Lung clearance index: normal values, repeatability, and reproducibility in healthy children and adolescents.

Abstract:

:There is increasing interest in using the Multiple Breath Washout technique and the lung clearance index (LCI) for detecting early pulmonary changes, for example, in cystic fibrosis lung disease. However, there are still limited data regarding equipment specific reference ranges, repeatability and reproducibility. The aim of this prospective study was to assess within-test repeatability, short term reproducibility and long term reproducibility, and to establish normal values for the LCI in healthy children and adolescents using the sidestream ultrasonic flow sensor (EasyOne Pro, MBW Module, ndd Medical Technologies, Switzerland). Fourty-four volunteers (5.3-20.3 years) were recruited for the 1st test. Twenty-two out of 44 were measured on a 2nd test occasion after an interval of 1 hr (2nd test). Thirty-four out of 44 agreed to come back for a follow up test 6-15 months later (3rd test). Mean LCI (SD) was 6.2 (0.4), 6.3 (0.4), and 6.0 (0.4) at the 1st, 2nd, and 3rd test. The upper limit of normal was 7.0 for all subjects. Within-test repeatability was 5.1%. Short-term reproducibility (1st test vs. 2nd test) was 4.2% with a mean difference of -0.13 (95% CI -0.350; 0.087). Long-term reproducibility (1st test vs. 3rd test) was 5.1%, with a mean difference of 0.017 (95% CI -0.016; 0.348). With this low variability of the LCI for both, within and between tests, our study demonstrates reliability and robustness of equipment, protocol and analysis and the reliability of the MBW technique in general. The present data will help to interpret the effect of therapeutic interventions and interpretation of longitudinal data in patients with pulmonary diseases.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Fuchs SI,Eder J,Ellemunter H,Gappa M

doi

10.1002/ppul.21093

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

1180-5

issue

12

eissn

8755-6863

issn

1099-0496

journal_volume

44

pub_type

杂志文章
  • FGR in the setting of preterm sterile intra-uterine milieu is associated with a decrease in RDS.

    abstract:OBJECTIVE:To determine if fetal growth restriction (FGR) in the setting of sterile intra-uterine milieu would be associated with a decrease in respiratory distress syndrome (RDS) of preterm-neonates. METHODS:The relationship between FGR and neonatal RDS was examined in 92 singleton preterm-neonates (gestational age [G...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23369

    authors: Park CW,Park JS,Jun JK,Yoon BH

    更新日期:2016-08-01 00:00:00

  • Normal values for forced oscillatory respiratory resistance in children.

    abstract::Forced oscillatory respiratory resistance was measured in 138 healthy children aged 2- to 16-years-old using a commercial unit. Regression analysis was performed using the resistance measurements obtained at frequencies of 6 Hz and 26 Hz and averages of measurements obtained at frequencies of from 6-26 Hz, 6-10 Hz, an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010305

    authors: Hordvik NL,König P,Morris DA,Kreutz C,Pimmel RL

    更新日期:1985-05-01 00:00:00

  • Cell phone intervention to improve adherence: cystic fibrosis care team, patient, and parent perspectives.

    abstract:BACKGROUND:Treatment regimens for patients with cystic fibrosis (CF) are time-consuming and complex, resulting in consistently low adherence rates. To date, few studies have evaluated innovative technologies to improve adherence in this population. Current infection control guidelines for patients with CF seek to minim...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21164

    authors: Marciel KK,Saiman L,Quittell LM,Dawkins K,Quittner AL

    更新日期:2010-02-01 00:00:00

  • Reference standards for forced expiratory indices in Chinese preschool children.

    abstract::Spirometric testing is traditionally achievable in children of school-age and beyond. Incorporation of interactive incentives motivates preschool children to facilitate measurement of forced expiratory indices. Validated spirometric reference standards are available for Caucasian preschoolers but lacking in Asians. We...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22773

    authors: Leung TF,Liu TC,Mak KK,Su X,Sy HY,Li AM,Lau JT,Lum S,Wong GW

    更新日期:2013-11-01 00:00:00

  • Regulation of pulmonary surfactant synthesis in fetal rat type II alveolar epithelial cells by microRNA-26a.

    abstract::Pulmonary surfactant, a unique developmentally regulated, phospholipid-rich lipoprotein, is synthesized by the type II epithelial cells (AECII) of the pulmonary alveolus, where it is stored in organelles termed lamellar bodies. The synthesis of pulmonary surfactant is under multifactorial control and is regulated by a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22975

    authors: Zhang XQ,Zhang P,Yang Y,Qiu J,Kan Q,Liang HL,Zhou XY,Zhou XG

    更新日期:2014-09-01 00:00:00

  • Daily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing: A systematic review.

