A simple method of reducing complications of pediatric nonbronchoscopic bronchoalveolar lavage.


:Our objective was to determine whether a simple method of maintaining positive pressure ventilation during nonbronchoscopic bronchoalveolar lavage (NB-BAL) would successfully reduce the incidence and/or severity of desaturation events. Our design was a clinical trial with historical controls. Seventy ventilated pediatric patients undergoing diagnostic NB-BAL participated. Two NB-BAL techniques were compared: 1) the "unsealed" method, where the suction catheter was passed through an open system, maintaining oxygenation but not airway pressure; and 2) the "sealed" technique, which was identical except that the catheter was passed through a diaphragm, maintaining positive pressure ventilation throughout. NB-BAL was performed on 35 patients using the "unsealed" technique and 2 years later on 35 patients using the "sealed" method. Heart rate and oxyhemoglobin saturation (SaO(2)) were recorded before, during, and after NB-BAL. There was no difference between groups with regard to demographic data, oxygenation, or ventilatory requirements (P >or= 0.1). The "sealed" group experienced a median drop in SaO(2) of 6.0% (range, -6% to 44%), and the "unsealed" group a drop of 13.0% (-2% to 61%), during NB-BAL (P < 0.05). Patients with oxygenation index greater than 10 experienced the most severe desaturation events in both groups: 53.8% of patients in the "sealed" group with oxygenation index >10 desaturated to <80% vs. 91.6% in the "unsealed" group (P < 0.05). In conclusion, we describe a simple, inexpensive modification of the NB-BAL technique that reduces the incidence and severity of desaturation during NB-BAL.


Pediatr Pulmonol


Pediatric pulmonology


Morrow B,Futter M,Argent A




Has Abstract


2004-09-01 00:00:00












  • The effects of an intensive behavior and nutrition intervention compared to standard of care on weight outcomes in CF.

    abstract::Inadequate intake and suboptimal growth are common problems for patients with CF and a critical target for intervention. The purpose of this study was to compare the growth outcomes of children with CF who participated in a randomized clinical trial to improve energy intake and weight to children with CF receiving sta...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验


    authors: Stark LJ,Opipari-Arrigan L,Quittner AL,Bean J,Powers SW

    更新日期:2011-01-01 00:00:00

  • Signaling molecules in the fetal rabbit model for congenital diaphragmatic hernia.

    abstract:RATIONALE AND OBJECTIVES:Little is known about molecular changes in lungs of fetal rabbits with surgically induced diaphragmatic hernia (DH). Therefore, we examined in this model gene expressions of pivotal molecules for the developing lung. METHODS:At day 23 of gestation, DH was created in 12 fetuses from 4 does. Bot...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Vuckovic A,Roubliova XI,Votino C,Naeije R,Jani JC

    更新日期:2012-11-01 00:00:00

  • Non invasive positive pressure ventilation in infants with respiratory failure.

    abstract:OBJECTIVE:To determine whether non-invasive positive pressure ventilation (NIPPV) delivered via nasal prongs can alleviate the need for tracheal intubation and invasive ventilation in infants admitted to the pediatric intensive care unit (PICU) with impending respiratory failure, and to find predictive factors for succ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Cavari Y,Sofer S,Rozovski U,Lazar I

    更新日期:2012-10-01 00:00:00

  • Current understanding of the inflammatory process in cystic fibrosis: onset and etiology.

    abstract::Although airway obstruction and chronic endobronchial infection have long been recognized as major factors in the pathogenesis of lung disease in cystic fibrosis (CF), only recently has it been recognized that the inflammatory process itself may be responsible in a major way for destroying the lungs. The most characte...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Konstan MW,Berger M

    更新日期:1997-08-01 00:00:00

  • Acute eosinophilic pneumonia occurring in a dedicator of cytokinesis 8 (DOCK8) deficient patient.

    abstract::Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive type of combined immunodeficiency with elevated IgE. In this report, we describe a Japanese girl of non-consanguineous family suffering from acute eosinophilic pneumonia (AEP) as a presenting feature of DOCK8 deficiency. Although AEP was self-limi...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Tsuge I,Ito K,Ohye T,Kando N,Kondo Y,Nakajima Y,Inuo C,Kurahashi H,Urisu A

