Abstract:
BACKGROUND:In young children with cystic fibrosis (CF) the forced expiratory volume in 1 second (FEV1 ) is often normal and a more sensitive measure to detect early obstructive lung disease is needed. AIM:To evaluate the progression of selected spirometry parameters with age in a cohort of CF patients and healthy children aged 6 to 20 years. METHODS:Retrospective comparison of longitudinal spirometry data from CF patients with data from two cohort studies in healthy subjects. Quantile regression was used to calculate the longitudinal 10th percentile (P10 ), 50th percentile (P50 ), and 90th percentile (P90 ) of forced vital capacity (FVC), FEV1 , and the forced expiratory flow at 75% of FVC (FEF75 ). Sample size estimates were calculated using these three parameters as clinical trial endpoints. RESULTS:FVC, FEV1 , and FEF75 were all significantly lower in CF patients than healthy children. Abnormalities in FEF75 occurred at younger ages and remained substantially larger than abnormalities in FEV1 or FVC throughout childhood. Therefore, fewer patients would be required to detect a similar treatment effect if FEF75 is used as a primary endpoint compared with FEV1 or FVC. CONCLUSIONS:Our data support the use of FEF75 as a more sensitive marker of early CF lung disease than FEV1 and FVC, because abnormalities in FEF75 occur at younger age and FEF75 is diminished more than other parameters.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Bakker EM,Borsboom GJ,van der Wiel-Kooij EC,Caudri D,Rosenfeld M,Tiddens HAdoi
10.1002/ppul.22777subject
Has Abstractpub_date
2013-11-01 00:00:00pages
1081-8issue
11eissn
8755-6863issn
1099-0496journal_volume
48pub_type
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journal_title:Pediatric pulmonology
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更新日期:2010-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21278
更新日期:2010-09-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:2004-12-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2015-01-01 00:00:00
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更新日期:2016-05-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25220
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更新日期:2013-06-01 00:00:00
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pub_type: 杂志文章
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