Respiratory resistance and transcutaneous PO2 during histamine provocation in children with bronchial asthma.

Abstract:

:Bronchial reactivity was assessed in 66 children with bronchial asthma (aged 8-15 years) by provocation with histamine-HCl during a symptom-free period. A significant bronchial reaction to histamine was defined as a 50% increase in the resistance of the respiratory system (Rrs) determined by the forced oscillation technique. The provocative dose causing a 50% increase in the Rrs (PD50Rrs) was interpolated from the log dose-response curve. The mean PD50Rrs was significantly lower in children with asthma (0.22 mg/mL) compared with a group of healthy children in the same age range (1.55 mg/mL) (P < 0.001). In children with clinically severe asthma, the mean PD50Rrs was lower (0.13 mg/mL) than in children with mild asthma (0.34 mg/mL) (P < 0.001). Transcutaneous PO2 (PtcO2) was monitored in 25 of the children with asthma. In this group the proportion of mild and severe asthma, the baseline lung function variables, and the PD50Rrs were not significantly different from those of the whole group of children. During the reaction, the PtcO2 fell on average by 29% of the baseline value (P < 0.001); in 88% of the children, the fall in PtcO2 was 20% or more of the baseline value. We conclude that histamine provocation tests using the forced oscillation technique and transcutaneous PO2 to assess a bronchial reaction have a good discriminatory capacity for different degrees of clinical severity of asthma in children.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Holmgren D,Engström I,Bjure J,Sixt R,Aberg N

doi

10.1002/ppul.1950150308

subject

Has Abstract

pub_date

1993-03-01 00:00:00

pages

168-74

issue

3

eissn

8755-6863

issn

1099-0496

journal_volume

15

pub_type

杂志文章
  • Carbon dioxide clearance using bubble CPAP with superimposed high-frequency oscillations in a premature infant lung model with abnormal lung mechanics.

    abstract:BACKGROUND:High-frequency (HF) oscillatory ventilation has been shown to improve carbon dioxide (CO2 ) clearance in premature infants. In a previous in vitro lung model with normal lung mechanics we demonstrated significantly improved CO2 washout by HF oscillation of bubble continuous positive airway pressure (BCPAP). ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25040

    authors: Sivieri EM,Eichenwald EC,Rub D,Abbasi S

    更新日期:2020-11-01 00:00:00

  • Reduced neurocognition in children who snore.

    abstract::Obstructive sleep apnea syndrome (OSAS) has been associated with reduced neurocognitive performance in children, but the underlying etiology is unclear. The aim of this study was to evaluate the relationship between hypoxemia, respiratory arousals, and neurocognitive performance in snoring children referred for adenot...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10453

    authors: Kennedy JD,Blunden S,Hirte C,Parsons DW,Martin AJ,Crowe E,Williams D,Pamula Y,Lushington K

    更新日期:2004-04-01 00:00:00

  • The association between birth season and future development of childhood asthma.

    abstract::The aim of this study was to examine a possible association between birth season (date of birth) and future development of asthma in children. A case-control study was designed to include asthmatic children aged 2-7 years, living in the city of Beer-Sheva, in southern Israel, registered in one pediatric center. Contro...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20442

    authors: Gazala E,Ron-Feldman V,Alterman M,Kama S,Novack L

    更新日期:2006-12-01 00:00:00

  • Reference standards for forced expiratory indices in Chinese preschool children.

    abstract::Spirometric testing is traditionally achievable in children of school-age and beyond. Incorporation of interactive incentives motivates preschool children to facilitate measurement of forced expiratory indices. Validated spirometric reference standards are available for Caucasian preschoolers but lacking in Asians. We...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22773

    authors: Leung TF,Liu TC,Mak KK,Su X,Sy HY,Li AM,Lau JT,Lum S,Wong GW

    更新日期:2013-11-01 00:00:00

  • 15-Year trends in respiratory care of extremely preterm infants: Contributing factors and consequences on health and growth during hospitalization.

    abstract:OBJECTIVES:To review 15-year trends in respiratory care of extremely preterm infants managed in a tertiary perinatal center; to identify the factors contributing to their evolution; and to determine whether these changes had an impact on infant mortality, severe morbidity, and growth. METHODS:Retrospective cohort stud...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24774

    authors: Habas F,Durand S,Milési C,Mesnage R,Combes C,Gavotto A,Picaud JC,Cambonie G

    更新日期:2020-08-01 00:00:00

  • Effect of night symptoms and disease severity on subjective sleep quality in children with non-cystic-fibrosis bronchiectasis.

