Predictive value of pulmonary function testing during pulmonary exacerbations in cystic fibrosis.

Abstract:

:The optimal duration of therapy for acute exacerbations of cystic fibrosis (CF) has not been defined, and the utility of serial pulmonary function testing in predicting the duration of therapy has yet to be established. In a review of 90 pulmonary exacerbations of 39 patients with CF requiring hospitalization, we found that 72% of the patients recovered following 2 weeks of intravenous antibiotics and aggressive chest physiotherapy, and that 28% required an extended third week of therapy. Recovery was delayed in patients with more severe chronic pulmonary disease, but the rate of improvement was independent of the degree of pulmonary deterioration with the acute exacerbation. A 40% recovery of FEV1 at 1 week was found to correlate significantly with the duration of hospitalization in the 90 patients. When prospectively applied to a second series of consecutively hospitalized patients with CF, 25/28 patients admitted for 2 weeks demonstrated > 40% improvement in FEV1 at 1 week, as compared to 5/10 patients subsequently treated for > or = 3 weeks (P = 0.030). The predictive values for 2- or 3-week hospitalizations with 1-week interval recovery of > 40% or < or = 40% in FEV1 were 79% and 62%, respectively. These findings suggest that the response to intensive therapy in CF exacerbations is variable and that improvements in pulmonary function after 1 week of therapy may be used to predict the subsequent duration of therapy in the majority of CF patients with pulmonary exacerbations.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Rosenberg SM,Schramm CM

doi

10.1002/ppul.1950160404

subject

Has Abstract

pub_date

1993-10-01 00:00:00

pages

227-35

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

16

pub_type

杂志文章
  • Monitoring theophylline levels in serum and saliva using fluorescence polarization immunoassay and Seralyzer.

    abstract::The reliability and predictive value of salivary theophylline levels was investigated in 58 children who were treated with oral sustained-release theophylline preparations for bronchial asthma. Serum and saliva levels were assessed by fluorescence polarization immunoassay (FPIA), and Seralyzer (reagent strip reflectan...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950060407

    authors: Schulte T,Buhr W,Schmidt M,Walkenbach A,Berdel D

    更新日期:1989-01-01 00:00:00

  • Doppler echocardiographic evaluation of pulmonary artery pressure in pneumonia of infants and children.

    abstract::Previously, there was insufficient evidence to confirm that pneumonia in infants and children might lead to the development of pulmonary hypertension. Recently, it has been shown that acceleration time corrected for heart rate (ATc) and the ratios of right ventricular preejection period to right ventricular ejection t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950100413

    authors: Du JB,Li SZ,Wang BL,Li YA

    更新日期:1991-01-01 00:00:00

  • Respiratory inductive plethysmography in the evaluation of lower airway obstruction during methacholine challenge in infants.

    abstract::Respiratory inductive plethysmography (RIP) is a simple technique for an objective, noninvasive assessment of thoracoabdominal asynchrony, which in turn is an indirect measure of airway obstruction. We evaluated different indices of asynchrony obtained by RIP before and after methacholine-induced airway obstruction. B...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950200610

    authors: Rusconi F,Gagliardi L,Aston H,Silverman M

    更新日期:1995-12-01 00:00:00

  • Preservation of pulmonary function in the ventilated neonatal piglet with normal lungs.

    abstract::Little attention has been focused on the progressive pulmonary deterioration which occurs in mechanically ventilated infants with normal or mildly abnormal lungs. We hypothesized that lung function would deteriorate over a 24-hr period in anesthetized neonatal piglets with normal lungs mechanically ventilated at 2 cm ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950190306

    authors: Easa D,Finn KC,Balaraman V,Sood S,Wilkerson S,Takenaka W,Mundie TG

    更新日期:1995-03-01 00:00:00

  • Viral and atypical bacterial infections in the outpatient pediatric cystic fibrosis clinic.

    abstract:BACKGROUND:Respiratory viral and atypical bacterial infections are associated with pulmonary exacerbations and hospitalisations in cystic fibrosis patients. We wanted to study the impact of such infections on children attending the outpatient clinic. METHODS:Seventy-five children were followed for 12 months at regular...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20517

    authors: Olesen HV,Nielsen LP,Schiotz PO

    更新日期:2006-12-01 00:00:00

  • Respiratory impedance in patients with Duchenne muscular dystrophy.

