sTREM-1 is elevated in cystic fibrosis and correlates with proteases.

Abstract:

BACKGROUND:sTREM-1 (soluble triggering receptor expressed on myeloid cells-1) is a novel inflammatory marker that may be of clinical use in cystic fibrosis (CF). Dysregulation of the TREM pathway has been demonstrated in other inflammatory diseases and modulation in animal models has therapeutic benefit. We hypothesised that sTREM-1 could act as a biomarker of disease in cystic fibrosis. METHODS:Plasma from 17 patients with CF (stable and pre and post pulmonary exacerbation) and eight healthy volunteers was analyzed for sTREM-1 and proteases (matrix metalloproteinase-8 (MMP-8), MMP-9, and human neutrophil elastase HNE). RESULTS:sTREM-1 Levels were elevated in stable CF subjects compared to controls (148 pg/ml (130-160) [median(IQR)] vs. 87 (55-118) (P < 0.01)) but were not further increased during pulmonary exacerbation nor decreased after antibiotic treatment in CF. Protease levels were increased in CF plasma compared to controls: MMP-8 = 3.1 ng/ml (1.5-7.6) vs. 0.3 (0.18-0.53) (P < 0.01) (Wilcoxon); MMP-9 = 170 ng/ml (124-282) vs. 49 (39-90) (P <  0.01); HNE = 30.2 ng/ml (22.7-30.9) vs. 17.5 (11.2-22.2) (P < 0.05). sTREM-1 correlated positively with protease levels lnMMP-8 r2  = 0.55 (P = 0.08), lnMMP-9 r2  =  0.61(P < 0.05), lnHNE r2  = 0.35 (P < 0.05). CONCLUSIONS:sTREM-1 is constitutively elevated in CF and positively correlates with protease levels. Modulation of this pathway may be of therapeutic benefit to patients with CF. Pediatr Pulmonol. 2017;52:467-471. © 2017 Wiley Periodicals, Inc.

journal_name

Pediatr Pulmonol

journal_title

Pediatric pulmonology

authors

Forrester DL,Barr HL,Fogarty A,Knox A

doi

10.1002/ppul.23650

subject

Has Abstract

pub_date

2017-04-01 00:00:00

pages

467-471

issue

4

eissn

8755-6863

issn

1099-0496

journal_volume

52

pub_type

杂志文章
  • An infant with a hyperlucent chest mass: An unexpected diagnosis.

    abstract:INTRODUCTION:We report an unusual finding of pneumatocele in an infant. CASE REPORT:A previously well four month old presented with worsening respiratory distress over 6 weeks. He had no antecedent signs or symptoms of respiratory infection. Chest radiograph demonstrated a lucent hemithorax concerning for tension pneu...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23257

    authors: Ehsan Z,Nathan JD,Kercsmar CM

    更新日期:2015-12-01 00:00:00

  • Development of the pulmonary airways in the fetal rat and its relation to the prenatal environment.

    abstract::We studied the left lung using multi-focus microphotography in 378 rat fetuses, assessing airway branching from day 13 to day 19 of gestation, and lung growth variables from day 13 to day 21. Longitudinal growth, and monopodial and dichotomous branching brought about a consistent airway pattern with variations within ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1099-0496(199604)21:4<219::AID-PPUL3

    authors: Rotschild A,Massoud EA,Solimano A,Puterman ML,Sekhon HS,Thurlbeck WM

    更新日期:1996-04-01 00:00:00

  • Relationship of symptoms to lung function abnormalities in preterm infants at follow-up.

    abstract::Recurrent respiratory symptoms are common in preterm infants in the first 2 years of life. The aim of this study was to determine the lung function abnormalities associated with such symptoms. Forty preterm infants, with a median gestational age of 29 weeks were studied at a median postnatal age of 12 months. Twenty-t...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950110304

    authors: Yuksel B,Greenough A

    更新日期:1991-01-01 00:00:00

  • Care recommendations for the respiratory complications of esophageal atresia-tracheoesophageal fistula.

    abstract::Tracheoesophageal fistula (TEF) with esophageal atresia (EA) is a common congenital anomaly that is associated with significant respiratory morbidity throughout life. The objective of this document is to provide a framework for the diagnosis and management of the respiratory complications that are associated with the ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24982

    authors: Koumbourlis AC,Belessis Y,Cataletto M,Cutrera R,DeBoer E,Kazachkov M,Laberge S,Popler J,Porcaro F,Kovesi T

    更新日期:2020-10-01 00:00:00

  • The role of polysomnography in tracheostomy decannulation of children with bronchopulmonary dysplasia.

