Development and validation of a questionnaire to assess asthma control in pediatrics.

Abstract:

OBJECTIVE:To develop and validate a questionnaire to assess asthma control in children (CAN). DESIGN:Two versions of the CAN (for carers and children) were developed. Both versions were validated in an observational, prospective, multicenter study performed in 38 hospital outpatient clinics throughout Spain. Four hundred fifteen patients and their carers agreed to participate. Of these, 414 patients under 14 years old with frequent episodic or persistent (moderate to severe) asthma completed the questionnaire on 3 occasions (baseline, week 2, and week 12). For patients aged 2-8 the questionnaire was only completed by the carers, but for patients aged 9-14 the questionnaire was completed by the carers and the children. Clinician ratings of asthma control were used as a gold standard to assess the sensitivity, specificity, PPV and NPV of the new measure. RESULTS:Evaluable responses were obtained from 215 carers for children aged 2-8 years and 199 children aged 9-14 years, and their parents. Using a questionnaire total score cut-off of 8 the patient version had a sensitivity of 76.3% and a specificity of 62.9%. For carer version these values were 73% and 69.7%, respectively. A cut point of 8 was selected to maximize the screening accuracy of the CAN questionnaire. Effect sizes in patients with clinician-rated improvements in asthma control were 0.33 and 0.57 for the carer and child versions, respectively. CONCLUSIONS:The screening accuracy and validity of the CAN questionnaire make it suitable for use in research and clinical practice. The sensitivity and specificity were close to 70%, which is acceptable for the study objective: obtain a tool to measure the level of asthma control.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Pérez-Yarza EG,Badía X,Badiola C,Cobos N,Garde J,Ibero M,Villa JR,CAN Investigator Group.

doi

10.1002/ppul.20929

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

54-63

issue

1

eissn

8755-6863

issn

1099-0496

journal_volume

44

pub_type

杂志文章
  • Combination antifungal therapy for Scedosporium species in cystic fibrosis.

    abstract:OBJECTIVE:To evaluate safety and efficacy of oral posaconazole and terbinafine for Lomentospora prolificans and Scedosporium apiospermum in children with cystic fibrosis. METHODS:Retrospective case review. RESULTS:There were five children (four girls), median age 15.0 years; three had S. apiospermum and two had L. pr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24789

    authors: Bentley S,Davies JC,Carr SB,Balfour-Lynn IM

    更新日期:2020-08-01 00:00:00

  • Pneumococcal serogroups and serotypes in severe pneumococcal pneumonia in Belgian children: theoretical coverage of the 7-valent and 9-valent pneumococcal conjugate vaccines.

    abstract:BACKGROUND:Although the causative pneumococcal serotypes of invasive diseases are already extensively studied, few data are available about the pneumococcal serotypes additionally isolated from broncho-alveolar lavage samples in childhood pneumonia. STUDY AIM:To identify the causative pneumococcal serotypes in culture...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20437

    authors: De Schutter I,Malfroot A,Piérard D,Lauwers S

    更新日期:2006-08-01 00:00:00

  • Occlusion of an aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug.

    abstract::Pulmonary sequestration is a rare anomaly and is conventionally treated with surgical excision. This report describes the successful occlusion of a large aberrant artery to an intralobar pulmonary sequestration using an Amplatzer Vascular Plug. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20882

    authors: Hwang HK,Tsai YS,Lin SM,Chen MR

    更新日期:2008-09-01 00:00:00

  • Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development.

    abstract::Exposure to chronic constant or intermittent hypoxia (CCH or CIH) may have different effects on growth and development in early life. In this work, we exposed postnatal day 2 (P2) CD1 mice to CCH or CIH (11% O2) for 4 weeks and examined the effect of hypoxia on body and organ growth until P30. Regression analysis show...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20729

    authors: Farahani R,Kanaan A,Gavrialov O,Brunnert S,Douglas RM,Morcillo P,Haddad GG

    更新日期:2008-01-01 00:00:00

  • Efficacy of fiberoptic bronchoscopy and bronchoalveolar lavage in childhood-onset, complicated plastic bronchitis.

    abstract:BACKGROUND:Plastic bronchitis (PB) is a rare, variable, and potentially fatal disease. This study aimed to assess the efficacy of fiberoptic bronchoscopy (FOB) and bronchoalveolar lavage (BAL) in treating children with PB. METHODS:In total, 15 children with PB, between 2012 and 2020, were enrolled in our study. Within...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25016

    authors: Wang L,Wang W,Sun JM,Ni SW,Ding JL,Zhu YL,Ding SG

    更新日期:2020-11-01 00:00:00

  • Airway epithelial cell signaling in response to bacterial pathogens.

