Abstract:
:The prognosis for patients with acute respiratory distress syndrome (ARDS) in adults and children has improved since its formal acceptance as a clinical entity in 1967. Because acute hypoxemic respiratory failure is the hallmark of acute lung injury and ARDS, the management of oxygenation is crucial. Physicians managing pediatric patients with acute lung injury or ARDS are faced with a complex array of options influencing oxygenation. Certain treatment strategies can influence clinical outcomes, such as a lung-protective ventilation strategy that specifies a low tidal volume (6 mL/kg) and a plateau pressure limit (30 cm H(2)O) (Acute Respiratory Distress Network, N Engl J Med 2000;342:1301-1308). Other lung-protective strategies such as different levels of positive end-expiratory pressure, altered inspiratory:expiratory ratios, recruitment maneuvers, prone positioning, and extraneous gases or drugs may impact clinical outcomes but require further clinical study. This paper reviews state-of-the-art strategies on the management of oxygenation in acute hypoxemic respiratory failure and attempts to guide pediatric pulmonologists in managing children with respiratory failure.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Matthews BD,Noviski Ndoi
10.1002/ppul.1159subject
Has Abstractpub_date
2001-12-01 00:00:00pages
459-70issue
6eissn
8755-6863issn
1099-0496pii
10.1002/ppul.1159journal_volume
32pub_type
杂志文章,评审abstract::The current bronchopulmonary dysplasia (BPD) is seen in infants born extremely premature, with less severe respiratory distress syndrome (RDS) and who received prenatal steroids-"new BPD". The pathophysiology of BPD is based on an impairment of lung maturation with prenatal and postnatal multi-hit insults and genetic ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.21508
更新日期:2011-12-01 00:00:00
abstract:AIM:Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course. METHODS:We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test. RESULTS:Fifty four children were included ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24337
更新日期:2019-07-01 00:00:00
abstract:BACKGROUND:The pH of exhaled breath condensate (EBC) of adolescent athletes engaged in vigorous physical activity is low compared to healthy controls; however, the ionic determinants of EBC pH and the acute effects of exercise on those determinants have not been definitively established. OBJECTIVES:This study had two ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.21055
更新日期:2009-08-01 00:00:00
abstract::Aerosolized recombinant human DNase (dornase alfa) reduces mucus viscoelasticity in vitro and improves pulmonary function in patients with cystic fibrosis (CF). We postulated that if dornase alfa could be delivered more peripherally to small airways in the lung in the form of smaller aerosol droplets in patients with ...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(sici)1099-0496(199802)25:2<83::aid-ppul2>
更新日期:1998-02-01 00:00:00
abstract::To determine whether doses of ipratropium bromide (IB) greater than those usually administered by aerosol (75-250 micrograms) give a greater degree of protection from exercise-induced asthma (EIA) in children, 12 patients with chronic asthma, ages 7-13 yr, were challenged with methacholine and exercise after inhalatio...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950060205
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Pressure rise time (PRT), also known as slope time to the peak inflating pressure can be set on some modern neonatal ventilators. On other ventilators, PRT is determined by the set circuit flow. Changing slope time can affect mean airway pressure (MAP), oxygenation, and carbon dioxide elimination. Our aim wa...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.24724
更新日期:2020-05-01 00:00:00
abstract:BACKGROUND:The diagnosis of community-acquired pneumonia (CAP) is based mainly on the patient's medical history and physical examination. However, in severe cases a further evaluation including chest X-ray (CXR) may be necessary. At present, lung ultrasound (LUS) is not included in the diagnostic work-up of pneumonia. ...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
doi:10.1002/ppul.22585
更新日期:2013-03-01 00:00:00
abstract::Recurrent respiratory symptoms are common in preterm infants in the first 2 years of life. The aim of this study was to determine the lung function abnormalities associated with such symptoms. Forty preterm infants, with a median gestational age of 29 weeks were studied at a median postnatal age of 12 months. Twenty-t...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950110304
更新日期:1991-01-01 00:00:00
abstract:INTRODUCTION:In moderate-severe asthma exacerbation, salbutamol by inhaler (MDI) is superior to salbutamol delivered by nebulizer (NEB); however, to our knowledge, no studies in children with exclusively severe exacerbations were performed. OBJECTIVE:To compare the efficacy of salbutamol and ipratropium bromide by MDI...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ppul.24244
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Although the causative pneumococcal serotypes of invasive diseases are already extensively studied, few data are available about the pneumococcal serotypes additionally isolated from broncho-alveolar lavage samples in childhood pneumonia. STUDY AIM:To identify the causative pneumococcal serotypes in culture...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20437
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Lung involvement in children with Niemann-Pick disease has rarely been studied systematically. OBJECTIVE:To assess the involvement of the lung and the value of bronchoalveolar lavage in children with Niemann-Pick diseases. DESIGN:Retrospective analysis of patient records. PATIENTS:Thirteen patients, with ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20725
更新日期:2007-12-01 00:00:00
abstract::Between October, 1985 and May 1987, 29 children (mean age 22 +/- 22 months, range 2-54 months) with AIDS or ARC developed acute respiratory illness. The initial diagnostic procedure was flexible fiberoptic bronchoscopy, with bronchoalveolar lavage (BAL). BAL was positive for Pneumocystis carinii in 14 and for respirat...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950030609
更新日期:1987-11-01 00:00:00
abstract:OBJECTIVES:Swallowing disorders which lead to aspiration are common in premature infants with a postmenstrual age (PMA) of >36 weeks. Aspiration is often silent and the unique symptom is desaturation during feeding. The aim of this study was 1) to determine the number of prematures with desaturations during feeding due...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23946
更新日期:2018-04-01 00:00:00