    abstract:BACKGROUND:Night-time symptoms and hypoxemia during sleep may affect sleep quality in children with chronic lung disease such as bronchiectasis. Poor sleep quality may impair growth, learning, and emotional development of children. Our aim was to assess the sleep quality and associated factors in children with non-cyst...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21454

    authors: Erdem E,Ersu R,Karadag B,Karakoc F,Gokdemir Y,Ay P,Akpinar IN,Dagli E

    更新日期:2011-09-01 00:00:00

  • Progressive lung and cardiac changes associated with pulmonary hypertension in the fetal rat.

    abstract::To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals rece...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1057

    authors: Fabris VE,Pato MD,Belik J

    更新日期:2001-05-01 00:00:00

  • Foreign-body aspiration mimicking congenital lobar emphysema in a forty-eight-day-old girl.

    abstract::Foreign-body aspiration (FBA) is a commonly encountered serious problem during childhood, accounting for 7% of lethal accidents in children aged 1-3 years. Bronchoscopy is indicated when a clear history of FBA is present, but the history may be unreliable. Clinical manifestations can be seen in various diseases, and w...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20128

    authors: Aslan AT,Yalcin E,Ozcelik U,Ciftci AO,Kiper N

    更新日期:2005-02-01 00:00:00

  • Adult-type pulmonary function tests in infants without respiratory disease.

    abstract::A new method that permits the measurement of adult-type maximal expiratory flow-volume curves and fractional lung volumes in sedated infants was recently described. The purpose of this study was to define the normal range for these new measures of pulmonary function in infants and young children. Measurements of force...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/1099-0496(200009)30:3<215::aid-ppul6>3.0.c

    authors: Castile R,Filbrun D,Flucke R,Franklin W,McCoy K

    更新日期:2000-09-01 00:00:00

  • Efficacy of fiberoptic bronchoscopy and bronchoalveolar lavage in childhood-onset, complicated plastic bronchitis.

    abstract:BACKGROUND:Plastic bronchitis (PB) is a rare, variable, and potentially fatal disease. This study aimed to assess the efficacy of fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in treating children with PB. METHODS:In total, 15 children with PB, between 2012 and 2020, were enrolled in our study. Within...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25016

    authors: Wang L,Wang W,Sun JM,Ni SW,Ding JL,Zhu YL,Ding SG

    更新日期:2020-11-01 00:00:00

  • Disease severity, mental health, and quality of life of children and adolescents with asthma.

    abstract::Asthma has been found related to a higher risk of psychological problems. Inconsistent results have been reported with respect to the quality of life of children with asthma. So there may be a complex relationship between asthma severity, quality of life, and psychological factors. The aim of this study was to examine...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20509

    authors: Goldbeck L,Koffmane K,Lecheler J,Thiessen K,Fegert JM

    更新日期:2007-01-01 00:00:00

  • Use of azithromycin for the prevention of bronchopulmonary dysplasia in preterm infants: a randomized, double-blind, placebo controlled trial.

    abstract:OBJECTIVE:Since preventive therapies for bronchopulmonary dysplasia (BPD) are limited we treated preterm infants with azithromycin to decrease the incidence of BPD. METHODS:Infants less than 1,250 g birth weight were randomized to azithromycin or placebo within 12 hr of beginning mechanical ventilation and within 72 h...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.21352

    authors: Ballard HO,Shook LA,Bernard P,Anstead MI,Kuhn R,Whitehead V,Grider D,Crawford TN,Hayes D Jr

    更新日期:2011-02-01 00:00:00

  • Preservation of pulmonary function in the ventilated neonatal piglet with normal lungs.

    abstract::Little attention has been focused on the progressive pulmonary deterioration which occurs in mechanically ventilated infants with normal or mildly abnormal lungs. We hypothesized that lung function would deteriorate over a 24-hr period in anesthetized neonatal piglets with normal lungs mechanically ventilated at 2 cm ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950190306

    authors: Easa D,Finn KC,Balaraman V,Sood S,Wilkerson S,Takenaka W,Mundie TG

    更新日期:1995-03-01 00:00:00

  • Pulmonary outcome measures in long-term survivors of infantile Pompe disease on enzyme replacement therapy: A case series.