    abstract:BACKGROUND:Most international asthma guidelines recommend that children ≤5 years with asthma or recurrent wheezing be treated with daily low- moderate dose inhaled corticosteroids (ICS) as the preferred controller and leukotriene receptor antagonists (LTRA) as alternative therapy. There is no systematic review comparin...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24176

    authors: Castro-Rodriguez JA,Rodriguez-Martinez CE,Ducharme FM

    更新日期:2018-12-01 00:00:00

  • Spanish multicentre study on morbidity and pathogenicity of tracheal bronchus in children.

    abstract::Tracheal bronchus (TRB) has been generally considered an anatomical variant of the tracheobronchial tree without a precise pathological effect. Its prevalence is estimated to be between 0.2% to 3% of all children undergoing bronchoscopy and scientific information has been limited to case reports or small case series. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/ppul.24435

    authors: Moreno M,Castillo-Corullón S,Pérez-Ruiz E,Luna MC,Antón-Pacheco JL,Mondejar-Lopez P,De-la-Serna O,Villa JR,Osona B,Torres-Borrego J,Santiago-Burruchaga M,Asensio O,Andres-Martin A,Delgado-Pecellin I,González Y,Palmero A,E

    更新日期:2019-10-01 00:00:00

  • Partitioning the respiratory effects of airway citric acid and normal saline in lambs.

    abstract::Aspiration is common in the intubated human neonate. Thus, the ventilatory and blood gas responses to citric acid and saline instillation into different airway sites were studied in ten awake, unanesthetised lambs, breathing spontaneously via a tracheostomy tube. With a system of balloons, 1 ml of saline or citric aci...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030112

    authors: Hutchison AA,Caton D,Thomas RG,Bucciarelli RL

    更新日期:1987-01-01 00:00:00

  • Transcutaneous electromyography of the diaphragm: A cardio-respiratory monitor for preterm infants.

    abstract:INTRODUCTION:Chest impedance (CI) is the current standard for cardio-respiratory monitoring in preterm infants but fails to provide direct and quantitative information on diaphragmatic activity. Transcutaneous electromyography (dEMG) is able to measure diaphragmatic activity, but its feasibility and repeatability to mo...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23116

    authors: Kraaijenga JV,Hutten GJ,de Jongh FH,van Kaam AH

    更新日期:2015-09-01 00:00:00

  • Lung function among infants born preterm, with or without bronchopulmonary dysplasia.

    abstract:OBJECTIVE:Both healthy preterm infants and those with bronchopulmonary dysplasia (BPD) have poor lung function during childhood and adolescence, although there is no evidence whether prematurity alone explains the reduction in lung function found in BPD infants. Our study seeks to know if lung function, measured in inf...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21609

    authors: Sanchez-Solis M,Garcia-Marcos L,Bosch-Gimenez V,Pérez-Fernandez V,Pastor-Vivero MD,Mondéjar-Lopez P

    更新日期:2012-07-01 00:00:00

  • Thoracic wall lesions in children.

    abstract::Our objective was to review the clinical features and radiographic manifestations of chest wall lesions in a pediatric chest unit. Twenty-five patients (11 males and 14 females, aged 14 months to 15 years) were suspected of having a chest wall lesion on the basis of clinical examination and chest radiograph. A retrosp...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10440

    authors: Wong KS,Hung IJ,Wang CR,Lien R

    更新日期:2004-03-01 00:00:00

  • Exhaled breath condensate pH in infants and children with acute and recurrent wheezy bronchitis.

    abstract::The analysis of exhaled breath condensate (EBC) is a promising new method to measure airway inflammation. So far only limited data exist about methodological issues of EBC sampling in infants and young children. We evaluated 18 children with acute wheezy bronchitis (median age 24.3 months (min-max: 4-89.9)), 54 childr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20712

    authors: Vogelberg C,Würfel C,Knoetzsch A,Kahlert A,Range U,Leupold W

    更新日期:2007-12-01 00:00:00

  • Parent-reported asthma in Puerto Rican children.

    abstract::We conducted a survey to determine parent-reported asthma prevalence, morbidity, and healthcare utilization among 3527 children attending public schools (n = 2849) and private schools (n = 678) in San Juan, Puerto Rico. Schools were randomly selected from each of 12 geographic regions of the San Juan metropolitan area...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20022

    authors: Nazario S,Casal JR,Torres-Palacios A,Rodriguez W,Delamater AM,Applegate EB,Piedimonte G,Wanner A

    更新日期:2004-05-01 00:00:00

  • New indicators for optimal lung recruitment during high frequency oscillator ventilation.

    abstract::Previous research has demonstrated the potential benefit derived from the combination of high frequency oscillatory ventilation and volume guarantee mode (HFOV-VG), a procedure that allows us to explore and control very low tidal volumes. We hypothesized that secondary spontaneous change in oscillation pressure amplit...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25084

    authors: Rodríguez Sánchez de la Blanca A,Sánchez Luna M,González Pacheco N,Ramos Navarro C,Santos González M,Tendillo Cortijo F

