Abstract:
:The raised lung volume technique is increasingly used to measure forced expiratory maneuvers in infants. However, there is no consensus regarding the optimal airway inflation pressure (P(inf)) required for such maneuvers, or the influence of small changes in P(inf) within and between infants. The aim of this study was to assess the effect of small differences (0.2-0.3 kPa) in P(inf) on forced vital capacity (FVC), forced expired volume in 0.5 sec (FEV(0.5)), and forced expired flow at 75% of vital capacity (FEF(75)), all derived from the raised volume rapid thoraco-abdominal compression (RVRTC) technique. Randomized paired forced expiratory maneuvers were obtained in 32 healthy infants ( 3.9-39.3 weeks old, 3.8-9.9 kg) with the safety pressure relief valve for P(inf) set to 2.7 kPa or 3.0 kPa (27 or 30 cm H(2)0). When mean (SD) P(inf) was increased by 8.4 (2.8)%, there was a significant (P < 0.01) increase in mean (SD) FVC, FEV(0.5), and FEF(75) by 5.8 (5.7)%, 6.1 (6)%, and 8.3 (16.2)%, respectively. In conclusion, relatively small differences in P(inf) will result in significant differences in FVC, FEV(0.5), and FEF(75) by RVRTC technique. Precision in setting and reporting the applied P(inf) is therefore essential, particularly if data are to be compared between centers.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Lum S,Hoo AF,Stocks Jdoi
10.1002/ppul.10060subject
Has Abstractpub_date
2002-02-01 00:00:00pages
130-4issue
2eissn
8755-6863issn
1099-0496pii
10.1002/ppul.10060journal_volume
33pub_type
临床试验,杂志文章,随机对照试验abstract::The choice of antibiotics for sinusitis in children with cystic fibrosis (CF) is empirical or based on lower airway cultures, because sinus cultures are difficult to obtain. The aim of this study was to identify the main organisms cultured from CF children with chronic sinusitis, and to evaluate the concordance of con...
journal_title:Pediatric pulmonology
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doi:10.1002/ppul.20396
更新日期:2006-05-01 00:00:00
abstract::The tidal flow volume (TFV) loop ratios of (1) time to peak flow (tPTEF) to total expiratory time (tE) [tPTEF/tE] and (2) volume to peak flow (VPTEF) to expired volume (VE) [VPTEF/VE] are reported to decrease with age in early life, and to decrease in subjects with obstructive airways disease (OAD). However, the mecha...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199712)24:6<391::aid-ppul3
更新日期:1997-12-01 00:00:00
abstract::During the final prenatal period of fetal lung development in humans, important maturational processes occur, including the production of surfactant necessary to decrease surface tension at the air-liquid interface of the alveoli. During early gestation, the glucocorticoid receptor is expressed in the fetal lung, and ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.1092
更新日期:2001-07-01 00:00:00
abstract::Neonatal exposure to intermittent hypoxia results in altered ventilatory response to subsequent hypoxia in animal models. The effect of similar exposure in human infants is unknown. Our objective was to determine the impact of sleep disordered breathing (SDB) in early infancy on ventilatory response in infants. We rec...
journal_title:Pediatric pulmonology
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doi:10.1002/ppul.22568
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.20909
更新日期:2008-11-01 00:00:00
abstract::Foreign-body aspiration (FBA) is a commonly encountered serious problem during childhood, accounting for 7% of lethal accidents in children aged 1-3 years. Bronchoscopy is indicated when a clear history of FBA is present, but the history may be unreliable. Clinical manifestations can be seen in various diseases, and w...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20128
更新日期:2005-02-01 00:00:00
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doi:10.1002/ppul.23477
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journal_title:Pediatric pulmonology
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doi:10.1002/ppul.23950
更新日期:2018-04-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2015-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/1099-0496(200011)30:5<393::aid-ppul5>3.0.c
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abstract:BACKGROUND:Several studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life. METHODS:We included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega-3 fatty acid Supplements, GRowth, And Development...
journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24242
更新日期:2019-03-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2018-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2003-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2003-08-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20804
更新日期:2008-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2000-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2003-07-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2000-02-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2013-08-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2017-10-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2007-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2001-08-01 00:00:00