Angiotensin II receptor inhibition prevents pneumocyte apoptosis in surfactant-depleted rat lungs.

abstract：BACKGROUND:Ivacaftor is a significant innovation in the treatment of cystic fibrosis (CF) with gating mutations. A substantial percentage of patients with CF have severe lung involvement, but these patients are usually excluded from phase III clinical trials. Thus, the effectiveness of ivacaftor in this population has ...

journal_title：Pediatric pulmonology

authors： Salvatore D,Carnovale V,Iacotucci P,Braggion C,Castellani C,Cimino G,Colangelo C,Francalanci M,Leonetti G,Lucidi V,Manca A,Vitullo P,Ferrara N

更新日期：2019-09-01 00:00:00

abstract：:During the final prenatal period of fetal lung development in humans, important maturational processes occur, including the production of surfactant necessary to decrease surface tension at the air-liquid interface of the alveoli. During early gestation, the glucocorticoid receptor is expressed in the fetal lung, and ...

journal_title：Pediatric pulmonology

authors： Bolt RJ,van Weissenbruch MM,Lafeber HN,Delemarre-van de Waal HA

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Simulated exhaled nitric oxide (eNO) depends on ventilatory settings used in different experimental conditions. OBJECTIVES:To normalize the simulated minute exhaled nitric oxide according to different ventilatory settings. WORKING HYPOTHESIS:Different ventilatory settings influence the concentrations of ex...

journal_title：Pediatric pulmonology

authors： Figueras-Aloy J,Berrueco R,Salvia-Roiges MD,Rodríguez-Miguélez JM,Miracle-Echegoyen X,Botet-Mussons F,Mur-Sierra A,Vall O,Carbonell-Estrany X

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVES:Childhood interstitial lung disease (chILD) is a group of rare chronic and complex disorders of variable pathology. There has been no systematic review of published chILD research. This study aimed to describe chILD classification systems, epidemiology, morbidity, treatments, outcomes, and the impact of chIL...

journal_title：Pediatric pulmonology

authors： Hime NJ,Zurynski Y,Fitzgerald D,Selvadurai H,Phu A,Deverell M,Elliott EJ,Jaffe A

更新日期：2015-12-01 00:00:00

abstract：:The purpose of this report is to describe the College of American Pathologists sweat testing (SW) proficiency testing program for cystic fibrosis, to evaluate its impact on test performance, and to describe the current practice of sweat testing in North America. The study analyzed participant summary reports of the SW...

journal_title：Pediatric pulmonology

authors： LeGrys VA

更新日期：2000-12-01 00:00:00

abstract：:The term "atypical" pneumonia has been used to differentiate infections caused by Chlamydia pneumoniae, Mycoplasma pneumoniae, Legionella, and other related organisms from pneumonia caused by classic bacteria, the prototype being Streptococcus pneumoniae. However, recent studies demonstrated that the clinical presenta...

journal_title：Pediatric pulmonology

authors： Hammerschlag MR

更新日期：2003-11-01 00:00:00

abstract：INTRODUCTION:Advance care planning (ACP), though recommended, has not been studied in adolescents with cystic fibrosis (CF). This quality improvement project engaged adolescents with advanced CF disease in ACP and assessed patient and CF provider attitudes and preferences regarding ACP discussions and tools. MATERIALS...

journal_title：Pediatric pulmonology

authors： Kazmerski TM,Weiner DJ,Matisko J,Schachner D,Lerch W,May C,Maurer SH

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Multiple breath washout (MBW) is increasingly used in the clinical assessment of patients with cystic fibrosis (CF). Guidelines for MBW quality control (QC) were developed primarily for retrospective assessment and central overreading. We assessed whether real-time QC of MBW data during the measurement impro...

journal_title：Pediatric pulmonology

authors： Frauchiger BS,Carlens J,Herger A,Moeller A,Latzin P,Ramsey KA

更新日期：2021-01-01 00:00:00

abstract：:To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals rece...

journal_title：Pediatric pulmonology

authors： Fabris VE,Pato MD,Belik J

更新日期：2001-05-01 00:00:00

abstract：INTRODUCTION:In this cohort study spanning an 18-year period, we evaluated the prevalence and associated mortality rate of epidemic strains of pseudomonas aeruginosa (PsA), especially Australian Epidemic Strain Type 1 (AES1), in a pediatric cystic fibrosis center practicing cohort segregation and early PsA eradication....

