Impact of home spirometry on medication adherence among adolescents with cystic fibrosis.

Abstract:

OBJECTIVE:Medication adherence among adolescents with cystic fibrosis (CF) is often suboptimal and this has significant impact on their health and quality of life. The purpose of the study was to evaluate the impact of frequent home pulmonary function (PFT) monitoring on medication adherence among adolescents with CF. HYPOTHESIS:We hypothesized that weekly home PFT monitoring will improve adherence while not significantly adding to the treatment burden. METHODS:Individuals aged 12-21 years with CF were provided a spirometer to measure PFTs weekly for 1 year. Results were reviewed weekly via telephone. PFT data were downloaded from the device during quarterly clinic visits. Adherence was calculated from prescription refill data and compared to the previous year. Perceptions of treatment burden were assessed using the CF questionnaire-revised (CFQ-R) quality of life measure. Health outcome measures including nutritional status and PFTs from clinic were collected for the study period and the year prior. RESULTS:Thirty-nine subjects participated in the study. Mean age was 15.89 ± 2.18 years and 54% were female. Mean adherence to weekly spirometry monitoring was 59.47 ± 24.60%. Values generated on the device showed good correlation with those obtained in clinic. Mean medication possession ratio (MPR) was 60% in the previous year and 65% during the study (P = 0.04). Mean treatment burden scaled score on the CFQ-R was 68 at enrollment and 66 at study completion (P = 0.14). CONCLUSIONS:Frequent home PFT monitoring is feasible in CF adolescents and could successfully improve medication adherence without significantly impacting treatment burden.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Shakkottai A,Kaciroti N,Kasmikha L,Nasr SZ

doi

10.1002/ppul.23950

subject

Has Abstract

pub_date

2018-04-01 00:00:00

pages

431-436

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

53

pub_type

杂志文章
  • Thoracoabdominal motion in newborns: Reliability between two interactive computing environments.

    abstract:BACKGROUND:Quantifying the chest wall is useful in documenting thoracoabdominal synchrony during the neonatal period. Subjective measures are often used rather than gold-standard methods due to their practicality in clinical practice. The aim of the present study is to compare the reliability between a newly proposed m...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24709

    authors: Gomes DC,Azevedo IG,de Figueiredo Araújo AG,da Costa Lopes LD,Nagem DAP,Magalhães FA,Pereira SA

    更新日期:2020-05-01 00:00:00

  • Evaluation of the multiple linear regression method to monitor respiratory mechanics in ventilated neonates and young children.

    abstract::A potentially useful method to monitor respiratory mechanics in artificially ventilated patients consists of analyzing the relationship between tracheal pressure (P), lung volume (V), and gas flow (V) by multiple linear regression (MLR) using a suitable model. Contrary to other methods, it does not require any particu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950130307

    authors: Rousselot JM,Peslin R,Duvivier C

    更新日期:1992-07-01 00:00:00

  • Early oxygen uptake recovery following exercise testing in children with chronic chest diseases.

    abstract::The value of exercise testing as an objective measure of disease severity in patients with chronic chest diseases (CCD) is becoming increasingly recognized. The aim of this study was to investigate changes in oxygen uptake (VO2) during early recovery following maximal cardiopulmonary exercise testing (CPXT) in relatio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21024

    authors: Stevens D,Oades PJ,Armstrong N,Williams CA

    更新日期:2009-05-01 00:00:00

  • Respiratory resistance and transcutaneous PO2 during histamine provocation in children with bronchial asthma.

    abstract::Bronchial reactivity was assessed in 66 children with bronchial asthma (aged 8-15 years) by provocation with histamine-HCl during a symptom-free period. A significant bronchial reaction to histamine was defined as a 50% increase in the resistance of the respiratory system (Rrs) determined by the forced oscillation tec...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950150308

    authors: Holmgren D,Engström I,Bjure J,Sixt R,Aberg N

    更新日期:1993-03-01 00:00:00

  • Fertility treatments and the risk of pediatric obstructive sleep apnea in the offspring-Results from a population-based cohort study.

