The delivery of therapeutic aerosols through endotracheal tubes.

Abstract:

:We used an in vitro model system to examine the sites of deposition of aqueous therapeutic aerosols administered through 3-mm, 6-mm, and 9-mm endotracheal tubes (commonly used in infants, children, and adults) at clinically relevant inspiratory flow rates. Aerosol was delivered to the endotracheal tube via a "T" piece and a 90 degree elbow. Aerosol exiting the endotracheal tube passed through an appropriately sized Plexiglas model of the trachea and mainstem bronchi, and then into an 80-liter bag. Aerosol deposited in the "T" and elbow, endotracheal tube, large airway model, and collection bag was quantitated separately using 0.1% uranine as a tracer. Study of a conventional aerosol typical of those in common clinical use (aerodynamic mass median diameter = 3.95 microns) showed that most of the aerosol delivered into each endotracheal tube was deposited before leaving the mainstem bronchi. Substitution of an alternative nebulizer that produced a much smaller aerosol particle size (aerodynamic mass median diameter = 0.54 micron) dramatically decreased aerosol deposition in the "T" and elbow, endotracheal tube, and large airway model, and increased the quantity of aerosol penetrating beyond the mainstem bronchi up to ninefold. The mass median particle diameter of the conventional aerosol was reduced during endotracheal tube and large airway passage by poorly defined aerodynamic mechanisms that selectively removed larger particles. The smaller submicron aerosol was not similarly affected. Thus, conventional therapeutic aerosols appear to penetrate poorly through endotracheal tubes. Use of smaller particle size aerosols in treatment of intubated patients may be an effective way to circumvent this problem.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Ahrens RC,Ries RA,Popendorf W,Wiese JA

doi

10.1002/ppul.1950020108

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

19-26

issue

1

eissn

8755-6863

issn

1099-0496

journal_volume

2

pub_type

杂志文章
  • Trampoline use as physiotherapy for cystic fibrosis patients.

    abstract::Physicians and physiotherapists who care for CF patients have recommended the use of trampolines as a physiotherapeutic tool for enhancing cardiopulmonary performance, encouraging sputum production, and improving general well-being. Despite some therapeutic and recreational benefits associated with trampoline use, pap...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20133

    authors: Barak A,Wexler ID,Efrati O,Bentur L,Augarten A,Mussaffi H,Avital A,Rivlin J,Aviram M,Yahav Y,Kerem E

    更新日期:2005-01-01 00:00:00

  • The highs and lows of wheezing: A review of the most popular adventitious lung sound.

    abstract::Wheezing is the most widely reported adventitious lung sound in the English language. It is recognized by health professionals as well as by lay people, although often with a different meaning. Wheezing is an indicator of airway obstruction and therefore of interest particularly for the assessment of young children an...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23930

    authors: Pasterkamp H

    更新日期:2018-02-01 00:00:00

  • Efficacy of corticosteroids in acute bronchiolitis: short-term and long-term follow-up.

    abstract::Corticosteroids continue to be used by many physicians to treat infants with bronchiolitis. The aim of this study was to examine the short-term and long-term efficacy of oral corticosteroid therapy when added to beta2-agonists in infants with mild to moderate bronchiolitis (defined as the first episode of wheezing ass...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/(sici)1099-0496(199809)26:3<162::aid-ppul2

    authors: Berger I,Argaman Z,Schwartz SB,Segal E,Kiderman A,Branski D,Kerem E

    更新日期:1998-09-01 00:00:00

  • Elevated vascular endothelial growth factor is correlated with elevated erythropoietin in stable, young cystic fibrosis patients.

    abstract::Angiogenesis is an important mechanism of airway remodeling in lung disease. We previously demonstrated that serum vascular endothelial growth factor (VEGF) is elevated in cystic fibrosis (CF) patients and declines with therapy for pulmonary exacerbation. We hypothesized that VEGF is elevated early in the course of CF...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21428

    authors: Watts KD,McColley SA

    更新日期:2011-07-01 00:00:00

  • Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.

    abstract::The gasdermin A (GSDMA) and gasdermin B (GSDMB) genes are located at 17q21.2. The GSDM family genes have been studied in the gastrointestinal tract but recent reports suggest that GSDMB is associated with childhood asthma in several populations. We investigated the association of the GSDMA and GSDMB variants with asth...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21424

    authors: Yu J,Kang MJ,Kim BJ,Kwon JW,Song YH,Choi WA,Shin YJ,Hong SJ

    更新日期:2011-07-01 00:00:00

  • Mechanically ventilated premature babies have sex differences in specific elastance: A pilot study.

