The use of biologic therapies for the management of pediatric asthma.

abstract：:Thirteen children with asthma were treated with cumulative doses of terbutaline delivered as a pressurized aerosol and from a new multidose powder inhaler (Turbuhaler) in a randomized cross-over dose-response study. The cumulative dose of terbutaline was 2 mg on each study day. All children used a correct aerosol inha...

journal_title：Pediatric pulmonology

authors： Fuglsang G,Pedersen S

更新日期：1989-01-01 00:00:00

abstract：:Environmental tobacco smoke, also called passive smoking, was shown to have adverse effects on the health of children. Hydrogen peroxide (H2O2) is proposed as a sensitive marker of oxidative injury and inflammatory processes in the airways, being increased in adult active cigarette smokers. We tested whether passive s...

journal_title：Pediatric pulmonology

authors： Doniec Z,Nowak D,Tomalak W,Pisiewicz K,Kurzawa R

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Socioeconomic status (SES) is a strong predictor of outcomes in cystic fibrosis (CF); however, there are no published studies evaluating this relationship in Canadians with CF. The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult...

journal_title：Pediatric pulmonology

authors： Stephenson A,Hux J,Tullis E,Austin PC,Corey M,Ray J

更新日期：2011-04-01 00:00:00

abstract：:Several enzyme-linked immunosorbent assays (ELISAs) based on mycobacterial antigens have been tried for the rapid diagnosis of tuberculosis (TB). In this study, the value of the 16 and 38-kDa mycobacterial antigens in the diagnosis of TB was investigated in pediatric patients in Izmir, Turkey in whom they were found u...

journal_title：Pediatric pulmonology

authors： Senol G,Ecevit C,Oztürk A

更新日期：2009-09-01 00:00:00

abstract：:Even though childhood asthma is assumed to comprise reversible airway obstruction, some children develop irreversible airway obstruction (not reversed by a bronchodilator or corticosteroids); this may be due to inflammation that has caused remodeling. Lately, it has been claimed that in the absence of treatment with i...

journal_title：Pediatric pulmonology

authors： König P

更新日期：2002-04-01 00:00:00

abstract：:Sudden unexplained deaths have been reported in 13% [corrected] of Familial Dysautonomia (FD) subjects. To characterize cardiorespiratory dysregulation in children with FD that might contribute to potential sudden death, respiratory inductance plethysmography (chest/abdomen), ECG, hemoglobin saturation, and pulse wave...

journal_title：Pediatric pulmonology

authors： Weese-Mayer DE,Kenny AS,Bennett HL,Ramirez JM,Leurgans SE

更新日期：2008-03-01 00:00:00

abstract：:Sleep disordered breathing (SDB) represents a spectrum of breathing disorders, ranging from snoring to obstructive sleep apnea syndrome (OSAS), that disrupt nocturnal respiration and sleep architecture. OSAS is a common disorder in children, with a prevalence of 2-3%. It is associated with neurobehavioral, cognitive, ...

journal_title：Pediatric pulmonology

authors： Goldbart AD,Tal A

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:Medication adherence among adolescents with cystic fibrosis (CF) is often suboptimal and this has significant impact on their health and quality of life. The purpose of the study was to evaluate the impact of frequent home pulmonary function (PFT) monitoring on medication adherence among adolescents with CF. ...

journal_title：Pediatric pulmonology

authors： Shakkottai A,Kaciroti N,Kasmikha L,Nasr SZ

更新日期：2018-04-01 00:00:00

abstract：:Five children with positive serology for human immunodeficiency virus (HIV) infection by enzyme-linked immunosorbent assay and Western blot were followed for chronic pulmonary disease. Lung biopsies were performed in all patients, and confirmed the diagnosis of pulmonary lymphoid hyperplasia. All children demonstrated...

journal_title：Pediatric pulmonology

authors： Rubinstein A,Bernstein LJ,Charytan M,Krieger BZ,Ziprkowski M

更新日期：1988-01-01 00:00:00

abstract：:Severe bronchopulmonary dysplasia (BPD) is frequently associated with asthma. The combination is often severe enough to necessitate corticosteroid therapy. There are no commercially available nebulizer solutions of corticosteroids for use in infants and young children. Seven infants and small children with very severe...

