Abstract:
:Viral colds are an important cause of respiratory symptoms in normal children. Studies in adults suggest that inflammation in the lower respiratory tract is associated with viral colds, but there are no data regarding inflammation and viral infection in the lower airway of normal children with colds. We, therefore, studied the lower airway of two groups of children: Group I, those with active coryzal symptoms and a respiratory virus isolated from bronchoalveolar lavage fluid (BALF); and Group II: asymptomatic children who had had a clinical cold within the previous 2 weeks and no respiratory virus in BALF. Both groups were compared to age- and weight-matched normal noninfected controls, who had had no coryzal symptoms for at least 8 weeks. Viruses isolated from BALF of Group I (n = 7) were: respiratory syncytial virus (n = 2), rhinovirus (n = 3), parainfluenza I (n = 1), and echovirus 11 (n = 1). Compared to normal controls, Group I had an increased BALF lymphocyte and neutrophil differential count (P < 0.05), a concomitant depressed alveolar macrophage differential count (P < 0.05), and increased BALF concentrations of soluble intercellular adhesion molecule-1 (sICAM-1) (P < 0.05, n = 6), total protein (P < 0.05, n = 6) and albumin (P < 0.05, n = 7). Similar changes were seen in Group II (n = 22), with an increased BALF neutrophil (P < 0.05) and lymphocyte (P < 0.01) differential count, and increased concentrations of sICAM-1 (P < 0.01, n = 15), total protein (P < 0.0001, n = 9) and albumin (P = 0.05, n = 17). Our results suggest that inflammation and viral infection in the lower airway are present during active colds, and that inflammation is also present during the convalescent period.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Grigg J,Riedler J,Robertson CFdoi
10.1002/(sici)1099-0496(199908)28:2<109::aid-ppul6subject
Has Abstractpub_date
1999-08-01 00:00:00pages
109-16issue
2eissn
8755-6863issn
1099-0496pii
10.1002/(SICI)1099-0496(199908)28:2<109::AID-PPUL6journal_volume
28pub_type
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journal_title:Pediatric pulmonology
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更新日期:2009-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1994-12-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2012-11-01 00:00:00
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更新日期:2018-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2011-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2016-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1992-05-01 00:00:00
abstract::Patients with cystic fibrosis (CF) often experience acute pulmonary exacerbations (APE) and may be treated with a wide variety of intravenous antibiotics. The aim of this review is to provide an evidence-based summary of pharmacokinetic/pharmacodynamic (PK/PD), tolerability, and efficacy studies utilizing the intraven...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22664
更新日期:2013-01-01 00:00:00
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更新日期:2017-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,随机对照试验
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更新日期:2006-03-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:1995-11-01 00:00:00