    abstract:OBJECTIVES:A pilot study to compare pulmonary mechanics in a neonatal intensive care unit (NICU) cohort, specifically, comparing lung elastance between male and female infants in the NICU. HYPOTHESIS:Anecdotally, male infants are harder to ventilate than females. We hypothesize that males have higher model-based elast...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24538

    authors: Kim KT,Knopp J,Dixon B,Chase JG

    更新日期:2020-01-01 00:00:00

  • Inflammation and sleep disordered breathing in children: a state-of-the-art review.

    abstract::Sleep disordered breathing (SDB) represents a spectrum of breathing disorders, ranging from snoring to obstructive sleep apnea syndrome (OSAS), that disrupt nocturnal respiration and sleep architecture. OSAS is a common disorder in children, with a prevalence of 2-3%. It is associated with neurobehavioral, cognitive, ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20943

    authors: Goldbart AD,Tal A

    更新日期:2008-12-01 00:00:00

  • Aeration properties of a new sleeping surface for infants.

    abstract:BACKGROUND:Prone sleeping position, use of soft mattresses and head covering by bedclothes are known risk factors for sudden infant death syndrome (SIDS). Rebreathing carbon dioxide (CO(2) ) may be a possible mechanism or a confounding factor of SIDS. OBJECTIVE:To compare the aeration properties of a new concept of in...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21351

    authors: Bar-Yishay E,Gaides M,Goren A,Szeinberg A

    更新日期:2011-02-01 00:00:00

  • Neuroendocrine cells in the developing human lung: morphologic and functional considerations.

    abstract::The structure, distribution, and frequency of neuroendocrine (NE) cells in human fetal lung from early stages of development to term are described. Neuroendocrine cells were studied by electron microscopy and immunostaining for serotonin and bombesin, recently identified markers of these cells in human lung. The diffe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:

    authors: Cutz E,Gillan JE,Bryan AC

    更新日期:1985-05-01 00:00:00

  • Recruitment of intercostal muscle activity during hypercapnia in kittens.

    abstract::Little is known about the respiratory behavior of the intercostal muscles within a neonatal and developmental context. We, therefore, examined intercostal muscle electromyographic (EMG) activity in kittens (1 month old, n = 8; 2 months old, n = 7) during eupnea and heightened respiratory drive induced by hypercapnia. ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950050407

    authors: Watchko JF,Klesh KW,O'Day TL,Guthrie RD

    更新日期:1988-01-01 00:00:00

  • Identification of CFTR variants in Latino patients with cystic fibrosis from the Dominican Republic and Puerto Rico.

    abstract:BACKGROUND:In cystic fibrosis (CF), the spectrum and frequency of CFTR variants differ by geography and race/ethnicity. CFTR variants in White patients are well-described compared with Latino patients. No studies of CFTR variants have been done in patients with CF in the Dominican Republic or Puerto Rico. METHODS:CFTR...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24549

    authors: Zeiger AM,McGarry ME,Mak ACY,Medina V,Salazar S,Eng C,Liu AK,Oh SS,Nuckton TJ,Jain D,Blackwell TW,Kang HM,Abecasis G,Oñate LC,Seibold MA,Burchard EG,Rodriguez-Santana J

    更新日期:2020-02-01 00:00:00

  • Ambulatory blood pressure monitoring in Chinese children with obstructive sleep apnea/hypopnea syndrome.

    abstract:OBJECTIVE:Obstructive sleep apnea/hypopnea syndrome (OSAHS) is a common sleep problem. The aim of this study is to investigate the association between OSAHS and blood pressure (BP) in snoring children. METHODS:Snoring children were recruited from January 2009 to December 2010. Clinical history was taken accompanied by...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22595

    authors: Xu Z,Li B,Shen K

    更新日期:2013-03-01 00:00:00

  • Risk factors for fixed airflow obstruction in children and adolescents with asthma: 4-Year follow-up.

    abstract:BACKGROUND:Asthma is a disease with reversible bronchoconstriction; however, some patients develop fixed airflow obstruction (FAO). Previous studies have reported the incidence and risk factors of FAO in adults; however, the corresponding factors in children remain poorly understood. AIM:To evaluate the incidence and ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24625

    authors: Sousa AW,Barros Cabral AL,Arruda Martins M,Carvalho CRF

    更新日期:2020-03-01 00:00:00

  • Is a longer time interval between recombinant human deoxyribonuclease (dornase alfa) and chest physiotherapy better? A multi-center, randomized crossover trial.