    更新日期:2020-12-01 00:00:00

  • Radiographic findings among children hospitalized with severe community-acquired pneumonia.

    abstract:BACKGROUND:Community-acquired pneumonia (CAP) is a leading cause of childhood death. There are few published reports of radiographic findings among children with severe CAP. OBJECTIVE:To describe chest X-ray (CXR) findings and assess association between these radiographic findings and pneumococcal isolation in childre...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1002/ppul.21287

    authors: Ferrero F,Nascimento-Carvalho CM,Cardoso MR,Camargos P,March MF,Berezin E,Ruvinsky R,Sant'Anna C,Feris-Iglesias J,Maggi R,Benguigui Y,CARIBE group.

    更新日期:2010-10-01 00:00:00

  • Bronchoscopy and airway management in patients with mucopolysaccharidoses (MPS).

    abstract:INTRODUCTION:Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders characterized by tissue deposition of glycosaminoglycans (GAG). Their musculoskeletal abnormalities and the GAG storage in the airway result in increased risk for patients undergoing anesthesia. This study evaluates a multi-disciplinary...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22629

    authors: Muhlebach MS,Shaffer CB,Georges L,Abode K,Muenzer J

    更新日期:2013-06-01 00:00:00

  • Is home spirometry useful in diagnosing asthma in children with nonspecific respiratory symptoms?

    abstract:BACKGROUND:Variation of lung function is considered to be a hallmark of asthma. Although guidelines recommend measuring it as a diagnostic tool for asthma, the usefulness of this approach has not been studied in children. AIM:To assess the usefulness of home spirometry in children with nonspecific lower respiratory tr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21183

    authors: Brouwer AF,Visser CA,Duiverman EJ,Roorda RJ,Brand PL

    更新日期:2010-04-01 00:00:00

  • Early versus late identification of infants at high risk of developing moderate to severe bronchopulmonary dysplasia.

    abstract::We developed a simple method to identify neonates at high risk of bronchopulmonary dysplasia (BPD) and determined whether early (8 hours) and late (14 days) risk assessment is equally useful. A retrospective cohort design was utilized of subjects enrolled in multi-dose surfactant trials to develop each risk identifica...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199606)21:6<345::AID-PPUL1

    authors: Rozycki HJ,Narla L

    更新日期:1996-06-01 00:00:00

  • Technique and use of transbronchial biopsy in children and adolescents.

    abstract::Since July 1988, a total of 92 transbronchial biopsies (TBB) have been performed in 18 patients (aged 3-16 years). Twelve patients (67%) were heart-lung transplant (HLT) recipients undergoing surveillance for pulmonary graft rejection and infection. The remainder included immunocompromised patients at risk of opportun...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950120408

    authors: Whitehead B,Scott JP,Helms P,Malone M,Macrae D,Higenbottam TW,Smyth RL,Wallwork J,Elliott M,de Leval M

    更新日期:1992-04-01 00:00:00

  • Vitamin D status in preterm neonates and the effects of its supplementation on respiratory distress syndrome.

    abstract:AIM:The aim of this study was to investigate the status and effects of vitamin D supplement as adjuvant therapy in the management of respiratory distress syndrome (RDS) in preterm infants. PATIENT AND METHODS:Vitamin D was prospectively studied in 196 preterm neonates, 96 of them developed RDS, which further subdivide...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24552

    authors: Al-Beltagi M,Rowiesha M,Elmashad A,Elrifaey SM,Elhorany H,Koura HG

    更新日期:2020-01-01 00:00:00

  • Endoscopy for the initial suspicion of vascular rings in tracheoesophageal compressions: correlation with surgical findings.

    abstract:UNLABELLED:Vascular rings (VR) may produce extrinsic compression of trachea and/or esophagus. Diagnosis relies on nonspecific clinical data from resulting compression and image studies, mainly angiography, computed tomography, and cardiovascular MRI. Because of their low incidence, diagnosis is often missed. The role o...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21216

    authors: Furuya ME,Vargas MH,Ramírez-Figueroa JL,Félix-Heredia JL,González-Ortíz B,Rodríguez-Hernández L,Vera-Canelo JM

    更新日期:2010-06-01 00:00:00

  • Comparison of airway reactivity induced by cold air and metacholine challenges in asthmatic children.

    abstract::Bronchial responsiveness to isocapnic hyperventilation with cold air (CAH) and to inhaled methacholine (MCH) was compared in 17 children with bronchial asthma. The response to cold air was expressed as the percent drop in FEV1 from baseline at 4 min. after the challenge (delta % FEV1 CAH), and the response to methacho...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ppul.1950190603

    authors: de Benedictis FM,Canny GJ,MacLusky IB,Levison H

    更新日期:1995-06-01 00:00:00

  • Looking beyond patients: Can parents' quality of life predict asthma control in children?