    abstract::Impulse oscillometry (IOS) evaluates non-effort-dependent respiratory mechanics, and thus it may be useful to evaluate patients with Duchenne muscular dystrophy (DMD). OBJECTIVES:We aimed (1) to describe the behavior of IOS parameters in patients with DMD, and compare it to those from a control group; (2) to determin...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23434

    authors: Gochicoa-Rangel L,Vargas MH,Alonso-Gómez JL,Rodríguez-Moreno L,Martínez-Briseño D,Baños-Mejía O,Torre-Bouscoulet L

    更新日期:2016-10-01 00:00:00

  • Asphyxiating tracheal bronchogenic cyst.

    abstract::We report on a 7-month old infant with severe respiratory distress secondary to a paratracheal bronchogenic cyst. Respiratory relief was achieved by transtracheal puncture of the cyst. Surgical removal of the cyst was performed 1 week later because of radiological evidence of reaccumulation of fluid. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10408

    authors: De Baets F,Van Daele S,Schelstraete P,Haerynck F,Vermassen F,Broers C

    更新日期:2004-12-01 00:00:00

  • Neurocognitive and behavioral impact of sleep disordered breathing in children.

    abstract::The consequences of poor quality and/or inadequate sleep in children and adolescents have become a major public health concern, and one in which pediatric health care professionals have become increasingly involved. In particular, insufficient and/or fragmented sleep resulting from primary sleep disorders such as obst...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20981

    authors: Owens JA

    更新日期:2009-05-01 00:00:00

  • Acquired somatic mutations in the microsatellite DNA, in children with bronchial asthma.

    abstract:OBJECTIVES:High incidence of genetic alterations at the microsatellite (MS) DNA level has been reported in asthmatic adults. WORKING HYPOTHESIS:The aim of this study was to investigate whether microsatellite instability (MSI) and loss of heterozygosity (LOH) were detectable phenomena in children with asthma. METHODOL...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21097

    authors: Thomou C,Paraskakis E,Neofytou E,Kalmanti M,Siafakas NM,Tzortzaki EG

    更新日期:2009-10-01 00:00:00

  • Pneumococcal serogroups and serotypes in severe pneumococcal pneumonia in Belgian children: theoretical coverage of the 7-valent and 9-valent pneumococcal conjugate vaccines.

    abstract:BACKGROUND:Although the causative pneumococcal serotypes of invasive diseases are already extensively studied, few data are available about the pneumococcal serotypes additionally isolated from broncho-alveolar lavage samples in childhood pneumonia. STUDY AIM:To identify the causative pneumococcal serotypes in culture...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20437

    authors: De Schutter I,Malfroot A,Piérard D,Lauwers S

    更新日期:2006-08-01 00:00:00

  • Cystic fibrosis database (CFDB): a new web-based tool for cystic fibrosis specialists.

    abstract::In order to help specialists involved in CF care and clinical research to know the current best evidence about clinical effectiveness of interventions in CF, we designed and developed a web-based, free access tool called "CFDB"--Cystic Fibrosis DataBase (www.inetflow.it/CFDB). The database was built by searching in Me...

    journal_title:Pediatric pulmonology

    pub_type: 信件

    doi:10.1002/ppul.22954

    authors: Buzzetti R,Cirilli N,Minicucci L,Raia V,Salvatore D,Maffeis P

    更新日期:2014-09-01 00:00:00

  • Infection and inflammation in induced sputum from preschool children with chronic airways diseases.

    abstract:BACKGROUND:We hypothesized airway inflammation can be detected non-invasively by induced sputum (IS) or peripheral blood eosinophilia, and IS can detect bacterial and viral infection in preschool children with airway disease, with results comparable to broncho-alveolar lavage (BAL). METHODS:Preschool children with cys...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23366

    authors: Jochmann A,Artusio L,Robson K,Nagakumar P,Collins N,Fleming L,Bush A,Saglani S

    更新日期:2016-08-01 00:00:00

  • Acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation.

    abstract:OBJECTIVE:To describe the clinical course and treatment of an infant with acute pulmonary toxicity following intralesional administration of bleomycin for a lymphovenous malformation. DESIGN:Case report. SETTING:A tertiary care University-affiliated hospital. PATIENT, INTERVENTION, AND RESULTS:An 8-month-old girl de...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21139

    authors: Atwa K,Abuhasna S,Shihab Z,Hashaykeh N,Hasan R

    更新日期:2010-02-01 00:00:00

  • Congenital tracheal stenosis with associated cardiopulmonary anomalies: report of two cases with a review of the literature.

