Abstract:
:Our objective was to study meconium-induced lung injury in isolated perfused rat lungs exposed to anoxia. Our working hypothesis was that meconium-induced lung injury is independent of preexisting hypoxia, and that hypoxia will increase severity of lung injury observed after meconium aspiration. We compared five different groups of animals (n = 5) for pulmonary arterial pressure (PAP), weight lung changes, and TNFalpha expression. Group I had lungs instilled with 4 ml of normal saline. Group II had lungs exposed to 5 min of anoxia. Group III had lungs instilled with 4 ml of 30% filtered human meconium. Group IV had lungs exposed to 5 min of anoxia and then instilled with 4 ml of 30% filtered human meconium. Group V had lungs instilled with 4 ml of 30% unfiltered human meconium. Our subjects were adult Sprague-Dawley rats. The isolated rat lung model was prepared according to Levey and Gast (J Appl Physiol 1966;21:313-316). Lungs were ventilated with room air. Anoxia was caused by the use of N(2). The pulmonary artery was cannulated, and pulmonary arterial pressure and lung weight were measured. Lung weight and pulmonary arterial pressure were monitored for 120 min, and TNFalpha levels were measured in effluent at 15, 30, 60, and 120 min. Experiments were done at the Michael Reese Hospital (Chicago, IL). At the end of the experiment, PAP reached its highest values in group V (10.0 +/- 1.7 mmHg). Final PAPs in groups I-IV were: 4.85 +/- 0.3, 4.99 +/- 0.4, 5.93 +/- 0.3, and 7.25 +/- 0.51 mmHg, respectively). Lung wet weight increased significantly only in groups IV and V vs. group I; at 120 min, they were: 0.96 +/- 0.3 g, P < 0.01, and 1.5 g +/- 0.2 g, P < 0.01, respectively. TNFalpha levels did not change significantly over time in group I. TNFalpha is a marker as well as proprietor of pulmonary inflammatory response. TNFalpha reached its highest levels in groups IV and V: 595 and 753 pg/ml at 120 min, respectively. In conclusion, a short episode of anoxia prior to meconium aspiration may increase lung sensitivity to meconium-induced lung injury. This effect may be moderated by the TNFalpha present in the pulmonary circulation.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Wisniewski WM,Zagariya AM,Pavuluri N,Srinivasan H,Shankarao S,Vidyasagar Ddoi
10.1002/ppul.20123subject
Has Abstractpub_date
2005-04-01 00:00:00pages
368-73issue
4eissn
8755-6863issn
1099-0496journal_volume
39pub_type
杂志文章abstract::Nicotine, 1 mg/kg body weight/day, was injected subcutaneously in 3 female rabbits during gestational and lactating periods, and the lungs of the offspring were studied by scanning and transmission electron microscopy (SEM and TEM) on days 5, 10, and 25 postpartum. Three other female rabbits served as controls. The si...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
abstract:INTRODUCTION:Interpregnancy interval (IPI) is defined as the period between a live birth and the conception of a subsequent fetus. Both short (IPI < 6 months) and long IPI (IPI > 60 months) have been shown to increase the risk for adverse perinatal outcomes, some of which, are known risk factors for obstructive sleep a...
journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1996-06-01 00:00:00
abstract::Short-acting β2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to β2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22723
更新日期:2013-10-01 00:00:00
abstract::With dual energy X-ray absorptiometry (DEXA), it is possible to quantitate important aspects of growth in children with cystic fibrosis (CF), supplementing the usual measures of height and weight. Of particular concern during growth is the accumulation of bone mineral, since osteoporosis and fractures are well-recogni...
journal_title:Pediatric pulmonology
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更新日期:1999-02-01 00:00:00
abstract::End-tidal PCO2 (PETCO2) measurements from two commercially available neonatal infrared capnometers with different sampling systems and a mass spectrometer were compared with arterial PCO2 (PaCO2) to determine whether the former could predict the latter in mechanically ventilated rabbits with and without lung injury. T...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950170309
更新日期:1994-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22526
更新日期:2012-10-01 00:00:00
abstract::Lung hypoplasia is the main cause of congenital diaphragmatic hernia (CDH)-associated death but pathogenesis remains unclear. MiR-455-5p is involved in lung hypoplasia. We hypothesized that nitrofen causes abnormal miR-455-5p expression during lung development and designed this study to determine the relationship betw...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24739
更新日期:2020-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24876
更新日期:2020-09-01 00:00:00
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journal_title:Pediatric pulmonology
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doi:10.1002/ppul.21570
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:2017-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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更新日期:1995-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(sici)1099-0496(200003)29:3<194::aid-ppul7
更新日期:2000-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22804
更新日期:2014-03-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2006-12-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950200108
更新日期:1995-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.20909
更新日期:2008-11-01 00:00:00
abstract::Exercise-induced asthma (EIA) is a possible cause of poor physical performance in children. No data are available on the value of respiratory symptoms to discriminate children with bad physical fitness from children with EIA. We evaluated respiratory symptoms in school-age children during and after exercise in relatio...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20185
更新日期:2005-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22570
更新日期:2012-11-01 00:00:00
abstract::The occurrence of a tracheoesophageal fistula (TEF) in the setting of lymphoma has only rarely been reported in the world literature. Most cases reported were associated with radiation therapy vs. chemotherapy alone. This report presents one case illustrating the difficulty encountered managing a TEF that developed wh...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.20405
更新日期:2006-07-01 00:00:00
abstract:INTRODUCTION:Acute bronchiolitis is a major cause of acute respiratory distress in infants. The soluble receptor for advanced glycation end-products (sRAGE) is a biomarker of pulmonary damage processes, with a diagnostic and a prognostic value in acute respiratory distress syndrome (ARDS). The RAGE pathway is also impl...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24141
更新日期:2018-10-01 00:00:00