Ionic determinants of exhaled breath condensate pH before and after exercise in adolescent athletes.

Abstract:

BACKGROUND:The pH of exhaled breath condensate (EBC) of adolescent athletes engaged in vigorous physical activity is low compared to healthy controls; however, the ionic determinants of EBC pH and the acute effects of exercise on those determinants have not been definitively established. OBJECTIVES:This study had two purposes: (1) to identify the ionic composition of EBC before and after exercise, and (2) to examine the effects of sample deaeration on EBC pH and composition. METHODS:EBC ionic composition was determined by ion chromatography and correlated with pH measured before and after deaeration. Bicarbonate concentration was calculated from the ion balance of other measured species and pH. RESULTS:EBC pH displayed a bimodal distribution, included values lower than expected for healthy individuals, and was correlated exclusively with volatile species, namely ammonia (mean concentration = 215 microM) and acetic (31.7 microM) and propionic acids (10.0 microM). Following exercise, raw EBC pH and ammonia concentration increased while propionic acid concentration fell. Following deaeration, EBC pH increased by one unit on average; however, the pH of samples with unusually low pH did not change significantly, and the concentrations of several ionic species were altered in a manner that cannot be explained in terms of volatility. CONCLUSIONS:We conclude that in healthy adolescents, exercise results in an acute increase in raw EBC pH in association with an increase in ammonium and a decrease in propionate concentration. Since exercise increases systemic ammonia and urea (which is hydrolyzed by oral bacteria to form ammonia), we propose that the likely source of these changes is gas-phase diffusion from epithelial and oral surface liquids and to a lesser extent, from pulmonary circulation.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Greenwald R,Ferdinands JM,Teague WG

doi

10.1002/ppul.21055

subject

Has Abstract

pub_date

2009-08-01 00:00:00

pages

768-77

issue

8

eissn

8755-6863

issn

1099-0496

journal_volume

44

pub_type

杂志文章
  • Bronchoscopic and histologic findings during lymphatic intervention for plastic bronchitis.

    abstract:BACKGROUND:Percutaneous lymphatic intervention (PCL) is a promising new therapy for plastic bronchitis (PB). We characterized bronchoalveolar lavage (BAL) and cast morphology in surgically repaired congenital heart disease (CHD) patients with PB during PCL. We quantified respiratory and bronchoscopic characteristics an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24161

    authors: Geanacopoulos AT,Savla JJ,Pogoriler J,Piccione J,Phinizy P,DeWitt AG,Blinder JJ,Pinto E,Itkin M,Dori Y,Goldfarb SB

    更新日期:2018-11-01 00:00:00

  • Impulse oscillometry: a measure for airway obstruction.

    abstract::The impulse oscillometry system (IOS) was introduced as a new technique to assess airflow obstruction in patients who are not able to perform forced breathing maneuvers, e.g., subjects with cerebral palsy or severe mental retardation, and young children. This study evaluates the sensitivity and specificity of IOS para...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10235

    authors: Vink GR,Arets HG,van der Laag J,van der Ent CK

    更新日期:2003-03-01 00:00:00

  • Generalized lymphangiomatosis and chylothorax in the pediatric age group.

    abstract::Four patients with generalized lymphangiomatosis presenting with chylothoraces are described. All four had bone involvement, two had involvement of the spleen, and one of the pericardium. The diagnosis was confirmed by typical radiology, histology, and in three patients by immunohistochemistry. Treatment was mainly pa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950140211

    authors: Shah AR,Dinwiddie R,Woolf D,Ramani R,Higgins JN,Matthew DJ

    更新日期:1992-10-01 00:00:00

  • Lung disease in Niemann-Pick disease.

    abstract:BACKGROUND:Lung involvement in children with Niemann-Pick disease has rarely been studied systematically. OBJECTIVE:To assess the involvement of the lung and the value of bronchoalveolar lavage in children with Niemann-Pick diseases. DESIGN:Retrospective analysis of patient records. PATIENTS:Thirteen patients, with ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20725

    authors: Guillemot N,Troadec C,de Villemeur TB,Clément A,Fauroux B

    更新日期:2007-12-01 00:00:00

  • A scoring system for lung function tests in infants.

