TNF-alpha, IL-8, soluble ICAM-1, and neutrophils in sputum of cystic fibrosis patients.

abstract：:With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

journal_title：Pediatric pulmonology

authors： Lovinsky-Desir S

更新日期：2020-03-01 00:00:00

abstract：:Progressive lung disease in patients with cystic fibrosis (CF) is caused by thick secretions, which cause airway obstruction and subsequent colonization and infection by inhaled pathogenic microorganisms. Recently, recombinant human DNase has been shown to reduce the viscoelasticity of sputum in patients with cystic f...

journal_title：Pediatric pulmonology

authors： Eng PA,Morton J,Douglass JA,Riedler J,Wilson J,Robertson CF

更新日期：1996-02-01 00:00:00

abstract：:Central ventilation disorders(1) and airway obstruction(2) with chronic hypoxemia are causally related to cor pulmonale. Pulmonary vascular resistance is often reversible, and hypoxic pulmonary hypertension often responds to treatment with supplemental oxygen. Oxygen therapy during sleep may be useful as a temporary p...

journal_title：Pediatric pulmonology

authors： Hoch B,Barth H

更新日期：2001-03-01 00:00:00

abstract：RATIONALE AND OBJECTIVES:Little is known about molecular changes in lungs of fetal rabbits with surgically induced diaphragmatic hernia (DH). Therefore, we examined in this model gene expressions of pivotal molecules for the developing lung. METHODS:At day 23 of gestation, DH was created in 12 fetuses from 4 does. Bot...

journal_title：Pediatric pulmonology

authors： Vuckovic A,Roubliova XI,Votino C,Naeije R,Jani JC

更新日期：2012-11-01 00:00:00

abstract：:To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals rece...

journal_title：Pediatric pulmonology

authors： Fabris VE,Pato MD,Belik J

更新日期：2001-05-01 00:00:00

abstract：:We have studied the effect of triamcinolone acetonide (TAC) on airway morphogenesis of the Sprague-Dawley fetal rat in whole organ lung cultures from day 15 to day 21 of equivalent gestational age (6 days in culture). TAC produced an increased number of peripheral buds from day 18 onward and the airway and airspaces h...

journal_title：Pediatric pulmonology

authors： Massoud EA,Sekhon HS,Rotschild A,Thurlbeck WM

更新日期：1992-09-01 00:00:00

abstract：:Asynchronous or paradoxic motion between the rib cage and abdomen may be seen in infants with lung disease. We have recently shown that after bronchodilator administration, the degree of asynchrony decreases proportionately to the improvement in lung mechanics. However, whether such thoraco-abdominal asynchrony (TAA) ...

journal_title：Pediatric pulmonology

authors： Allen JL,Greenspan JS,Deoras KS,Keklikian E,Wolfson MR,Shaffer TH

更新日期：1991-01-01 00:00:00

abstract：UNLABELLED:Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others have not. A possible explanation for these in...

journal_title：Pediatric pulmonology

authors： Stevens TP,Dylag A,Panthagani I,Pryhuber G,Halterman J

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Premature neonates frequently require oxygen supplementation as a therapeutic intervention that, while necessary, also exposes the lung to significant oxidant stress. We hypothesized that hyperoxia has a deleterious effect on alveolar epithelial barrier function rendering the neonatal lung susceptible to inj...

journal_title：Pediatric pulmonology

authors： Vyas-Read S,Vance RJ,Wang W,Colvocoresses-Dodds J,Brown LA,Koval M

更新日期：2018-01-01 00:00:00

abstract：:Traumatic injuries to the pediatric trachea are uncommon events that require prompt diagnosis and management. When they do occur, tracheal injuries often arise in the setting of high impact trauma and are accompanied by major injuries to other organ systems. In this report, we present the diagnosis and conservative ma...

journal_title：Pediatric pulmonology

authors： Sidell DR,Wood RE,Hart CK

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Our objective was to determine those characteristics associated with reversibility of airflow obstruction and response to maximal bronchodilation in children with severe asthma through the Severe Asthma Research Program (SARP). METHODS:We performed a cross-sectional analysis evaluating children ages 6 to 17...

journal_title：Pediatric pulmonology

authors： Coverstone AM,Bacharier LB,Wilson BS,Fitzpatrick AM,Teague WG,Phipatanakul W,Wenzel SE,Gaston BM,Bleecker ER,Moore WC,Ramratnam S,Jarjour NN,Ly NP,Fahy JV,Mauger DT,Schechtman KB,Yin-DeClue H,Boomer JS,Castro M