    abstract::We present two infants with congenital tracheal stenosis with complete tracheal rings. Both had associated congenital anomalies. The first case showed cardiac malformations, and the second case had agenesis of the right lung. We review the literature, in particular with reference to tracheal stenosis and pulmonary age...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950020414

    authors: Voland JR,Benirschke K,Saunders B

    更新日期:1986-07-01 00:00:00

  • Respiratory syncytial virus infections in SR Croatia, Yugoslavia.

    abstract::The prevalence of respiratory syncytial virus (RSV) infection was studied during three consecutive annual outbreaks (1983-1986) in SR Croatia, Yugoslavia. A total of 1,238 subjects were examined, using RSV isolation and immunofluorescent (DTFA) methods, with 1,042 showing the signs of respiratory infection and 207 of ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030505

    authors: Mlinarić-Galinović G,Ugrcić I,Bozikov J

    更新日期:1987-09-01 00:00:00

  • The association between birth season and future development of childhood asthma.

    abstract::The aim of this study was to examine a possible association between birth season (date of birth) and future development of asthma in children. A case-control study was designed to include asthmatic children aged 2-7 years, living in the city of Beer-Sheva, in southern Israel, registered in one pediatric center. Contro...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20442

    authors: Gazala E,Ron-Feldman V,Alterman M,Kama S,Novack L

    更新日期:2006-12-01 00:00:00

  • Fine needle aspiration biopsy cytology as an adjunct in the diagnosis of childhood sarcoidosis.

    abstract::Fine needle aspiration biopsy cytology performed in three children with sarcoidosis expedited clinical investigation and diagnosis of their disease. Each patient had a different clinical presentation; in two of them lymphoma was part of the initial differential diagnosis. Aspiration cytology in all cases revealed coll...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950130211

    authors: Wakely PE Jr,Silverman JF,Holbrook CT,Fairman RP,Daeschner CW 3rd,Joshi VV

    更新日期:1992-06-01 00:00:00

  • Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis.

    abstract:BACKGROUND/AIM:There has been recent interest in dry powder inhaled mannitol as a therapeutic agent in patients with cystic fibrosis (CF). It is has been shown to increase mucociliary clearance (MCC) by rehydrating the airway. To date there have been no studies exclusively in children with CF examining the effect of dr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20903

    authors: Minasian C,Wallis C,Metcalfe C,Bush A

    更新日期:2008-11-01 00:00:00

  • Lung function among infants born preterm, with or without bronchopulmonary dysplasia.

    abstract:OBJECTIVE:Both healthy preterm infants and those with bronchopulmonary dysplasia (BPD) have poor lung function during childhood and adolescence, although there is no evidence whether prematurity alone explains the reduction in lung function found in BPD infants. Our study seeks to know if lung function, measured in inf...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21609

    authors: Sanchez-Solis M,Garcia-Marcos L,Bosch-Gimenez V,Pérez-Fernandez V,Pastor-Vivero MD,Mondéjar-Lopez P

    更新日期:2012-07-01 00:00:00

  • Infrared end-tidal CO2 measurement does not accurately predict arterial CO2 values or end-tidal to arterial PCO2 gradients in rabbits with lung injury.

    abstract::End-tidal PCO2 (PETCO2) measurements from two commercially available neonatal infrared capnometers with different sampling systems and a mass spectrometer were compared with arterial PCO2 (PaCO2) to determine whether the former could predict the latter in mechanically ventilated rabbits with and without lung injury. T...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950170309

    authors: Hopper AO,Nystrom GA,Deming DD,Brown WR,Peabody JL

    更新日期:1994-03-01 00:00:00

  • Accurate lung volume measurements in vitro using a novel inert gas washout method suitable for infants.

    abstract:BACKGROUND:Multiple breath washout (MBW) in infants presents a number of technical challenges. Conventional MBW is based on simultaneous measurement of flow and gas concentrations. These two signals are aligned and combined to derive expired gas volumes from which lung volumes and measures of ventilation inhomogeneity ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23348

    authors: Shawcross A,Murray CS,Goddard N,Gupta R,Watson S,Horsley A

    更新日期:2016-05-01 00:00:00

  • Respiration rate monitoring methods: a review.

