Combination antifungal therapy for Scedosporium species in cystic fibrosis.

Abstract:

OBJECTIVE:To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis. METHODS:Retrospective case review. RESULTS:There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. prolificans. Treatment duration: median 5 months (range: 5-18 m). In no patient was eradication achieved, with the follow-up range being 6 months to 4 years. Effect on lung function was variable but encouraging. No adverse effects were reported, one child had transient elevation of liver enzymes. CONCLUSIONS:While the combination therapy was well tolerated, it was unsuccessful at eradication.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Bentley S,Davies JC,Carr SB,Balfour-Lynn IM

doi

10.1002/ppul.24789

subject

Has Abstract

pub_date

2020-08-01 00:00:00

pages

1993-1995

issue

8

eissn

8755-6863

issn

1099-0496

journal_volume

55

pub_type

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