abstract::We report on a 7-month old infant with severe respiratory distress secondary to a paratracheal bronchogenic cyst. Respiratory relief was achieved by transtracheal puncture of the cyst. Surgical removal of the cyst was performed 1 week later because of radiological evidence of reaccumulation of fluid. ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10408
更新日期:2004-12-01 00:00:00
abstract::Our study was aimed at elucidating the effect of strenuous maternal exercise (running at a speed of 20 m/min) on fetal somatic growth and lung development. Dams were separated into three groups: (1) exercising during the entire course of pregnancy; (2) exercising from the 16th to the 20th gestational day; and (3) cont...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950150604
更新日期:1993-06-01 00:00:00
abstract::In 1994-1995 a cross-sectional epidemiological study investigating the respiratory health of school children in two Taiwan areas was conducted; one area was located in a region with petrochemical manufacturing complexes (Linyuan), and the other was situated in a reference area with no local industrial emissions (Taihs...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199805)25:5<299::aid-ppul2
更新日期:1998-05-01 00:00:00
abstract::Pneumomediastinum is uncommon in pediatric medical practice, outside the neonatal period. While asthma or respiratory infections are the most frequent underlying causes, it is important not to forget the possibility of foreign body aspiration, particularly after the clinical presentation. ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10295
更新日期:2003-07-01 00:00:00
abstract:BACKGROUND/AIM:There has been recent interest in dry powder inhaled mannitol as a therapeutic agent in patients with cystic fibrosis (CF). It is has been shown to increase mucociliary clearance (MCC) by rehydrating the airway. To date there have been no studies exclusively in children with CF examining the effect of dr...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20903
更新日期:2008-11-01 00:00:00
abstract::Two male patients with cystic fibrosis (CF), both 18 years old, developed frontal lobe brain abscesses. Both patients presented with histories of intermittent headache over several days and occasional vomiting. Headache was not more evident in the mornings and not associated with visual disturbance in either patient. ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950170609
更新日期:1994-06-01 00:00:00
abstract::Neutrophil elastase is present at high levels in airway fluid of patients with cystic fibrosis (CF), and is responsible for considerable inflammatory damage. Human monocyte/neutrophil elastase inhibitor (MNEI), a 42-kDa serpin protein, is an effective inhibitor of neutrophil elastase, cathepsin G, and proteinase-3, re...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20167
更新日期:2005-02-01 00:00:00
abstract:INTRODUCTION:Foreign body (FB) aspiration is a frequent and preventable source of morbidity and mortality, especially in children under 4 years of age. Few comprehensive studies exist on presentation and outcome of apple aspirations in children. METHODS:In a retrospective analysis of bronchoscopy records of a tertiary...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24768
更新日期:2020-07-01 00:00:00
abstract::In order to help specialists involved in CF care and clinical research to know the current best evidence about clinical effectiveness of interventions in CF, we designed and developed a web-based, free access tool called "CFDB"--Cystic Fibrosis DataBase (www.inetflow.it/CFDB). The database was built by searching in Me...
journal_title:Pediatric pulmonology
pub_type: 信件
doi:10.1002/ppul.22954
更新日期:2014-09-01 00:00:00
abstract::Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24982
更新日期:2020-10-01 00:00:00
abstract::A neonate with severe neonatal asphyxia was treated with therapeutic hypothermia. He developed hypothermia-induced respiratory deterioration, after which congenital tracheal stenosis and pulmonary artery sling were diagnosed. Even low-grade hypothermia is likely to induce bronchial narrowing in neonates, especially in...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23538
更新日期:2017-03-01 00:00:00
abstract::In a double-blind, randomized trial, we compared the effects of aerosolized metaproterenol to subcutaneous epinephrine in 35 episodes of acute asthma in children between 6 and 19 years of age. Patients were randomized to two parallel groups and then received both a placebo medication and an active medication to a maxi...
journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ppul.1950020411
更新日期:1986-07-01 00:00:00
abstract:OBJECTIVES:a: To evaluate the long-term outcome of parapneumonic effusions (PPE) in children regarding lung function and exercise tolerance, (b) to investigate the role of bronchial asthma in the outcome of PPE. METHODS:The design of the study included 51 children with PPE, at least 2 years after the initial infection...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23054
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Chronic colonization with Pseudomonas (P.) aeruginosa worsens the prognosis of cystic fibrosis (CF) patients. This study aims to analyze the functional properties of neutrophils in CF patients with P. aeruginosa colonization. METHODS:Patients with CF (n = 16) were grouped by positivity of P. aeruginosa in s...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25294
更新日期:2021-01-29 00:00:00
abstract:BACKGROUND:Accelerated lung function decline in cystic fibrosis (CF) is associated with mucoid Pseudomonas aeruginosa infection. Recent data suggest that mucoid P. aeruginosa may amenable to elimination from the airway. We aim to determine whether the initiation of an aggressive antibiotic eradication regimen upon init...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22543
更新日期:2012-11-01 00:00:00
abstract::Inadequate intake and suboptimal growth are common problems for patients with CF and a critical target for intervention. The purpose of this study was to compare the growth outcomes of children with CF who participated in a randomized clinical trial to improve energy intake and weight to children with CF receiving sta...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,随机对照试验
doi:10.1002/ppul.21322
更新日期:2011-01-01 00:00:00
abstract::Mucus plugging constitutes a nutrient-rich nidus for a bacterial infection that has long been recognized as a potent stimulus for neutrophilic airway inflammation driving progressive lung damage in people with cystic fibrosis (CF). However, mucus plugging and neutrophilic inflammation are already present in many infan...
journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.24462
更新日期:2019-11-01 00:00:00