    abstract:BACKGROUND:Patients with bronchopulmonary dysplasia (BPD) may require tracheostomy for long-term mechanical ventilation. Polysomnography (PSG) may predict successful decannulation in children, however it is unclear how this success compares with children without a PSG. To better evaluate this role, we compared decannul...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24474

    authors: Quinlan C,Piccione J,Kim JY,Beck SE,Brooks L,Chandy-Patel R,Escobar E,Afolabi-Brown O

    更新日期:2019-11-01 00:00:00

  • DRESS syndrome in a patient with cystic fibrosis: A case report.

    abstract::Drug reaction with eosinophilia and systemic symptom (DRESS) syndrome is a rare and severe side-effect, mainly described after intake of anticonvulsants, allopurinol, or antibiotics. It usually begins within 2 months after drug introduction. Symptoms include cutaneous rash, hematologic abnormalities, and internal orga...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23567

    authors: Gohy S,Froidure A,Lebecque P

    更新日期:2017-04-01 00:00:00

  • Sidestream microstream end tidal carbon dioxide measurements and blood gas correlations in neonatal intensive care unit.

    abstract:OBJECTIVE:The study was designed to assess the use of newer sidestream microstream end tidal carbon dioxide (ETCO(2) ) device in predicting blood carbon dioxide (PCO(2) ) measurements in very low birth weight (VLBW = birth weight <1,500 g) and non-VLBW NICU neonates. STUDY DESIGN:Sidestream microstream ETCO(2) detecto...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22593

    authors: Singh BS,Gilbert U,Singh S,Govindaswami B

    更新日期:2013-03-01 00:00:00

  • Exhaled breath condensate pH in infants and children with acute and recurrent wheezy bronchitis.

    abstract::The analysis of exhaled breath condensate (EBC) is a promising new method to measure airway inflammation. So far only limited data exist about methodological issues of EBC sampling in infants and young children. We evaluated 18 children with acute wheezy bronchitis (median age 24.3 months (min-max: 4-89.9)), 54 childr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20712

    authors: Vogelberg C,Würfel C,Knoetzsch A,Kahlert A,Range U,Leupold W

    更新日期:2007-12-01 00:00:00

  • Trial of an intervention to reduce passive smoking in infancy.

    abstract::We tested a health education intervention program to reduce passive smoking in infancy. The aim was to develop an instrument for study of tobacco smoke exposure and childhood respiratory illness. One hundred and eighty-four women who had smoked during pregnancy were allocated by month of delivery to an intervention gr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030311

    authors: Woodward A,Owen N,Grgurinovich N,Griffith F,Linke H

    更新日期:1987-05-01 00:00:00

  • Management of empyema in children.

    abstract::The incidence of empyema complicating community-acquired pneumonia is increasing and causes significant childhood morbidity. Pneumococcal infection remains the most common isolated cause in developed countries, with Staphylococcus aureus the predominant pathogen in the developing world. Newer molecular techniques util...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20251

    authors: Jaffé A,Balfour-Lynn IM

    更新日期:2005-08-01 00:00:00

  • Use of bilevel positive pressure ventilation in patients with bronchiolitis.

    abstract:RATIONAL:This study aims at describing the use of bilevel positive airway pressure (BiPAP) in infants with severe bronchiolitis. WORKING HYPOTHESIS:The use of BiPAP in infants with bronchiolitis may be associated with a worst outcome. STUDY DESIGN:A single-center retrospective study performed from October 2013 to Apr...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25033

    authors: Delacroix E,Millet A,Pin I,Mortamet G

    更新日期:2020-11-01 00:00:00

  • CFTR, bicarbonate, and the pathophysiology of cystic fibrosis.

    abstract::The gene that encodes for the cystic fibrosis transmembrane regulator protein (CFTR) was identified in 1989, yet major pathophysiologic questions remain unanswered. There is emerging evidence that CFTR is a bicarbonate channel, a driver of chloride-bicarbonate exchange and through its action on local pH, a regulator o...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.23247

    authors: Borowitz D

    更新日期:2015-10-01 00:00:00

  • Nonlinear pressure/volume relationship and measurements of lung mechanics in infants.

    abstract::We examined the effects of within-breath changes in compliance (C) upon the accuracy of measurements of compliance and resistance (R) by linear regression analysis and by Mead and Wittenberger's method. These effects were illustrated by a computer model and by lung models with linear and nonlinear pressure/volume rela...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950120304

    authors: Silva Neto G,Gerhardt T,Silberberg A,Gerhardt T,Claure N,Duara S,Bancalari E

