PL,Hammond K,Davies Z,Foy C,Noone PG,Knowles MR

    更新日期:2004-05-01 00:00:00

  • US pediatric pulmonology workforce.

    abstract:AIM:Children with respiratory conditions benefit from care provided by pediatric pulmonologists. As these physicians are a small portion of the overall pediatric workforce, it is necessary to understand the practices and career plans of these specialists. METHODS:An internet survey was developed by the American Academ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24253

    authors: Harris C,Katkin J,Cataletto M,Dorkin H,Laskosz L,Ruch-Ross H

    更新日期:2019-04-01 00:00:00

  • Inflammation and sleep disordered breathing in children: a state-of-the-art review.

    abstract::Sleep disordered breathing (SDB) represents a spectrum of breathing disorders, ranging from snoring to obstructive sleep apnea syndrome (OSAS), that disrupt nocturnal respiration and sleep architecture. OSAS is a common disorder in children, with a prevalence of 2-3%. It is associated with neurobehavioral, cognitive, ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20943

    authors: Goldbart AD,Tal A

    更新日期:2008-12-01 00:00:00

  • Long-term tobramycin aerosol therapy in cystic fibrosis.

    abstract::The long-term efficacy and safety of aminoglycoside aerosol therapy for Pseudomonas aeruginosa colonization/infection in cystic fibrosis has not been fully investigated. In the present study, 14 patients with cystic fibrosis, ages 8-19 years (mean: 13.3 years), received tobramycin aerosol therapy for a mean duration o...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950060207

    authors: Steinkamp G,Tümmler B,Gappa M,Albus A,Potel J,Döring G,von der Hardt H

    更新日期:1989-01-01 00:00:00

  • Identification of CFTR variants in Latino patients with cystic fibrosis from the Dominican Republic and Puerto Rico.

    abstract:BACKGROUND:In cystic fibrosis (CF), the spectrum and frequency of CFTR variants differ by geography and race/ethnicity. CFTR variants in White patients are well-described compared with Latino patients. No studies of CFTR variants have been done in patients with CF in the Dominican Republic or Puerto Rico. METHODS:CFTR...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24549

    authors: Zeiger AM,McGarry ME,Mak ACY,Medina V,Salazar S,Eng C,Liu AK,Oh SS,Nuckton TJ,Jain D,Blackwell TW,Kang HM,Abecasis G,Oñate LC,Seibold MA,Burchard EG,Rodriguez-Santana J

    更新日期:2020-02-01 00:00:00

  • The lung is involved in juvenile dermatomyositis.

    abstract:BACKGROUND:Juvenile dermatomyositis (JDM) is the main cause of chronic idiopathic inflammatory myopathy of autoimmune origin in children. The aim of this multicenter prospective study was to describe respiratory status and treatment of children followed for JDM. METHODS AND PATIENTS:Clinical manifestations, pulmonary ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.22742

    authors: Pouessel G,Deschildre A,Le Bourgeois M,Cuisset JM,Catteau B,Karila C,Nève V,Thumerelle C,Quartier P,Tillie-Leblond I

    更新日期:2013-10-01 00:00:00

  • Respiratory morbidity in children with profound intellectual and multiple disability.

    abstract:BACKGROUND:'Profound intellectual and multiple disability' (PIMD) is defined as a profound cognitive disability with severe sensory and motor impairments. The aim of this study was to evaluate the respiratory morbidity in children with PIMD and investigate possible risk factors. METHODS:In 10 specialized facilities fo...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23114

    authors: Proesmans M,Vreys M,Huenaerts E,Haest E,Coremans S,Vermeulen F,Feys H

    更新日期:2015-10-01 00:00:00

  • Pediatric pulmonology year in review 2016: Part 2.

    abstract::Pediatric Pulmonology continues to publish research and clinical topics related to the entire range of children's respiratory disorders. As we have done annually in recent years, we here summarize some of the past year's publications in our major topic areas, as well as selected literature in these areas from other co...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23719

    authors: Auten R,Ren C,Yilmaz O,Noah TL

    更新日期:2017-09-01 00:00:00

  • Effect of spontaneous and mechanical breathing on dynamic lung mechanics in hyaline membrane disease.

    abstract::We measured then compared the dynamic lung mechanics of spontaneous breaths and mechanical breaths in 9 mechanically ventilated neonates with hyaline membrane disease. All were receiving intermittent mandatory ventilation. All breathed spontaneously between ventilator breaths. Tidal volume, transpulmonary pressure, dy...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950080403

    authors: Mammel MC,Fisher JB,Bing DR,Gatto CW,Boros SJ

    更新日期:1990-01-01 00:00:00

  • AMPK and FoxO1 regulate catalase expression in hypoxic pulmonary arterial smooth muscle.

    abstract:BACKGROUND:Hypoxia and reactive oxygen species (ROS) including H(2)O(2) play major roles in triggering and progression of pulmonary vascular remodeling in persistent pulmonary hypertension. Catalase (CAT), the major endogenous enzyme scavenging H(2)O(2), is regulated in a tissue- and context-specific manner. OBJECTIVE...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22919

    authors: Awad H,Nolette N,Hinton M,Dakshinamurti S

    更新日期:2014-09-01 00:00:00

  • Appetite stimulants use in cystic fibrosis.

