Angiotensin-converting enzyme insertion/deletion gene polymorphism in Egyptian children with CAP: A case-control study.

Abstract:

BACKGROUND:Community-acquired pneumonia (CAP) is a major cause of childhood morbidity and mortality worldwide. The angiotensin-converting enzyme (ACE) gene is a potential candidate gene for CAP risk. OBJECTIVES:In this study, we aimed to investigate whether the ACE insertion/deletion (I/D) polymorphism (rs4340) could be a genetic marker for CAP susceptibility in Egyptian children, and we also measured the serum ACE level to assess its relation to such polymorphism. METHODS:This was a prospective case-control study included 300 patients with CAP, and 300 age, gender, and ethnicity matched healthy controls. The ACE I/D polymorphism (rs4340) at intron 16 was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while the serum ACE levels were measured by ELISA. RESULTS:Compared to the controls subjects, the frequencies of the ACE DD genotype and D allele were overrepresented in patients with CAP (OR = 3.05; [95%CI: 2.14-4.35] for the DD genotype; P < 0.001) and (OR: 1.8; [95%CI: 1.42-2.29]; for the D allele; P < 0.01, respectively). Patients with the DD genotype had significantly higher mean serum ACE levels (45.6 ± 11.4 U/L) compared to those with ID genotype (36.5 ± 8.3 U/L) and II genotype (21.6 ± 5.7 U/L); P < 0.01, respectively. CONCLUSION:The ACE I/D polymorphism (rs4340) may contribute to the genetic susceptibility of CAP in Egyptian children. The ACE D allele and DD genotype were associated with higher serum ACE levels among studied CAP patients.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Abouzeid H,Alkholy UM,Abdou MA,Morsy SM,Abdelrahman HM,Sherif AM,Abdalmonem N,Hamed ME,Allah MAN,Al Morshedy S,Elashkar SSA,Noah MA,Hegab MS,Akeel NE,Hashem MIA,Gawish HH,Fattah LA

doi

10.1002/ppul.23886

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

1592-1598

issue

12

eissn

8755-6863

issn

1099-0496

journal_volume

52

pub_type

杂志文章
  • Apnea and periodic breathing in normal full-term infants during the first twelve months.

    abstract::The pediatric pneumogram is a frequently used tool in the diagnosis and management of apnea during infancy. We analyzed 287 pneumographic recordings from 123 full-term infants (63 males) obtained during the first 12 months of life to establish normative values for apnea, periodic breathing, and bradycardia. The result...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010409

    authors: Kelly DH,Stellwagen LM,Kaitz E,Shannon DC

    更新日期:1985-07-01 00:00:00

  • Measurement of respiratory system resistance by forced oscillation in normal children: a comparison with spirometric values.

    abstract::In 377 children, the commercially available Siregnost FD-5 was used to measure respiratory system resistance (Rrs) by forced oscillation at 10 Hz. The children were between 3 and 18 years of age and, by a detailed questionnaire and conventional pulmonary function testing in 335, they were shown to be representative of...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100214

    authors: Lebecque P,Desmond K,Swartebroeckx Y,Dubois P,Lulling J,Coates A

    更新日期:1991-01-01 00:00:00

  • Effect of cumulative oxygen exposure on respiratory symptoms during infancy among VLBW infants without bronchopulmonary dysplasia.

    abstract:UNLABELLED:Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others have not. A possible explanation for these in...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21199

    authors: Stevens TP,Dylag A,Panthagani I,Pryhuber G,Halterman J

    更新日期:2010-04-01 00:00:00

  • Association among lung function, exhaled nitric oxide, and the CAN questionnaire to assess asthma control in children.

    abstract:BACKGROUND:The aim of this study was to investigate the association among a validated symptom-based questionnaire for asthma control in children (CAN), forced expiratory volume in 1 sec (FEV(1)), and fractional exhaled nitric oxide (FE(NO)). METHODS:Observational cross-sectional study was performed in a consecutive sa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21144

    authors: Sardón-Prado O,Korta-Murua J,Valverde-Molina J,Fernández-Paredes JJ,Mintegui J,Corcuera-Elosegui P,Emparanza JI,Pérez-Yarza EG

    更新日期:2010-05-01 00:00:00

  • Tuberculosis of the endothoracic fascia.

    abstract::A 13-year-old boy presented with a history of respiratory infection that had progressed for 3 months. A chest X-ray showed pathological findings that suggested endothoracic fascia compromise (Skarby sign). The thorax computerized axial tomography scan revealed multiple opacities in the fascia. A biopsy was performed, ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20379

    authors: Broglia B,Bisero E,Sclavo L,Andreozzi P

    更新日期:2006-05-01 00:00:00

  • Anti-inflammatory effects of macrolides in lung disease.