    更新日期:2014-03-01 00:00:00

  • Pulmonary function and structure following mild preterm birth in lambs.

    abstract::Our objective was to determine whether postnatal respiratory function, lung growth, and lung structure are affected by preterm birth which did not require neonatal respiratory support. Two groups of preterm (P) lambs were delivered 2 weeks before term, at 133 days of gestational age (GA). Tissue was collected at term ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Cock M,Hanna M,Sozo F,Wallace M,Yawno T,Suzuki K,Maritz G,Hooper S,Harding R

    更新日期:2005-10-01 00:00:00

  • Sleep-disordered breathing in 3,680 Greek children.

    abstract::The goal of the present investigation was to describe the prevalence of and clinical factors associated with sleep-disordered breathing in children and adolescents. Children and adolescents (3,680 in all, 1-18 years old) attending schools in central Greece were surveyed by questionnaires distributed to parents. We fou...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章


    authors: Kaditis AG,Finder J,Alexopoulos EI,Starantzis K,Tanou K,Gampeta S,Agorogiannis E,Christodoulou S,Pantazidou A,Gourgoulianis K,Molyvdas PA

    更新日期:2004-06-01 00:00:00

  • Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomy.

    abstract:BACKGROUND:Asthma and obstructive sleep apnea (OSA) in children share multiple epidemiological risk factors and the prevalence of snoring is higher in asthmatic children, suggesting that the latter may be at increased risk for OSA. Since both asthma and OSA are inflammatory disorders, we hypothesized that polysomnograp...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Kheirandish-Gozal L,Dayyat EA,Eid NS,Morton RL,Gozal D

    更新日期:2011-09-01 00:00:00

  • Neuroendocrine cells in the developing human lung: morphologic and functional considerations.

    abstract::The structure, distribution, and frequency of neuroendocrine (NE) cells in human fetal lung from early stages of development to term are described. Neuroendocrine cells were studied by electron microscopy and immunostaining for serotonin and bombesin, recently identified markers of these cells in human lung. The diffe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Cutz E,Gillan JE,Bryan AC

    更新日期:1985-05-01 00:00:00

  • Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) is a complication commonly encountered in patients with CF that produces significant respiratory morbidity. Chronic airway colonization with Aspergillus induces strong inflammatory responses with high IgE levels. Current guidelines for therapy include prolonged courses of...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Zirbes JM,Milla CE

    更新日期:2008-06-01 00:00:00

  • Effect of cumulative oxygen exposure on respiratory symptoms during infancy among VLBW infants without bronchopulmonary dysplasia.

    abstract:UNLABELLED:Very low birth weight (VLBW) infants, even those without bronchopulmonary dysplasia (BPD) are at risk for pulmonary morbidity during infancy. Although some studies have found an association between the level of neonatal oxygen exposure and later morbidity, others have not. A possible explanation for these in...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Stevens TP,Dylag A,Panthagani I,Pryhuber G,Halterman J

    更新日期:2010-04-01 00:00:00

  • Assessing the need for adenotonsillectomy for sleep-disordered breathing in a community setting: A secondary outcome measures analysis of a randomized controlled study.

    abstract:OBJECTIVE:To assess whether children with sleep-disordered breathing (SDB) symptom severity above a certain level, measured by a validated questionnaire, improve after adenotonsillectomy (AT) compared to no intervention. METHODS:Children with snoring and tonsillar hypertrophy (4 to 10-years old), who were candidates f...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验


    authors: Papadakis CE,Chaidas K,Chimona TS,Zisoglou M,Ladias A,Proimos EK,Miligkos M,Kaditis AG

    更新日期:2019-10-01 00:00:00

  • Primary small cell bronchogenic carcinoma in a 14-year-old boy.

    abstract::A 14-year-old Korean boy was admitted with cough, hemoptysis, and fever. A chest X-ray showed a solitary pulmonary mass and pneumonitis. Bronchial biopsy by fiberoptic bronchoscopy revealed a poorly differentiated small cell carcinoma. All of the staging information indicated that the patient had limited disease. Duri...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Kim CK,Chung CY,Koh YY

    更新日期:2000-04-01 00:00:00

  • Bone mineral content and body composition in children and young adults with cystic fibrosis.

