Partitioning of alterations in pulmonary mechanics due to vascular engorgement in piglets.

Abstract:

:The aim of our study was to determine the effects of pulmonary vascular engorgement on airways and pulmonary tissues in juvenile animals before and after methacholine (Mch)-induced changes in lung function. Five anesthetized, paralyzed, and thoracotomized piglets were studied before and during pulmonary vascular engorgement, induced by inflating a left atrial balloon catheter and by calculating respiratory mechanics from measurements of airway opening (Pao) and alveolar pressures (PA), respiratory flow (V'), and volume (V) recorded during mechanical ventilation, using the multilinear regression technique. A maximal increase of 15 mmHg in pulmonary artery pressure (Ppa) resulted in a mean increase in total lung elastance (EL) of 28.6% and in total lung resistance (RL) of 14.9%. Mch increased EL by 21.7% and RL by 29.0%. Inflation of the left atrial balloon with an associated increase in Ppa by 15 mmHg in the presence of Mch resulted in an increase in EL by a further 12.4% (to 135.4% of baseline) and in RL by a further 9.0% (to 139.5% of baseline). The change in RL was associated with a qualitatively similar change in both tissue resistance (Vti) and airway resistance (Raw) before and after Mch-induced changes in lung function. We conclude that increasing pulmonary vascular pressures, by increasing left partial pressure, alters lung function in juvenile animals by altering the mechanical properties of both airways and lung tissues. The methods used in the present study allow a direct assessment of the site of action of vascular engorgement in the lungs and provide a useful model for studying this phenomenon further.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Wildhaber JH,Uhlig T,Sly PD

doi

10.1002/(sici)1099-0496(199801)25:1<45::aid-ppul5>

subject

Has Abstract

pub_date

1998-01-01 00:00:00

pages

45-51

issue

1

eissn

8755-6863

issn

1099-0496

pii

10.1002/(SICI)1099-0496(199801)25:1<45::AID-PPUL5>

journal_volume

25

pub_type

杂志文章
  • Pulmonary function sequelae after respiratory syncytial virus lower respiratory tract infection in children: A systematic review.

    abstract::Respiratory syncytial virus (RSV) lower respiratory tract infection (LRTI) during early childhood may be associated with subsequent pulmonary sequelae, including recurrent wheezing and asthma. We undertook a systematic review to investigate the pulmonary function sequelae following RSV LRTI in the first 3 years of lif...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24804

    authors: Verwey C,Nunes MC,Dangor Z,Madhi SA

    更新日期:2020-07-01 00:00:00

  • Sodium cromoglycate and carbachol-induced bronchoprovocation in asthmatic children.

    abstract::Ten children with mild bronchial asthma underwent bronchial challenge with carbachol on three consecutive days; using a double-blind technique, they were given inhaled saline placebo on the first day and placebo or sodium cromoglycate (SCG) on the second and third days 15 min prior to the bronchial provocation test wi...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ppul.1950030309

    authors: Barbato A,Pisetta F,Mesirca P,Ragusa A,Zacchello F

    更新日期:1987-05-01 00:00:00

  • Nocturnal dry cough in the first 7 years of life is associated with asthma at school age.

    abstract:BACKGROUND:Childhood wheeze is an important, well-known risk factor for asthma, yet little is known about the contribution of nocturnal dry cough. We investigated the association of nocturnal dry cough at ages 1-7 years with doctor-diagnosed asthma at 8 years of age, both in the presence and absence of wheeze. METHODS...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23092

    authors: Boudewijn IM,Savenije OE,Koppelman GH,Wijga AH,Smit HA,de Jongste JC,Gehring U,Postma DS,Kerkhof M

    更新日期:2015-09-01 00:00:00

  • The use of biologic therapies for the management of pediatric asthma.

    abstract::With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24613

    authors: Lovinsky-Desir S

    更新日期:2020-03-01 00:00:00

  • Respiratory morbidity 20 years after RSV infection in infancy.

    abstract::Epidemiological data suggest that respiratory syncytial virus (RSV) infection in early life is a risk factor for later asthma. There are no prospective studies on RSV infection starting from infancy progressing through childhood into adulthood. We followed up a cohort of children, hospitalized for RSV bronchiolitis or...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20058

    authors: Korppi M,Piippo-Savolainen E,Korhonen K,Remes S

    更新日期:2004-08-01 00:00:00

  • Outcomes of a methicillin-resistant Staphylococcus aureus (MRSA) eradication protocol in pediatric cystic fibrosis (CF) patients.