    abstract::During the past five decades there has been increasing interest in the potential anti-inflammatory effects of macrolide antibiotics. Low-dose macrolide therapy has dramatically increased survival in patients with diffuse panbronchiolitis, a disease with many similarities to cystic fibrosis (CF). This has led to furthe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.1076

    authors: Jaffé A,Bush A

    更新日期:2001-06-01 00:00:00

  • Elevated vascular endothelial growth factor is correlated with elevated erythropoietin in stable, young cystic fibrosis patients.

    abstract::Angiogenesis is an important mechanism of airway remodeling in lung disease. We previously demonstrated that serum vascular endothelial growth factor (VEGF) is elevated in cystic fibrosis (CF) patients and declines with therapy for pulmonary exacerbation. We hypothesized that VEGF is elevated early in the course of CF...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21428

    authors: Watts KD,McColley SA

    更新日期:2011-07-01 00:00:00

  • Is home spirometry useful in diagnosing asthma in children with nonspecific respiratory symptoms?

    abstract:BACKGROUND:Variation of lung function is considered to be a hallmark of asthma. Although guidelines recommend measuring it as a diagnostic tool for asthma, the usefulness of this approach has not been studied in children. AIM:To assess the usefulness of home spirometry in children with nonspecific lower respiratory tr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21183

    authors: Brouwer AF,Visser CA,Duiverman EJ,Roorda RJ,Brand PL

    更新日期:2010-04-01 00:00:00

  • Morphometric and biochemical changes in lungs of growing rats treated with a calmodulin antagonist.

    abstract::To determine the role of calmodulin in postnatal lung growth and development, 4-week-old rats were injected intraperitoneally on consecutive days with trifluoperazine (TFP), a potent and specific calmodulin antagonist, for a period fo 3 weeks and studied in comparison with normal controls and undernourished weight-mat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100110

    authors: Ofulue AF,Sekhon H,Cherukupalli K,Khadempour H,Thurlbeck WM

    更新日期:1991-01-01 00:00:00

  • Accurate lung volume measurements in vitro using a novel inert gas washout method suitable for infants.

    abstract:BACKGROUND:Multiple breath washout (MBW) in infants presents a number of technical challenges. Conventional MBW is based on simultaneous measurement of flow and gas concentrations. These two signals are aligned and combined to derive expired gas volumes from which lung volumes and measures of ventilation inhomogeneity ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23348

    authors: Shawcross A,Murray CS,Goddard N,Gupta R,Watson S,Horsley A

    更新日期:2016-05-01 00:00:00

  • Predictors of proper inhaler technique and asthma control in pediatric patients with asthma.

    abstract:BACKGROUND:Improper use of asthma inhalers is one of the potential factors of poor asthma control among children. This study aimed to assess the proper handling of asthma inhalers and asthma control in addition to factors influencing them among pediatric patients who self-administer their inhalers. METHODS:A cross-sec...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25263

    authors: Almomani BA,Al-Qawasmeh BS,Al-Shatnawi SF,Awad S,Alzoubi SA

    更新日期:2021-01-26 00:00:00

  • Socioeconomic status and risk of hospitalization among individuals with cystic fibrosis in Ontario, Canada.

    abstract:BACKGROUND:Socioeconomic status (SES) is a strong predictor of outcomes in cystic fibrosis (CF); however, there are no published studies evaluating this relationship in Canadians with CF. The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21368

    authors: Stephenson A,Hux J,Tullis E,Austin PC,Corey M,Ray J

    更新日期:2011-04-01 00:00:00

  • Nonbronchoscopic approach to bronchoalveolar lavage in children with artificial airways.

    abstract::Bronchoalveolar lavage (BAL) performed with a fiberoptic bronchoscope (FOB) is a useful method for sampling alveolar contents. Since the smallest FOB with a channel has a diameter of 3.6 mm, BAL is difficult to accomplish through artificial airways (AA) less than 5.0 mm I.D. We used a 4F balloon wedge pressure cathete...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950130110

    authors: Alpert BE,O'Sullivan BP,Panitch HB

    更新日期:1992-05-01 00:00:00

  • Sex differences in response to steroids in preterm sheep lungs are not explained by glucocorticoid receptor number or binding affinity.

    abstract::We recently reported that prenatal glucocorticoid therapy is less effective at promoting an improvement in lung function in male than in female sheep. This observation, and the higher incidence of respiratory distress syndrome in human males, suggests that the male fetal lung may be less responsive to glucocorticoids ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1082

    authors: Kovar J,Waddell BJ,Sly PD,Willet KE

    更新日期:2001-07-01 00:00:00

  • Pentraxin 3 as a clinical marker in children with lower respiratory tract infection.