    abstract::With dual energy X-ray absorptiometry (DEXA), it is possible to quantitate important aspects of growth in children with cystic fibrosis (CF), supplementing the usual measures of height and weight. Of particular concern during growth is the accumulation of bone mineral, since osteoporosis and fractures are well-recogni...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Henderson RC,Madsen CD

    更新日期:1999-02-01 00:00:00

  • Endoscopy for the initial suspicion of vascular rings in tracheoesophageal compressions: correlation with surgical findings.

    abstract:UNLABELLED:Vascular rings (VR) may produce extrinsic compression of trachea and/or esophagus. Diagnosis relies on nonspecific clinical data from resulting compression and image studies, mainly angiography, computed tomography, and cardiovascular MRI. Because of their low incidence, diagnosis is often missed. The role o...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Furuya ME,Vargas MH,Ramírez-Figueroa JL,Félix-Heredia JL,González-Ortíz B,Rodríguez-Hernández L,Vera-Canelo JM

    更新日期:2010-06-01 00:00:00

  • Blood L-arginine levels in early respiratory distress syndrome.

    abstract::L-arginine is the precursor of nitric oxide which plays an important role on pulmonary circulation and pulmonary vascular tone. Our aim was to compare the levels of L-arginine between infants with respiratory distress syndrome and infants without respiratory distress syndrome and to determine the relationship between ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Canpolat FE,Yurdakök M,Yiğit S,Korkmaz A,Tekinalp G

    更新日期:2005-12-01 00:00:00

  • Advance care planning in adolescents with cystic fibrosis: A quality improvement project.

    abstract:INTRODUCTION:Advance care planning (ACP), though recommended, has not been studied in adolescents with cystic fibrosis (CF). This quality improvement project engaged adolescents with advanced CF disease in ACP and assessed patient and CF provider attitudes and preferences regarding ACP discussions and tools. MATERIALS...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Kazmerski TM,Weiner DJ,Matisko J,Schachner D,Lerch W,May C,Maurer SH

    更新日期:2016-12-01 00:00:00

  • Relationship between peak cough flow and spirometry in Duchenne muscular dystrophy.

    abstract::Spirometry is used to monitor respiratory progress in children with Duchenne muscular dystrophy (DMD). Mucociliary clearance depends on cough strength, which can be measured by peak cough flow (PCF). It is not routinely measured in most centers. When the PCF falls below 270 l/min, mucociliary clearance is likely to be...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Gauld LM,Boynton A

    更新日期:2005-05-01 00:00:00

  • Trial of an intervention to reduce passive smoking in infancy.

    abstract::We tested a health education intervention program to reduce passive smoking in infancy. The aim was to develop an instrument for study of tobacco smoke exposure and childhood respiratory illness. One hundred and eighty-four women who had smoked during pregnancy were allocated by month of delivery to an intervention gr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Woodward A,Owen N,Grgurinovich N,Griffith F,Linke H

    更新日期:1987-05-01 00:00:00

  • Safety and tolerability of inhaled hypertonic saline in young children with cystic fibrosis.

    abstract:BACKGROUND:Inhaled hypertonic saline (HS) improves lung function and decreases pulmonary exacerbations in older patients with cystic fibrosis (CF). Initiating therapies in young patients has potential to preserve lung function. Before conducting a therapeutic trial of HS in this population, its safety must be evaluated...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章


    authors: Dellon EP,Donaldson SH,Johnson R,Davis SD

    更新日期:2008-11-01 00:00:00

  • Airway stents in children.

    abstract::Airway obstruction in children is a rare, but difficult clinical problem, with no clear agreement on optimal therapeutic approach. Stenting of the airway has been used successfully in adults, and is an attractive alternative in children. Fundamental differences of pediatric compared to adult use include the benign nat...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审


    authors: Nicolai T

    更新日期:2008-04-01 00:00:00

  • Limitations of electronic compensation for measuring plethysmographic airway resistance in infants.

    abstract::Electronic compensation to overcome thermal artifacts during plethysmographic estimations of airway resistance is now used routinely in adults and school-age children, and was shown to be a valuable means of discriminating airway function between preschool children with and without lung disease. A similar system is no...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章


    authors: Subbarao P,Hulskamp G,Stocks J

    更新日期:2005-07-01 00:00:00

  • Assessment of passive respiratory compliance in healthy preterm infants: a critical evaluation.