    abstract:BACKGROUND:Although the benefits of recombinant human deoxyribonuclease (dornase alfa) in patients with cystic fibrosis (CF) are established, its optimal timing in relation to physiotherapy is unknown. As its enzymatic effect lasts for 6-11 hr, dornase alfa may be more efficacious if the time interval between inhalatio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/ppul.20704

    authors: Wilson CJ,Robbins LJ,Murphy JM,Chang AB

    更新日期:2007-12-01 00:00:00

  • Bone mineral content and body composition in children and young adults with cystic fibrosis.

    abstract::With dual energy X-ray absorptiometry (DEXA), it is possible to quantitate important aspects of growth in children with cystic fibrosis (CF), supplementing the usual measures of height and weight. Of particular concern during growth is the accumulation of bone mineral, since osteoporosis and fractures are well-recogni...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(sici)1099-0496(199902)27:2<80::aid-ppul3>

    authors: Henderson RC,Madsen CD

    更新日期:1999-02-01 00:00:00

  • A novel combined treatment for plasminogen deficiency with lung involvement.

    abstract::Plasminogen deficiency is characterized by fibrin-rich pseudomembrane formation on all mucosal surfaces, particularly the conjunctiva. Respiratory system involvement is common; fibrin often obstructs the upper or lower respiratory tract, causing death. Although many treatments have been applied, no definitive treatmen...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24563

    authors: Kilinc AA,Tarcin G,Kurugoglu S,Schuster V,Cokugras H,Celkan T

    更新日期:2020-01-01 00:00:00

  • Irreversible airway obstruction in childhood asthma? A clinician's viewpoint.

    abstract::Even though childhood asthma is assumed to comprise reversible airway obstruction, some children develop irreversible airway obstruction (not reversed by a bronchodilator or corticosteroids); this may be due to inflammation that has caused remodeling. Lately, it has been claimed that in the absence of treatment with i...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10090

    authors: König P

    更新日期:2002-04-01 00:00:00

  • Characterization of successful and failed autoresuscitation in human infants, including those dying of SIDS.

    abstract::Our purpose was to identify and further characterize physiologic mechanisms relevant to autoresuscitation from hypoxic apnea in infants dying suddenly and unexpectedly. We studied cardiorespiratory recordings of 24 infants (age range, 0.8-21 months) who died suddenly while being monitored at home. These recordings wer...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.10287

    authors: Sridhar R,Thach BT,Kelly DH,Henslee JA

    更新日期:2003-08-01 00:00:00

  • The bronchodilator effect of a fixed-combination metered aerosol (fenoterol and ipratropium bromide).

    abstract::The fixed-combination metered aerosol lK6 (fenoterol 0.05 mg/puff, ipratropium bromide 0.02 mg/puff--Berodual, Boehringer-Ingelheim Ltd., Ridgefield, Conn.) was administered to 12 children (8 boys, 4 girls) aged 3 1/2 to 6 2/12 years who had extrinsic bronchial asthma. Three forms of administration, each with a differ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950010605

    authors: Berdel D,Kellersmann U

    更新日期:1985-11-01 00:00:00

  • Prenatal exposure to VOCs and NOx and lung function in preschoolers.

    abstract:BACKGROUND:Several studies have shown that exposure to air pollutants affects lung growth and development and can result in poor respiratory health in early life. METHODS:We included a subsample of 772 Mexican preschoolers whose mothers participated in a Prenatal Omega-3 fatty acid Supplements, GRowth, And Development...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24889

    authors: Gutiérrez-Delgado RI,Barraza-Villarreal A,Escamilla-Núñez MC,Hernández-Cadena L,Cortez-Lugo M,Sly P,Romieu I

    更新日期:2020-08-01 00:00:00

  • Allogeneic mesenchymal stromal cells: Novel therapeutic option for mutated FLNA-associated respiratory failure in the pediatric setting.

    abstract:BACKGROUND:Mesenchymal stromal cell (MSC)-mediated therapeutic effects have been observed in the treatment of lung diseases. For the first time, this treatment was used as rescue therapy in a pediatric patient with a life-threatening respiratory syndrome associated with the filamin A (FLNA) gene mutation. METHODS:A ch...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24497

    authors: Pelizzo G,Avanzini MA,Lenta E,Mantelli M,Croce S,Catenacci L,Acquafredda G,Ferraro AL,Giambanco C,D'Amelio L,Giordano S,Re G,Zennaro F,Calcaterra V

    更新日期:2020-01-01 00:00:00

  • Protective effect of albuterol delivered via a spacer device (Babyhaler) against methacholine induced bronchoconstriction in young wheezy children.