    abstract:OBJECTIVE:While the impact of fertility treatments on the perinatal outcome is well established, the long-term effects on offspring are yet to be determined. The current study aimed to investigate the risk of long-term obstructive sleep apnea (OSA) among children born following in vitro fertilization (IVF) and ovulatio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24428

    authors: Imterat M,Wainstock T,Sheiner E,Landau D,Walfisch A,Harlev A

    更新日期:2019-10-01 00:00:00

  • A comparison between high-flow nasal cannula and noninvasive ventilation in the management of infants and young children with acute bronchiolitis in the PICU.

    abstract:BACKGROUND:Different modalities of noninvasive respiratory support have been recommended for the management of acute bronchiolitis in the pediatric intensive care unit (PICU). High-flow nasal cannula (HFNC) is among the new modalities that have been widely used in the last decade. METHODS:This is a retrospective study...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24553

    authors: Habra B,Janahi IA,Dauleh H,Chandra P,Veten A

    更新日期:2020-02-01 00:00:00

  • Effect of night symptoms and disease severity on subjective sleep quality in children with non-cystic-fibrosis bronchiectasis.

    abstract:BACKGROUND:Night-time symptoms and hypoxemia during sleep may affect sleep quality in children with chronic lung disease such as bronchiectasis. Poor sleep quality may impair growth, learning, and emotional development of children. Our aim was to assess the sleep quality and associated factors in children with non-cyst...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21454

    authors: Erdem E,Ersu R,Karadag B,Karakoc F,Gokdemir Y,Ay P,Akpinar IN,Dagli E

    更新日期:2011-09-01 00:00:00

  • Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease.

    abstract::Deficiency of mannose-binding lectin has been shown to be a risk factor for cystic fibrosis (CF) patients. We, therefore, decided to treat a patient with CF, mannose-binding lectin deficiency, severe bronchopulmonary Pseudomonas aeruginosa infection, and rapid deterioration of lung function with purified mannose-bindi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10064

    authors: Garred P,Pressler T,Lanng S,Madsen HO,Moser C,Laursen I,Balstrup F,Koch C,Koch C

    更新日期:2002-03-01 00:00:00

  • Acquired somatic mutations in the microsatellite DNA, in children with bronchial asthma.

    abstract:OBJECTIVES:High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults. WORKING HYPOTHESIS:The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma. METHODOL...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21097

    authors: Thomou C,Paraskakis E,Neofytou E,Kalmanti M,Siafakas NM,Tzortzaki EG

    更新日期:2009-10-01 00:00:00

  • Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6.

    abstract::Fetal lung hypoplasia is a common finding in several fetal conditions such as congenital diaphragmatic hernia (CDH). Interestingly, previous studies have demonstrated that hypoplastic lungs have the ability to recover to normal size, when relieved from mechanical factors. However, the underlying mechanisms remain larg...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20840

    authors: Nogueira-Silva C,Moura RS,Esteves N,Gonzaga S,Correia-Pinto J

    更新日期:2008-07-01 00:00:00

  • Extralobar pulmonary sequestration with combined gastric and intradiaphragmatic locations.

    abstract::Extralobar pulmonary sequestration is a congenital lung malformation characterized by a non-functional lung segment with systemic feeding vessel. Over 90% of sequestrations are found in the thorax with less than 10% located in the abdomen. We present an unusual case of intra abdominal pulmonary sequestration, located ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22891

    authors: Chouikh T,Berteloot L,Revillon Y,Delacourt C,Khen-Dunlop N

    更新日期:2014-05-01 00:00:00

  • Pilot study for the development of a monitoring device for ventilated children.

    abstract::Airway pressure and air flow were measured at the endotracheal tube in 13 children on a variety of ventilators. These signals were stored for analysis on a computer. Further data sets were obtained after 24 hours or following major interventions. Air flow rate was integrated to give volume. Pulmonary resistance and el...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950110315

    authors: Wensley DF,Noonan P,Seear MD,Werner H,Pirie GE

    更新日期:1991-01-01 00:00:00

  • Interleukin-10 -1082 G/A polymorphism and risk of death or bronchopulmonary dysplasia in ventilated very low birth weight infants.

    abstract::IL-10 is an anti-inflammatory cytokine that may have a protective role in acute lung injury. IL-10 expression is affected by a single-nucleotide polymorphism (SNP) located at position -1082 (G to A). The A allele is associated with lower IL-10 production. Low IL-10 production has been linked to the development of BPD....

