Hering-Breuer reflex, lung volume and position in prematurely born infants.

Abstract:

OBJECTIVES:To investigate the effect of position on the strength of the Hering-Breuer reflex in prematurely born infants and determine whether any differences seen were related to differences in lung or tidal volume between positions. WORKING HYPOTHESIS:Position related differences in the strength of the Hering-Breuer reflex relate to differences in lung or tidal volume. STUDY DESIGN:Prospective observational study. PATIENT/SUBJECT SELECTION: Eighteen infants, median gestational age 30 (range 25-32) weeks were studied. METHODOLOGY:Infants were examined in the supine and prone position, each position was maintained for 2 hr. At the end of each 2-hr period, the strength of the Hering-Breuer reflex was assessed by determining the prolongation of expiration following an end inspiratory occlusion. In addition, tidal volume and functional residual capacity (FRC) were assessed in each position. RESULTS:The strength of the Hering-Breuer reflex was greater (P = 0.01) and the mean FRC was higher (P < 0.0001) in the prone compared to the supine position. The position related differences in the strength of the reflex correlated significantly with position related differences in FRC (P = 0.05). CONCLUSIONS:The Hering-Breuer reflex is stronger in the prone compared to the supine position. Our results suggest this is explained by position related differences in lung volume.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Landolfo F,Saiki T,Peacock J,Hannam S,Rafferty GF,Greenough A

doi

10.1002/ppul.20855

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

767-71

issue

8

eissn

8755-6863

issn

1099-0496

journal_volume

43

pub_type

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