The effects of bone marrow transplantation on pulmonary function in children.

Abstract:

:The effects of current methods of bone marrow transplantation (BMT) on pulmonary function in children have not been extensively studied. We reviewed serial pulmonary function tests (PFTs) in 25 children (median age, 9 yr; range, 4-15) who received allogeneic (n = 14) or autologous (n = 11) BMT for neoplastic diseases at The Johns Hopkins Hospital. The PFTs were obtained before BMT and at 6 months (early) and 15 months (late) after transplant. In all but 6 patients, PFTs were normal before BMT. A mild transient decline in carbon monoxide diffusing capacity (DLCO) was observed early after BMT but returned to baseline levels in the late post-BMT period. A trend towards worsening of PFTs with increasing age of patients was observed. The presence of graft-versus-host disease (GVHD) and pretransplant seropositivity for cytomegalovirus (CMV) were associated with significant decrements in several measurements of pulmonary function in the early post-BMT period. Patients given bulsulfan-containing preparative regimens tended to have less impairment of PFTs than those given other regimens using other combination high-dose chemotherapeutic agents or total body irradiation. These findings suggest that abnormalities in PFTs are common in the first months after BMT in pediatric patients but are not consistently associated with impairment of lung function when studied 15 months post-transplant.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Quigley PM,Yeager AM,Loughlin GM

doi

10.1002/ppul.1950180604

subject

Has Abstract

pub_date

1994-12-01 00:00:00

pages

361-7

issue

6

eissn

8755-6863

issn

1099-0496

journal_volume

18

pub_type

杂志文章
  • Nonlinear pressure/volume relationship and measurements of lung mechanics in infants.

    abstract::We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume rela...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950120304

    authors: Silva Neto G,Gerhardt T,Silberberg A,Gerhardt T,Claure N,Duara S,Bancalari E

    更新日期:1992-03-01 00:00:00

  • Bronchiolitis Score of Sant Joan de Déu: BROSJOD Score, validation and usefulness.

    abstract:OBJECTIVE:To validate the bronchiolitis score of Sant Joan de Déu (BROSJOD) and to examine the previously defined scoring cutoff. PATIENTS AND METHODS:Prospective, observational study. BROSJOD scoring was done by two independent physicians (at admission, 24 and 48 hr). Internal consistency of the score was assessed us...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23546

    authors: Balaguer M,Alejandre C,Vila D,Esteban E,Carrasco JL,Cambra FJ,Jordan I

    更新日期:2017-04-01 00:00:00

  • Comparison of normal infants and infants with cystic fibrosis using forced expiratory flows breathing air and heliox.

    abstract::SUMMARY. The detection of early airway disease in infants with cystic fibrosis (CF) may lead to earlier intervention and an improved prognosis. We hypothesized that the ratio of maximal expiratory flows while breathing a mixture of helium and oxygen (heliox) and air, referred to as density dependence (DD), would ident...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200101)31:1<17::aid-ppul1002>3.0

    authors: Davis S,Jones M,Kisling J,Howard J,Tepper RS

    更新日期:2001-01-01 00:00:00

  • Subcutaneous terbutaline in children with chronic severe asthma.

    abstract::A continuous subcutaneous infusion of terbutaline (CSIT) was used to treat 8 children with chronic severe asthma who continued to experience frequent symptoms, despite treatment with regular oral prednisolone. Five patients experienced a symptomatic improvement from CSIT, leading to a reduction in regular medication. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10081

    authors: Payne DN,Balfour-Lynn IM,Biggart EA,Bush A,Rosenthal M

    更新日期:2002-05-01 00:00:00

  • Do New Zealand children with non-cystic fibrosis bronchiectasis show disease progression?

    abstract:BACKGROUND:There is minimal literature available on the long-term outcome of pediatric non-cystic fibrosis (CF) bronchiectasis. AIM:To document 5-year outcomes of children with chest computerized tomography (CT) scan diagnosed bronchiectasis from a tertiary New Zealand (NZ) respiratory clinic. METHODS:Review of a cli...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21331

    authors: Munro KA,Reed PW,Joyce H,Perry D,Twiss J,Byrnes CA,Edwards EA

    更新日期:2011-02-01 00:00:00

  • Elimination of Australian epidemic strain (AES1) pseudomonas aeruginosa in a pediatric cystic fibrosis center.

    abstract:INTRODUCTION:In this cohort study spanning an 18-year period, we evaluated the prevalence and associated mortality rate of epidemic strains of pseudomonas aeruginosa (PsA), especially Australian Epidemic Strain Type 1 (AES1), in a pediatric cystic fibrosis center practicing cohort segregation and early PsA eradication....

