Ventilation homogeneity improves with growth early in life.

Abstract:

:Some studies have suggested that lung clearance index (LCI) is age-independent among healthy subjects early in life, which implies that ventilation distribution does not vary with growth. However, other studies of older children and adolescents suggest that ventilation becomes more homogenous with somatic growth. We describe a new technique to obtain multiple breath washout (MBWO) in sedated infants and toddlers using slow augmented inflation breaths that yields an assessment of LCI and the slope of phase III, which is another index of ventilation inhomogeneity. We evaluated whether ventilation becomes more homogenous with increasing age early in life, and whether infants with chronic lung disease of infancy (CLDI) have increased ventilation inhomogeneity relative to full-term controls (FT). FT (N = 28) and CLDI (N = 22) subjects between 3 and 28 months corrected-age were evaluated. LCI decreased with increasing age; however, there was no significant difference between the two groups (9.3 vs. 9.5; P = 0.56). Phase III slopes adjusted for expired volume (S(ND)) increased with increasing breath number during the washout and decreased with increasing age. There was no significant difference in S(ND) between full-term and CLDI subjects (211 vs. 218; P = 0.77). Our findings indicate that ventilation becomes more homogenous with lung growth and maturation early in life; however, there is no evidence that ventilation inhomogeneity is a significant component of the pulmonary pathophysiology of CLDI.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Chakr VC,Llapur CJ,Sarria EE,Mattiello R,Kisling J,Tiller C,Kimmel R,Poindexter B,Tepper RS

doi

10.1002/ppul.21553

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

373-80

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

47

pub_type

杂志文章
  • Lung disease in Niemann-Pick disease.

    abstract:BACKGROUND:Lung involvement in children with Niemann-Pick disease has rarely been studied systematically. OBJECTIVE:To assess the involvement of the lung and the value of bronchoalveolar lavage in children with Niemann-Pick diseases. DESIGN:Retrospective analysis of patient records. PATIENTS:Thirteen patients, with ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20725

    authors: Guillemot N,Troadec C,de Villemeur TB,Clément A,Fauroux B

    更新日期:2007-12-01 00:00:00

  • Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children.

    abstract::Tracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.24435

    authors: Moreno M,Castillo-Corullón S,Pérez-Ruiz E,Luna MC,Antón-Pacheco JL,Mondejar-Lopez P,De-la-Serna O,Villa JR,Osona B,Torres-Borrego J,Santiago-Burruchaga M,Asensio O,Andres-Martin A,Delgado-Pecellin I,González Y,Palmero A,E

    更新日期:2019-10-01 00:00:00

  • Congenital lung abnormality quantification by computed tomography: The CLAQ method.

    abstract:INTRODUCTION:To date, no consensus has been reached on the optimal management of congenital lung abnormalities, and factors predicting postnatal outcome have not been identified. We developed an objective quantitative computed tomography (CT) scoring method, and assessed its value for clinical decision-making. METHODS...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25032

    authors: Hermelijn SM,Dragt OV,Bosch JJ,Hijkoop A,Riera L,Ciet P,Wijnen RMH,Schnater JM,Tiddens HAWM

    更新日期:2020-11-01 00:00:00

  • Predicting survival in infants with persistent pulmonary hypertension of the newborn.

    abstract::Since persistent pulmonary hypertension of the newborn (PPHN) often occurs as a life-threatening illness, it would be advantageous to identify the highest-risk infants within the first 24 hours of life so that transfer to centers with extracorporeal membrane oxygenation (ECMO) or high-frequency ventilation can be faci...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050103

    authors: Davis JM,Spitzer AR,Cox C,Fox WW

    更新日期:1988-01-01 00:00:00

  • Waist circumference associated with pulmonary function in children.

    abstract::In adults abdominal obesity is related to lung dysfunction and waist circumference (WC) predicts pulmonary function. It is not known how WC affects pulmonary function in children. A cross-sectional study of 718 children 6-17 years of age was conducted in a rural community to determine the predictability of WC for pulm...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20854

    authors: Chen Y,Rennie D,Cormier Y,Dosman JA

    更新日期:2009-03-01 00:00:00

  • Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood.

