Management of oxygenation in pediatric acute hypoxemic respiratory failure.

Abstract:

:The prognosis for patients with acute respiratory distress syndrome (ARDS) in adults and children has improved since its formal acceptance as a clinical entity in 1967. Because acute hypoxemic respiratory failure is the hallmark of acute lung injury and ARDS, the management of oxygenation is crucial. Physicians managing pediatric patients with acute lung injury or ARDS are faced with a complex array of options influencing oxygenation. Certain treatment strategies can influence clinical outcomes, such as a lung-protective ventilation strategy that specifies a low tidal volume (6 mL/kg) and a plateau pressure limit (30 cm H(2)O) (Acute Respiratory Distress Network, N Engl J Med 2000;342:1301-1308). Other lung-protective strategies such as different levels of positive end-expiratory pressure, altered inspiratory:expiratory ratios, recruitment maneuvers, prone positioning, and extraneous gases or drugs may impact clinical outcomes but require further clinical study. This paper reviews state-of-the-art strategies on the management of oxygenation in acute hypoxemic respiratory failure and attempts to guide pediatric pulmonologists in managing children with respiratory failure.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Matthews BD,Noviski N

doi

10.1002/ppul.1159

subject

Has Abstract

pub_date

2001-12-01 00:00:00

pages

459-70

issue

6

eissn

8755-6863

issn

1099-0496

pii

10.1002/ppul.1159

journal_volume

32

pub_type

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