    abstract::Measurements of thoracic gas volume (TGV), airway resistance (Raw), and airway conductance (Gaw) were calculated in a group of 42 normal infants using a whole-body plethysmograph. Maximum expiratory flow at functional residual capacity was measured in a separate group of 108 normal infants. Using data obtained from th...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950140303

    authors: Hampton F,Beardsmore CS,Morgan W,Williams A,Taussig L,Thompson JR

    更新日期:1992-11-01 00:00:00

  • New indicators for optimal lung recruitment during high frequency oscillator ventilation.

    abstract::Previous research has demonstrated the potential benefit derived from the combination of high frequency oscillatory ventilation and volume guarantee mode (HFOV-VG), a procedure that allows us to explore and control very low tidal volumes. We hypothesized that secondary spontaneous change in oscillation pressure amplit...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25084

    authors: Rodríguez Sánchez de la Blanca A,Sánchez Luna M,González Pacheco N,Ramos Navarro C,Santos González M,Tendillo Cortijo F

    更新日期:2020-12-01 00:00:00

  • Care recommendations for the respiratory complications of esophageal atresia-tracheoesophageal fistula.

    abstract::Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24982

    authors: Koumbourlis AC,Belessis Y,Cataletto M,Cutrera R,DeBoer E,Kazachkov M,Laberge S,Popler J,Porcaro F,Kovesi T

    更新日期:2020-10-01 00:00:00

  • Disseminated aspergillosis in a patient with cystic fibrosis and allergic bronchopulmonary aspergillosis.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) is a well-known complication of cystic fibrosis (CF), with an estimated incidence of up to 11%. In patients with CF, the diagnosis of ABPA must be based on significant elevation of Aspergillus fumigatus (Af) antibody and total serum IgE, since it is common to already have...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950170210

    authors: Chung Y,Kraut JR,Stone AM,Valaitis J

    更新日期:1994-02-01 00:00:00

  • Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease.

    abstract::Cystic fibrosis (CF) patients with advanced lung disease are at risk for developing pulmonary vascular disease and pulmonary hypertension, characterized by progressive exercise intolerance beyond the exercise-limiting effects of airways disease in CF. We report on a patient with severe CF lung disease who experienced ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20393

    authors: Montgomery GS,Sagel SD,Taylor AL,Abman SH

    更新日期:2006-04-01 00:00:00

  • Predictors of need for mechanical ventilation at discharge after tracheostomy in the PICU.

    abstract:BACKGROUND:The objective of this study was to determine factors predictive of need for mechanical ventilation (MV) upon discharge from the pediatric intensive care unit (PICU) among patients who receive a tracheostomy during their stay. METHODS:This was a retrospective cohort study using the Virtual PICU Systems (VPS)...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23195

    authors: McCrory MC,Lee KJ,Scanlon MC,Wakeham MK

    更新日期:2016-01-01 00:00:00

  • Pulmonary malacoplakia in an immunocompetent girl: a case report.

    abstract::Malacoplakia is an unusual inflammatory condition with distinctive histologic features. Involvement of the lung is quite uncommon and is rarely described in paediatrics. We report on a case of pulmonary malacoplakia in a teenage girl. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10386

    authors: Kumar P,Rassl DM,Hamilton JR,Spencer DA

    更新日期:2003-11-01 00:00:00

  • Adolescent girls with asthma have worse asthma control and health-related quality of life than boys-A population based study.

    abstract:BACKGROUND:Population-based studies investigating health-related quality of life (HRQoL) among asthmatic adolescents are rare. Further, among subjects with asthma, HRQoL may be affected by asthma control and severity. AIM:To investigate HRQoL in relation to asthma control and asthma severity among adolescents. METHOD...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23723

    authors: Stridsman C,Backman H,Eklund BM,Rönmark E,Hedman L

    更新日期:2017-07-01 00:00:00

  • Effects of meconium aspiration in isolated perfused rat lungs.

    abstract::Our objective was to study meconium-induced lung injury in isolated perfused rat lungs exposed to anoxia. Our working hypothesis was that meconium-induced lung injury is independent of preexisting hypoxia, and that hypoxia will increase severity of lung injury observed after meconium aspiration. We compared five diffe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20123

    authors: Wisniewski WM,Zagariya AM,Pavuluri N,Srinivasan H,Shankarao S,Vidyasagar D

    更新日期:2005-04-01 00:00:00

  • Lung ultrasound scoring in invasive mechanically ventilated children with severe bronchiolitis.

