Pulmonary manifestations of HIV infection in children.

Abstract:

:We retrospectively reviewed the spectrum, course, and outcome of pulmonary diseases in 66 children with AIDS, hospitalized between 1982 and 1988, prior to the use of zidovudine. Fifty-two of the 66 (79%) patients developed pulmonary problems. In fifty-two percent of all patients, a pulmonary problem was the first symptom of HIV infection. The most common respiratory illness requiring hospitalization was an episode of respiratory distress with normal PaO2 and unchanged X-ray with a 9.7 +/- 6.8 days mean duration of hospitalization. Bacterial pneumonia, Pneumocystis carinii pneumonia (PCP) and pulmonary lymphoid hyperplasia/lymphoid interstitial pneumonia occurred in 30%, 32% and 22% of the patients, respectively. Bacterial pneumonia and PCP were associated with a high mortality rate. Sixty-eight percent of the patients died within 24 months of the onset of pulmonary disease. In 50% of the children, pulmonary disease was a primary cause of death. The results of this study can be useful in developing prospective studies for the prevention and treatment of pulmonary complications of HIV infection.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Marolda J,Pace B,Bonforte RJ,Kotin NM,Rabinowitz J,Kattan M

doi

10.1002/ppul.1950100402

subject

Has Abstract

pub_date

1991-01-01 00:00:00

pages

231-5

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

10

pub_type

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