journal_title：Pediatric pulmonology

authors： Kevat A,Carzino R,Massie J,Harrison J,Griffiths AL

更新日期：2018-11-01 00:00:00

abstract：:Five children with positive serology for human immunodeficiency virus (HIV) infection by enzyme-linked immunosorbent assay and Western blot were followed for chronic pulmonary disease. Lung biopsies were performed in all patients, and confirmed the diagnosis of pulmonary lymphoid hyperplasia. All children demonstrated...

journal_title：Pediatric pulmonology

authors： Rubinstein A,Bernstein LJ,Charytan M,Krieger BZ,Ziprkowski M

更新日期：1988-01-01 00:00:00

abstract：:The clinical course of sarcoidosis in children has not been well defined. Eight children with symptomatic sarcoidosis included in this study underwent pulmonary function tests and bronchoscopy with bronchoalveolar lavage (BAL) before treatment and during steroid therapy. At the start of therapy, functional parameters,...

journal_title：Pediatric pulmonology

authors： Chadelat K,Baculard A,Grimfeld A,Tournier G,Boule M,Boccon-Gibod L,Clement A

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Improper use of asthma inhalers is one of the potential factors of poor asthma control among children. This study aimed to assess the proper handling of asthma inhalers and asthma control in addition to factors influencing them among pediatric patients who self-administer their inhalers. METHODS:A cross-sec...

journal_title：Pediatric pulmonology

authors： Almomani BA,Al-Qawasmeh BS,Al-Shatnawi SF,Awad S,Alzoubi SA

更新日期：2021-01-26 00:00:00

abstract：BACKGROUND:Disease burden in cystic fibrosis (CF) impacts quality of life, distress, and treatment adherence. The promoting resilience in stress management (PRISM), is a brief patient-focused intervention to promote resilience in adolescents and young adults (AYAs), which may mitigate the negative outcomes, and is prov...

journal_title：Pediatric pulmonology

authors： Toprak D,Nay L,McNamara S,Rosenberg AR,Rosenfeld M,Yi-Frazier JP

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Chronic colonization with Pseudomonas (P.) aeruginosa worsens the prognosis of cystic fibrosis (CF) patients. This study aims to analyze the functional properties of neutrophils in CF patients with P. aeruginosa colonization. METHODS:Patients with CF (n = 16) were grouped by positivity of P. aeruginosa in s...

journal_title：Pediatric pulmonology

authors： Aslanhan U,Cakir E,Ozyigit LP,Kucuksezer UC,Gelmez YM,Yuksel M,Deniz G,Aktas EC

更新日期：2021-01-29 00:00:00

abstract：OBJECTIVE:To define the benefits of a flexible bronchoscopy (FB) service in a Paediatric Intensive Care Unit (PICU). DESIGN:Review of the first 200 FBs undertaken in a large PICU. SETTING:Large cardiac and medical PICU in the United Kingdom, also providing extra-corporeal life support. PATIENTS:129 patients (78 male...

journal_title：Pediatric pulmonology

authors： Davidson MG,Coutts J,Bell G

更新日期：2008-12-01 00:00:00

abstract：:In adults, the term specific pulmonary renal syndrome describes disorders with pulmonary and glomerular manifestations and includes Wegener's granulomatosis, Goodpasture disease, and systemic lupus erythematosus. Nonspecific pulmonary renal syndrome refers to either pulmonary disease complicating glomerular disease, o...

journal_title：Pediatric pulmonology

authors： von Vigier RO,Trummler SA,Laux-End R,Sauvain MJ,Truttmann AC,Bianchetti MG

更新日期：2000-05-01 00:00:00

abstract：PURPOSE:To examine the independent association of asthma and obesity and of their co-existence with functional exercise capacity among urban adolescents. METHODS:One hundred eighteen Hispanic- and African-American adolescents including 33 obese asthmatics, 18 normal-weight asthmatics, 38 obese non-asthmatics, and 29 n...

journal_title：Pediatric pulmonology

authors： Rastogi D,Khan UI,Isasi CR,Coupey SM

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults. WORKING HYPOTHESIS:The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma. METHODOL...

journal_title：Pediatric pulmonology

authors： Thomou C,Paraskakis E,Neofytou E,Kalmanti M,Siafakas NM,Tzortzaki EG

更新日期：2009-10-01 00:00:00

abstract：:We compared the performance of selected ultrasonic and jet nebulizers when aerosolizing several antibiotic formulations to determine optimum combinations for delivery of a respirable antibiotic aerosol. Three ultrasonic devices were tested: the UltraNeb 99/100, the UltraAIR and the Aerosonic. The reusable jet nebulize...