    abstract:OBJECTIVE:Lung ultrasound (LUS) is an emerging tool that may be used in the diagnosis and follow-up of children with viral bronchiolitis. In this study, we describe LUS abnormalities in children receiving invasive mechanical ventilation (IMV) for severe bronchiolitis in the pediatric intensive care unit (PICU). Our aim...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24974

    authors: Ingelse SA,Pisani L,Westdorp MHA,Almakdase M,Schultz MJ,van Woensel JBM,Bem RA

    更新日期:2020-10-01 00:00:00

  • Outcomes of a methicillin-resistant Staphylococcus aureus (MRSA) eradication protocol in pediatric cystic fibrosis (CF) patients.

    abstract:OBJECTIVE:Methicillin-resistant Staphylococcus aureus (MRSA) infections in cystic fibrosis (CF) patients have greatly increased in prevalence in the past two decades and may lead to a more rapid rate of lung function decline. The objective of this study was to determine the impact of a MRSA eradication protocol on long...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24628

    authors: Belarski E,Pettit R

    更新日期:2020-03-01 00:00:00

  • Ability of new lung function tests to assess methacholine-induced airway obstruction in infants.

    abstract::We assessed the ability of innovative lung function tests to detect bronchial obstruction induced by methacholine bronchial challenge. Fifty-five recurrently wheezy infants (mean age 16 +/- 5.2 months) free of respiratory symptoms underwent baseline lung function tests. Forty-two completed the methacholine challenge. ...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ppul.1950180508

    authors: Benoist MR,Brouard JJ,Rufin P,Delacourt C,Waernessyckle S,Scheinmann P

    更新日期:1994-11-01 00:00:00

  • Compliance in cystic fibrosis: an examination of infection control guidelines.

    abstract::The goal of this research was to begin the process of evaluating acceptability of infection control (IC) recommendations to CF patients and their families, determine whether compliance with IC guidelines differs from compliance with traditional CF medical treatment with respect to the variables predictive of complianc...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20781

    authors: Masterson T,Wildman BG,Newberry B,Omlor G,Bryson E,Kukay A

    更新日期:2008-05-01 00:00:00

  • Greater length of stay and hospital charges for severe asthma in children with depression or anxiety.

    abstract:RATIONALE:Asthma is one of the most common chronic disorders of childhood and is associated with significant healthcare utilization and costs. Comorbid psychiatric illnesses, specifically depression and anxiety, are more prevalent in patients with asthma and associated with worse asthma control, more emergency departme...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25061

    authors: Munoz FA,Benton LD,Kops SA,Kowalek KA,Seckeler MD

    更新日期:2020-11-01 00:00:00

  • Neuroendocrine cells in the developing human lung: morphologic and functional considerations.

    abstract::The structure, distribution, and frequency of neuroendocrine (NE) cells in human fetal lung from early stages of development to term are described. Neuroendocrine cells were studied by electron microscopy and immunostaining for serotonin and bombesin, recently identified markers of these cells in human lung. The diffe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:

    authors: Cutz E,Gillan JE,Bryan AC

    更新日期:1985-05-01 00:00:00

  • Effect of neonatal surfactant therapy on lung function at school age in children born very preterm.

    abstract::Our aim was to evaluate long-term effects of exogenous surfactant therapy on pulmonary functional outcome in children born very preterm. We examined 40 children aged 7-12 years who were born before 30 weeks of gestation with an immature surfactant system, and were randomized to one of three treatment groups: human sur...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1099-0496(199803)25:3<182::aid-ppul8

    authors: Pelkonen AS,Hakulinen AL,Turpeinen M,Hallman M

    更新日期:1998-03-01 00:00:00

  • A comprehensive approach to the prevention of bronchopulmonary dysplasia.

    abstract::The current bronchopulmonary dysplasia (BPD) is seen in infants born extremely premature, with less severe respiratory distress syndrome (RDS) and who received prenatal steroids-"new BPD". The pathophysiology of BPD is based on an impairment of lung maturation with prenatal and postnatal multi-hit insults and genetic ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.21508

    authors: Kugelman A,Durand M

    更新日期:2011-12-01 00:00:00

  • Effect of spontaneous and mechanical breathing on dynamic lung mechanics in hyaline membrane disease.