    abstract:OBJECTIVE:Methicillin-resistant Staphylococcus aureus (MRSA) infections in cystic fibrosis (CF) patients have greatly increased in prevalence in the past two decades and may lead to a more rapid rate of lung function decline. The objective of this study was to determine the impact of a MRSA eradication protocol on long...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24628

    authors: Belarski E,Pettit R

    更新日期:2020-03-01 00:00:00

  • Infrared end-tidal CO2 measurement does not accurately predict arterial CO2 values or end-tidal to arterial PCO2 gradients in rabbits with lung injury.

    abstract::End-tidal PCO2 (PETCO2) measurements from two commercially available neonatal infrared capnometers with different sampling systems and a mass spectrometer were compared with arterial PCO2 (PaCO2) to determine whether the former could predict the latter in mechanically ventilated rabbits with and without lung injury. T...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950170309

    authors: Hopper AO,Nystrom GA,Deming DD,Brown WR,Peabody JL

    更新日期:1994-03-01 00:00:00

  • Preferences for disclosing adverse childhood experiences for children and adults with cystic fibrosis.

    abstract:INTRODUCTION:The 2017-2018 National Survey of Children's Health estimates that 30 million (42%) US children have experienced at least one adverse childhood experience (ACE), including abuse, neglect, and household dysfunction. ACEs negatively impact long-term health, and there has been no study of ACEs in cystic fibros...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25243

    authors: Williams WA 2nd,Jain M,Laguna TA,McColley SA

    更新日期:2020-12-26 00:00:00

  • Technical and practical issues for tidal breathing measurements of nasal nitric oxide in children.

    abstract::To promote early screening of patients with suspected Primary Ciliary Dyskinesia (PCD), nasal nitric oxide (nNO) measurements during tidal breathing (TB) have been developed for children unable to ensure velum closure (VC) during breath hold or expiration against resistance. To investigate technical and practical issu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.23167

    authors: Beydon N,Chambellan A,Alberti C,de Blic J,Clément A,Escudier E,Le Bourgeois M

    更新日期:2015-12-01 00:00:00

  • Familial neuroendocrine cell hyperplasia of infancy.

    abstract:BACKGROUND:Neuroendocrine cell hyperplasia of infancy (NEHI) is a recently described children's interstitial lung disease (chILD) disorder of unknown etiology. It manifests clinically with tachypnea, retractions, hypoxemia, and crackles. The characteristic radiographic appearance consists of pulmonary hyperexpansion an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21219

    authors: Popler J,Gower WA,Mogayzel PJ Jr,Nogee LM,Langston C,Wilson AC,Hay TC,Deterding RR

    更新日期:2010-08-01 00:00:00

  • Pulmonary outcome measures in long-term survivors of infantile Pompe disease on enzyme replacement therapy: A case series.

    abstract:OBJECTIVES:To report the respiratory function of school-aged children with infantile Pompe disease (IPD) who started enzyme replacement therapy (ERT) in infancy and early childhood. STUDY DESIGN:This is a retrospective chart review of pulmonary function tests of: (a) patients with IPD 5 to 18 years of age, (b) who wer...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24621

    authors: ElMallah MK,Desai AK,Nading EB,DeArmey S,Kravitz RM,Kishnani PS

    更新日期:2020-03-01 00:00:00

  • Pulmonary function and structure following mild preterm birth in lambs.

    abstract::Our objective was to determine whether postnatal respiratory function, lung growth, and lung structure are affected by preterm birth which did not require neonatal respiratory support. Two groups of preterm (P) lambs were delivered 2 weeks before term, at 133 days of gestational age (GA). Tissue was collected at term ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20274

    authors: Cock M,Hanna M,Sozo F,Wallace M,Yawno T,Suzuki K,Maritz G,Hooper S,Harding R

    更新日期:2005-10-01 00:00:00

  • Hering-Breuer reflex, lung volume and position in prematurely born infants.

