Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

abstract：:"Pulmonary Interstitial Glycogenosis: Diagnostic Evaluation and Clinical Course," written by Liptzin et al is a timely and insightful phenotypic summary of a rare pediatric interstitial lung disease. Twenty-four infants with biopsy-proven pulmonary interstitial glycogenosis (PIG) were reviewed at their center. Genetic...

journal_title：Pediatric pulmonology

authors： Yonker LM,Kinane TB

更新日期：2018-12-01 00:00:00

abstract：INTRODUCTION:Foreign body (FB) aspiration is a frequent and preventable source of morbidity and mortality, especially in children under 4 years of age. Few comprehensive studies exist on presentation and outcome of apple aspirations in children. METHODS:In a retrospective analysis of bronchoscopy records of a tertiary...

journal_title：Pediatric pulmonology

authors： Zychlinsky Scharff A,Schwerk N,Baumann U,Burmester H,Carlens J,Dopfer C,Grewendorf S,Mueller C,Schütz K,Voelker M,Hansen G,Happle C,Wetzke M

更新日期：2020-07-01 00:00:00

abstract：:Nicotine, 1 mg/kg body weight/day, was injected subcutaneously in 3 female rabbits during gestational and lactating periods, and the lungs of the offspring were studied by scanning and transmission electron microscopy (SEM and TEM) on days 5, 10, and 25 postpartum. Three other female rabbits served as controls. The si...

journal_title：Pediatric pulmonology

authors： Chen MF,Diotallevi MJ,Kimizuka G,King M,Wang NS

更新日期：1985-11-01 00:00:00

abstract：:We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume rela...

journal_title：Pediatric pulmonology

authors： Silva Neto G,Gerhardt T,Silberberg A,Gerhardt T,Claure N,Duara S,Bancalari E

更新日期：1992-03-01 00:00:00

abstract：BACKGROUND:Treatment regimens for patients with cystic fibrosis (CF) are time-consuming and complex, resulting in consistently low adherence rates. To date, few studies have evaluated innovative technologies to improve adherence in this population. Current infection control guidelines for patients with CF seek to minim...

journal_title：Pediatric pulmonology

authors： Marciel KK,Saiman L,Quittell LM,Dawkins K,Quittner AL

更新日期：2010-02-01 00:00:00

abstract：:Allergic bronchopulmonary aspergillosis (ABPA) is a well-known complication of cystic fibrosis (CF), with an estimated incidence of up to 11%. In patients with CF, the diagnosis of ABPA must be based on significant elevation of Aspergillus fumigatus (Af) antibody and total serum IgE, since it is common to already have...

journal_title：Pediatric pulmonology

authors： Chung Y,Kraut JR,Stone AM,Valaitis J

更新日期：1994-02-01 00:00:00

abstract：:Fetuses of diabetic mothers who were exposed to excessive glucose show delayed maturation. Under these conditions, altered growth factor expression or signaling may have important regulatory influences. We examined the role of epidermal growth factor (EGF) in lung development and maternal diabetes in the rat. In order...

journal_title：Pediatric pulmonology

authors： Thulesen J,Poulsen SS,Nexø E,Raaberg L

更新日期：2000-02-01 00:00:00

abstract：:We conducted a survey to determine parent-reported asthma prevalence, morbidity, and healthcare utilization among 3527 children attending public schools (n = 2849) and private schools (n = 678) in San Juan, Puerto Rico. Schools were randomly selected from each of 12 geographic regions of the San Juan metropolitan area...

journal_title：Pediatric pulmonology

authors： Nazario S,Casal JR,Torres-Palacios A,Rodriguez W,Delamater AM,Applegate EB,Piedimonte G,Wanner A

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To determine the effect of changing electrode positions on vital signs and respiratory effort parameters measured with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants. METHODS:In this observational study, simultaneous dEMG measurements were performed at the standard position and at...

journal_title：Pediatric pulmonology

authors： van Leuteren RW,Bekhuis RE,de Waal CG,de Jongh FH,van Kaam AH,Hutten GJ

更新日期：2020-02-01 00:00:00

abstract：:The airway occlusion techniques for assessing passive respiratory mechanics have become well established methods in fullterm neonates and older infants. The single breath technique (SBT) is frequently used for assessing lung function in intubated infants on neonatal intensive care units. However, less is known about t...