    abstract::We measured then compared the dynamic lung mechanics of spontaneous breaths and mechanical breaths in 9 mechanically ventilated neonates with hyaline membrane disease. All were receiving intermittent mandatory ventilation. All breathed spontaneously between ventilator breaths. Tidal volume, transpulmonary pressure, dy...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950080403

    authors: Mammel MC,Fisher JB,Bing DR,Gatto CW,Boros SJ

    更新日期:1990-01-01 00:00:00

  • Ambulatory blood pressure monitoring in Chinese children with obstructive sleep apnea/hypopnea syndrome.

    abstract:OBJECTIVE:Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a common sleep problem. The aim of this study is to investigate the association between OSAHS and blood pressure (BP) in snoring children. METHODS:Snoring children were recruited from January 2009 to December 2010. Clinical history was taken accompanied by...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22595

    authors: Xu Z,Li B,Shen K

    更新日期:2013-03-01 00:00:00

  • Fractional exhaled nitric oxide in preterm-born subjects: A systematic review and meta-analysis.

    abstract:BACKGROUND:Decreased lung function is common in preterm-born survivors. Increased fractional exhaled nitric oxide (FeNO) appears to be a reliable test for eosinophillic airway inflammation especially in asthma. We, systematically, reviewed the literature to compare FeNO levels in preterm-born children and adults who di...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,meta分析

    doi:10.1002/ppul.24270

    authors: Course CW,Kotecha S,Kotecha SJ

    更新日期:2019-05-01 00:00:00

  • Effectiveness and tolerability of high-dose salmeterol in cystic fibrosis.

    abstract::The efficacy and tolerability of high-dose salmeterol (100 mcg, BID) and albuterol (2.5 mg, BID) were compared with those of albuterol (2.5 mg, BID) in outpatients with cystic fibrosis in a randomized, double-blind, double-dummy, placebo-controlled, crossover study with both short- (4 weeks of each) and long-term (24 ...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/ppul.10162

    authors: Hordvik NL,Sammut PH,Judy CG,Colombo JL

    更新日期:2002-10-01 00:00:00

  • Interpretation of respiratory input impedance in healthy infants.

    abstract::Respiratory input impedance (Zin) is a potentially informative test of pulmonary function in infants who are unable to perform standard tests commonly performed in children and adults Analysis of Zin in dogs using the six-element model of DuBois et al. (J Appl Physiol 8:587, 1956) provides estimates of airways resista...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199612)22:6<364::AID-PPUL5

    authors: Jackson AC,Neff KM,Dorkin HL,Lutchen KR

    更新日期:1996-12-01 00:00:00

  • Variability and accuracy in interpretation of consolidation on chest radiography for diagnosing pneumonia in children under 5 years of age.

    abstract:BACKGROUND:Consolidation on chest radiography is widely used as the reference standard for defining pneumonia and variability in interpretation is well known but not well explored or explained. METHODS:Three pediatric sub-specialists (infectious diseases, radiology and respiratory medicine) viewed 3,033 chest radiogra...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22806

    authors: Williams GJ,Macaskill P,Kerr M,Fitzgerald DA,Isaacs D,Codarini M,McCaskill M,Prelog K,Craig JC

    更新日期:2013-12-01 00:00:00

  • Factors that influence adherence to exercise and their effectiveness: application to cystic fibrosis.

    abstract::Appropriate, regular exercise is of benefit to patients with cystic fibrosis (CF). As with other segments of the population, it has been difficult to devise exercise programs to which most patients will adhere for long periods of time. In healthy children, factors that are related to positive exercise compliance inclu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.10126

    authors: Prasad SA,Cerny FJ

    更新日期:2002-07-01 00:00:00

  • Lung function in hyper IgE syndrome.

    abstract::Pneumatoceles and bronchiectasis are secondary complications of respiratory infections in patients with hyper IgE syndrome (HIgES). We report on a patient with HIgES and recurrent pneumonias since 1 year of age, with progression to pneumatoceles and bronchiectasis and fatal outcome, with disseminated infection and sus...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22532

    authors: Roxo P Jr,Torres LA,Menezes UP,Melo JM

    更新日期:2013-01-01 00:00:00

  • Polysomnography Provides Useful Clinical Information in the Liberation from Respiratory Technology: A Retrospective Review.

    abstract::Background The prevalence of respiratory-technology dependent children is increasing although for most children the goal is liberation from technology. Liberation from home mechanical ventilation (HMV) and decannulation strategies vary due to the lack of clinical practice standards. The primary objective of this study...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24164

    authors: Bashir A,Henningfeld JK,Thompson NE,D'Andrea LA

    更新日期:2018-11-01 00:00:00