Abstract:
OBJECTIVES:First, create a clinical severity score for patients with chronic lung disease of infancy (CLDi) following neonatal intensive care unit (NICU) stay. Second, using California wide population-based data, identify factors associated with clinical severity of CLDi at 4-9 months corrected gestational age (CGA). STUDY DESIGN:Pediatric pulmonologists ranked and weighted eight factors reflecting clinical severity of CLDi. Utilizing these data we scored and assigned these to 4-9 month old CGA moderate/severe bronchopulmonary dysplasia (BPD) infants, born<30 weeks gestational age (GA), within the California High Risk Infant Follow up (HRIF) program. Infants were studied relative to factors from the California Perinatal Quality Care Collaborative (CPQCC). RESULTS:We received survey responses from 43/88 pediatric pulmonologists from 28/53 North American training centers who are experts in CLDi. Strong agreement between ranking (72-100%) of respiratory system parameters and weighting (out of 100 points weighting was within 20 points) was observed with severity of CLDi. Data from 940 CLDi premature infants <30 weeks GA were obtained. Infants with severe CLDi scores at 4-9 months CGA (relative to a zero score) showed positive associations with being male, odds ratio[OR] = 2.45[confidence interval (CI) 1.26-4.77]), >30 ventilator days, OR = 3.82 (1.30-11.2), postnatal steroids OR = 3.94 (1.94-7.84), and a surprising inverse association with retinopathy of prematurity stage 3-4, OR = 0.24 (0.09-0.67) CONCLUSIONS: The CLDi clinical severity score allowed for standardized assessment of pulmonary morbidity, and evaluation of risk factors in the NICU for CLDi following NICU discharge. These observations point to risk factors associated with CLDi outcomes at 4-9 months CGA.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Gage S,Kan P,Oehlert J,Gould JB,Stevenson DK,Shaw GM,O'Brodovich HMdoi
10.1002/ppul.23148subject
Has Abstractpub_date
2015-09-01 00:00:00pages
878-88issue
9eissn
8755-6863issn
1099-0496journal_volume
50pub_type
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ppul.24335
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric pulmonology
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pub_type: 临床试验,杂志文章
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更新日期:2008-11-01 00:00:00
abstract::Cystic fibrosis (CF) is an autosomal recessive disease. It affects multiple body organs. The lungs and pancreas are the most affected which results in progressive lung damage and pancreatic insufficiency. Due to the disease process, CF patients require significantly higher caloric intake than recommended for other ind...
journal_title:Pediatric pulmonology
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更新日期:2015-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20058
更新日期:2004-08-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950110412
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abstract::Airway obstruction in children is a rare, but difficult clinical problem, with no clear agreement on optimal therapeutic approach. Stenting of the airway has been used successfully in adults, and is an attractive alternative in children. Fundamental differences of pediatric compared to adult use include the benign nat...
journal_title:Pediatric pulmonology
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更新日期:2016-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20076
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1991-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2016-08-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199906)27:6<388::aid-ppul5
更新日期:1999-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
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