    abstract:OBJECTIVES:To report the respiratory function of school-aged children with infantile Pompe disease (IPD) who started enzyme replacement therapy (ERT) in infancy and early childhood. STUDY DESIGN:This is a retrospective chart review of pulmonary function tests of: (a) patients with IPD 5 to 18 years of age, (b) who wer...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24621

    authors: ElMallah MK,Desai AK,Nading EB,DeArmey S,Kravitz RM,Kishnani PS

    更新日期:2020-03-01 00:00:00

  • Connective tissue, mechanical, and morphometric changes in the lungs of weanling rats fed a low protein diet.

    abstract::We studied the effect of low-protein diet (8% casein) on lung growth in rats from 3 to 7 weeks of age. Their diet was isocaloric with that of control animals fed a diet of 20% casein. The calorie intake of experimental animals was increased during the first 3 weeks of the experiment, but they increased less (about 10%...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950070308

    authors: Matsui R,Thurlbeck WM,Fujita Y,Yu SY,Kida K

    更新日期:1989-01-01 00:00:00

  • The use of biologic therapies for the management of pediatric asthma.

    abstract::With better understanding of the role of type 2 inflammation in allergic asthma, there has been progress made in the development of new biologic therapies targeting these specific pathways. This review will consider diagnostic criteria for using biologic therapies for pediatric asthma with special emphasis on populati...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.24613

    authors: Lovinsky-Desir S

    更新日期:2020-03-01 00:00:00

  • Lung clearance index: normal values, repeatability, and reproducibility in healthy children and adolescents.

    abstract::There is increasing interest in using the Multiple Breath Washout technique and the lung clearance index (LCI) for detecting early pulmonary changes, for example, in cystic fibrosis lung disease. However, there are still limited data regarding equipment specific reference ranges, repeatability and reproducibility. The...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21093

    authors: Fuchs SI,Eder J,Ellemunter H,Gappa M

    更新日期:2009-12-01 00:00:00

  • Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children.

    abstract::Tracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.24435

    authors: Moreno M,Castillo-Corullón S,Pérez-Ruiz E,Luna MC,Antón-Pacheco JL,Mondejar-Lopez P,De-la-Serna O,Villa JR,Osona B,Torres-Borrego J,Santiago-Burruchaga M,Asensio O,Andres-Martin A,Delgado-Pecellin I,González Y,Palmero A,E

    更新日期:2019-10-01 00:00:00

  • Pseudomonas aeruginosa colonization in cystic fibrosis: Impact on neutrophil functions and cytokine secretion capacity.

    abstract:BACKGROUND:Chronic colonization with Pseudomonas (P.) aeruginosa worsens the prognosis of cystic fibrosis (CF) patients. This study aims to analyze the functional properties of neutrophils in CF patients with P. aeruginosa colonization. METHODS:Patients with CF (n = 16) were grouped by positivity of P. aeruginosa in s...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25294

    authors: Aslanhan U,Cakir E,Ozyigit LP,Kucuksezer UC,Gelmez YM,Yuksel M,Deniz G,Aktas EC

    更新日期:2021-01-29 00:00:00

  • Optimization of anti-pseudomonal antibiotics for cystic fibrosis pulmonary exacerbations: IV. colistimethate sodium.

    abstract::Patients with cystic fibrosis (CF) often experience acute pulmonary exacerbations (APE) and may be treated with a wide variety of intravenous antibiotics. The aim of this review is to provide an evidence-based summary of pharmacokinetic/pharmacodynamic (PK/PD), tolerability, and efficacy studies utilizing the intraven...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22664

    authors: Young DC,Zobell JT,Waters CD,Ampofo K,Stockmann C,Sherwin CM,Spigarelli MG

    更新日期:2013-01-01 00:00:00

  • Pediatrician intervention impacts parental smoking in cystic fibrosis, diabetes and bronchiolitis.

    abstract:BACKGROUND:Child exposure to cigarette smoke is harmful. It should be reduced through parental smoking cessation interventions. The aim of our study was to determine the impact of simple advice provided by the pediatrician on the smoking habits of parents of children with cystic fibrosis (CF), diabetes mellitus (DM) an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25277

    authors: Lafont M,Morin C,Arrouy A,Rabeau A,Labouret G,Roditis L,Michelet M,Mittaine M

    更新日期:2021-01-22 00:00:00

  • A cost effectiveness analysis of omitting radiography in diagnosis of acute bronchiolitis.

    abstract:OBJECTIVE:To carry out a cost-effectiveness analysis of omitting chest radiography in the diagnosis of infant bronchiolitis. HYPOTHESIS:Omitting chest radiographs in the diagnosis of typical bronchiolitis was expected to reduce costs without adversely affecting the detection rate of alternate diseases. STUDY DESIGN:A...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20948

    authors: Yong JH,Schuh S,Rashidi R,Vanderby S,Lau R,Laporte A,Nauenberg E,Ungar WJ

