Abstract:
AIM:Our aim was to evaluate the correlation of Adenosine monophosphate challenge test (AMP-PCW) results with the patients' subsequent clinical course. METHODS:We performed a 6-year retrospective cohort study of young children with suspected asthma who underwent AMP-PCW test. RESULTS:Fifty four children were included in the study (median age, 50.5 months; range, 26-90). AMP-PCW was positive in 35 (65%) children. During the 3-year follow-up period, among 22 of 35 patients in the positive AMP-PCW group and among 17 of 19 in the negative AMP-PCW group-prophylactic therapy was not changed. Prophylactic therapy was initiated or its dose was escalated in 12 of 13 (92.3%) of the children with a positive AMP-PCW test compared to none of the children with a negative challenge test (P < 0.001). Prophylactic therapy was discontinued in only one (7.6%) of the children with a positive test as compared to two (100%) of the children with a negative test (P < 0.001). There were significantly fewer severe asthma exacerbations during a 3-year follow-up period after the challenge test as compared to the preceding 3-year period both in children with a positive (from 34 to 9 total events, P = 0.01) or a negative challenge test (from 16 to 0 events P = 0.01). The severity of airway hyper responsiveness was found to associate with the number of severe asthma exacerbations (P = 0.04) and with a diagnosis of asthma during the following 3 years (P = 0.02). CONCLUSIONS:AMP-PCW test results correlates with the subsequent clinical course of young children with suspected asthma performing the test.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Levin G,Rottensctreich A,Picard E,Avital A,Springer C,Cohen Sdoi
10.1002/ppul.24337subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1087-1092issue
7eissn
8755-6863issn
1099-0496journal_volume
54pub_type
杂志文章abstract:OBJECTIVES:A pilot study to compare pulmonary mechanics in a neonatal intensive care unit (NICU) cohort, specifically, comparing lung elastance between male and female infants in the NICU. HYPOTHESIS:Anecdotally, male infants are harder to ventilate than females. We hypothesize that males have higher model-based elast...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:2010-03-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2006-09-01 00:00:00
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journal_title:Pediatric pulmonology
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doi:10.1002/(sici)1099-0496(199911)28:5<380::aid-ppul1
更新日期:1999-11-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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更新日期:1988-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:1985-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20505
更新日期:2006-12-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:2012-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20107
更新日期:2004-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950020414
更新日期:1986-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950030609
更新日期:1987-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23507
更新日期:2017-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20903
更新日期:2008-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22675
更新日期:2013-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Pediatric pulmonology
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更新日期:1986-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:2005-08-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25119
更新日期:2021-01-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10172
更新日期:2002-11-01 00:00:00
abstract:INTRODUCTION:Mucopolysaccharidoses (MPS) are a group of lysosomal storage disorders characterized by tissue deposition of glycosaminoglycans (GAG). Their musculoskeletal abnormalities and the GAG storage in the airway result in increased risk for patients undergoing anesthesia. This study evaluates a multi-disciplinary...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22629
更新日期:2013-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20403
更新日期:2006-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22919
更新日期:2014-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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更新日期:2003-11-01 00:00:00