journal_title：Pediatric pulmonology

authors： Gappa M,Rabbette PS,Costeloe KL,Stocks J

更新日期：1993-05-01 00:00:00

abstract：:The long-term efficacy and safety of aminoglycoside aerosol therapy for Pseudomonas aeruginosa colonization/infection in cystic fibrosis has not been fully investigated. In the present study, 14 patients with cystic fibrosis, ages 8-19 years (mean: 13.3 years), received tobramycin aerosol therapy for a mean duration o...

journal_title：Pediatric pulmonology

authors： Steinkamp G,Tümmler B,Gappa M,Albus A,Potel J,Döring G,von der Hardt H

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS:Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed us...

journal_title：Pediatric pulmonology

authors： Balaguer M,Alejandre C,Vila D,Esteban E,Carrasco JL,Cambra FJ,Jordan I

更新日期：2017-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is often cultured from the airways of children with tracheostomies. P. aeruginosa produces exotoxin A (ETA) and type III cytotoxins. This study tested the hypothesis that children with tracheostomies are colonized by P. aeruginosa that express these virulence factors and will have antibodies dir...

journal_title：Pediatric pulmonology

authors： Rao AR,Splaingard MS,Gershan WM,Havens PL,Thill A,Barbieri JT

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:Disease burden in cystic fibrosis (CF) impacts quality of life, distress, and treatment adherence. The promoting resilience in stress management (PRISM), is a brief patient-focused intervention to promote resilience in adolescents and young adults (AYAs), which may mitigate the negative outcomes, and is prov...

journal_title：Pediatric pulmonology

authors： Toprak D,Nay L,McNamara S,Rosenberg AR,Rosenfeld M,Yi-Frazier JP

更新日期：2020-03-01 00:00:00

abstract：:Pulmonary hemorrhage (PH) is a serious complication causing acute respiratory distress in the premature infant, and it is associated with significant mortality and morbidity. The role of inflammatory mediators in this condition is largely undefined. Serial tracheal aspirates (TA) were obtained at intervals from 65 mec...

journal_title：Pediatric pulmonology

authors： Baier RJ,Loggins J,Kruger TE

更新日期：2002-08-01 00:00:00

abstract：:Our study was aimed at elucidating the effect of strenuous maternal exercise (running at a speed of 20 m/min) on fetal somatic growth and lung development. Dams were separated into three groups: (1) exercising during the entire course of pregnancy; (2) exercising from the 16th to the 20th gestational day; and (3) cont...

journal_title：Pediatric pulmonology

authors： Nagai A,Sakamoto K,Konno K

更新日期：1993-06-01 00:00:00

abstract：:The reliability and predictive value of salivary theophylline levels was investigated in 58 children who were treated with oral sustained-release theophylline preparations for bronchial asthma. Serum and saliva levels were assessed by fluorescence polarization immunoassay (FPIA), and Seralyzer (reagent strip reflectan...

journal_title：Pediatric pulmonology

authors： Schulte T,Buhr W,Schmidt M,Walkenbach A,Berdel D

更新日期：1989-01-01 00:00:00

abstract：AIMS:To explore whether gender differences in the Scandinavian Cystic Fibrosis (CF) patients exist in the areas of key clinical parameters, complications, and medication. METHODS:Cross-sectional data on 890 (416 female) pancreatic insufficient CF patients were evaluated regarding chronic infection, body mass index, lu...

journal_title：Pediatric pulmonology

authors： Olesen HV,Pressler T,Hjelte L,Mared L,Lindblad A,Knudsen PK,Laerum BN,Johannesson M,Scandinavian Cystic Fibrosis Study Consortium.