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20182

    authors: Yanamandra K,Boggs P,Loggins J,Baier RJ

    更新日期:2005-05-01 00:00:00

  • Respiratory syncytial virus infections in SR Croatia, Yugoslavia.

    abstract::The prevalence of respiratory syncytial virus (RSV) infection was studied during three consecutive annual outbreaks (1983-1986) in SR Croatia, Yugoslavia. A total of 1,238 subjects were examined, using RSV isolation and immunofluorescent (DTFA) methods, with 1,042 showing the signs of respiratory infection and 207 of ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030505

    authors: Mlinarić-Galinović G,Ugrcić I,Bozikov J

    更新日期:1987-09-01 00:00:00

  • Pneumonia due to Chlamydia pneumoniae in children: epidemiology, diagnosis, and treatment.

    abstract::The term "atypical" pneumonia has been used to differentiate infections caused by Chlamydia pneumoniae, Mycoplasma pneumoniae, Legionella, and other related organisms from pneumonia caused by classic bacteria, the prototype being Streptococcus pneumoniae. However, recent studies demonstrated that the clinical presenta...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.10326

    authors: Hammerschlag MR

    更新日期:2003-11-01 00:00:00

  • Care recommendations for the respiratory complications of esophageal atresia-tracheoesophageal fistula.

    abstract::Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24982

    authors: Koumbourlis AC,Belessis Y,Cataletto M,Cutrera R,DeBoer E,Kazachkov M,Laberge S,Popler J,Porcaro F,Kovesi T

    更新日期:2020-10-01 00:00:00

  • Quantitative chest computerized tomography and FEV1 equally identify pulmonary exacerbation risk in children with cystic fibrosis.

    abstract:BACKGROUND:Chest computerized tomography (CT) scores are associated with the frequency of future pulmonary exacerbations in people with cystic fibrosis (CF). However, cut-off values to identify children with mild lung disease with different risks for frequent future pulmonary exacerbations have not been identified. ME...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.24144

    authors: Sanders DB,Li Z,Parker-McGill K,Farrell P,Brody AS

    更新日期:2018-10-01 00:00:00

  • Outcome of idiopathic apparent life-threatening events: infant and mother perspectives.

    abstract::The objective of this study was to determine the neurodevelopmental and temperamental outcome of infants who suffered an idiopathic apparent life-threatening event (IALTE) and their mothers' perceptions of such an event, and to compare such infants with a matched group of babies hospitalized for nonthreatening events....

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1099-0496(199907)28:1<47::aid-ppul8>

    authors: Tirosh E,Kessel A,Jaffe M,Cohen A

    更新日期:1999-07-01 00:00:00

  • Laryngeal ultrasound for the diagnosis of laryngomalacia in infants.

    abstract:INTRODUCTION:Laryngomalacia is the most prevalent cause of congenital stridor. Flexible laryngobronchoscopy (FLB) is the gold standard for diagnosis. However, FLB requires venous access, deep sedation or general anesthesia, and is associated with patient's and parental discomfort and a considerable cost. Laryngeal ultr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23964

    authors: Friedman S,Sadot E,Gut G,Armoni Domany K,Sivan Y

    更新日期:2018-06-01 00:00:00

  • High-sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry.

    abstract:BACKGROUND:Asthma is the most common chronic inflammatory disease in childhood and some reports have demonstrated systemic inflammation. The relevance of high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in ch...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21539

    authors: Deraz TE,Kamel TB,El-Kerdany TA,El-Ghazoly HM

    更新日期:2012-03-01 00:00:00

  • Preferences for disclosing adverse childhood experiences for children and adults with cystic fibrosis.

    abstract:INTRODUCTION:The 2017-2018 National Survey of Children's Health estimates that 30 million (42%) US children have experienced at least one adverse childhood experience (ACE), including abuse, neglect, and household dysfunction. ACEs negatively impact long-term health, and there has been no study of ACEs in cystic fibros...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25243

    authors: Williams WA 2nd,Jain M,Laguna TA,McColley SA

    更新日期:2020-12-26 00:00:00

  • Socioeconomic status and risk of hospitalization among individuals with cystic fibrosis in Ontario, Canada.