journal_title：Pediatric pulmonology

authors： König P,Shatley M,Levine C,Mawhinney TP

更新日期：1992-08-01 00:00:00

abstract：:Little is known about the respiratory behavior of the intercostal muscles within a neonatal and developmental context. We, therefore, examined intercostal muscle electromyographic (EMG) activity in kittens (1 month old, n = 8; 2 months old, n = 7) during eupnea and heightened respiratory drive induced by hypercapnia. ...

journal_title：Pediatric pulmonology

authors： Watchko JF,Klesh KW,O'Day TL,Guthrie RD

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a common sleep problem. The aim of this study is to investigate the association between OSAHS and blood pressure (BP) in snoring children. METHODS:Snoring children were recruited from January 2009 to December 2010. Clinical history was taken accompanied by...

journal_title：Pediatric pulmonology

authors： Xu Z,Li B,Shen K

更新日期：2013-03-01 00:00:00

abstract：:The airway epithelium represents a primary site for the introduction and deposition of potentially pathogenic microorganisms into the body, through inspired air. The epithelial mucosa is an important component of the innate immune system that recognizes conserved structures in microorganisms and initiates appropriate ...

journal_title：Pediatric pulmonology

authors： Gómez MI,Prince A

更新日期：2008-01-01 00:00:00

abstract：:The prevalence and morbidity of asthma are growing problems that appear to affect urban populations and particularly impoverished centers disproportionately. Poor children are more likely to be hospitalized for asthma than nonpoor children, and are more likely to experience clinical and social dysfunction due to asthm...

journal_title：Pediatric pulmonology

authors： Shapiro GG,Stout JW

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Asthma is the most common chronic inflammatory disease in childhood and some reports have demonstrated systemic inflammation. The relevance of high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in ch...

journal_title：Pediatric pulmonology

authors： Deraz TE,Kamel TB,El-Kerdany TA,El-Ghazoly HM

更新日期：2012-03-01 00:00:00

abstract：:Oxygen supplementation may improve exercise tolerance and the physiological response to exercise in cystic fibrosis (CF) patients. Elevated barometric pressure at low altitude is a simple means of increasing the quantity of inspired oxygen. Our objectives were to examine the effect of natural oxygen enrichment (at the...

journal_title：Pediatric pulmonology

authors： Falk B,Nini A,Zigel L,Yahav Y,Aviram M,Rivlin J,Bentur L,Avital A,Dotan R,Blau H

更新日期：2006-03-01 00:00:00

abstract：:Neutrophil elastase is present at high levels in airway fluid of patients with cystic fibrosis (CF), and is responsible for considerable inflammatory damage. Human monocyte/neutrophil elastase inhibitor (MNEI), a 42-kDa serpin protein, is an effective inhibitor of neutrophil elastase, cathepsin G, and proteinase-3, re...

journal_title：Pediatric pulmonology

authors： Woods DE,Cantin A,Cooley J,Kenney DM,Remold-O'Donnell E

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Our therapeutic approach to a habit/tic cough is simple reassurance in a single consultation. To quality assure our practice, we followed up children to determine outcomes at least 3 months after diagnosis. DESIGN:Consecutive children diagnosed over 6 years were studied. Medical records were analyzed retros...

journal_title：Pediatric pulmonology

authors： Wright MFA,Balfour-Lynn IM

更新日期：2018-04-01 00:00:00

abstract：:Two patients with intractable chronic cough were found to have tonsillar tissue impinging on their epiglottis. In both case, tonsillectomy was curative. The observations in these patients are consistent with a previous report indicating chronic cough from the uvula in contact with the epiglottis with cough cessation f...

journal_title：Pediatric pulmonology

authors： Gurgel RK,Brookes JT,Weinberger MM,Smith RJ

更新日期：2008-11-01 00:00:00

abstract：:The purpose of this study was to compare the pathogens obtained by oropharyngeal suction (OPS) and bronchoalveolar lavage (BAL) in children with chronic pulmonary infections. Forty-four children (mean age of 6.1 years; range 4 months to 15 years) were included in the study (27 children with recurrent localized lung in...

journal_title：Pediatric pulmonology

authors： Avital A,Uwyyed K,Picard E,Godfrey S,Springer C

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Severe inflammation plays a vital role in the pathogenesis of meconium aspiration syndrome (MAS). Intratracheal (IT) instillation of corticosteroids may be beneficial for MAS in optimizing local effect and reducing systemic adverse effects, but the optimum dosing course remains open to question. METHODS:Thi...