    abstract::Cystic fibrosis (CF) is an autosomal recessive disease. It affects multiple body organs. The lungs and pancreas are the most affected which results in progressive lung damage and pancreatic insufficiency. Due to the disease process, CF patients require significantly higher caloric intake than recommended for other ind...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20766

    authors: Nasr SZ,Drury D

    更新日期:2008-03-01 00:00:00

  • Morphometric and biochemical changes in lungs of growing rats treated with a calmodulin antagonist.

    abstract::To determine the role of calmodulin in postnatal lung growth and development, 4-week-old rats were injected intraperitoneally on consecutive days with trifluoperazine (TFP), a potent and specific calmodulin antagonist, for a period fo 3 weeks and studied in comparison with normal controls and undernourished weight-mat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100110

    authors: Ofulue AF,Sekhon H,Cherukupalli K,Khadempour H,Thurlbeck WM

    更新日期:1991-01-01 00:00:00

  • Interleukin-10 -1082 G/A polymorphism and risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants.

    abstract::IL-10 is an anti-inflammatory cytokine that may have a protective role in acute lung injury. IL-10 expression is affected by a single-nucleotide polymorphism (SNP) located at position -1082 (G to A). The A allele is associated with lower IL-10 production. Low IL-10 production has been linked to the development of BPD....

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20182

    authors: Yanamandra K,Boggs P,Loggins J,Baier RJ

    更新日期:2005-05-01 00:00:00

  • Elimination of Australian epidemic strain (AES1) pseudomonas aeruginosa in a pediatric cystic fibrosis center.

    abstract:INTRODUCTION:In this cohort study spanning an 18-year period, we evaluated the prevalence and associated mortality rate of epidemic strains of pseudomonas aeruginosa (PsA), especially Australian Epidemic Strain Type 1 (AES1), in a pediatric cystic fibrosis center practicing cohort segregation and early PsA eradication....

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24173

    authors: Kevat A,Carzino R,Massie J,Harrison J,Griffiths AL

    更新日期:2018-11-01 00:00:00

  • Respiratory syncytial virus infections in SR Croatia, Yugoslavia.

    abstract::The prevalence of respiratory syncytial virus (RSV) infection was studied during three consecutive annual outbreaks (1983-1986) in SR Croatia, Yugoslavia. A total of 1,238 subjects were examined, using RSV isolation and immunofluorescent (DTFA) methods, with 1,042 showing the signs of respiratory infection and 207 of ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030505

    authors: Mlinarić-Galinović G,Ugrcić I,Bozikov J

    更新日期:1987-09-01 00:00:00

  • Lung clearance index: normal values, repeatability, and reproducibility in healthy children and adolescents.

    abstract::There is increasing interest in using the Multiple Breath Washout technique and the lung clearance index (LCI) for detecting early pulmonary changes, for example, in cystic fibrosis lung disease. However, there are still limited data regarding equipment specific reference ranges, repeatability and reproducibility. The...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21093

    authors: Fuchs SI,Eder J,Ellemunter H,Gappa M

    更新日期:2009-12-01 00:00:00

  • Impact of a multidisciplinary day program on disease and healthcare costs in children and adolescents with severe asthma: a two-year follow-up study.

    abstract::For patients whose asthma remains in poor control necessitating high utilization of medical services, a referral to a specialized "center of excellence" is often considered. A decade ago, we evaluated our pediatric asthma program of long-term hospitalization (median stay of 75 days) and found significant decreases in ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1027

    authors: Bratton DL,Price M,Gavin L,Glenn K,Brenner M,Gelfand EW,Klinnert MD

    更新日期:2001-03-01 00:00:00

  • Induced sputum to detect lung pathogens in young children with cystic fibrosis.

    abstract:INTRODUCTION:Induced sputum sampling holds promise as a method for obtaining samples representative of the lower airways in young children. Collection of induced sputum samples in young children differs from older children and adults' as pharyngeal suctioning is often required. Our aim was to determine the sensitivity ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23636

    authors: D'Sylva P,Caudri D,Shaw N,Turkovic L,Douglas T,Bew J,Keil AD,Stick S,Schultz A

    更新日期:2017-02-01 00:00:00

  • Respiratory inductive plethysmography in the evaluation of lower airway obstruction during methacholine challenge in infants.

    abstract::Respiratory inductive plethysmography (RIP) is a simple technique for an objective, noninvasive assessment of thoracoabdominal asynchrony, which in turn is an indirect measure of airway obstruction. We evaluated different indices of asynchrony obtained by RIP before and after methacholine-induced airway obstruction. B...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950200610

    authors: Rusconi F,Gagliardi L,Aston H,Silverman M

    更新日期:1995-12-01 00:00:00

  • Subcutaneous emphysema secondary to foreign-body aspiration.