更新日期：2010-10-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Little is known about molecular changes in lungs of fetal rabbits with surgically induced diaphragmatic hernia (DH). Therefore, we examined in this model gene expressions of pivotal molecules for the developing lung. METHODS:At day 23 of gestation, DH was created in 12 fetuses from 4 does. Bot...

journal_title：Pediatric pulmonology

authors： Vuckovic A,Roubliova XI,Votino C,Naeije R,Jani JC

更新日期：2012-11-01 00:00:00

abstract：:Lung hypoplasia is the main cause of congenital diaphragmatic hernia (CDH)-associated death but pathogenesis remains unclear. MiR-455-5p is involved in lung hypoplasia. We hypothesized that nitrofen causes abnormal miR-455-5p expression during lung development and designed this study to determine the relationship betw...

journal_title：Pediatric pulmonology

authors： Zheng J,He Q,Tang H,Li J,Xu H,Mao X,Liu G

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Severe inflammation plays a vital role in the pathogenesis of meconium aspiration syndrome (MAS). Intratracheal (IT) instillation of corticosteroids may be beneficial for MAS in optimizing local effect and reducing systemic adverse effects, but the optimum dosing course remains open to question. METHODS:Thi...

journal_title：Pediatric pulmonology

authors： Lin CH,Jeng MJ,Yang YC,Hsiao YH,Kou YR

更新日期：2017-07-01 00:00:00

abstract：:With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

journal_title：Pediatric pulmonology

authors： Lovinsky-Desir S

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis. METHODS:Retrospective case review. RESULTS:There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. pr...

journal_title：Pediatric pulmonology

authors： Bentley S,Davies JC,Carr SB,Balfour-Lynn IM

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVE:To carry out a cost-effectiveness analysis of omitting chest radiography in the diagnosis of infant bronchiolitis. HYPOTHESIS:Omitting chest radiographs in the diagnosis of typical bronchiolitis was expected to reduce costs without adversely affecting the detection rate of alternate diseases. STUDY DESIGN:A...

journal_title：Pediatric pulmonology

authors： Yong JH,Schuh S,Rashidi R,Vanderby S,Lau R,Laporte A,Nauenberg E,Ungar WJ

更新日期：2009-02-01 00:00:00

abstract：:Neonatal exposure to intermittent hypoxia results in altered ventilatory response to subsequent hypoxia in animal models. The effect of similar exposure in human infants is unknown. Our objective was to determine the impact of sleep disordered breathing (SDB) in early infancy on ventilatory response in infants. We rec...

journal_title：Pediatric pulmonology

authors： MacLean JE,Tan S,Fitzgerald DA,Waters KA

更新日期：2013-03-01 00:00:00

abstract：:Over the past year, a series of papers have reviewed the literature concerning assessment and interpretation of lung function in infants and young children with chronic lung disease of infancy. This manuscript, which represents the final paper in that series, summarizes the findings to date and highlights key areas fo...

journal_title：Pediatric pulmonology

authors： Stocks J,Coates A,Bush A

更新日期：2007-01-01 00:00:00

abstract：:Pediatric Pulmonology continues to publish research and clinical topics related to the entire range of children's respiratory disorders. As we have done annually in recent years, we here summarize some of the past year's publications in our major topic areas, as well as selected literature in these areas from other co...

journal_title：Pediatric pulmonology

authors： Auten R,Ren C,Yilmaz O,Noah TL

更新日期：2017-09-01 00:00:00

abstract：:The cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-8 (IL-8), and intercellular adhesion molecule-1 (ICAM-1) have important roles in regulating neutrophil migration and the inflammatory response. To determine whether the concentration of these cytokines and soluble ICAM-1 (sICAM-1) in sputum was increas...

journal_title：Pediatric pulmonology

authors： Salva PS,Doyle NA,Graham L,Eigen H,Doerschuk CM

更新日期：1996-01-01 00:00:00

abstract：INTRODUCTION:Chest impedance (CI) is the current standard for cardio-respiratory monitoring in preterm infants but fails to provide direct and quantitative information on diaphragmatic activity. Transcutaneous electromyography (dEMG) is able to measure diaphragmatic activity, but its feasibility and repeatability to mo...

journal_title：Pediatric pulmonology

authors： Kraaijenga JV,Hutten GJ,de Jongh FH,van Kaam AH

更新日期：2015-09-01 00:00:00

abstract：:With dual energy X-ray absorptiometry (DEXA), it is possible to quantitate important aspects of growth in children with cystic fibrosis (CF), supplementing the usual measures of height and weight. Of particular concern during growth is the accumulation of bone mineral, since osteoporosis and fractures are well-recogni...

journal_title：Pediatric pulmonology

authors： Henderson RC,Madsen CD

更新日期：1999-02-01 00:00:00