Acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation.

Abstract:

OBJECTIVE:To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation. DESIGN:Case report. SETTING:A tertiary care University-affiliated hospital. PATIENT, INTERVENTION, AND RESULTS:An 8-month-old girl developed acute respiratory distress with profound hypoxemia complicated by pneumothorax and pneumomediastinum 1 day following intralesional administration of bleomycin. She was treated with bilateral chest tube insertion, systemic corticosteroids, pentoxifylline, and supportive care. At the most recent follow-up 5 months after the onset of the respiratory event, the patient is active, walks, and talks without any evidence of pulmonary diseases clinically. This is the youngest infant reported, to date, with acute bleomycin pulmonary toxicity following intralesional administration of bleomycin resulting in acute respiratory insufficiency followed by complete recovery. CONCLUSIONS:This case illustrates the importance of early recognition and aggressive treatment of acute bleomycin toxicity resulting from intralesional administration of this medication for lymphovenous malformations.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Atwa K,Abuhasna S,Shihab Z,Hashaykeh N,Hasan R

doi

10.1002/ppul.21139

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

192-6

issue

2

eissn

8755-6863

issn

1099-0496

journal_volume

45

pub_type

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