    abstract::The airway epithelium represents a primary site for the introduction and deposition of potentially pathogenic microorganisms into the body, through inspired air. The epithelial mucosa is an important component of the innate immune system that recognizes conserved structures in microorganisms and initiates appropriate ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20735

    authors: Gómez MI,Prince A

    更新日期:2008-01-01 00:00:00

  • Glucocorticoid receptor disruption delays structural maturation in the lungs of newborn mice.

    abstract::In order to better understand the regulation of lung maturation by glucocorticoid-glucocorticoid receptor signaling, we studied glucocorticoid receptor (GR) hypomorphic mice with a mixed C57Bl6/129 sv background, in which disruption of exon 2 of the GR gene produces an N-terminal truncated GR protein. Four groups of m...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20746

    authors: Nemati B,Atmodjo W,Gagnon S,Humes D,McKerlie C,Kaplan F,Sweezey NB

    更新日期:2008-02-01 00:00:00

  • Daily inhaled corticosteroids or montelukast for preschoolers with asthma or recurrent wheezing: A systematic review.

    abstract:BACKGROUND:Most international asthma guidelines recommend that children ≤5 years with asthma or recurrent wheezing be treated with daily low- moderate dose inhaled corticosteroids (ICS) as the preferred controller and leukotriene receptor antagonists (LTRA) as alternative therapy. There is no systematic review comparin...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24176

    authors: Castro-Rodriguez JA,Rodriguez-Martinez CE,Ducharme FM

    更新日期:2018-12-01 00:00:00

  • Pulmonary manifestations of HIV infection in children.

    abstract::We retrospectively reviewed the spectrum, course, and outcome of pulmonary diseases in 66 children with AIDS, hospitalized between 1982 and 1988, prior to the use of zidovudine. Fifty-two of the 66 (79%) patients developed pulmonary problems. In fifty-two percent of all patients, a pulmonary problem was the first symp...

    journal_title:Pediatric pulmonology

    pub_type: 评论,杂志文章

    doi:10.1002/ppul.1950100402

    authors: Marolda J,Pace B,Bonforte RJ,Kotin NM,Rabinowitz J,Kattan M

    更新日期:1991-01-01 00:00:00

  • Recruitment of intercostal muscle activity during hypercapnia in kittens.

    abstract::Little is known about the respiratory behavior of the intercostal muscles within a neonatal and developmental context. We, therefore, examined intercostal muscle electromyographic (EMG) activity in kittens (1 month old, n = 8; 2 months old, n = 7) during eupnea and heightened respiratory drive induced by hypercapnia. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050407

    authors: Watchko JF,Klesh KW,O'Day TL,Guthrie RD

    更新日期:1988-01-01 00:00:00

  • Prophylaxis against respiratory syncytial virus in young children with cystic fibrosis.

    abstract:INTRODUCTION:In cystic fibrosis (CF) patients, respiratory syncytial virus (RSV) infection is associated with significant morbidity. Although passive prophylaxis with palivizumab lowers hospitalization rate for RSV infection in populations at risk of severe infection, its use is not recommended in infants with CF disea...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20751

    authors: Giebels K,Marcotte JE,Podoba J,Rousseau C,Denis MH,Fauvel V,Laberge S

    更新日期:2008-02-01 00:00:00

  • Polysomnography Provides Useful Clinical Information in the Liberation from Respiratory Technology: A Retrospective Review.

    abstract::Background The prevalence of respiratory-technology dependent children is increasing although for most children the goal is liberation from technology. Liberation from home mechanical ventilation (HMV) and decannulation strategies vary due to the lack of clinical practice standards. The primary objective of this study...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24164

    authors: Bashir A,Henningfeld JK,Thompson NE,D'Andrea LA

    更新日期:2018-11-01 00:00:00

  • The bronchodilator effect of a fixed-combination metered aerosol (fenoterol and ipratropium bromide).

    abstract::The fixed-combination metered aerosol lK6 (fenoterol 0.05 mg/puff, ipratropium bromide 0.02 mg/puff--Berodual, Boehringer-Ingelheim Ltd., Ridgefield, Conn.) was administered to 12 children (8 boys, 4 girls) aged 3 1/2 to 6 2/12 years who had extrinsic bronchial asthma. Three forms of administration, each with a differ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010605

    authors: Berdel D,Kellersmann U

    更新日期:1985-11-01 00:00:00

  • Long-term effects of prednisolone in the acute phase of bronchiolitis caused by respiratory syncytial virus.

