Protective effect of albuterol delivered via a spacer device (Babyhaler) against methacholine induced bronchoconstriction in young wheezy children.

Abstract:

:Nine young asthmatic children aged 2-5 years underwent methacholine challenge after placebo or albuterol administered by metered dose inhaler through a spacer device (Babyhaler) with a face mask in a double-blind, cross-over, randomized study. The methacholine challenge was performed using chest auscultation to define the provocative concentration of methacholine that causes wheezing (PCW). The PCW increased from a geometric mean of 0.28 mg/mL after placebo to 3.59 mg/mL after albuterol (P < 0.0001). The protective effect of albuterol against methacholine-induced bronchospasm was 3.7 +/- 1.2 doubling doses. We conclude that administration of drugs from a metered dose inhaler through the Babyhaler with a face mask is effective. Albuterol causes a major reduction in the bronchial hyperreactivity in young wheezy children shortly after administration.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Avital A,Godfrey S,Schachter J,Springer C

doi

10.1002/ppul.1950170503

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

281-4

issue

5

eissn

8755-6863

issn

1099-0496

journal_volume

17

pub_type

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