    abstract:OBJECTIVES:To investigate the effect of position on the strength of the Hering-Breuer reflex in prematurely born infants and determine whether any differences seen were related to differences in lung or tidal volume between positions. WORKING HYPOTHESIS:Position related differences in the strength of the Hering-Breuer...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20855

    authors: Landolfo F,Saiki T,Peacock J,Hannam S,Rafferty GF,Greenough A

    更新日期:2008-08-01 00:00:00

  • Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development.

    abstract::Exposure to chronic constant or intermittent hypoxia (CCH or CIH) may have different effects on growth and development in early life. In this work, we exposed postnatal day 2 (P2) CD1 mice to CCH or CIH (11% O2) for 4 weeks and examined the effect of hypoxia on body and organ growth until P30. Regression analysis show...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20729

    authors: Farahani R,Kanaan A,Gavrialov O,Brunnert S,Douglas RM,Morcillo P,Haddad GG

    更新日期:2008-01-01 00:00:00

  • Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model.

    abstract::Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate the effects in a surgical model, where the retinoid signaling pathway is not primarily disrupted by the toxic agent. We created DH in fetal ra...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20829

    authors: Gallot D,Coste K,Jani J,Roubliova X,Marceau G,Velemir L,Verheyen A,Lemery D,Sapin V,Deprest J

    更新日期:2008-06-01 00:00:00

  • Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.

    abstract::The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relatio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21024

    authors: Stevens D,Oades PJ,Armstrong N,Williams CA

    更新日期:2009-05-01 00:00:00

  • Early factors related to mortality in children treated with bi-level noninvasive ventilation and CPAP.

    abstract:OBJECTIVE:To describe and analyze the characteristics and the early risk factors for mortality of noninvasive ventilation (NIV) in critically ill children. STUDY DESIGN:A multicenter, prospective, observational 2-year study carried out with critically ill patients (1 month - 18 years of age) who needed NIV. Clinical d...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25246

    authors: López J,Pons-Òdena M,Medina A,Molinos-Norniella C,Palanca-Arias D,Demirkol D,León-González JS,López-Fernández YM,Perez-Baena L,López-Herce J,NIV Research Group.

    更新日期:2020-12-31 00:00:00

  • Airway stents in children.

    abstract::Airway obstruction in children is a rare, but difficult clinical problem, with no clear agreement on optimal therapeutic approach. Stenting of the airway has been used successfully in adults, and is an attractive alternative in children. Fundamental differences of pediatric compared to adult use include the benign nat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20790

    authors: Nicolai T

    更新日期:2008-04-01 00:00:00

  • Short and long interpregnancy interval and the risk for pediatric obstructive sleep apnea in the offspring.

    abstract:INTRODUCTION:Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI < 6 months) and long IPI (IPI > 60 months) have been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25240

    authors: Rapaport Pasternak H,Sheiner E,Goldbart A,Wainstock T

    更新日期:2020-12-31 00:00:00

  • Localization of the T-cell response to RSV infection is altered in infant mice.

    abstract:OBJECTIVES:Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract infections worldwide, causing disproportionate morbidity and mortality in infants and children. Infants with stronger Th1 responses have less severe disease, yet little is known about the infant T-cell response within the air spa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23911

    authors: Eichinger KM,Kosanovich JL,Empey KM

    更新日期:2018-02-01 00:00:00

  • DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins.

    abstract::Stachybotrys chartarum (atra) is a toxic mold that grows on water-damaged cellulose-based materials. Research has revealed also that inhalation of S. chartarum spores caused marked changes in respiratory epithelium, especially to developing lungs. We analyzed the epigenetic potential of S. chartarum spore toxins on de...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20608

    authors: McCrae KC,Rand TG,Shaw RA,Mantsch HH,Sowa MG,Thliveris JA,Scott JE

    更新日期:2007-07-01 00:00:00

  • TNF-alpha, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients.

    abstract::The cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and intercellular adhesion molecule-1 (ICAM-1) have important roles in regulating neutrophil migration and the inflammatory response. To determine whether the concentration of these cytokines and soluble ICAM-1 (sICAM-1) in sputum was increas...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199601)21:1<11::AID-PPUL2>

    authors: Salva PS,Doyle NA,Graham L,Eigen H,Doerschuk CM

    更新日期:1996-01-01 00:00:00

  • The etiology of tracheal mucosal injury in proximal esophageal atresia plus distal tracheoesophageal fistula: an animal study.