    abstract:BACKGROUND:Social and family factors may influence the probability of achieving asthma control in children. Parents' quality of life has been insufficiently explored as a predictive factor linked to the probability of achieving disease control in asthmatic children. OBJECTIVE:Determine whether the parents' quality of ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23336

    authors: Cano-Garcinuño A,Mora-Gandarillas I,Bercedo-Sanz A,Callén-Blecua MT,Castillo-Laita JA,Casares-Alonso I,Forns-Serrallonga D,Tauler-Toro E,Alonso-Bernardo LM,García-Merino Á,Moneo-Hernández I,Cortés-Rico O,Carvajal-Urueña I,Morel

    更新日期:2016-07-01 00:00:00

  • Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction.

    abstract::Exercise-induced asthma (EIA) is a possible cause of poor physical performance in children. No data are available on the value of respiratory symptoms to discriminate children with bad physical fitness from children with EIA. We evaluated respiratory symptoms in school-age children during and after exercise in relatio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20185

    authors: De Baets F,Bodart E,Dramaix-Wilmet M,Van Daele S,de Bilderling G,Masset S,Vermeire P,Michel O

    更新日期:2005-04-01 00:00:00

  • The role of polysomnography in tracheostomy decannulation of children with bronchopulmonary dysplasia.

    abstract:BACKGROUND:Patients with bronchopulmonary dysplasia (BPD) may require tracheostomy for long-term mechanical ventilation. Polysomnography (PSG) may predict successful decannulation in children, however it is unclear how this success compares with children without a PSG. To better evaluate this role, we compared decannul...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24474

    authors: Quinlan C,Piccione J,Kim JY,Beck SE,Brooks L,Chandy-Patel R,Escobar E,Afolabi-Brown O

    更新日期:2019-11-01 00:00:00

  • Predicting survival in infants with persistent pulmonary hypertension of the newborn.

    abstract::Since persistent pulmonary hypertension of the newborn (PPHN) often occurs as a life-threatening illness, it would be advantageous to identify the highest-risk infants within the first 24 hours of life so that transfer to centers with extracorporeal membrane oxygenation (ECMO) or high-frequency ventilation can be faci...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050103

    authors: Davis JM,Spitzer AR,Cox C,Fox WW

    更新日期:1988-01-01 00:00:00

  • Apnea and periodic breathing in normal full-term infants during the first twelve months.

    abstract::The pediatric pneumogram is a frequently used tool in the diagnosis and management of apnea during infancy. We analyzed 287 pneumographic recordings from 123 full-term infants (63 males) obtained during the first 12 months of life to establish normative values for apnea, periodic breathing, and bradycardia. The result...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010409

    authors: Kelly DH,Stellwagen LM,Kaitz E,Shannon DC

    更新日期:1985-07-01 00:00:00

  • Specific airway resistance in children: panting or tidal breathing?

    abstract:BACKGROUND:The measurement of specific airway resistance during tidal breathing (sRaw(tb)) has gained popularity in children, but methodological concerns have been raised regarding the electronic compensation for the thermal artifact. The panting method (sRaw(p)) is efficient in minimizing the latter, but may be associ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22829

    authors: Coutier L,Varechova S,Demoulin B,Bonabel C,Roman-Amat C,Tuan TL,Ioan I,Schweitzer C,Marchal F

    更新日期:2014-03-01 00:00:00

  • Long-term effects of prednisolone in the acute phase of bronchiolitis caused by respiratory syncytial virus.

    abstract::Follow-up studies have demonstrated that bronchiolitis caused by respiratory syncytial virus (RSV) is strongly associated with wheezing in the ensuing years. During the acute infection the immune response may induce long-lasting detrimental effects, thereby contributing to post-bronchiolitis wheezing (PBW). Therefore,...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1099-0496(200008)30:2<92::aid-ppul3>3.0.co

    authors: van Woensel JB,Kimpen JL,Sprikkelman AB,Ouwehand A,van Aalderen WM

    更新日期:2000-08-01 00:00:00

  • Sidestream microstream end tidal carbon dioxide measurements and blood gas correlations in neonatal intensive care unit.

    abstract:OBJECTIVE:The study was designed to assess the use of newer sidestream microstream end tidal carbon dioxide (ETCO(2) ) device in predicting blood carbon dioxide (PCO(2) ) measurements in very low birth weight (VLBW = birth weight <1,500 g) and non-VLBW NICU neonates. STUDY DESIGN:Sidestream microstream ETCO(2) detecto...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22593

    authors: Singh BS,Gilbert U,Singh S,Govindaswami B

    更新日期:2013-03-01 00:00:00