Abstract:
:We developed a simple method to identify neonates at high risk of bronchopulmonary dysplasia (BPD) and determined whether early (8 hours) and late (14 days) risk assessment is equally useful. A retrospective cohort design was utilized of subjects enrolled in multi-dose surfactant trials to develop each risk identification model. Prospective testing of the late 14-day model was done to determine accuracy. The primary outcome variable (moderate to severe BPD) was defined as the need for oxygen and mechanical ventilation beyond 28 days of life and significant chest X-ray changes. Variables were screened for inclusion in the models by univariate and multiple regression analysis of data available at 14 days or 8 hours of life, converted to yes-no variables by the use of receiver-operator curves; the final model was based on those variables that gave the highest sensitivity and specificity for identifying BPD risk. Thirty-eight out of 116 of the 14-day model subjects developed BPD. The 14-day model (F1O2 > or = 0.30 and ventilation index (defined as 10,000/peak pressure x rate x PCO2) < 0.510 (or < 0.800 if previously septic)] had a sensitivity of 82% and specificity of 89%. It accurately identified 83% of cases (51/61) during at 1-year prospective test. The positive predictive value was 81% and negative predictive value 88%. Forty-four of the 698 early 8-hour model subjects developed BPD. The 8-hour model [gestational age < 31 weeks, 5-minute Apgar < 9, ventilator rate > 23 breaths/min, and ventilation index < 0.895] had a sensitivity of 73%, specificity of 83%, negative predictive value of 98% but positive predictive value of only 22%. These observation indicated that clinical data can create an accurate and simple model to classify infants into high- or low-risk groups for BPD. Using such models very early in life (e.g., at 8 hours) may lead to a high number of false-positive identifications.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Rozycki HJ,Narla Ldoi
10.1002/(SICI)1099-0496(199606)21:6<345::AID-PPUL1subject
Has Abstractpub_date
1996-06-01 00:00:00pages
345-52issue
6eissn
8755-6863issn
1099-0496pii
10.1002/(SICI)1099-0496(199606)21:6<345::AID-PPUL1journal_volume
21pub_type
杂志文章abstract::To determine the natural history of lung vascular remodeling and cardiac changes in the rat model of persistent pulmonary hypertension syndrome (PPHN) of the newborn, we studied fetal rats subjected to maternal indomethacin administration initiated on day 19 of gestation and continued for 2, 3, or 4 days. Animals rece...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1057
更新日期:2001-05-01 00:00:00
abstract:BACKGROUND:Pneumonia is a leading killer of children under-5 years, with a high burden in Nigeria. We aimed to quantify the regional burden and risks of pediatric pneumonia in Nigeria, and specifically the states of Lagos and Jigawa. METHODS:We conducted a scoping literature search for studies of pneumonia morbidity a...
journal_title:Pediatric pulmonology
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更新日期:2020-06-01 00:00:00
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journal_title:Pediatric pulmonology
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doi:10.1002/ppul.1950070412
更新日期:1989-01-01 00:00:00
abstract::Our aim was to evaluate long-term effects of exogenous surfactant therapy on pulmonary functional outcome in children born very preterm. We examined 40 children aged 7-12 years who were born before 30 weeks of gestation with an immature surfactant system, and were randomized to one of three treatment groups: human sur...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1099-0496(199803)25:3<182::aid-ppul8
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Childhood wheeze is an important, well-known risk factor for asthma, yet little is known about the contribution of nocturnal dry cough. We investigated the association of nocturnal dry cough at ages 1-7 years with doctor-diagnosed asthma at 8 years of age, both in the presence and absence of wheeze. METHODS...
journal_title:Pediatric pulmonology
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doi:10.1002/ppul.23092
更新日期:2015-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1099
更新日期:2001-08-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2002-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950100110
更新日期:1991-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2006-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
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更新日期:1986-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2015-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24428
更新日期:2019-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950200210
更新日期:1995-08-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0496(199603)21:3<159::AID-PPUL2
更新日期:1996-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(SICI)1099-0496(199604)21:4<219::AID-PPUL3
更新日期:1996-04-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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更新日期:2017-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:2017-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23100
更新日期:2015-02-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199801)25:1<45::aid-ppul5>
更新日期:1998-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2001-12-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2017-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:1999-10-01 00:00:00