Abstract:
:In children unable to perform reliable spirometry, the interrupter resistance (R(int) ) technique for assessing respiratory resistance is easy to perform. However, few data are available on the possibility to use R(int) as a surrogate for spirometry. We aimed at comparing R(int) and spirometry at baseline and after bronchodilator administration in a large population of asthmatic children. We collected retrospectively R(int) and spirometry results measured in 695 children [median age 7.8 (range 4.8-13.9) years] referred to our lab for routine assessment of asthma disease. Correlations between R(int) and spirometry were studied using data expressed as z-scores. Receiver operator characteristic curves for the baseline R(int) value (z-score) and the bronchodilator effect (percentage predicted value and z-score) were generated to assess diagnostic performance. At baseline, the relationship between raw values of R(int) and FEV(1) was not linear. Despite a highly significant inverse correlation between R(int) and all of the spirometry indices (FEV(1) , FVC, FEV(1) /FVC, FEF(25-75%) ; P < 0.0001), R(int) could detect baseline obstruction (FEV(1) z-score ≤ -2) with only 42% sensitivity and 95% specificity. Post-bronchodilator changes in R(int) and FEV(1) were inversely correlated (rhô = -0.50, P < 0.0001), and R(int) (≥35% predicted value decrease) detected FEV(1) reversibility (>12% baseline increase) with 70% sensitivity and 69% specificity (AUC = 0.79). R(int) measurements fitted a one-compartment model that explained the relationship between flows and airway resistance. We found that R(int) had poor sensitivity to detect baseline obstruction, but fairly good sensitivity and specificity to detect reversibility. However, in order to implement asthma guidelines for children unable to produce reliable spirometry, bronchodilator response measured by R(int) should be systematically studied and further assessed in conjunction with clinical outcomes.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Beydon N,Mahut B,Maingot L,Guillo H,La Rocca MC,Medjahdi N,Koskas M,Boulé M,Delclaux Cdoi
10.1002/ppul.22526subject
Has Abstractpub_date
2012-10-01 00:00:00pages
987-93issue
10eissn
8755-6863issn
1099-0496journal_volume
47pub_type
杂志文章abstract:OBJECTIVE:Lung ultrasound (LUS) is an emerging tool that may be used in the diagnosis and follow-up of children with viral bronchiolitis. In this study, we describe LUS abnormalities in children receiving invasive mechanical ventilation (IMV) for severe bronchiolitis in the pediatric intensive care unit (PICU). Our aim...
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更新日期:2008-06-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2008-12-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:1991-01-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22568
更新日期:2013-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1992-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25033
更新日期:2020-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950120309
更新日期:1992-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1990-01-01 00:00:00
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更新日期:1992-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950170309
更新日期:1994-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23636
更新日期:2017-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2011-09-01 00:00:00
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更新日期:2013-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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更新日期:1995-06-01 00:00:00