    abstract::Pneumomediastinum is uncommon in pediatric medical practice, outside the neonatal period. While asthma or respiratory infections are the most frequent underlying causes, it is important not to forget the possibility of foreign body aspiration, particularly after the clinical presentation. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10295

    authors: Findlay CA,Morrissey S,Paton JY

    更新日期:2003-07-01 00:00:00

  • Normal values for forced oscillatory respiratory resistance in children.

    abstract::Forced oscillatory respiratory resistance was measured in 138 healthy children aged 2- to 16-years-old using a commercial unit. Regression analysis was performed using the resistance measurements obtained at frequencies of 6 Hz and 26 Hz and averages of measurements obtained at frequencies of from 6-26 Hz, 6-10 Hz, an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010305

    authors: Hordvik NL,König P,Morris DA,Kreutz C,Pimmel RL

    更新日期:1985-05-01 00:00:00

  • Modifiable lifestyle factors impact airway health in non-asthmatic prepubescent boys but not girls.

    abstract:INTRODUCTION:The prevalence of both childhood obesity and childhood asthma has increased dramatically over the past few decades. Little is known concerning the role of body composition and lifestyle influences on airway health in children. PURPOSE:To determine whether body composition, fruit and vegetable intake (FV) ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21393

    authors: Rosenkranz SK,Swain KE,Rosenkranz RR,Beckman B,Harms CA

    更新日期:2011-05-01 00:00:00

  • Apnea and periodic breathing in normal full-term infants during the first twelve months.

    abstract::The pediatric pneumogram is a frequently used tool in the diagnosis and management of apnea during infancy. We analyzed 287 pneumographic recordings from 123 full-term infants (63 males) obtained during the first 12 months of life to establish normative values for apnea, periodic breathing, and bradycardia. The result...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010409

    authors: Kelly DH,Stellwagen LM,Kaitz E,Shannon DC

    更新日期:1985-07-01 00:00:00

  • Is home spirometry useful in diagnosing asthma in children with nonspecific respiratory symptoms?

    abstract:BACKGROUND:Variation of lung function is considered to be a hallmark of asthma. Although guidelines recommend measuring it as a diagnostic tool for asthma, the usefulness of this approach has not been studied in children. AIM:To assess the usefulness of home spirometry in children with nonspecific lower respiratory tr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21183

    authors: Brouwer AF,Visser CA,Duiverman EJ,Roorda RJ,Brand PL

    更新日期:2010-04-01 00:00:00

  • Determinants of cough and caregivers' quality of life in pediatric asthma exacerbations.

    abstract:OBJECTIVES:In hospitalized and nonhospitalized children with asthma exacerbations, we evaluated the determinants of (a) prolonged cough on day-14 and (b) asthma quality of life (QoL) questionnaires for parents (PACQLQ) on day-21. We hypothesized that children with more severe acute asthma are more likely to have prolon...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25168

    authors: Teoh L,Chatfield MD,Acworth JP,McCallum GB,Chang AB

    更新日期:2020-11-12 00:00:00

  • Adolescent girls with asthma have worse asthma control and health-related quality of life than boys-A population based study.

    abstract:BACKGROUND:Population-based studies investigating health-related quality of life (HRQoL) among asthmatic adolescents are rare. Further, among subjects with asthma, HRQoL may be affected by asthma control and severity. AIM:To investigate HRQoL in relation to asthma control and asthma severity among adolescents. METHOD...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23723

    authors: Stridsman C,Backman H,Eklund BM,Rönmark E,Hedman L

    更新日期:2017-07-01 00:00:00

  • Alveolar data in healthy, awake neonates during spontaneous ventilation: a preliminary investigation.

    abstract::A computerized method for the measurement of alveolar ventilation (VA) and the mean alveolar partial pressures of CO2 and O2 is described and tested in healthy, awake fullterm (FT) newborns and preterm (PT) infants (postnatal age 40 days). This study emphasizes the technical pitfalls generally encountered when dealing...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050409

    authors: Lagneaux D,Mossay C,Geubelle F,Christiaens G

    更新日期:1988-01-01 00:00:00

  • Pulmonary dysfunction after primary closure of an abdominal wall defect and its improvement with bronchodilators.

    abstract::To determine the extent of pulmonary dysfunction following primary closure of an abdominal wall defect, we obtained pulmonary function tests (PFT) in 11 newborn infants with gastroschisis and 6 with large omphaloceles admitted to a newborn ICU in a children's hospital. Patients were 1 to 30 days of age at the time of ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950120309

    authors: Nakayama DK,Mutich R,Motoyama EK

    更新日期:1992-03-01 00:00:00

  • Pulmonary interstitial glycogenosis: Diagnostic evaluation and clinical course.

    abstract:OBJECTIVES:We sought to describe the phenotype for patients with P.I.G. including presentation, evaluation, cardiac co-morbidities, high resolution computed tomography findings, and outcomes. METHODS:With institutional review board approval, we performed a retrospective review of patients with biopsy-proven P.I.G. Bio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24123

    authors: Liptzin DR,Baker CD,Darst JR,Weinman JP,Dishop MK,Galambos C,Brinton JT,Deterding RR

    更新日期:2018-12-01 00:00:00