    更新日期:1992-03-01 00:00:00

  • Management of the pediatric organ donor to optimize lung donation.

    abstract::Lung transplantation in childhood is a highly specialized clinical practice confined to a few centers around the world. Organ availability remains an important limiting factor in extending the application of this procedure to more infants, children and adolescents. The lungs are the organ most vulnerable to injury, in...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,评审

    doi:10.1002/ppul.20997

    authors: Mallory GB Jr,Schecter MG,Elidemir O

    更新日期:2009-06-01 00:00:00

  • Sweat-testing in preterm and full-term infants less than 6 weeks of age.

    abstract::Our objective was to examine the characteristics of preterm and full-term infants < or = 6 weeks old that influence the success of obtaining sufficient sweat for diagnosis of CF, and corresponding sweat chloride concentrations. A retrospective chart review of 119 sweat tests was performed on 103 preterm and full-term ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20235

    authors: Eng W,LeGrys VA,Schechter MS,Laughon MM,Barker PM

    更新日期:2005-07-01 00:00:00

  • Steroid-sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis.

    abstract::Allergic bronchopulmonary aspergillosis (ABPA) is a complication commonly encountered in patients with CF that produces significant respiratory morbidity. Chronic airway colonization with Aspergillus induces strong inflammatory responses with high IgE levels. Current guidelines for therapy include prolonged courses of...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20804

    authors: Zirbes JM,Milla CE

    更新日期:2008-06-01 00:00:00

  • Effects of birthweight and oxygen supplementation on lung function in late childhood in children of very low birth weight.

    abstract::Impaired respiratory function has been found frequently in ex-premature children, but it is unclear which specific factors influence this impairment the most. The aim of this study was to determine the importance of the contributions of birth weight, gestational age, neonatal respiratory disease, and its treatment on ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/1099-0496(200007)30:1<32::aid-ppul6>3.0.co

    authors: Kennedy JD,Edward LJ,Bates DJ,Martin AJ,Dip SN,Haslam RR,McPhee AJ,Staugas RE,Baghurst P

    更新日期:2000-07-01 00:00:00

  • Comparison of the occlusion and inflation techniques for measuring total respiratory compliance in sick, intubated infants.

    abstract::Respiratory system compliance (Crs) can be used to assess lung stiffness in sick, intubated infants, avoiding the use of an esophageal balloon. Crs was assessed in a group of 15 sick, intubated infants using the occlusion and inflation techniques. The occlusion technique gave satisfactory results in 13 infants. Apneic...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950030207

    authors: Heaf DP,Turner H,Stocks J,Helms P

    更新日期:1987-03-01 00:00:00

  • Thoracoabdominal motion in newborns: Reliability between two interactive computing environments.

    abstract:BACKGROUND:Quantifying the chest wall is useful in documenting thoracoabdominal synchrony during the neonatal period. Subjective measures are often used rather than gold-standard methods due to their practicality in clinical practice. The aim of the present study is to compare the reliability between a newly proposed m...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24709

    authors: Gomes DC,Azevedo IG,de Figueiredo Araújo AG,da Costa Lopes LD,Nagem DAP,Magalhães FA,Pereira SA

    更新日期:2020-05-01 00:00:00

  • Induced sputum to detect lung pathogens in young children with cystic fibrosis.

    abstract:INTRODUCTION:Induced sputum sampling holds promise as a method for obtaining samples representative of the lower airways in young children. Collection of induced sputum samples in young children differs from older children and adults' as pharyngeal suctioning is often required. Our aim was to determine the sensitivity ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23636

    authors: D'Sylva P,Caudri D,Shaw N,Turkovic L,Douglas T,Bew J,Keil AD,Stick S,Schultz A

    更新日期:2017-02-01 00:00:00

  • Quantitative chest computerized tomography and FEV1 equally identify pulmonary exacerbation risk in children with cystic fibrosis.

    abstract:BACKGROUND:Chest computerized tomography (CT) scores are associated with the frequency of future pulmonary exacerbations in people with cystic fibrosis (CF). However, cut-off values to identify children with mild lung disease with different risks for frequent future pulmonary exacerbations have not been identified. ME...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/ppul.24144

    authors: Sanders DB,Li Z,Parker-McGill K,Farrell P,Brody AS

    更新日期:2018-10-01 00:00:00

  • Familial susceptibility to severe respiratory infection in early life.