    abstract:BACKGROUND:It is uncertain whether folate is risk or preventive factor for allergic and respiratory diseases. OBJECTIVE:To determine the relationship between maternal or offspring folate status and subsequent development of allergic and respiratory diseases in early childhood. METHODS:In total, 917 mother-child pairs...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23025

    authors: Kim JH,Jeong KS,Ha EH,Park H,Ha M,Hong YC,Bhang SY,Lee SJ,Lee KY,Lee SH,Kim Y,Kim MH,Chang N

    更新日期:2015-02-01 00:00:00

  • Adolescent girls with asthma have worse asthma control and health-related quality of life than boys-A population based study.

    abstract:BACKGROUND:Population-based studies investigating health-related quality of life (HRQoL) among asthmatic adolescents are rare. Further, among subjects with asthma, HRQoL may be affected by asthma control and severity. AIM:To investigate HRQoL in relation to asthma control and asthma severity among adolescents. METHOD...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23723

    authors: Stridsman C,Backman H,Eklund BM,Rönmark E,Hedman L

    更新日期:2017-07-01 00:00:00

  • The highs and lows of wheezing: A review of the most popular adventitious lung sound.

    abstract::Wheezing is the most widely reported adventitious lung sound in the English language. It is recognized by health professionals as well as by lay people, although often with a different meaning. Wheezing is an indicator of airway obstruction and therefore of interest particularly for the assessment of young children an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23930

    authors: Pasterkamp H

    更新日期:2018-02-01 00:00:00

  • Efficacy of fiberoptic bronchoscopy and bronchoalveolar lavage in childhood-onset, complicated plastic bronchitis.

    abstract:BACKGROUND:Plastic bronchitis (PB) is a rare, variable, and potentially fatal disease. This study aimed to assess the efficacy of fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in treating children with PB. METHODS:In total, 15 children with PB, between 2012 and 2020, were enrolled in our study. Within...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25016

    authors: Wang L,Wang W,Sun JM,Ni SW,Ding JL,Zhu YL,Ding SG

    更新日期:2020-11-01 00:00:00

  • Short and long interpregnancy interval and the risk for pediatric obstructive sleep apnea in the offspring.

    abstract:INTRODUCTION:Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI < 6 months) and long IPI (IPI > 60 months) have been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25240

    authors: Rapaport Pasternak H,Sheiner E,Goldbart A,Wainstock T

    更新日期:2020-12-31 00:00:00

  • Validation of a questionnaire instrument for prediction of obstructive sleep apnea in Hong Kong Chinese children.

    abstract::To develop and validate a questionnaire scale that can be used as a screening tool to investigate for the presence of childhood obstructive sleep apnea syndrome (OSAS) in Hong Kong Chinese children. Subjects suspected to have OSAS and controls were recruited. Parents completed a Hong Kong children sleep questionnaire ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20505

    authors: Li AM,Cheung A,Chan D,Wong E,Ho C,Lau J,Wing YK

    更新日期:2006-12-01 00:00:00

  • A scoring system for lung function tests in infants.

    abstract::Measurements of thoracic gas volume (TGV), airway resistance (Raw), and airway conductance (Gaw) were calculated in a group of 42 normal infants using a whole-body plethysmograph. Maximum expiratory flow at functional residual capacity was measured in a separate group of 108 normal infants. Using data obtained from th...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950140303

    authors: Hampton F,Beardsmore CS,Morgan W,Williams A,Taussig L,Thompson JR

    更新日期:1992-11-01 00:00:00

  • Membranous obliterative bronchitis: a proposed unifying model.

    abstract::Three adults with cystic fibrosis (one after lung transplantation) presented with fever, chest pain, and acute radiographic changes. The changes included a cavitary lesion of the lung, acute dense infiltrates, and lobar collapse. After failing conventional antibiotic therapy, the patients underwent flexible bronchosco...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20348

    authors: Colin AA,Tsiligiannis T,Nosé V,Waltz DA

    更新日期:2006-02-01 00:00:00

  • Reference equations for the interpretation of forced expiratory and plethysmographic measurements in infants.

    abstract:BACKGROUND:Pulmonary function testing is commonly performed for diagnosis and clinical management of respiratory diseases. It is important to use appropriate reference equations from healthy subjects for interpretation of data from infants with lung disease. This study aimed to determine if published reference equation...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24063

    authors: Lu Z,Foong RE,Kowalik K,Moraes TJ,Dubeau A,Lefebvre D,Davis SD,Balkovec S,Becker A,Mandhane P,Turvey SE,Lou W,Sears MR,Ratjen F,Subbarao P