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24173

    authors: Kevat A,Carzino R,Massie J,Harrison J,Griffiths AL

    更新日期:2018-11-01 00:00:00

  • Quantitative chest computerized tomography and FEV1 equally identify pulmonary exacerbation risk in children with cystic fibrosis.

    abstract:BACKGROUND:Chest computerized tomography (CT) scores are associated with the frequency of future pulmonary exacerbations in people with cystic fibrosis (CF). However, cut-off values to identify children with mild lung disease with different risks for frequent future pulmonary exacerbations have not been identified. ME...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.24144

    authors: Sanders DB,Li Z,Parker-McGill K,Farrell P,Brody AS

    更新日期:2018-10-01 00:00:00

  • Alveolar concentration and bronchial flux of nitric oxide: two linear modeling methods evaluated in children and adolescents with allergic rhinitis and atopic asthma.

    abstract:OBJECTIVE:Alveolar concentration (C(A)NO) and bronchial flux (J(aw)NO) of nitric oxide (NO) characterize the contributions of peripheral and proximal airways to exhaled NO. Both parameters can be estimated using a two-compartment model if the fraction of NO in orally exhaled air (FE(NO)) is measured at multiple constan...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22550

    authors: Chládková J,Senkerík M,Havlínová Z,Krcmová I,Chládek J

    更新日期:2012-11-01 00:00:00

  • A simple method of reducing complications of pediatric nonbronchoscopic bronchoalveolar lavage.

    abstract::Our objective was to determine whether a simple method of maintaining positive pressure ventilation during nonbronchoscopic bronchoalveolar lavage (NB-BAL) would successfully reduce the incidence and/or severity of desaturation events. Our design was a clinical trial with historical controls. Seventy ventilated pediat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20082

    authors: Morrow B,Futter M,Argent A

    更新日期:2004-09-01 00:00:00

  • Diaphragmatic electromyography in preterm infants: The influence of electrode positioning.

    abstract:OBJECTIVE:To determine the effect of changing electrode positions on vital signs and respiratory effort parameters measured with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants. METHODS:In this observational study, simultaneous dEMG measurements were performed at the standard position and at...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24585

    authors: van Leuteren RW,Bekhuis RE,de Waal CG,de Jongh FH,van Kaam AH,Hutten GJ

    更新日期:2020-02-01 00:00:00

  • Assessing the need for adenotonsillectomy for sleep-disordered breathing in a community setting: A secondary outcome measures analysis of a randomized controlled study.

    abstract:OBJECTIVE:To assess whether children with sleep-disordered breathing (SDB) symptom severity above a certain level, measured by a validated questionnaire, improve after adenotonsillectomy (AT) compared to no intervention. METHODS:Children with snoring and tonsillar hypertrophy (4 to 10-years old), who were candidates f...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.24427

    authors: Papadakis CE,Chaidas K,Chimona TS,Zisoglou M,Ladias A,Proimos EK,Miligkos M,Kaditis AG

    更新日期:2019-10-01 00:00:00

  • Pulmonary function and structure following mild preterm birth in lambs.

    abstract::Our objective was to determine whether postnatal respiratory function, lung growth, and lung structure are affected by preterm birth which did not require neonatal respiratory support. Two groups of preterm (P) lambs were delivered 2 weeks before term, at 133 days of gestational age (GA). Tissue was collected at term ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20274

    authors: Cock M,Hanna M,Sozo F,Wallace M,Yawno T,Suzuki K,Maritz G,Hooper S,Harding R

    更新日期:2005-10-01 00:00:00

  • Ventilation homogeneity improves with growth early in life.

    abstract::Some studies have suggested that lung clearance index (LCI) is age-independent among healthy subjects early in life, which implies that ventilation distribution does not vary with growth. However, other studies of older children and adolescents suggest that ventilation becomes more homogenous with somatic growth. We d...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21553

    authors: Chakr VC,Llapur CJ,Sarria EE,Mattiello R,Kisling J,Tiller C,Kimmel R,Poindexter B,Tepper RS

    更新日期:2012-04-01 00:00:00

  • Corticosteroid treatment for pulmonary lymphoid hyperplasia in children with the acquired immune deficiency syndrome.