    abstract::The airway occlusion techniques for assessing passive respiratory mechanics have become well established methods in fullterm neonates and older infants. The single breath technique (SBT) is frequently used for assessing lung function in intubated infants on neonatal intensive care units. However, less is known about t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Gappa M,Rabbette PS,Costeloe KL,Stocks J

    更新日期:1993-05-01 00:00:00

  • High-sensitivity C reactive protein as a biomarker for grading of childhood asthma in relation to clinical classification, induced sputum cellularity, and spirometry.

    abstract:BACKGROUND:Asthma is the most common chronic inflammatory disease in childhood and some reports have demonstrated systemic inflammation. The relevance of high-sensitivity assays for C-reactive protein (hs-CRP), which are known to be a sensitive marker of low-grade systemic inflammation, has not been fully studied in ch...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Deraz TE,Kamel TB,El-Kerdany TA,El-Ghazoly HM

    更新日期:2012-03-01 00:00:00

  • Prenatal cigarette smoke exposure and postnatal respiratory responses to hypoxia and hypercapnia.

    abstract::Prenatal cigarette smoke (CS) exposure, in combination with hypoxia and/or hyperthermia can lead to gasping and attenuated recovery from hypoxia in 7 days old rat pups. We studied 95 unanesthetized spontaneously breathing 14 days old rat pups to investigate if the destabilizing effects of increased ambient temperature...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Pendlebury JD,Yusuf K,Bano S,Lumb KJ,Schneider JM,Hasan SU

    更新日期:2012-05-01 00:00:00

  • Respiratory symptoms of primary school children living in a petrochemical polluted area in Taiwan.

    abstract::In 1994-1995 a cross-sectional epidemiological study investigating the respiratory health of school children in two Taiwan areas was conducted; one area was located in a region with petrochemical manufacturing complexes (Linyuan), and the other was situated in a reference area with no local industrial emissions (Taihs...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Yang CY,Wang JD,Chan CC,Hwang JS,Chen PC

    更新日期:1998-05-01 00:00:00

  • Fungal pleural effusion secondary to a rare cause of pancreatic pseudocyst.

    abstract::We report a case of fungal pleural effusion secondary to presumed valproate induced pancreatitis with pseudocyst and stricture formation. A child with dyskinetic cerebral palsy who had been on sodium valproate for several years was transferred for drainage of a left sided pleural effusion. Pleural fluid culture consis...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Gupta A,Marrs T,Urquhart D,Clarke S,Rosenthal M,Bush A

    更新日期:2009-06-01 00:00:00

  • Heme oxygenase-1 alleviates eosinophilic inflammation by inhibiting STAT3-SOCS3 signaling.

    abstract::Airway inflammation of eosinophilic asthma (EA) attributes to Th2 response, leaving the role of Th17 response unknown. Signal transducer and activator of transcription 3 (STAT3) induce both suppressors of cytokine signaling 3 (SOCS3) and retinoic acid receptor-related orphan nuclear receptor γ (RORγt) to initiate Th17...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Lin X,Lv J,Ge D,Bai H,Yang Y,Wu J

    更新日期:2020-06-01 00:00:00

  • Pediatric pulmonology year in review 2016: Part 2.

    abstract::Pediatric Pulmonology continues to publish research and clinical topics related to the entire range of children's respiratory disorders. As we have done annually in recent years, we here summarize some of the past year's publications in our major topic areas, as well as selected literature in these areas from other co...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审


    authors: Auten R,Ren C,Yilmaz O,Noah TL

    更新日期:2017-09-01 00:00:00

  • Subcutaneous terbutaline in children with chronic severe asthma.

    abstract::A continuous subcutaneous infusion of terbutaline (CSIT) was used to treat 8 children with chronic severe asthma who continued to experience frequent symptoms, despite treatment with regular oral prednisolone. Five patients experienced a symptomatic improvement from CSIT, leading to a reduction in regular medication. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章


    authors: Payne DN,Balfour-Lynn IM,Biggart EA,Bush A,Rosenthal M

    更新日期:2002-05-01 00:00:00