C-reactive protein in acute pulmonary exacerbations of patients with cystic fibrosis.

Abstract:

:C-reactive protein (CRP) concentrations were evaluated in 9 cystic fibrosis (CF) patients with acute pulmonary exacerbations and 14 patients with acute exacerbations of asthma without any symptoms of an acute infection. CRP concentrations were serially evaluated over the course of therapy in CF patients and compared with pulmonary function tests (PFTs) and clinical scores. CF patients were treated with aerosolized bronchodilators, intravenous fluids, and chest physiotherapy for 48 hours. Intravenous antibiotic therapy was added after 48 hours. Initial CRP concentrations differed significantly between patients with CF and those with asthma. CRP concentrations were elevated in 7 of 9 CF patients versus 3 of 14 asthma patients (P < 0.02). In CF patients, CRP concentrations did not correlate with PFTs (except on day 0) or clinical scores. Frequently PFTs and clinical scores continued to improve after CRP levels had reached their lowest concentrations. CRP concentrations decreased only after the addition of antibiotic therapy.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Friesen CA,Wiens LA,Burry VF,Portnoy J,Roberts CC

doi

10.1002/ppul.1950200403

subject

Has Abstract

pub_date

1995-10-01 00:00:00

pages

215-9

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

20

pub_type

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