    abstract::Follow-up studies have demonstrated that bronchiolitis caused by respiratory syncytial virus (RSV) is strongly associated with wheezing in the ensuing years. During the acute infection the immune response may induce long-lasting detrimental effects, thereby contributing to post-bronchiolitis wheezing (PBW). Therefore,...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1099-0496(200008)30:2<92::aid-ppul3>3.0.co

    authors: van Woensel JB,Kimpen JL,Sprikkelman AB,Ouwehand A,van Aalderen WM

    更新日期:2000-08-01 00:00:00

  • Neuroendocrine cells in the developing human lung: morphologic and functional considerations.

    abstract::The structure, distribution, and frequency of neuroendocrine (NE) cells in human fetal lung from early stages of development to term are described. Neuroendocrine cells were studied by electron microscopy and immunostaining for serotonin and bombesin, recently identified markers of these cells in human lung. The diffe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:

    authors: Cutz E,Gillan JE,Bryan AC

    更新日期:1985-05-01 00:00:00

  • Respiratory impedance in patients with Duchenne muscular dystrophy.

    abstract::Impulse oscillometry (IOS) evaluates non-effort-dependent respiratory mechanics, and thus it may be useful to evaluate patients with Duchenne muscular dystrophy (DMD). OBJECTIVES:We aimed (1) to describe the behavior of IOS parameters in patients with DMD, and compare it to those from a control group; (2) to determin...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23434

    authors: Gochicoa-Rangel L,Vargas MH,Alonso-Gómez JL,Rodríguez-Moreno L,Martínez-Briseño D,Baños-Mejía O,Torre-Bouscoulet L

    更新日期:2016-10-01 00:00:00

  • Short and long interpregnancy interval and the risk for pediatric obstructive sleep apnea in the offspring.

    abstract:INTRODUCTION:Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI < 6 months) and long IPI (IPI > 60 months) have been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep a...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25240

    authors: Rapaport Pasternak H,Sheiner E,Goldbart A,Wainstock T

    更新日期:2020-12-31 00:00:00

  • Effects of maternal retinoic acid administration in a congenital diaphragmatic hernia rabbit model.

    abstract::Maternal retinoid administration has beneficial effects on lung development in the nitrofen rodent toxic model of congenital diaphragmatic hernia (DH). We wanted to investigate the effects in a surgical model, where the retinoid signaling pathway is not primarily disrupted by the toxic agent. We created DH in fetal ra...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20829

    authors: Gallot D,Coste K,Jani J,Roubliova X,Marceau G,Velemir L,Verheyen A,Lemery D,Sapin V,Deprest J

    更新日期:2008-06-01 00:00:00

  • Cheyne-Stokes respiration as an additional risk factor for pulmonary hypertension in a boy with trisomy 21 and atrioventricular septal defect.

    abstract::Central ventilation disorders(1) and airway obstruction(2) with chronic hypoxemia are causally related to cor pulmonale. Pulmonary vascular resistance is often reversible, and hypoxic pulmonary hypertension often responds to treatment with supplemental oxygen. Oxygen therapy during sleep may be useful as a temporary p...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1037

    authors: Hoch B,Barth H

    更新日期:2001-03-01 00:00:00

  • Obstructive sleep apnea in poorly controlled asthmatic children: effect of adenotonsillectomy.

    abstract:BACKGROUND:Asthma and obstructive sleep apnea (OSA) in children share multiple epidemiological risk factors and the prevalence of snoring is higher in asthmatic children, suggesting that the latter may be at increased risk for OSA. Since both asthma and OSA are inflammatory disorders, we hypothesized that polysomnograp...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21451

    authors: Kheirandish-Gozal L,Dayyat EA,Eid NS,Morton RL,Gozal D

    更新日期:2011-09-01 00:00:00

  • Hepatic enzyme abnormalities in children on triple therapy for tuberculosis.

    abstract::Standard chemotherapy for tuberculosis (TB) in children uses hepatotoxic drugs. Published data and guidelines on monitoring of liver function during TB treatment are often contradictory and not directly relevant to the pediatric population. We carefully monitored 43 children (age 6.6 years, 0.7-15.1 [median, range]; 4...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1099-0496(199901)27:1<37::aid-ppul8>

    authors: Corrigan D,Paton J

    更新日期:1999-01-01 00:00:00

  • Perception of intrinsic and extrinsic respiratory loads in children with life-threatening asthma.

    abstract::There is a subpopulation of asthmatic patients with a history of life-threatening asthma (LTA) who have a reduced perception of respiratory loads. The aim of this study was to determine if these patients have a reduced perception of both intrinsic and extrinsic loads. Children with asthma were classified into life-thr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10199

    authors: Julius SM,Davenport KL,Davenport PW

    更新日期:2002-12-01 00:00:00

  • Effects of birthweight and oxygen supplementation on lung function in late childhood in children of very low birth weight.