    更新日期:2018-07-01 00:00:00

  • Angiotensin II receptor inhibition prevents pneumocyte apoptosis in surfactant-depleted rat lungs.

    abstract::Pneumocyte apoptosis is implicated in the pathophysiology of acute inflammatory lung injuries in newborns and adults. Pulmonary angiotensin (ANG) II contributes to lung epithelial apoptosis in vitro, but its role in acute lung injury in vivo is unclear. We therefore studied the effects of ANG II receptor action on the...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20187

    authors: Lukkarinen HP,Laine J,Aho H,Zagariya A,Vidyasagar D,Kääpä PO

    更新日期:2005-04-01 00:00:00

  • The role of polysomnography in tracheostomy decannulation of children with bronchopulmonary dysplasia.

    abstract:BACKGROUND:Patients with bronchopulmonary dysplasia (BPD) may require tracheostomy for long-term mechanical ventilation. Polysomnography (PSG) may predict successful decannulation in children, however it is unclear how this success compares with children without a PSG. To better evaluate this role, we compared decannul...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24474

    authors: Quinlan C,Piccione J,Kim JY,Beck SE,Brooks L,Chandy-Patel R,Escobar E,Afolabi-Brown O

    更新日期:2019-11-01 00:00:00

  • Intrinsic catch-up growth of hypoplastic fetal lungs is mediated by interleukin-6.

    abstract::Fetal lung hypoplasia is a common finding in several fetal conditions such as congenital diaphragmatic hernia (CDH). Interestingly, previous studies have demonstrated that hypoplastic lungs have the ability to recover to normal size, when relieved from mechanical factors. However, the underlying mechanisms remain larg...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20840

    authors: Nogueira-Silva C,Moura RS,Esteves N,Gonzaga S,Correia-Pinto J

    更新日期:2008-07-01 00:00:00

  • The lung is involved in juvenile dermatomyositis.

    abstract:BACKGROUND:Juvenile dermatomyositis (JDM) is the main cause of chronic idiopathic inflammatory myopathy of autoimmune origin in children. The aim of this multicenter prospective study was to describe respiratory status and treatment of children followed for JDM. METHODS AND PATIENTS:Clinical manifestations, pulmonary ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.22742

    authors: Pouessel G,Deschildre A,Le Bourgeois M,Cuisset JM,Catteau B,Karila C,Nève V,Thumerelle C,Quartier P,Tillie-Leblond I

    更新日期:2013-10-01 00:00:00

  • Ultrastructural ciliary defects in children with recurrent infections of the lower respiratory tract.

    abstract::One hundred fifty-four children with recurrent or chronic infections of the lower respiratory tract compatible with the diagnosis of primary ciliary dyskinesia (PCD) were evaluated for the presence of ultrastructural ciliary abnormalities. Studies were performed on multiple samples of respiratory mucosa obtained by na...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100104

    authors: Barlocco EG,Valletta EA,Canciani M,Lungarella G,Gardi C,De Santi MM,Mastella G

    更新日期:1991-01-01 00:00:00

  • Factors that correlate with sleep oxygenation in children with cystic fibrosis.

    abstract:OBJECTIVE:Cystic fibrosis (CF) patients may develop hypoxemia during sleep. Limited information is available on nocturnal oxygen saturation in CF children with less severe lung disease. The aim of this study was to investigate the degree of nocturnal oxygen desaturation and factors that correlate with nocturnal oxygena...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20643

    authors: Uyan ZS,Ozdemir N,Ersu R,Akpinar I,Keskin S,Cakir E,Karadağ B,Karakoç F,Dağli E

    更新日期:2007-08-01 00:00:00

  • Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter.

    abstract::Most pneumatoceles disappear spontaneously and do not cause severe symptoms. Treatment alternatives include various conventional or surgical methods. However, an enlarging, complicated pneumatocele with cardiorespiratory instability requires imaging-guided catheter drainage or surgery. Here, we report the case of a ne...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23311

    authors: Park TH,Kim JK

    更新日期:2016-02-01 00:00:00

  • Regulation of pulmonary surfactant synthesis in fetal rat type II alveolar epithelial cells by microRNA-26a.