    abstract:BACKGROUND:Pentraxin 3 (PTX-3) is an acute-phase protein that increases in the plasma during inflammation. OBJECTIVE:We aimed to evaluate the usefulness of PTX-3 as a clinical marker in children with lower respiratory tract infection (LRTI) and examine the correlation of PTX-3 with other biomarkers such as C-reactive ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23199

    authors: Kim HS,Won S,Lee EK,Chun YH,Yoon JS,Kim HH,Kim JT

    更新日期:2016-01-01 00:00:00

  • Prevalence of respiratory syncytial virus infection in Italian infants hospitalized for acute lower respiratory tract infections, and association between respiratory syncytial virus infection risk factors and disease severity.

    abstract::This study was designed to collect data on the prevalence of respiratory syncytial virus (RSV) infection in Italy in infants hospitalized for lower respiratory tract infections, and to evaluate which of the recognized risk factors might be associated with disease severity. Thirty-two centers throughout Italy participa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.10047

    authors: Lanari M,Giovannini M,Giuffré L,Marini A,Rondini G,Rossi GA,Merolla R,Zuccotti GV,Salvioli GP,Investigators R.A.DA.R. Study Group.

    更新日期:2002-06-01 00:00:00

  • Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis.

    abstract:BACKGROUND/AIM:There has been recent interest in dry powder inhaled mannitol as a therapeutic agent in patients with cystic fibrosis (CF). It is has been shown to increase mucociliary clearance (MCC) by rehydrating the airway. To date there have been no studies exclusively in children with CF examining the effect of dr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20903

    authors: Minasian C,Wallis C,Metcalfe C,Bush A

    更新日期:2008-11-01 00:00:00

  • Respiratory impedance in patients with Duchenne muscular dystrophy.

    abstract::Impulse oscillometry (IOS) evaluates non-effort-dependent respiratory mechanics, and thus it may be useful to evaluate patients with Duchenne muscular dystrophy (DMD). OBJECTIVES:We aimed (1) to describe the behavior of IOS parameters in patients with DMD, and compare it to those from a control group; (2) to determin...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23434

    authors: Gochicoa-Rangel L,Vargas MH,Alonso-Gómez JL,Rodríguez-Moreno L,Martínez-Briseño D,Baños-Mejía O,Torre-Bouscoulet L

    更新日期:2016-10-01 00:00:00

  • Relief of central airways obstruction following spinal release in a patient with idiopathic scoliosis.

    abstract::SUMMARY. Patients with idiopathic scoliosis are reported to have a restrictive pattern on pulmonary function tests. A case is presented of a teenage girl with juvenile idiopathic scoliosis who had evidence of airways obstruction in addition to restriction on pulmonary function tests (PFT). Examination of flow-volume l...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200101)31:1<86::aid-ppul1012>3.0

    authors: Borowitz D,Armstrong D,Cerny F

    更新日期:2001-01-01 00:00:00

  • Correlation between lung scintigraphy and long-term outcome in survivors of congenital diaphragmatic hernia.

    abstract::Lung scintigraphy has been used to evaluate the degree of pulmonary hypoplasia in infants with congenital diaphragmatic hernia (CDH). However, the relationship between lung scintigraphy and long-term outcome of CDH remains unclear. The aim of this study is to determine whether lung scintigraphy correlates with long-te...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20466

    authors: Okuyama H,Kubota A,Kawahara H,Oue T,Kitayama Y,Yagi M

    更新日期:2006-09-01 00:00:00

  • Validation of novel wheeze phenotypes using longitudinal airway function and atopic sensitization data in the first 6 years of life: evidence from the Southampton Women's survey.

    abstract:BACKGROUND:In 1995 the Tucson Children's Respiratory Study (TCRS) identified clinically distinct phenotypes amongst early wheezers; the Avon Longitudinal Study of Parents And Children (ALSPAC) has recently re-examined these. OBJECTIVES:To validate statistically derived ALSPAC phenotypes in the Southampton Women's Surv...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22766

    authors: Collins SA,Pike KC,Inskip HM,Godfrey KM,Roberts G,Holloway JW,Lucas JS,Southampton Women's Survey Study Group.