    更新日期:2009-02-01 00:00:00

  • Dynamics of spontaneous breathing during patient-triggered partial liquid ventilation.

    abstract::This study evaluates different ventilator strategies during gas (GV) and partial liquid ventilation (PLV) in spontaneously breathing animals. We hypothesized that during PLV, spontaneously breathing animals would self-regulate respiratory parameters by increasing respiratory rate (RR) and minute ventilation (V'E) when...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199811)26:5<319::aid-ppul3

    authors: Bendel-Stenzel EM,Mrozek JD,Bing DR,Meyers PA,Connett JE,Mammel MC

    更新日期:1998-11-01 00:00:00

  • Sleep and breathing in Prader-Willi syndrome.

    abstract::Prader-Willi syndrome (PWS) is a genetic disorder, with hypotonia being the predominant feature in infancy, and developmental delay, obesity, and behavioral problems becoming more prominent in childhood and adolescence. Children with this disorder frequently suffer from excessive daytime sleepiness and have a primary ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.10152

    authors: Nixon GM,Brouillette RT

    更新日期:2002-09-01 00:00:00

  • Recurrent lower respiratory tract infections in a 14-year-old boy with tracheobronchomegaly (Mounier-Kuhn syndrome).

    abstract::Tracheobronchomegaly (Mounier-Kuhn syndrome) is characterized by dilatation of the central airways, tracheobronchial outpouchings, and chronic tracheobronchitis. Most cases are diagnosed in adulthood. We report the clinical, radiographic, and bronchoscopic findings in a 14-year-old boy with tracheobronchomegaly, ptosi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(200006)29:6<476::aid-ppul1

    authors: Benesch M,Eber E,Pfleger A,Zach MS

    更新日期:2000-06-01 00:00:00

  • Airway hyperreactivity is frequent in non-asthmatic children with sickle cell disease.

    abstract:BACKGROUND:Asthma is associated with poorer outcomes in sickle cell disease (SCD). Whether AHR can exist in SCD as a distinct entity, separate and independent of asthma, is unknown. AIMS:Our goal was to elucidate the prevalence of AHR, as measured by a methacholine challenge test (MCT), in children with SCD who did no...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23374

    authors: Shilo NR,Alawadi A,Allard-Coutu A,Robitaille N,Pastore Y,Bérubé D,Jacob SV,Abish S,Dauletbaev N,Lands LC

    更新日期:2016-09-01 00:00:00

  • Reference values for spirometric parameters in healthy children living in a Colombian city located at 2640 m altitude.

    abstract:OBJECTIVES:To identify the spirometric equations that are most appropriate for use in children and adolescents living in Bogota, Colombia after evaluating a set of relevant previously-developed equations, including the Global Lung Function Initiative (GLI) 2012 spirometry reference equations. METHODS:Healthy children ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24331

    authors: Aristizabal-Duque R,Castiblanco E,Rodriguez I,Sossa-Briceño MP,Rodriguez-Martinez CE

    更新日期:2019-06-01 00:00:00

  • Irreversible airway obstruction in childhood asthma? A clinician's viewpoint.

    abstract::Even though childhood asthma is assumed to comprise reversible airway obstruction, some children develop irreversible airway obstruction (not reversed by a bronchodilator or corticosteroids); this may be due to inflammation that has caused remodeling. Lately, it has been claimed that in the absence of treatment with i...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10090

    authors: König P

    更新日期:2002-04-01 00:00:00

  • Efficacy of mycophenolate on lung disease and autoimmunity in children with immunodeficiency.

    abstract::The autoimmune manifestations of primary immunodeficiencies, such as autoimmune lymphoproliferative syndrome (ALPS) and common variable immunodeficiency (CVID), often constitute a great therapeutic challenge and have a significant impact on patients' morbidity and mortality. The most common autoimmune presentations ar...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23757

    authors: Bucciol G,Petrone A,Putti MC

    更新日期:2017-10-01 00:00:00

  • A correction formula for computing specific airway resistance from a single-step measurement.

    abstract::Specific airway resistance (SRaw) is conventionally determined by multiplying the plethysmographically measured values of airway resistance and functional residual capacity (FRC). An alternative single-step method, which avoids the need for airway occlusion during determination of FRC, has been described by Dab and Al...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950060212

    authors: Haluszka J,Willim G,Cutrera R,Ronchetti R,Filtcher S

    更新日期:1989-01-01 00:00:00