    abstract::Pulmonary surfactant, a unique developmentally regulated, phospholipid-rich lipoprotein, is synthesized by the type II epithelial cells (AECII) of the pulmonary alveolus, where it is stored in organelles termed lamellar bodies. The synthesis of pulmonary surfactant is under multifactorial control and is regulated by a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22975

    authors: Zhang XQ,Zhang P,Yang Y,Qiu J,Kan Q,Liang HL,Zhou XY,Zhou XG

    更新日期:2014-09-01 00:00:00

  • Evaluation of the interrupter technique for the use of assessing airway obstruction in children.

    abstract::The purpose of this study was to determine if the interrupter technique, a noninvasive method for measuring airflow resistance, could be used to assess airway obstruction in children. In 107 children (74 with asthma, 12 with cystic fibrosis, and 21 without lung disease) conductance (mostly of airways) measured with th...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950170402

    authors: Carter ER,Stecenko AA,Pollock BH,Jaeger MJ

    更新日期:1994-04-01 00:00:00

  • Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children.

    abstract:BACKGROUND:Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. OBJECTIVES:To investigate if FeNO concentrations we...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22705

    authors: Oh MA,Shim JY,Jung YH,Seo JH,Young Kim H,Kwon JW,Kim BJ,Kim HB,Kim WK,Lee SY,Jang GC,Song DJ,Kim HJ,Shin YJ,Park JW,Cho SH,Lee JS,Hong SJ

    更新日期:2013-06-01 00:00:00

  • Interpretation of respiratory input impedance in healthy infants.

    abstract::Respiratory input impedance (Zin) is a potentially informative test of pulmonary function in infants who are unable to perform standard tests commonly performed in children and adults Analysis of Zin in dogs using the six-element model of DuBois et al. (J Appl Physiol 8:587, 1956) provides estimates of airways resista...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199612)22:6<364::AID-PPUL5

    authors: Jackson AC,Neff KM,Dorkin HL,Lutchen KR

    更新日期:1996-12-01 00:00:00

  • Diaphragmatic electromyography in preterm infants: The influence of electrode positioning.

    abstract:OBJECTIVE:To determine the effect of changing electrode positions on vital signs and respiratory effort parameters measured with transcutaneous electromyography of the diaphragm (dEMG) in preterm infants. METHODS:In this observational study, simultaneous dEMG measurements were performed at the standard position and at...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24585

    authors: van Leuteren RW,Bekhuis RE,de Waal CG,de Jongh FH,van Kaam AH,Hutten GJ

    更新日期:2020-02-01 00:00:00

  • Comparative study using oral solutions of bambuterol once daily or terbutaline three times daily in 2-5-year-old children with asthma. Bambuterol Multicentre Study Group.

    abstract::The aim of this study was to compare safety and efficacy of bambuterol hydrochloride (10 mg) oral solution administered once daily in the evening with terbutaline sulphate (0.075 mg/kg body weight) oral solution administered three times daily in 2-5-year-old children with asthma. There were two treatment groups: (2/3)...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(sici)1099-0496(200003)29:3<194::aid-ppul7

    authors: Kuusela AL,Marenk M,Sandahl G,Sanderud J,Nikolajev K,Persson B

    更新日期:2000-03-01 00:00:00

  • Management of empyema in children.

    abstract::The incidence of empyema complicating community-acquired pneumonia is increasing and causes significant childhood morbidity. Pneumococcal infection remains the most common isolated cause in developed countries, with Staphylococcus aureus the predominant pathogen in the developing world. Newer molecular techniques util...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20251

    authors: Jaffé A,Balfour-Lynn IM

    更新日期:2005-08-01 00:00:00

  • CF: an X-ray database to assess effect of aerosolized tobramycin.

    abstract::This paper assesses the effectiveness of aerosolized tobramycin (TOBI) on cystic fibrosis (CF) lung disease, using a radiologic tool. The published tool, the age-based severity curve (ABS), is derived from Brasfield scoring of chest X-rays (CXR). This study evaluates both the usefulness of the ABS as an assessment too...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20032

    authors: Slattery DM,Zurakowski D,Colin AA,Cleveland RH

    更新日期:2004-07-01 00:00:00

  • Mucus obstruction and inflammation in early cystic fibrosis lung disease: Emerging role of the IL-1 signaling pathway.

    abstract::Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24462

    authors: Balázs A,Mall MA

    更新日期:2019-11-01 00:00:00