    更新日期:2013-07-01 00:00:00

  • Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

    abstract::Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24462

    authors: Balázs A,Mall MA

    更新日期:2019-11-01 00:00:00

  • A decade of pediatric tracheostomies: Indications, outcomes, and long-term prognosis.

    abstract:OBJECTIVE:To define the mortality and long-term outcomes of children undergoing tracheostomy. DESIGN:Retrospective chart and Texas Department of Health Bureau of Vital Statistics review of patients admitted to a Pediatric Intensive Care Unit who underwent a tracheostomy between 2001 and 2011. Mortality and decannulati...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23657

    authors: McPherson ML,Shekerdemian L,Goldsworthy M,Minard CG,Nelson CS,Stein F,Graf JM

    更新日期:2017-07-01 00:00:00

  • The effects of bone marrow transplantation on pulmonary function in children.

    abstract::The effects of current methods of bone marrow transplantation (BMT) on pulmonary function in children have not been extensively studied. We reviewed serial pulmonary function tests (PFTs) in 25 children (median age, 9 yr; range, 4-15) who received allogeneic (n = 14) or autologous (n = 11) BMT for neoplastic diseases ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950180604

    authors: Quigley PM,Yeager AM,Loughlin GM

    更新日期:1994-12-01 00:00:00

  • Safety and use of sputum induction in children with cystic fibrosis.

    abstract::We assessed the safety and use of induced sputum (IS) in children with cystic fibrosis (CF). Forty-eight children (19 males) with CF, mean age 12.6 (range, 7.3-17.0) years and median forced expired volume in 1 sec (FEV(1)) 48% (range, 14-77%) predicted were recruited. Patients spontaneously expectorated sputum and the...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10226

    authors: Suri R,Marshall LJ,Wallis C,Metcalfe C,Shute JK,Bush A

    更新日期:2003-04-01 00:00:00

  • An apple a day won't keep the doctor away: presentation, treatment, and outcome in pediatric apple aspirations.

    abstract:INTRODUCTION:Foreign body (FB) aspiration is a frequent and preventable source of morbidity and mortality, especially in children under 4 years of age. Few comprehensive studies exist on presentation and outcome of apple aspirations in children. METHODS:In a retrospective analysis of bronchoscopy records of a tertiary...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24768

    authors: Zychlinsky Scharff A,Schwerk N,Baumann U,Burmester H,Carlens J,Dopfer C,Grewendorf S,Mueller C,Schütz K,Voelker M,Hansen G,Happle C,Wetzke M

    更新日期:2020-07-01 00:00:00

  • Exercise-induced stridor due to abnormal movement of the arytenoid area: videoendoscopic diagnosis and characterization of the "at risk" group.

    abstract::We evaluated 4 patients who developed severe, symptomatic stridor during maximal cardiopulmonary exercise testing, all referred due to exercise-related dyspnea. All underwent resting, unsedated transnasal fiberoptic laryngoscopy and had normal findings. Four patients performed repeat maximal exercise testing with fibe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20076

    authors: Fahey JT,Bryant NJ,Karas D,Goldberg B,Destefano R,Gracco LC

    更新日期:2005-01-01 00:00:00

  • Parent-reported asthma in Puerto Rican children.

    abstract::We conducted a survey to determine parent-reported asthma prevalence, morbidity, and healthcare utilization among 3527 children attending public schools (n = 2849) and private schools (n = 678) in San Juan, Puerto Rico. Schools were randomly selected from each of 12 geographic regions of the San Juan metropolitan area...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20022

    authors: Nazario S,Casal JR,Torres-Palacios A,Rodriguez W,Delamater AM,Applegate EB,Piedimonte G,Wanner A

    更新日期:2004-05-01 00:00:00

  • Pediatricians' attitudes and costs of bronchiolitis in the emergency department: a prospective multicentre study.

    abstract:BACKGROUND:How pediatricians manage bronchiolitis and the derived total costs (direct and indirect) in the emergency department (ED) have not been fully characterized. The aim of the present study is to calculate those costs in a European country. METHODS:A prospective and observational study, including 10 EDs of tert...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.22906

    authors: Garcia-Marcos L,Valverde-Molina J,Pavlovic-Nesic S,Claret-Teruel G,Peñalba-Citores AC,Nehme-Álvarez D,Korta-Murua J,Sánchez-Etxaniz J,Alonso-Salas MT,Campos-Calleja C,Fernández-Villar A,Rodríguez-Suarez J,BCOST group.

    更新日期:2014-10-01 00:00:00

  • Subcutaneous terbutaline in children with chronic severe asthma.

    abstract::A continuous subcutaneous infusion of terbutaline (CSIT) was used to treat 8 children with chronic severe asthma who continued to experience frequent symptoms, despite treatment with regular oral prednisolone. Five patients experienced a symptomatic improvement from CSIT, leading to a reduction in regular medication. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10081

    authors: Payne DN,Balfour-Lynn IM,Biggart EA,Bush A,Rosenthal M

    更新日期:2002-05-01 00:00:00