    abstract::Nine young asthmatic children aged 2-5 years underwent methacholine challenge after placebo or albuterol administered by metered dose inhaler through a spacer device (Babyhaler) with a face mask in a double-blind, cross-over, randomized study. The methacholine challenge was performed using chest auscultation to define...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/ppul.1950170503

    authors: Avital A,Godfrey S,Schachter J,Springer C

    更新日期:1994-05-01 00:00:00

  • Modifiable lifestyle factors impact airway health in non-asthmatic prepubescent boys but not girls.

    abstract:INTRODUCTION:The prevalence of both childhood obesity and childhood asthma has increased dramatically over the past few decades. Little is known concerning the role of body composition and lifestyle influences on airway health in children. PURPOSE:To determine whether body composition, fruit and vegetable intake (FV) ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.21393

    authors: Rosenkranz SK,Swain KE,Rosenkranz RR,Beckman B,Harms CA

    更新日期:2011-05-01 00:00:00

  • Successful treatment of pulmonary hemangioma with propranolol.

    abstract::Pulmonary hemangioma is a rare benign tumor of the lungs. Airway hemangiomas in particular may lead to feeding difficulties, barking cough, stridor, respiratory distress, and even acute airway obstruction. Hence, such hemangiomas usually require early and aggressive treatment; however, the treatment modalities employe...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23008

    authors: Emiralioğlu N,Oğuz B,Akyüz C,Yalçın B,Kiper N,Ersöz DD,Yalçın E,Özçelik U

    更新日期:2014-08-01 00:00:00

  • Exercise-induced respiratory symptoms are poor predictors of bronchoconstriction.

    abstract::Exercise-induced asthma (EIA) is a possible cause of poor physical performance in children. No data are available on the value of respiratory symptoms to discriminate children with bad physical fitness from children with EIA. We evaluated respiratory symptoms in school-age children during and after exercise in relatio...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20185

    authors: De Baets F,Bodart E,Dramaix-Wilmet M,Van Daele S,de Bilderling G,Masset S,Vermeire P,Michel O

    更新日期:2005-04-01 00:00:00

  • Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children.

    abstract:BACKGROUND:Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. OBJECTIVES:To investigate if FeNO concentrations we...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22705

    authors: Oh MA,Shim JY,Jung YH,Seo JH,Young Kim H,Kwon JW,Kim BJ,Kim HB,Kim WK,Lee SY,Jang GC,Song DJ,Kim HJ,Shin YJ,Park JW,Cho SH,Lee JS,Hong SJ

    更新日期:2013-06-01 00:00:00

  • Sensitivity and specificity of oropharyngeal suction versus bronchoalveolar lavage in identifying respiratory tract pathogens in children with chronic pulmonary infection.

    abstract::The purpose of this study was to compare the pathogens obtained by oropharyngeal suction (OPS) and bronchoalveolar lavage (BAL) in children with chronic pulmonary infections. Forty-four children (mean age of 6.1 years; range 4 months to 15 years) were included in the study (27 children with recurrent localized lung in...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950200108

    authors: Avital A,Uwyyed K,Picard E,Godfrey S,Springer C

    更新日期:1995-07-01 00:00:00

  • Assessing bronchodilator responsiveness in infants using partial expiratory flow-volume curves.

    abstract::Our objective was to compare the effectiveness of maximum forced expiratory flow measured at functional residual capacity (V'maxFRC) and the ratio of flow at 75% of the forced expiratory volume to peak forced expiratory flow (FEF(75)/FEF(peak)) for detecting bronchodilator-related changes in wheezy infants. In 55 infa...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章

    doi:10.1002/ppul.10325

    authors: Sheikh S,Castile R,Hayes J,McCoy K,Eid N

    更新日期:2003-09-01 00:00:00

  • Interpretative consequences of adopting the Global Lungs 2012 reference equations for spirometry for children and adolescents.

    abstract:OBJECTIVE:To determine the interpretative consequences of adopting the Global Lungs 2012 (GLI-2012) spirometric prediction equations in a pediatric hospital population. MATERIAL:Spirometric records from 2,192 white boys and 1,842 white girls, and 412 and 334 African-American boys and girls, respectively, aged 6.0-18.0...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22876

    authors: Quanjer PH,Weiner DJ

    更新日期:2014-02-01 00:00:00

  • Prolonged recovery from exercise-induced asthma with increasing age in childhood.

    abstract::It has been suggested that children with asthma recover more quickly from exercise-induced bronchoconstriction than adults. On the basis of clinical observation we hypothesized that recovery rate from exercise-induced asthma (EIA) in childhood also decreases with age. In 14 children (aged 7-12 years) with a history of...

    journal_title:Pediatric pulmonology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/ppul.1950200309

    authors: Hofstra WB,Sterk PJ,Neijens HJ,Kouwenberg JM,Duiverman EJ

    更新日期:1995-09-01 00:00:00