    abstract::Five children with positive serology for human immunodeficiency virus (HIV) infection by enzyme-linked immunosorbent assay and Western blot were followed for chronic pulmonary disease. Lung biopsies were performed in all patients, and confirmed the diagnosis of pulmonary lymphoid hyperplasia. All children demonstrated...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950040105

    authors: Rubinstein A,Bernstein LJ,Charytan M,Krieger BZ,Ziprkowski M

    更新日期:1988-01-01 00:00:00

  • Asphyxiating tracheal bronchogenic cyst.

    abstract::We report on a 7-month old infant with severe respiratory distress secondary to a paratracheal bronchogenic cyst. Respiratory relief was achieved by transtracheal puncture of the cyst. Surgical removal of the cyst was performed 1 week later because of radiological evidence of reaccumulation of fluid. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10408

    authors: De Baets F,Van Daele S,Schelstraete P,Haerynck F,Vermassen F,Broers C

    更新日期:2004-12-01 00:00:00

  • RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.

    abstract::Short-acting β2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to β2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22723

    authors: Labuda M,Laberge S,Brière J,Bérubé D,Krajinovic M

    更新日期:2013-10-01 00:00:00

  • Domestic exposure to aeroallergens in Hong Kong families with asthmatic children.

    abstract::Indoor aeroallergen exposures increased asthma symptoms in Caucasians, but their determinants and relationship to asthma and allergy in Asians are unclear. This study investigated exposures to cat, cockroach, and Blomia tropicalis allergens in 115 Hong Kong families with asthmatic children. Patients underwent exhaled ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21391

    authors: Leung TF,Wong YS,Chan IH,Yung E,Sy HY,Lam CW,Wong GW

    更新日期:2011-07-01 00:00:00

  • Pilot study for the development of a monitoring device for ventilated children.

    abstract::Airway pressure and air flow were measured at the endotracheal tube in 13 children on a variety of ventilators. These signals were stored for analysis on a computer. Further data sets were obtained after 24 hours or following major interventions. Air flow rate was integrated to give volume. Pulmonary resistance and el...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950110315

    authors: Wensley DF,Noonan P,Seear MD,Werner H,Pirie GE

    更新日期:1991-01-01 00:00:00

  • Performance of a tracheostomy removal protocol for pediatric patients in rehabilitation after acquired brain injury: Factors associated with timing and possibility of decannulation.

    abstract:OBJECTIVES:We assessed the performance of a tracheostomy decannulation protocol privileging safety over quickness, in pediatric patients undergoing rehabilitation from severe acquired brain injury. We analyzed factors associated with decannulation timing and possibility and examined cases of failure. HYPOTHESIS:A safe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23832

    authors: Pozzi M,Galbiati S,Locatelli F,Clementi E,Strazzer S

    更新日期:2017-11-01 00:00:00

  • Sex differences in response to steroids in preterm sheep lungs are not explained by glucocorticoid receptor number or binding affinity.

    abstract::We recently reported that prenatal glucocorticoid therapy is less effective at promoting an improvement in lung function in male than in female sheep. This observation, and the higher incidence of respiratory distress syndrome in human males, suggests that the male fetal lung may be less responsive to glucocorticoids ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1082

    authors: Kovar J,Waddell BJ,Sly PD,Willet KE

    更新日期:2001-07-01 00:00:00

  • Telomere length and lung function in a population-based cohort of children and mid-life adults.

    abstract:OBJECTIVE:Telomere length is associated with poorer lung health in older adults, possibly from cumulative risk factor exposure, but data are lacking in pediatric and population-based cohorts. We examined associations of telomere length with lung function in children and mid-life adults. METHODS:Data were drawn from a ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24489

    authors: Nguyen MT,Saffery R,Burgner D,Lycett K,Vryer R,Grobler A,Dwyer T,Ranganathan S,Wake M

    更新日期:2019-12-01 00:00:00

  • Exhaled breath condensate pH in infants and children with acute and recurrent wheezy bronchitis.

    abstract::The analysis of exhaled breath condensate (EBC) is a promising new method to measure airway inflammation. So far only limited data exist about methodological issues of EBC sampling in infants and young children. We evaluated 18 children with acute wheezy bronchitis (median age 24.3 months (min-max: 4-89.9)), 54 childr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20712

    authors: Vogelberg C,Würfel C,Knoetzsch A,Kahlert A,Range U,Leupold W

    更新日期:2007-12-01 00:00:00

  • Longitudinal measures of lung function in infants with bronchopulmonary dysplasia.