更新日期：2019-11-01 00:00:00

abstract：:The raised lung volume technique is increasingly used to measure forced expiratory maneuvers in infants. However, there is no consensus regarding the optimal airway inflation pressure (P(inf)) required for such maneuvers, or the influence of small changes in P(inf) within and between infants. The aim of this study was...

journal_title：Pediatric pulmonology

authors： Lum S,Hoo AF,Stocks J

更新日期：2002-02-01 00:00:00

abstract：:Specific airway resistance (SRaw) is conventionally determined by multiplying the plethysmographically measured values of airway resistance and functional residual capacity (FRC). An alternative single-step method, which avoids the need for airway occlusion during determination of FRC, has been described by Dab and Al...

journal_title：Pediatric pulmonology

authors： Haluszka J,Willim G,Cutrera R,Ronchetti R,Filtcher S

更新日期：1989-01-01 00:00:00

abstract：:Airway obstruction in children is a rare, but difficult clinical problem, with no clear agreement on optimal therapeutic approach. Stenting of the airway has been used successfully in adults, and is an attractive alternative in children. Fundamental differences of pediatric compared to adult use include the benign nat...

journal_title：Pediatric pulmonology

authors： Nicolai T

更新日期：2008-04-01 00:00:00

abstract：:The purpose of the study was to analyze the respiratory-dependent intraarterial blood pressure variations (pulsus paradoxus, PP) in intensive care unit patients with obstructive and restrictive pulmonary disease, and to evaluate the usefulness of PP for assessment of disease severity. One-minute paper recordings of ar...

journal_title：Pediatric pulmonology

authors： Frey B,Freezer N

更新日期：2001-02-01 00:00:00

abstract：:Pulmonary surfactant, a unique developmentally regulated, phospholipid-rich lipoprotein, is synthesized by the type II epithelial cells (AECII) of the pulmonary alveolus, where it is stored in organelles termed lamellar bodies. The synthesis of pulmonary surfactant is under multifactorial control and is regulated by a...

journal_title：Pediatric pulmonology

authors： Zhang XQ,Zhang P,Yang Y,Qiu J,Kan Q,Liang HL,Zhou XY,Zhou XG

更新日期：2014-09-01 00:00:00

abstract：:We have evaluated the role of eosinophil cationic protein (ECP) concentrations in serum in predicting wheezing after bronchiolitis, during infancy and early childhood. A prospective study at a university hospital serving all pediatric patients in a defined area was designed. Serum ECP concentrations were measured in 9...

journal_title：Pediatric pulmonology

authors： Reijonen TM,Korppi M,Kuikka L,Savolainen K,Kleemola M,Mononen I,Remes K

更新日期：1997-06-01 00:00:00

abstract：:We studied the effect of low-protein diet (8% casein) on lung growth in rats from 3 to 7 weeks of age. Their diet was isocaloric with that of control animals fed a diet of 20% casein. The calorie intake of experimental animals was increased during the first 3 weeks of the experiment, but they increased less (about 10%...

journal_title：Pediatric pulmonology

authors： Matsui R,Thurlbeck WM,Fujita Y,Yu SY,Kida K

更新日期：1989-01-01 00:00:00

abstract：:Allergic bronchopulmonary aspergillosis (ABPA) is a well-known complication of cystic fibrosis (CF), with an estimated incidence of up to 11%. In patients with CF, the diagnosis of ABPA must be based on significant elevation of Aspergillus fumigatus (Af) antibody and total serum IgE, since it is common to already have...

journal_title：Pediatric pulmonology

authors： Chung Y,Kraut JR,Stone AM,Valaitis J

更新日期：1994-02-01 00:00:00

abstract：INTRODUCTION:Advance care planning (ACP), though recommended, has not been studied in adolescents with cystic fibrosis (CF). This quality improvement project engaged adolescents with advanced CF disease in ACP and assessed patient and CF provider attitudes and preferences regarding ACP discussions and tools. MATERIALS...

journal_title：Pediatric pulmonology

authors： Kazmerski TM,Weiner DJ,Matisko J,Schachner D,Lerch W,May C,Maurer SH

更新日期：2016-12-01 00:00:00

abstract：:In cystic fibrosis the bronchiectatic conducting airways have large numbers of neutrophils in their walls and in their luminal contents. The neutrophil's primary granule enzyme activities of elastase and peroxidase are increased in the sputum of these patients. It has been postulated that these enzymes--together or in...