    abstract::Lower respiratory tract infections (LRTI) are common in the first year of life and are mostly caused by viruses. Severity of LRTI in infants is associated with early-life environmental factors. Genetic association studies also suggest a role of heredity in susceptibility to acute bronchiolitis. We designed a case cont...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20069

    authors: Goetghebuer T,Kwiatkowski D,Thomson A,Hull J

    更新日期:2004-10-01 00:00:00

  • Effects of sildenafil on pulmonary hypertension and exercise tolerance in severe cystic fibrosis-related lung disease.

    abstract::Cystic fibrosis (CF) patients with advanced lung disease are at risk for developing pulmonary vascular disease and pulmonary hypertension, characterized by progressive exercise intolerance beyond the exercise-limiting effects of airways disease in CF. We report on a patient with severe CF lung disease who experienced ...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20393

    authors: Montgomery GS,Sagel SD,Taylor AL,Abman SH

    更新日期:2006-04-01 00:00:00

  • Chiari I malformation presenting as chronic cough.

    abstract::We present a 9-month-old infant with persistent cough refractory to conventional asthma therapy. An extensive evaluation eventually revealed a Chiari I malformation with syringohydromyelia. His cough resolved one month after surgical decompression, suggesting that brainstem compression from the Chiari malformation dir...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.20912

    authors: Amos LB,Quintero DR

    更新日期:2008-10-01 00:00:00

  • Nonsurgical management of an enlarging pneumatocele by fibrin sealant injection via pigtail catheter.

    abstract::Most pneumatoceles disappear spontaneously and do not cause severe symptoms. Treatment alternatives include various conventional or surgical methods. However, an enlarging, complicated pneumatocele with cardiorespiratory instability requires imaging-guided catheter drainage or surgery. Here, we report the case of a ne...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23311

    authors: Park TH,Kim JK

    更新日期:2016-02-01 00:00:00

  • Polysomnography Provides Useful Clinical Information in the Liberation from Respiratory Technology: A Retrospective Review.

    abstract::Background The prevalence of respiratory-technology dependent children is increasing although for most children the goal is liberation from technology. Liberation from home mechanical ventilation (HMV) and decannulation strategies vary due to the lack of clinical practice standards. The primary objective of this study...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.24164

    authors: Bashir A,Henningfeld JK,Thompson NE,D'Andrea LA

    更新日期:2018-11-01 00:00:00

  • Relative contribution of ribcage and abdomen during augmented breaths in infants.

    abstract::Changes in the relative contribution of ribcage and abdomen during augmented breaths were assessed in two groups of infants (less than 2 weeks and 4-12 weeks old). In both groups ribcage and abdominal movements increased during augmented breaths in quiet sleep. In the older infants the relative increase was greater fo...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.1950040303

    authors: Mathew OP,Pronske ML,Clark ML

    更新日期:1988-01-01 00:00:00

  • RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients.

    abstract::Short-acting β2-adrenergic receptor agonists are commonly used bronchodilators for symptom relief in asthmatics. Recent evidence demonstrated that prolonged exposure of cultured airway smooth muscle cells to β2 agonists directly augments procontractile signaling pathways with the change in expression of regulator of G...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.22723

    authors: Labuda M,Laberge S,Brière J,Bérubé D,Krajinovic M

    更新日期:2013-10-01 00:00:00

  • Diffuse panbronchiolitis in a 10-year-old boy.

    abstract::Diffuse panbronchiolitis is a progressive fatal respiratory disease of unknown cause seen predominantly in Southeast Asian adults. We report this condition in a 10-year-old child of Korean birth because of the uncommon presentation at this age and the favorable outcome associated with early diagnosis. Our objective wa...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.23176

    authors: Weinberger M,Fischer A,Kao S

    更新日期:2015-09-01 00:00:00

  • Pseudomonas aeruginosa colonization in cystic fibrosis: Impact on neutrophil functions and cytokine secretion capacity.

    abstract:BACKGROUND:Chronic colonization with Pseudomonas (P.) aeruginosa worsens the prognosis of cystic fibrosis (CF) patients. This study aims to analyze the functional properties of neutrophils in CF patients with P. aeruginosa colonization. METHODS:Patients with CF (n = 16) were grouped by positivity of P. aeruginosa in s...

    journal_title:Pediatric pulmonology

    pub_type: 杂志文章

    doi:10.1002/ppul.25294

    authors: Aslanhan U,Cakir E,Ozyigit LP,Kucuksezer UC,Gelmez YM,Yuksel M,Deniz G,Aktas EC

    更新日期:2021-01-29 00:00:00