DNA fragmentation in developing lung fibroblasts exposed to Stachybotrys chartarum (atra) toxins.

abstract：BACKGROUND:Evidence from recent studies suggests that IRT/PAP protocols may be successfully used as a purely biochemical newborn screening (NBS) for cystic fibrosis (CF) that does not require genetic screening. However, the experience with the performance of different IRT/PAP protocols remains limited. In this study, w...

journal_title：Pediatric pulmonology

authors： Sommerburg O,Hammermann J,Lindner M,Stahl M,Muckenthaler M,Kohlmueller D,Happich M,Kulozik AE,Stopsack M,Gahr M,Hoffmann GF,Mall MA

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:Treatment regimens for patients with cystic fibrosis (CF) are time-consuming and complex, resulting in consistently low adherence rates. To date, few studies have evaluated innovative technologies to improve adherence in this population. Current infection control guidelines for patients with CF seek to minim...

journal_title：Pediatric pulmonology

authors： Marciel KK,Saiman L,Quittell LM,Dawkins K,Quittner AL

更新日期：2010-02-01 00:00:00

abstract：:The tidal flow volume (TFV) loop ratios of (1) time to peak flow (tPTEF) to total expiratory time (tE) [tPTEF/tE] and (2) volume to peak flow (VPTEF) to expired volume (VE) [VPTEF/VE] are reported to decrease with age in early life, and to decrease in subjects with obstructive airways disease (OAD). However, the mecha...

journal_title：Pediatric pulmonology

authors： Lødrup Carlsen KC,Stenzler A,Carlsen KH

更新日期：1997-12-01 00:00:00

abstract：:Progressive lung disease in patients with cystic fibrosis (CF) is caused by thick secretions, which cause airway obstruction and subsequent colonization and infection by inhaled pathogenic microorganisms. Recently, recombinant human DNase has been shown to reduce the viscoelasticity of sputum in patients with cystic f...

journal_title：Pediatric pulmonology

authors： Eng PA,Morton J,Douglass JA,Riedler J,Wilson J,Robertson CF

更新日期：1996-02-01 00:00:00

abstract：:Asynchronous or paradoxic motion between the rib cage and abdomen may be seen in infants with lung disease. We have recently shown that after bronchodilator administration, the degree of asynchrony decreases proportionately to the improvement in lung mechanics. However, whether such thoraco-abdominal asynchrony (TAA) ...

journal_title：Pediatric pulmonology

authors： Allen JL,Greenspan JS,Deoras KS,Keklikian E,Wolfson MR,Shaffer TH

更新日期：1991-01-01 00:00:00

abstract：:Our objective was to compare the effectiveness of maximum forced expiratory flow measured at functional residual capacity (V'maxFRC) and the ratio of flow at 75% of the forced expiratory volume to peak forced expiratory flow (FEF(75)/FEF(peak)) for detecting bronchodilator-related changes in wheezy infants. In 55 infa...

journal_title：Pediatric pulmonology

authors： Sheikh S,Castile R,Hayes J,McCoy K,Eid N

更新日期：2003-09-01 00:00:00

abstract：:Neonatal exposure to intermittent hypoxia results in altered ventilatory response to subsequent hypoxia in animal models. The effect of similar exposure in human infants is unknown. Our objective was to determine the impact of sleep disordered breathing (SDB) in early infancy on ventilatory response in infants. We rec...

journal_title：Pediatric pulmonology

authors： MacLean JE,Tan S,Fitzgerald DA,Waters KA

更新日期：2013-03-01 00:00:00

abstract：:The aim of this study was to examine a possible association between birth season (date of birth) and future development of asthma in children. A case-control study was designed to include asthmatic children aged 2-7 years, living in the city of Beer-Sheva, in southern Israel, registered in one pediatric center. Contro...

journal_title：Pediatric pulmonology

authors： Gazala E,Ron-Feldman V,Alterman M,Kama S,Novack L

更新日期：2006-12-01 00:00:00

abstract：:Lung transplantation in childhood is a highly specialized clinical practice confined to a few centers around the world. Organ availability remains an important limiting factor in extending the application of this procedure to more infants, children and adolescents. The lungs are the organ most vulnerable to injury, in...

journal_title：Pediatric pulmonology

authors： Mallory GB Jr,Schecter MG,Elidemir O

更新日期：2009-06-01 00:00:00

abstract：:The occurrence of a tracheoesophageal fistula (TEF) in the setting of lymphoma has only rarely been reported in the world literature. Most cases reported were associated with radiation therapy vs. chemotherapy alone. This report presents one case illustrating the difficulty encountered managing a TEF that developed wh...

journal_title：Pediatric pulmonology

authors： Moree JS,Bhakta MG,Ledbetter J

更新日期：2006-07-01 00:00:00

abstract：:For patients whose asthma remains in poor control necessitating high utilization of medical services, a referral to a specialized "center of excellence" is often considered. A decade ago, we evaluated our pediatric asthma program of long-term hospitalization (median stay of 75 days) and found significant decreases in ...