    abstract::Impaired respiratory function has been found frequently in ex-premature children, but it is unclear which specific factors influence this impairment the most. The aim of this study was to determine the importance of the contributions of birth weight, gestational age, neonatal respiratory disease, and its treatment on ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200007)30:1<32::aid-ppul6>3.0.co

    authors: Kennedy JD,Edward LJ,Bates DJ,Martin AJ,Dip SN,Haslam RR,McPhee AJ,Staugas RE,Baghurst P

    更新日期:2000-07-01 00:00:00

  • Primary small cell bronchogenic carcinoma in a 14-year-old boy.

    abstract::A 14-year-old Korean boy was admitted with cough, hemoptysis, and fever. A chest X-ray showed a solitary pulmonary mass and pneumonitis. Bronchial biopsy by fiberoptic bronchoscopy revealed a poorly differentiated small cell carcinoma. All of the staging information indicated that the patient had limited disease. Duri...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(200004)29:4<317::aid-ppul1

    authors: Kim CK,Chung CY,Koh YY

    更新日期:2000-04-01 00:00:00

  • Non invasive positive pressure ventilation in infants with respiratory failure.

    abstract:OBJECTIVE:To determine whether non-invasive positive pressure ventilation (NIPPV) delivered via nasal prongs can alleviate the need for tracheal intubation and invasive ventilation in infants admitted to the pediatric intensive care unit (PICU) with impending respiratory failure, and to find predictive factors for succ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22561

    authors: Cavari Y,Sofer S,Rozovski U,Lazar I

    更新日期:2012-10-01 00:00:00

  • Lung disease in Niemann-Pick disease.

    abstract:BACKGROUND:Lung involvement in children with Niemann-Pick disease has rarely been studied systematically. OBJECTIVE:To assess the involvement of the lung and the value of bronchoalveolar lavage in children with Niemann-Pick diseases. DESIGN:Retrospective analysis of patient records. PATIENTS:Thirteen patients, with ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20725

    authors: Guillemot N,Troadec C,de Villemeur TB,Clément A,Fauroux B

    更新日期:2007-12-01 00:00:00

  • Assessing ventilatory control in infants at high risk of sleep disordered breathing: a study of infants with cleft lip and/or palate.

    abstract::Neonatal exposure to intermittent hypoxia results in altered ventilatory response to subsequent hypoxia in animal models. The effect of similar exposure in human infants is unknown. Our objective was to determine the impact of sleep disordered breathing (SDB) in early infancy on ventilatory response in infants. We rec...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22568

    authors: MacLean JE,Tan S,Fitzgerald DA,Waters KA

    更新日期:2013-03-01 00:00:00

  • Vitamin D status in preterm neonates and the effects of its supplementation on respiratory distress syndrome.

    abstract:AIM:The aim of this study was to investigate the status and effects of vitamin D supplement as adjuvant therapy in the management of respiratory distress syndrome (RDS) in preterm infants. PATIENT AND METHODS:Vitamin D was prospectively studied in 196 preterm neonates, 96 of them developed RDS, which further subdivide...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24552

    authors: Al-Beltagi M,Rowiesha M,Elmashad A,Elrifaey SM,Elhorany H,Koura HG

    更新日期:2020-01-01 00:00:00

  • A multi-center controlled trial of growth hormone treatment in children with cystic fibrosis.

    abstract:OBJECTIVES:We evaluated safety and efficacy of recombinant human growth hormone (rhGH) for improving growth, lean body mass (LBM), pulmonary function, and exercise tolerance in children with cystic fibrosis (CF) and growth restriction. STUDY DESIGN:Multicenter, open-label, controlled clinical trial comparing outcomes ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ppul.21546

    authors: Stalvey MS,Anbar RD,Konstan MW,Jacobs JR,Bakker B,Lippe B,Geller DE

    更新日期:2012-03-01 00:00:00

  • Extralobar pulmonary sequestration with combined gastric and intradiaphragmatic locations.

    abstract::Extralobar pulmonary sequestration is a congenital lung malformation characterized by a non-functional lung segment with systemic feeding vessel. Over 90% of sequestrations are found in the thorax with less than 10% located in the abdomen. We present an unusual case of intra abdominal pulmonary sequestration, located ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22891

    authors: Chouikh T,Berteloot L,Revillon Y,Delacourt C,Khen-Dunlop N

    更新日期:2014-05-01 00:00:00