Abstract:
:The main physiological impact of high flow nasal cannula (HFNC) therapy is presumed to be a decrease in work of breathing (WOB). To assess this, diaphragmatic electrical activity and esophageal pressure changes were measured off then on HFNC delivered at 2 L/kg/min, in 14 infants with bronchiolitis and 14 cardiac infants. Electrical activity of the diaphragm (Edi) was measured using an Edi catheter with calculations of signal peak (EdiMAX ) and amplitude (EdiAMPL ). Pressure-rate and pressure-time products (PRP, PTP) were calculated from analyses of esophageal pressure. Changes in end-expiratory lung volume were measured using respiratory inductance plethysmography (RIPEEL ). The EdiMAX and EdiAMPL were significantly higher in infants with bronchiolitis than in cardiac infants (P < 0.05). Within the bronchiolitis group, both were significantly reduced between HFNC states from 27.9 µV [20.4, 35.4] to 21.0 µV [14.8, 27.2] and from 25.1 µV [18.0, 32.2] to 19.2 µV [13.3, 25.1], respectively (mean, 95% CI, P < 0.05). A less prominent offload of the diaphragm was observed in cardiac infants (P < 0.05). WOB decreased in both groups with a significant reduction of PRP and PTP (P < 0.05). RIPEEL increased significantly in bronchiolitis only (P < 0.05). HFNC offloads the diaphragm and reduces the WOB in bronchiolitis. A similar effect was demonstrated in cardiac infants, a group without signs of airway-obstruction.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Pham TM,O'Malley L,Mayfield S,Martin S,Schibler Adoi
10.1002/ppul.23060subject
Has Abstractpub_date
2015-07-01 00:00:00pages
713-20issue
7eissn
8755-6863issn
1099-0496journal_volume
50pub_type
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2021-01-22 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ppul.21278
更新日期:2010-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22550
更新日期:2012-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22990
更新日期:2014-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.20040
更新日期:2004-09-01 00:00:00