    abstract:BACKGROUND:Socioeconomic status (SES) is a strong predictor of outcomes in cystic fibrosis (CF); however, there are no published studies evaluating this relationship in Canadians with CF. The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21368

    authors: Stephenson A,Hux J,Tullis E,Austin PC,Corey M,Ray J

    更新日期:2011-04-01 00:00:00

  • Early factors related to mortality in children treated with bi-level noninvasive ventilation and CPAP.

    abstract:OBJECTIVE:To describe and analyze the characteristics and the early risk factors for mortality of noninvasive ventilation (NIV) in critically ill children. STUDY DESIGN:A multicenter, prospective, observational 2-year study carried out with critically ill patients (1 month - 18 years of age) who needed NIV. Clinical d...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25246

    authors: López J,Pons-Òdena M,Medina A,Molinos-Norniella C,Palanca-Arias D,Demirkol D,León-González JS,López-Fernández YM,Perez-Baena L,López-Herce J,NIV Research Group.

    更新日期:2020-12-31 00:00:00

  • Measurement of single breath-hold carbon monoxide diffusing capacity in healthy infants and toddlers.

    abstract::We describe a method for measuring carbon monoxide diffusing capacity (DL(CO)) and alveolar volume (V(A)) in sleeping infants, using a single 4-sec breath-hold technique. The breath-hold maneuver is obtained by inducing a respiratory pause of the respiratory system. Several inflations of the respiratory system with ro...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20403

    authors: Castillo A,Llapur CJ,Martinez T,Kisling J,Williams-Nkomo T,Coates C,Tepper RS

    更新日期:2006-06-01 00:00:00

  • Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient.

    abstract::Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive type of combined immunodeficiency with elevated IgE. In this report, we describe a Japanese girl of non-consanguineous family suffering from acute eosinophilic pneumonia (AEP) as a presenting feature of DOCK8 deficiency. Although AEP was self-limi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22814

    authors: Tsuge I,Ito K,Ohye T,Kando N,Kondo Y,Nakajima Y,Inuo C,Kurahashi H,Urisu A

    更新日期:2014-03-01 00:00:00

  • Flexible bronchoscopy in pediatric intensive care.

    abstract:OBJECTIVE:To define the benefits of a flexible bronchoscopy (FB) service in a Paediatric Intensive Care Unit (PICU). DESIGN:Review of the first 200 FBs undertaken in a large PICU. SETTING:Large cardiac and medical PICU in the United Kingdom, also providing extra-corporeal life support. PATIENTS:129 patients (78 male...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20910

    authors: Davidson MG,Coutts J,Bell G

    更新日期:2008-12-01 00:00:00

  • Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

    abstract::Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24462

    authors: Balázs A,Mall MA

    更新日期:2019-11-01 00:00:00

  • Prophylaxis against respiratory syncytial virus in young children with cystic fibrosis.

    abstract:INTRODUCTION:In cystic fibrosis (CF) patients, respiratory syncytial virus (RSV) infection is associated with significant morbidity. Although passive prophylaxis with palivizumab lowers hospitalization rate for RSV infection in populations at risk of severe infection, its use is not recommended in infants with CF disea...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20751

    authors: Giebels K,Marcotte JE,Podoba J,Rousseau C,Denis MH,Fauvel V,Laberge S

    更新日期:2008-02-01 00:00:00

  • Necrotizing sarcoid granulomatosis: a rarity in childhood.

    abstract::Necrotizing sarcoid granulomatosis (NSG) is characterized by pulmonary nodular infiltrates, a typical histology, and a benign clinical course. The etiology and pathogenesis of the disease are still unknown. In childhood, it is extremely rare, with only three reported cases so far. Here we report on an 8-year-old girl,...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10242

    authors: Heinrich D,Gordjani N,Trusen A,Marx A,Hebestreit H

    更新日期:2003-05-01 00:00:00

  • The use of biologic therapies for the management of pediatric asthma.

    abstract::With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24613

    authors: Lovinsky-Desir S

    更新日期:2020-03-01 00:00:00