Abstract:
:The free running test is a useful method for evaluation of exercise-induced bronchospasm in children. In young children this test simulates real-life circumstances and can be done more easily than histamine or methacholine challenges. The interrupter technique is a noninvasive method for measuring airflow resistance during tidal breathing. This approach requires minimal cooperation, and is therefore promising for use in young children. Fifty children aged 5-15 years with asthma symptoms were tested by exercise challenge consisting of free outdoor running for 8 min at 85% of maximal predicted heart rate for age. Pulmonary function was measured by using the interrupter technique (IR), with a Wright's peak flow meter (WPEF), and by flow-volume spirometry (FVS). The measurements were done before and 10 min after exercise. In addition, WPEF was measured at 5, 15, and 20 min after exercise. A fall of 15% or more in WPEF associated with wheezing or cough symptoms was considered a positive test. The exercise challenge was positive in 16 (32%) of the 50 children. Measurements at 10 min by WPEF identified 9 positive cases. At the same time point the IR identified 10 positive cases; a rise in resistance of 15% or more was considered positive, giving it 80% sensitivity and 93% specificity. The repeatability coefficient (CoR) for the interrupter technique was 0.06 kPa x L(-1) x s (13%) before and 0.07 kPa x L(-1) x s (14%) after exercise. The IR provides a useful alternative for estimation of airway obstruction in children following exercise challenge. The results were comparable with the current reference methods of forced expiratory volume in 1 s and peak flow measurements.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Kannisto S,Vanninen E,Remes K,Korppi Mdoi
10.1002/(sici)1099-0496(199903)27:3<203::aid-ppul9subject
Has Abstractpub_date
1999-03-01 00:00:00pages
203-7issue
3eissn
8755-6863issn
1099-0496pii
10.1002/(SICI)1099-0496(199903)27:3<203::AID-PPUL9journal_volume
27pub_type
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章
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更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2000-03-01 00:00:00
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