Short and long interpregnancy interval and the risk for pediatric obstructive sleep apnea in the offspring.


INTRODUCTION:Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI < 6 months) and long IPI (IPI > 60 months) have been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep apnea syndrome (OSAS) in the offspring. AIMS:To study the association between IPI and risk for offspring OSAS, during a follow-up period of up to 18 years. STUDY DESIGN:Population-based cohort. SUBJECTS:In this population-based cohort analysis, all singleton live births, born to a mother with at least one previous birth occurring between 1991 and 2014, were included. Congenital malformations were excluded. MATERIALS AND METHODS:Hospitalizations of the offspring due to OSAS diagnosis up to 18 years of age, were evaluated according to IPI length. Intermediate IPI (6-60 months) was considered as the reference. A Kaplan-Meier survival curve and a Cox hazards regression model were used to compare the incidence of OSAS between the groups, and to adjust for confounding variables. RESULTS:The study population included 144,397 deliveries, of which 13.1% (n = 18,947) were followed by short IPI, 7.9% (n = 11,438) and 79.0% (n = 114,012) were followed by long and intermediate IPI, respectively. OSAS hospitalization rates were significantly higher among the long IPI group compared to intermediate and short IPIs (0.9%; 0.7% and 0.6%, respectively, p = .001). The association between long IPI and offspring pediatric OSAS remained significant after controlling for preterm delivery, maternal diabetes, and smoking, and mode of delivery, (adjusted HR = 1.45; 95% CI, 1.17-1.80). CONCLUSIONS:Children born following long IPI are at increased risk for pediatric OSAS.


Pediatr Pulmonol


Pediatric pulmonology


Rapaport Pasternak H,Sheiner E,Goldbart A,Wainstock T




Has Abstract


2020-12-31 00:00:00






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