journal_title：Pediatric pulmonology

authors： Weber A,Morlin G,Cohen M,Williams-Warren J,Ramsey B,Smith A

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Child exposure to cigarette smoke is harmful. It should be reduced through parental smoking cessation interventions. The aim of our study was to determine the impact of simple advice provided by the pediatrician on the smoking habits of parents of children with cystic fibrosis (CF), diabetes mellitus (DM) an...

journal_title：Pediatric pulmonology

authors： Lafont M,Morin C,Arrouy A,Rabeau A,Labouret G,Roditis L,Michelet M,Mittaine M

更新日期：2021-01-22 00:00:00

abstract：:In children unable to perform reliable spirometry, the interrupter resistance (R(int) ) technique for assessing respiratory resistance is easy to perform. However, few data are available on the possibility to use R(int) as a surrogate for spirometry. We aimed at comparing R(int) and spirometry at baseline and after br...

journal_title：Pediatric pulmonology

authors： Beydon N,Mahut B,Maingot L,Guillo H,La Rocca MC,Medjahdi N,Koskas M,Boulé M,Delclaux C

更新日期：2012-10-01 00:00:00

abstract：:The quantity and composition of airway surface liquid (ASL) are essential to host defense. To date, attempts to harvest ASL and measure its composition have yielded conflicting results. We investigated the physical principles underlying two techniques that were proposed for harvesting ASL: filter paper pledgets and po...

journal_title：Pediatric pulmonology

authors： Landry JS,Landry C,Cowley EA,Govindaraju K,Eidelman DH

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis. METHODS:Retrospective case review. RESULTS:There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. pr...

journal_title：Pediatric pulmonology

authors： Bentley S,Davies JC,Carr SB,Balfour-Lynn IM

更新日期：2020-08-01 00:00:00

abstract：:Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...

journal_title：Pediatric pulmonology

authors： Koumbourlis AC,Belessis Y,Cataletto M,Cutrera R,DeBoer E,Kazachkov M,Laberge S,Popler J,Porcaro F,Kovesi T

更新日期：2020-10-01 00:00:00

abstract：:Patients with cystic fibrosis (CF) often experience acute pulmonary exacerbations (APE) and may be treated with a wide variety of intravenous antibiotics. The aim of this review is to provide an evidence-based summary of pharmacokinetic/pharmacodynamic (PK/PD), tolerability, and efficacy studies utilizing the intraven...

journal_title：Pediatric pulmonology

authors： Young DC,Zobell JT,Waters CD,Ampofo K,Stockmann C,Sherwin CM,Spigarelli MG

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVES:To investigate the adherence and the self-reported barriers to general and respiratory exercises reported by individuals with cystic fibrosis (CF). STUDY DESIGN:An exploratory, experimental study. METHODS:Community-dwelling individuals aged 16 years and over, diagnosed with CF, who were accompanied in refe...

journal_title：Pediatric pulmonology

authors： Santuzzi CH,Liberato FMG,Morau SAC,de Oliveira NFF,Nascimento LR

更新日期：2020-10-01 00:00:00

abstract：:Acute mycoplasma pneumonia may be accompanied by wheeze in some children considered not to have asthma. The aim of the present study was to evaluate cytokine secretion in children with acute mycoplasma pneumonia and wheeze. We studied 58 patients with mycoplasma pneumonia (12 with wheeze, Group 1; 46 without wheeze, G...

journal_title：Pediatric pulmonology

authors： Choi IS,Byeon JH,Yoo Y,Lee KC,Choung JT

更新日期：2009-05-01 00:00:00

abstract：:Tracheobronchomegaly (Mounier-Kuhn syndrome) is characterized by dilatation of the central airways, tracheobronchial outpouchings, and chronic tracheobronchitis. Most cases are diagnosed in adulthood. We report the clinical, radiographic, and bronchoscopic findings in a 14-year-old boy with tracheobronchomegaly, ptosi...

journal_title：Pediatric pulmonology

authors： Benesch M,Eber E,Pfleger A,Zach MS

更新日期：2000-06-01 00:00:00

abstract：:Indoor aeroallergen exposures increased asthma symptoms in Caucasians, but their determinants and relationship to asthma and allergy in Asians are unclear. This study investigated exposures to cat, cockroach, and Blomia tropicalis allergens in 115 Hong Kong families with asthmatic children. Patients underwent exhaled ...

journal_title：Pediatric pulmonology

authors： Leung TF,Wong YS,Chan IH,Yung E,Sy HY,Lam CW,Wong GW

更新日期：2011-07-01 00:00:00