journal_title：Pediatric pulmonology

authors： Bratton DL,Price M,Gavin L,Glenn K,Brenner M,Gelfand EW,Klinnert MD

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Matrix metalloproteinase-9 (MMP-9) plasma levels correlate with C-reactive protein (CRP) concentrations and they are both increased in adults with obstructive sleep apnea (OSA). No studies have evaluated MMP-9 levels in children with sleep apnea and CRP is not consistently elevated in pediatric OSA. The aim ...

journal_title：Pediatric pulmonology

authors： Kaditis AG,Alexopoulos EI,Karathanasi A,Ntamagka G,Oikonomidi S,Kiropoulos TS,Zintzaras E,Gourgoulianis K

更新日期：2010-07-01 00:00:00

abstract：INTRODUCTION:The efficacy of nebulized hypertonic saline (HS) therapy for shortening hospital length of stay (LOS) or improving bronchiolitic symptoms remains controversial. Most studies enrolled small numbers of subjects and did not consider the role of respiratory syncytial virus (RSV), the most common cause of acute...

journal_title：Pediatric pulmonology

authors： Morikawa Y,Miura M,Furuhata MY,Morino S,Omori T,Otsuka M,Chiga M,Obonai T,Hataya H,Kaneko T,Ishikura K,Honda M,Hasegawa Y,Tokyo Pediatric Clinical Research Network.

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:In cystic fibrosis (CF), the spectrum and frequency of CFTR variants differ by geography and race/ethnicity. CFTR variants in White patients are well-described compared with Latino patients. No studies of CFTR variants have been done in patients with CF in the Dominican Republic or Puerto Rico. METHODS:CFTR...

journal_title：Pediatric pulmonology

authors： Zeiger AM,McGarry ME,Mak ACY,Medina V,Salazar S,Eng C,Liu AK,Oh SS,Nuckton TJ,Jain D,Blackwell TW,Kang HM,Abecasis G,Oñate LC,Seibold MA,Burchard EG,Rodriguez-Santana J

更新日期：2020-02-01 00:00:00

abstract：:The purpose of this study was to compare the pathogens obtained by oropharyngeal suction (OPS) and bronchoalveolar lavage (BAL) in children with chronic pulmonary infections. Forty-four children (mean age of 6.1 years; range 4 months to 15 years) were included in the study (27 children with recurrent localized lung in...

journal_title：Pediatric pulmonology

authors： Avital A,Uwyyed K,Picard E,Godfrey S,Springer C

更新日期：1995-07-01 00:00:00

abstract：:The aim of this study was to assess if the Hering-Breuer reflex could be provoked in young children. Thirty asthmatic children with a mean age of 5.3 years and 18 healthy children with a mean age of 7.0 years were studied. The presence of the reflex was indicated by prolongation of the spontaneous expiratory time foll...

journal_title：Pediatric pulmonology

authors： Greenough A,Pool J

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to validate our Dalhousie Dyspnea Scales in children referred for histamine bronchoprovocation challenge. Seventy-four children rated their dyspnea after each FEV(1) measurement following inhalation of doubling histamine concentrations from 0.125 to 8.0 mg/ml by the standard tidal breathing m...

journal_title：Pediatric pulmonology

authors： Pianosi P,Smith CP,Almudevar A,McGrath PJ

更新日期：2006-12-01 00:00:00

abstract：:Previous research has demonstrated the potential benefit derived from the combination of high frequency oscillatory ventilation and volume guarantee mode (HFOV-VG), a procedure that allows us to explore and control very low tidal volumes. We hypothesized that secondary spontaneous change in oscillation pressure amplit...

journal_title：Pediatric pulmonology

authors： Rodríguez Sánchez de la Blanca A,Sánchez Luna M,González Pacheco N,Ramos Navarro C,Santos González M,Tendillo Cortijo F

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:We hypothesized airway inflammation can be detected non-invasively by induced sputum (IS) or peripheral blood eosinophilia, and IS can detect bacterial and viral infection in preschool children with airway disease, with results comparable to broncho-alveolar lavage (BAL). METHODS:Preschool children with cys...

journal_title：Pediatric pulmonology

authors： Jochmann A,Artusio L,Robson K,Nagakumar P,Collins N,Fleming L,Bush A,Saglani S

更新日期：2016-08-01 00:00:00

abstract：:Epidemiological data suggest that respiratory syncytial virus (RSV) infection in early life is a risk factor for later asthma. There are no prospective studies on RSV infection starting from infancy progressing through childhood into adulthood. We followed up a cohort of children, hospitalized for RSV bronchiolitis or...