    abstract::Tracheal mucosal damage has been reported in autopsy specimens of cases with proximal esophageal atresia and distal tracheoesophageal fistula (EA-TEF) (Gross classification type C). Such changes have not been reported for isolated EA (Gross classification type A). Our hypothesis is that passage of amniotic fluid (AF) ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20490

    authors: Ateş O,Hakgüder G,Olguner M,Ozer E,Akgür FM

    更新日期:2006-11-01 00:00:00

  • Prenatal exposure to VOCs and NOx and lung function in preschoolers.

    abstract:BACKGROUND:Several studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life. METHODS:We included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega-3 fatty acid Supplements, GRowth, And Development...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24889

    authors: Gutiérrez-Delgado RI,Barraza-Villarreal A,Escamilla-Núñez MC,Hernández-Cadena L,Cortez-Lugo M,Sly P,Romieu I

    更新日期:2020-08-01 00:00:00

  • Evaluation of pulmonary reexpansion in a porcine model of bronchial foreign body.

    abstract:OBJECTIVES:This study was designed to establish a porcine model of reversible obstruction of endobronchial foreign body (FB) and to assess the natural pulmonary reexpansion process using radiology and histopathology after removal of the bronchial FB. METHODS:A metal stent was placed in the right lower lobe bronchial l...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23947

    authors: Wang S,Tu J,Song Y

    更新日期:2018-03-01 00:00:00

  • Effects of antenatal corticosteroid treatment on pulmonary ventilation and circulation in neonatal lambs with hypoplastic lungs.

    abstract::Our aim was to determine whether antenatal corticosteroids improve perinatal adaptation of the pulmonary circulation in lambs with lung hypoplasia (LH). LH was induced in 12 ovine fetuses between 105 and 140 days gestation (term approximately 147 days); in 6 of these the ewe was given a single dose of betamethasone (1...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20453

    authors: Suzuki K,Hooper SB,Wallace MJ,Probyn ME,Harding R

    更新日期:2006-09-01 00:00:00

  • Effects of different modes of delivery on lung volumes of newborn infants.

    abstract::The aim of our study was to examine the effect of labor and birth canal compression on the rate of clearance of lung fluid. We recruited 10 babies born by vaginal delivery and 10 born by elective cesarean section (ECS). Thoracic gas volume (TGV) was measured using total body plethysmography, and functional residual ca...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199905)27:5<318::aid-ppul4

    authors: Lee S,Hassan A,Ingram D,Milner AD

    更新日期:1999-05-01 00:00:00

  • Perception of intrinsic and extrinsic respiratory loads in children with life-threatening asthma.

    abstract::There is a subpopulation of asthmatic patients with a history of life-threatening asthma (LTA) who have a reduced perception of respiratory loads. The aim of this study was to determine if these patients have a reduced perception of both intrinsic and extrinsic loads. Children with asthma were classified into life-thr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10199

    authors: Julius SM,Davenport KL,Davenport PW

    更新日期:2002-12-01 00:00:00

  • Adherence to the 2007 cystic fibrosis pulmonary guidelines: a national survey of CF care centers.

    abstract:OBJECTIVE:To examine cystic fibrosis (CF) physician adherence to the 2007 CF Foundation (CFF) Pulmonary Guidelines for Chronic Medications. Specifically adherence and barriers to prescribing level A medication recommendations (i.e., inhaled tobramycin and dornase alfa) and level B medication recommendations (i.e., macr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21573

    authors: Glauser TA,Nevins PH,Williamson JC,Abdolrasulnia M,Salinas GD,Zhang J,Debonnett L,Riekert KA

    更新日期:2012-05-01 00:00:00

  • Trampoline use as physiotherapy for cystic fibrosis patients.

    abstract::Physicians and physiotherapists who care for CF patients have recommended the use of trampolines as a physiotherapeutic tool for enhancing cardiopulmonary performance, encouraging sputum production, and improving general well-being. Despite some therapeutic and recreational benefits associated with trampoline use, pap...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20133

    authors: Barak A,Wexler ID,Efrati O,Bentur L,Augarten A,Mussaffi H,Avital A,Rivlin J,Aviram M,Yahav Y,Kerem E

    更新日期:2005-01-01 00:00:00