Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood.

Abstract:

BACKGROUND:It is uncertain whether folate is risk or preventive factor for allergic and respiratory diseases. OBJECTIVE:To determine the relationship between maternal or offspring folate status and subsequent development of allergic and respiratory diseases in early childhood. METHODS:In total, 917 mother-child pairs from a prospective birth cohort in South Korea were studied. Data regarding the children's allergic and respiratory outcomes were obtained from standardized questionnaires completed by the mothers at postnatal months 6, 12, and 24. Serum folate levels were measured in the mothers at mid- and late-pregnancy, and in their children at 24 months of age. Atopic biomarkers were measured in the cord blood (CB) and at 24 months after birth. Biomarkers and clinical outcomes were analyzed and compared between the mother-child pairs divided into two groups according to median serum folate status at mid- and late-pregnancy. RESULTS:Serum folate levels during mid-pregnancy were inversely associated with CB eosinophil count (adjusted odds ratio [OR] 0.72, 95% confidence interval [CI], 0.54-0.96) and positively associated with CB interleukin-10 levels (1.47, 1.11-1.94). Maternal folate level above the median value (≥9.5 ng/ml) during mid-pregnancy was associated with a decreased risk for the child of lower respiratory tract infections (LRTIs) at 6 months of age (adjusted OR 0.50, 95% CI 0.28-0.91) and atopic dermatitis (AD) at 24 months (adjusted OR 0.52, 95% CI 0.31-0.88), but not with LRTIs and AD at other ages. CONCLUSIONS:A relatively high maternal serum folate level in mid-pregnancy was associated with a decreased risk of LRTIs and AD in early childhood.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Kim JH,Jeong KS,Ha EH,Park H,Ha M,Hong YC,Bhang SY,Lee SJ,Lee KY,Lee SH,Kim Y,Kim MH,Chang N

doi

10.1002/ppul.23025

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

155-63

issue

2

eissn

8755-6863

issn

1099-0496

journal_volume

50

pub_type

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