    abstract::Respiration rate is an important indicator of a person's health, and thus it is monitored when performing clinical evaluations. There are different approaches for respiration monitoring, but generally they can be classed as contact or noncontact. For contact methods, the sensing device (or part of the instrument conta...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.21416

    authors: Al-Khalidi FQ,Saatchi R,Burke D,Elphick H,Tan S

    更新日期:2011-06-01 00:00:00

  • Identification of CFTR variants in Latino patients with cystic fibrosis from the Dominican Republic and Puerto Rico.

    abstract:BACKGROUND:In cystic fibrosis (CF), the spectrum and frequency of CFTR variants differ by geography and race/ethnicity. CFTR variants in White patients are well-described compared with Latino patients. No studies of CFTR variants have been done in patients with CF in the Dominican Republic or Puerto Rico. METHODS:CFTR...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24549

    authors: Zeiger AM,McGarry ME,Mak ACY,Medina V,Salazar S,Eng C,Liu AK,Oh SS,Nuckton TJ,Jain D,Blackwell TW,Kang HM,Abecasis G,Oñate LC,Seibold MA,Burchard EG,Rodriguez-Santana J

    更新日期:2020-02-01 00:00:00

  • Pulmonary hypertension in childhood interstitial lung disease: A systematic review of the literature.

    abstract::Childhood interstitial lung disease (chILD) comprises a wide heterogeneous group of rare parenchymal lung disorders associated with substantial morbidity and mortality. Pulmonary hypertension is a common comorbidity in adults with interstitial lung disease (ILD) and associated with poor survival. We aimed to systemati...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23632

    authors: Bromley S,Vizcaya D

    更新日期:2017-05-01 00:00:00

  • Relationship between antimicrobial proteins and airway inflammation and infection in cystic fibrosis.

    abstract::Antimicrobial proteins are important in lung defense and are potential therapeutic agents in chronic airways infection such as seen in cystic fibrosis (CF). In preparation for future clinical studies, we sought (1) to determine levels of three antimicrobial proteins [lactoferrin, lysozyme, and secretory leukoprotease ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21028

    authors: Sagel SD,Sontag MK,Accurso FJ

    更新日期:2009-04-01 00:00:00

  • Early factors related to mortality in children treated with bi-level noninvasive ventilation and CPAP.

    abstract:OBJECTIVE:To describe and analyze the characteristics and the early risk factors for mortality of noninvasive ventilation (NIV) in critically ill children. STUDY DESIGN:A multicenter, prospective, observational 2-year study carried out with critically ill patients (1 month - 18 years of age) who needed NIV. Clinical d...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25246

    authors: López J,Pons-Òdena M,Medina A,Molinos-Norniella C,Palanca-Arias D,Demirkol D,León-González JS,López-Fernández YM,Perez-Baena L,López-Herce J,NIV Research Group.

    更新日期:2020-12-31 00:00:00

  • Pediatric pulmonology year in review 2016: Part 2.

    abstract::Pediatric Pulmonology continues to publish research and clinical topics related to the entire range of children's respiratory disorders. As we have done annually in recent years, we here summarize some of the past year's publications in our major topic areas, as well as selected literature in these areas from other co...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23719

    authors: Auten R,Ren C,Yilmaz O,Noah TL

    更新日期:2017-09-01 00:00:00

  • Bone mineral content and body composition in children and young adults with cystic fibrosis.

    abstract::With dual energy X-ray absorptiometry (DEXA), it is possible to quantitate important aspects of growth in children with cystic fibrosis (CF), supplementing the usual measures of height and weight. Of particular concern during growth is the accumulation of bone mineral, since osteoporosis and fractures are well-recogni...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199902)27:2<80::aid-ppul3>

    authors: Henderson RC,Madsen CD

    更新日期:1999-02-01 00:00:00

  • A scoring system for lung function tests in infants.

    abstract::Measurements of thoracic gas volume (TGV), airway resistance (Raw), and airway conductance (Gaw) were calculated in a group of 42 normal infants using a whole-body plethysmograph. Maximum expiratory flow at functional residual capacity was measured in a separate group of 108 normal infants. Using data obtained from th...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950140303

    authors: Hampton F,Beardsmore CS,Morgan W,Williams A,Taussig L,Thompson JR

    更新日期:1992-11-01 00:00:00

  • 2014 year in review: Cystic fibrosis.

    abstract::In this article, we highlight cystic fibrosis (CF) research published in Pediatric Pulmonology during 2014, as well as related articles published in other journals. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23309

    authors: Savant AP,McColley SA

    更新日期:2015-11-01 00:00:00