journal_title：Pediatric pulmonology

authors： Lin CH,Jeng MJ,Yang YC,Hsiao YH,Kou YR

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Asthma and obstructive sleep apnea (OSA) in children share multiple epidemiological risk factors and the prevalence of snoring is higher in asthmatic children, suggesting that the latter may be at increased risk for OSA. Since both asthma and OSA are inflammatory disorders, we hypothesized that polysomnograp...

journal_title：Pediatric pulmonology

authors： Kheirandish-Gozal L,Dayyat EA,Eid NS,Morton RL,Gozal D

更新日期：2011-09-01 00:00:00

abstract：:SUMMARY. The detection of early airway disease in infants with cystic fibrosis (CF) may lead to earlier intervention and an improved prognosis. We hypothesized that the ratio of maximal expiratory flows while breathing a mixture of helium and oxygen (heliox) and air, referred to as density dependence (DD), would ident...

journal_title：Pediatric pulmonology

authors： Davis S,Jones M,Kisling J,Howard J,Tepper RS

更新日期：2001-01-01 00:00:00

abstract：:We present two infants with congenital tracheal stenosis with complete tracheal rings. Both had associated congenital anomalies. The first case showed cardiac malformations, and the second case had agenesis of the right lung. We review the literature, in particular with reference to tracheal stenosis and pulmonary age...

journal_title：Pediatric pulmonology

authors： Voland JR,Benirschke K,Saunders B

更新日期：1986-07-01 00:00:00

abstract：:Allergic bronchopulmonary aspergillosis (ABPA) is a well-known complication of cystic fibrosis (CF), with an estimated incidence of up to 11%. In patients with CF, the diagnosis of ABPA must be based on significant elevation of Aspergillus fumigatus (Af) antibody and total serum IgE, since it is common to already have...

journal_title：Pediatric pulmonology

authors： Chung Y,Kraut JR,Stone AM,Valaitis J

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:The mammalian lung possesses the highest level of angiotensin converting enzyme (ACE) amongst all the organs. ACE is known to generate angiotensin (AT)-II from AT-I and to regulate serum bradykinin level, thereby controlling blood pressure. Recent data, however, indicate a role for ACE derived AT-II in ang...

journal_title：Pediatric pulmonology

authors： Castro EC,Parks WT,Galambos C

更新日期：2014-10-01 00:00:00

abstract：:Respiratory symptoms, atopy, and bronchial reactivity were measured in primary school children living in Lake Munmorah (LM), a coastal town near two power stations, and in Nelson Bay (NB), a coastal town free from any possible major sources of outdoor air pollution. A prevalence survey and longitudinal follow-up study...

journal_title：Pediatric pulmonology

authors： Henry RL,Abramson R,Adler JA,Wlodarcyzk J,Hensley MJ

更新日期：1991-01-01 00:00:00

abstract：:Phrenic nerve paralysis is a condition typically occurring after invasive procedures in the chest and neck. Here we describe a case of transient unilateral diaphragmatic paralysis in a child with status asthmaticus complicated by complete right lung atelectasis. Common causes of this disorder and possible implications...

journal_title：Pediatric pulmonology

authors： Santuz P,Piccoli A,Zaglia F,Biban P

更新日期：2004-09-01 00:00:00

abstract：:The goal of this research was to begin the process of evaluating acceptability of infection control (IC) recommendations to CF patients and their families, determine whether compliance with IC guidelines differs from compliance with traditional CF medical treatment with respect to the variables predictive of complianc...

journal_title：Pediatric pulmonology

authors： Masterson T,Wildman BG,Newberry B,Omlor G,Bryson E,Kukay A

更新日期：2008-05-01 00:00:00

abstract：:We evaluated 4 patients who developed severe, symptomatic stridor during maximal cardiopulmonary exercise testing, all referred due to exercise-related dyspnea. All underwent resting, unsedated transnasal fiberoptic laryngoscopy and had normal findings. Four patients performed repeat maximal exercise testing with fibe...

journal_title：Pediatric pulmonology

authors： Fahey JT,Bryant NJ,Karas D,Goldberg B,Destefano R,Gracco LC

更新日期：2005-01-01 00:00:00