Abstract:
:Phrenic nerve pacing has been used since 1966 to support breathing in quadriplegics and patients with central hypoventilation syndrome (CHS). Recently, using low-frequency, long-inspiratory-time (Ti) stimulation, phrenic nerve pacing has been used successfully to support breathing 24 hours per day in adults and older children. However, no similar experience exists for infants and young children. Therefore, in 27 studies in 14 infants and children we determined the effects of changing Ti and interpulse interval (the inverse of stimulus frequency) on ventilation. Diaphragmatic action potentials, airflow, tidal volume, PACO2 and SaO2 were measured during sleep. Phrenic nerve pacing proved useful in 13 of 14 patients to support breathing either during wakefulness (n = 7) or during sleep (n = 6). We found that adequate ventilation could be achieved at significantly longer interpulse intervals, 95 +/- 25 (mean +/- SD) ms, and shorter Ti, 580 +/- 80 ms, than previously reported. At an average respiratory rate of 21 +/- 8 breaths/min it was thus possible to maintain adequate ventilation despite a marked reduction in the number of phrenic nerve stimuli. Theoretically, these reductions in phrenic nerve stimulation should minimize the chance of pacing-induced diaphragmatic damage. These results suggest that 24 hour per day phrenic nerve pacing may be a realistic goal in selected infants and children.
journal_name
Pediatr Pulmonoljournal_title
Pediatric pulmonologyauthors
Brouillette RT,Ilbawi MN,Klemka-Walden L,Hunt CEdoi
10.1002/ppul.1950040108subject
Has Abstractpub_date
1988-01-01 00:00:00pages
33-8issue
1eissn
8755-6863issn
1099-0496journal_volume
4pub_type
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journal_title:Pediatric pulmonology
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更新日期:1994-03-01 00:00:00
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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更新日期:2014-09-01 00:00:00
abstract:BACKGROUND:Magnetic Resonance Imaging (MRI) techniques to image the larynx have evolved rapidly into a promising and safe imaging modality, without need for sedation or ionizing radiation. MRI is therefore of great interest to image pediatric laryngeal diseases. Our aim was to review MRI developments relevant for the p...
journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23434
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23318
更新日期:2016-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23913
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/ppul.25294
更新日期:2021-01-29 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1950030311
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10090
更新日期:2002-04-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章,评审
doi:10.1002/ppul.23245
更新日期:2015-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 临床试验,杂志文章
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更新日期:2000-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23769
更新日期:2017-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 信件
doi:10.1002/ppul.22954
更新日期:2014-09-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199712)24:6<391::aid-ppul3
更新日期:1997-12-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24242
更新日期:2019-03-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199906)27:6<388::aid-ppul5
更新日期:1999-06-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.22558
更新日期:2012-10-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24464
更新日期:2019-11-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/(sici)1099-0496(199705)23:5<362::aid-ppul8
更新日期:1997-05-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.24063
更新日期:2018-07-01 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.1082
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Discussions on the diagnostic and management of acquired pediatric lung pathology are usually published by large tertiary children's hospitals. It is likely that much of this pathology is actually seen and managed in nonacademic practices. METHODS:A 10-year retrospective review of patients under 18-years of...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25254
更新日期:2021-01-02 00:00:00
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journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.10320
更新日期:2003-10-01 00:00:00
abstract::Most pneumatoceles disappear spontaneously and do not cause severe symptoms. Treatment alternatives include various conventional or surgical methods. However, an enlarging, complicated pneumatocele with cardiorespiratory instability requires imaging-guided catheter drainage or surgery. Here, we report the case of a ne...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.23311
更新日期:2016-02-01 00:00:00
abstract:INTRODUCTION:There are few published data on the efficacy of systemic corticosteroids in preterm infants with very severe forms of bronchopulmonary dysplasia (BPD), requiring respiratory support after 3 months of age. The aim of this study was to report the use of pulses of methylprednisolone in this population and its...
journal_title:Pediatric pulmonology
pub_type: 杂志文章
doi:10.1002/ppul.25109
更新日期:2021-01-01 00:00:00