journal_title：Pediatric pulmonology

authors： Korppi M,Piippo-Savolainen E,Korhonen K,Remes S

更新日期：2004-08-01 00:00:00

abstract：INTRODUCTION:Advance care planning (ACP), though recommended, has not been studied in adolescents with cystic fibrosis (CF). This quality improvement project engaged adolescents with advanced CF disease in ACP and assessed patient and CF provider attitudes and preferences regarding ACP discussions and tools. MATERIALS...

journal_title：Pediatric pulmonology

authors： Kazmerski TM,Weiner DJ,Matisko J,Schachner D,Lerch W,May C,Maurer SH

更新日期：2016-12-01 00:00:00

abstract：:Our purpose was to identify and further characterize physiologic mechanisms relevant to autoresuscitation from hypoxic apnea in infants dying suddenly and unexpectedly. We studied cardiorespiratory recordings of 24 infants (age range, 0.8-21 months) who died suddenly while being monitored at home. These recordings wer...

journal_title：Pediatric pulmonology

authors： Sridhar R,Thach BT,Kelly DH,Henslee JA

更新日期：2003-08-01 00:00:00

abstract：:Sudden unexplained deaths have been reported in 13% [corrected] of Familial Dysautonomia (FD) subjects. To characterize cardiorespiratory dysregulation in children with FD that might contribute to potential sudden death, respiratory inductance plethysmography (chest/abdomen), ECG, hemoglobin saturation, and pulse wave...

journal_title：Pediatric pulmonology

authors： Weese-Mayer DE,Kenny AS,Bennett HL,Ramirez JM,Leurgans SE

更新日期：2008-03-01 00:00:00

abstract：INTRODUCTION:Laryngomalacia is the most prevalent cause of congenital stridor. Flexible laryngobronchoscopy (FLB) is the gold standard for diagnosis. However, FLB requires venous access, deep sedation or general anesthesia, and is associated with patient's and parental discomfort and a considerable cost. Laryngeal ultr...

journal_title：Pediatric pulmonology

authors： Friedman S,Sadot E,Gut G,Armoni Domany K,Sivan Y

更新日期：2018-06-01 00:00:00

abstract：:The purpose of this report is to describe the College of American Pathologists sweat testing (SW) proficiency testing program for cystic fibrosis, to evaluate its impact on test performance, and to describe the current practice of sweat testing in North America. The study analyzed participant summary reports of the SW...

journal_title：Pediatric pulmonology

authors： LeGrys VA

更新日期：2000-12-01 00:00:00

abstract：:We describe a method for measuring carbon monoxide diffusing capacity (DL(CO)) and alveolar volume (V(A)) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with ro...

journal_title：Pediatric pulmonology

authors： Castillo A,Llapur CJ,Martinez T,Kisling J,Williams-Nkomo T,Coates C,Tepper RS

更新日期：2006-06-01 00:00:00

abstract：RATIONALE:Nitric oxide (NO) produced in the lung is an important mediator of normal lung development, vascular smooth muscle relaxation, and ventilation perfusion matching. NO is synthesized from arginine by the action of NO-synthase (NOS). Asymmetric dimethylarginine (ADMA), an endogenous derivate of arginine, inhibit...

journal_title：Pediatric pulmonology

authors： Richir MC,van Leeuwen PA,van den Berg A,Wessels R,Twisk JW,Rauwerda JA,Teerlink T,de Vries TP,van Elburg RM

更新日期：2008-12-01 00:00:00

abstract：:We measured then compared the dynamic lung mechanics of spontaneous breaths and mechanical breaths in 9 mechanically ventilated neonates with hyaline membrane disease. All were receiving intermittent mandatory ventilation. All breathed spontaneously between ventilator breaths. Tidal volume, transpulmonary pressure, dy...

journal_title：Pediatric pulmonology

authors： Mammel MC,Fisher JB,Bing DR,Gatto CW,Boros SJ

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:It is uncertain whether folate is risk or preventive factor for allergic and respiratory diseases. OBJECTIVE:To determine the relationship between maternal or offspring folate status and subsequent development of allergic and respiratory diseases in early childhood. METHODS:In total, 917 mother-child pairs...

journal_title：Pediatric pulmonology

authors： Kim JH,Jeong KS,Ha EH,Park H,Ha M,Hong YC,Bhang SY,Lee SJ,Lee KY,Lee SH,Kim Y,Kim MH,Chang N

更新日期：2015-02-01 00:00:00

abstract：:Respiratory syncytial virus (RSV) infection can be severe in pediatric patients. Risk factors for severe disease include age less than 6 months, prematurity, preexisting heart or lung disease or malformations, gastroesophageal reflux, and immunodeficiency. The aim of the present study was to investigate the influence ...

journal_title：Pediatric pulmonology

authors： Trefny P,Stricker T,Baerlocher C,Sennhauser FH

更新日期：2000-10-01 00:00:00