journal_title：Pediatric pulmonology

authors： Regelmann WE,Schneider LA,Fahrenkrug SC,Gray BH,Johnson S,Herron JM,Clawson CC,Clawson DJ,Wangensteen OD

更新日期：1997-07-01 00:00:00

abstract：BACKGROUND:Population-based studies investigating health-related quality of life (HRQoL) among asthmatic adolescents are rare. Further, among subjects with asthma, HRQoL may be affected by asthma control and severity. AIM:To investigate HRQoL in relation to asthma control and asthma severity among adolescents. METHOD...

journal_title：Pediatric pulmonology

authors： Stridsman C,Backman H,Eklund BM,Rönmark E,Hedman L

更新日期：2017-07-01 00:00:00

abstract：:Multiresistance in Stenotrophomonas maltophilia limits the effectiveness of antimicrobial therapy for infections due to this organism. It can be of special concern in cystic fibrosis (CF) patients due to frequent antimicrobial administration. The in vitro activity of 41 antimicrobial agents against 76 epidemiologicall...

journal_title：Pediatric pulmonology

authors： Cantón R,Valdezate S,Vindel A,Sánchez Del Saz B,Maíz L,Baquero F

更新日期：2003-02-01 00:00:00

abstract：:Antimicrobial proteins are important in lung defense and are potential therapeutic agents in chronic airways infection such as seen in cystic fibrosis (CF). In preparation for future clinical studies, we sought (1) to determine levels of three antimicrobial proteins [lactoferrin, lysozyme, and secretory leukoprotease ...

journal_title：Pediatric pulmonology

authors： Sagel SD,Sontag MK,Accurso FJ

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine factors predictive of need for mechanical ventilation (MV) upon discharge from the pediatric intensive care unit (PICU) among patients who receive a tracheostomy during their stay. METHODS:This was a retrospective cohort study using the Virtual PICU Systems (VPS)...

journal_title：Pediatric pulmonology

authors： McCrory MC,Lee KJ,Scanlon MC,Wakeham MK

更新日期：2016-01-01 00:00:00

abstract：:Our objective was to determine whether postnatal respiratory function, lung growth, and lung structure are affected by preterm birth which did not require neonatal respiratory support. Two groups of preterm (P) lambs were delivered 2 weeks before term, at 133 days of gestational age (GA). Tissue was collected at term ...

journal_title：Pediatric pulmonology

authors： Cock M,Hanna M,Sozo F,Wallace M,Yawno T,Suzuki K,Maritz G,Hooper S,Harding R

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:Socioeconomic status (SES) is a strong predictor of outcomes in cystic fibrosis (CF); however, there are no published studies evaluating this relationship in Canadians with CF. The objective of this study was to assess the effect of SES on annual hospitalization rates in a large cohort of pediatric and adult...

journal_title：Pediatric pulmonology

authors： Stephenson A,Hux J,Tullis E,Austin PC,Corey M,Ray J

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND:Asthma and obstructive sleep apnea (OSA) in children share multiple epidemiological risk factors and the prevalence of snoring is higher in asthmatic children, suggesting that the latter may be at increased risk for OSA. Since both asthma and OSA are inflammatory disorders, we hypothesized that polysomnograp...

journal_title：Pediatric pulmonology

authors： Kheirandish-Gozal L,Dayyat EA,Eid NS,Morton RL,Gozal D

更新日期：2011-09-01 00:00:00

abstract：OBJECTIVE:To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS:Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed us...

journal_title：Pediatric pulmonology

authors： Balaguer M,Alejandre C,Vila D,Esteban E,Carrasco JL,Cambra FJ,Jordan I

更新日期：2017-04-01 00:00:00

abstract：:Polyvinyl chloride (PVC) nasogastric feeding catheters are used clinically to measure intraesophageal pressure as an estimate of pleural pressure for calculating lung compliance in infants. The accuracy of pressure measurement of 4 French gauge (FG) catheter sizes and three brands of liquid-filled catheter manometer s...

journal_title：Pediatric pulmonology

authors： Hartford CG,Rogers GG,Turner MJ

更新日期：1997-05-01 00:00:00