    abstract::We previously demonstrated that infants with a history of bronchopulmonary dysplasia (BPD) exhibit airflow obstruction and air trapping. The purpose of this study was to assess longitudinal changes in pulmonary function in infants with a history of BPD over the first 3 years of life, and the relationship to somatic gr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21378

    authors: Filbrun AG,Popova AP,Linn MJ,McIntosh NA,Hershenson MB

    更新日期:2011-04-01 00:00:00

  • Signaling molecules in the fetal rabbit model for congenital diaphragmatic hernia.

    abstract:RATIONALE AND OBJECTIVES:Little is known about molecular changes in lungs of fetal rabbits with surgically induced diaphragmatic hernia (DH). Therefore, we examined in this model gene expressions of pivotal molecules for the developing lung. METHODS:At day 23 of gestation, DH was created in 12 fetuses from 4 does. Bot...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22512

    authors: Vuckovic A,Roubliova XI,Votino C,Naeije R,Jani JC

    更新日期:2012-11-01 00:00:00

  • Treatment of anorexia and weight loss with megestrol acetate in patients with cystic fibrosis.

    abstract::Four patients with severe cystic fibrosis lung disease, anorexia and weight loss, received Megestrol Acetate (MA), as an appetite stimulant. The initial dose was 400-800 mg daily and was continued for 6-15 months. Appetite was improved, with significant weight gain in all patients and an increase in their weight for a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199911)28:5<380::aid-ppul1

    authors: Nasr SZ,Hurwitz ME,Brown RW,Elghoroury M,Rosen D

    更新日期:1999-11-01 00:00:00

  • Multiple breath washout quality control in the clinical setting.

    abstract:BACKGROUND:Multiple breath washout (MBW) is increasingly used in the clinical assessment of patients with cystic fibrosis (CF). Guidelines for MBW quality control (QC) were developed primarily for retrospective assessment and central overreading. We assessed whether real-time QC of MBW data during the measurement impro...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25119

    authors: Frauchiger BS,Carlens J,Herger A,Moeller A,Latzin P,Ramsey KA

    更新日期:2021-01-01 00:00:00

  • A novel combined treatment for plasminogen deficiency with lung involvement.

    abstract::Plasminogen deficiency is characterized by fibrin-rich pseudomembrane formation on all mucosal surfaces, particularly the conjunctiva. Respiratory system involvement is common; fibrin often obstructs the upper or lower respiratory tract, causing death. Although many treatments have been applied, no definitive treatmen...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24563

    authors: Kilinc AA,Tarcin G,Kurugoglu S,Schuster V,Cokugras H,Celkan T

    更新日期:2020-01-01 00:00:00

  • The effectiveness of magnesium sulfate for status asthmaticus outside the intensive care setting.

    abstract:AIM:Magnesium is an adjunctive therapy used in patients with status asthmaticus who do not respond to conventional therapy. The optimal time from initiation of therapy, to determination of response and administration of magnesium has not yet been resolved. Our objective was to determine if magnesium administered in the...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24013

    authors: DeSanti RL,Agasthya N,Hunter K,Hussain MJ

    更新日期:2018-07-01 00:00:00

  • Predicting arterial oxygen tension from maximum expiratory flow volume curves in cystic fibrosis.

    abstract::Measurements of arterial oxygen tension (PaO2) while breathing room air, and maximum expiratory flow volume curves were performed in 34 patients with cystic fibrosis (age range 7-27 years, 24 males and 10 females). Logistic regression was performed using forced vital capacity (FVC), forced expiratory volume in 1 secon...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950060108

    authors: Stecenko AA,Postotnik L,Thomas RG

    更新日期:1989-01-01 00:00:00

  • Polysomnography Provides Useful Clinical Information in the Liberation from Respiratory Technology: A Retrospective Review.

    abstract::Background The prevalence of respiratory-technology dependent children is increasing although for most children the goal is liberation from technology. Liberation from home mechanical ventilation (HMV) and decannulation strategies vary due to the lack of clinical practice standards. The primary objective of this study...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24164

    authors: Bashir A,Henningfeld JK,Thompson NE,D'Andrea LA

    更新日期:2018-11-01 00:00:00