Management of breast cancer patients failing adjuvant chemotherapy with adriamycin-containing regimens.

abstract：BACKGROUND:Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single-time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS:In all, 276 patients with chronic phase CML on imatinib therap...

journal_title：Cancer

authors： Kantarjian H,O'Brien S,Shan J,Huang X,Garcia-Manero G,Faderl S,Ravandi-Kashani F,Verstovsek S,Beth Rios M,Cortes J

更新日期：2008-02-15 00:00:00

abstract：BACKGROUND:Melanoma vaccine treatment appears to slow the progression of melanoma in some patients, particularly in patients in whom it stimulates cellular antimelanoma immune responses. The relationship of vaccine-induced antibody responses to clinical outcome is less clear. The purpose of this study was to investigat...

journal_title：Cancer

authors： Miller K,Abeles G,Oratz R,Zeleniuch-Jacquotte A,Cui J,Roses DF,Harris MN,Bystryn JC

更新日期：1995-01-15 00:00:00

abstract：:Lymphoblasts from "null cell" acute lymphocytic leukemia (ALL) were analyzed for the pattern of proliferation displayed in a mixed lymphocyte reaction (MLR), the presence of a B cell surface antigen, and for the presence of intracytoplasmic immunoglobulin (ICIg). "Null cell" ALL was defined by cytologic and cytochemic...

journal_title：Cancer

authors： Davey FR,Dock NL,Wolos JA,Terzian JA,Gottlieb AJ

更新日期：1979-11-01 00:00:00

abstract：:The data of an epidemiologic study of multiple primary malignant neoplasms in breast cancer patients in Israel are presented. During the 18-year period of the study 12,302 cases of breast carcinoma were diagnosed, and, of these, 984 patients (8%) had multiple primary malignant tumors. Forty-seven of these patients dev...

journal_title：Cancer

authors： Schenker JG,Levinsky R,Ohel G

更新日期：1984-07-01 00:00:00

abstract：BACKGROUND:There is concern that antioxidant supplement use during chemotherapy and radiation therapy may decrease treatment effects, yet the effects of such supplements on recurrence and survival are largely unknown. METHODS:The authors prospectively examined the associations between antioxidant use after breast canc...

journal_title：Cancer

authors： Greenlee H,Kwan ML,Kushi LH,Song J,Castillo A,Weltzien E,Quesenberry CP Jr,Caan BJ

更新日期：2012-04-15 00:00:00

abstract：:The effect of immunotherapy with Nocardia rubra cell-wall skeleton (N-CWS) on remission duration and survival of adults with acute myelogenous leukemia (AML) was studied in a prospective randomized controlled study. After having been induced into complete remission and having been consolidated, 73 patients were random...

journal_title：Cancer

authors： Ohno R,Nakamura H,Kodera Y,Ezaki K,Yokomaku S,Oguma S,Kubota Y,Shibata H,Ogawa N,Masaoka T

更新日期：1986-04-15 00:00:00

abstract：:Acid phosphatase activity biochemically in the primary tumor of 20 patients with prostatic carcinoma, was studied in an attempt to understand the basis for a correlation or lack of correlation between serum and/or bone marrow acid phosphatase levels and the presence and/or clinical behavior of prostatic carcinoma. The...

journal_title：Cancer

authors： Copland GT,Whitehurst GB,Pretlow TP,Boohaker EA,Bartolucci AA,Pretlow TG 2nd

更新日期：1983-07-01 00:00:00

abstract：BACKGROUND:The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15-30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract sympto...

journal_title：Cancer

authors： Romaguera JE,Medeiros LJ,Hagemeister FB,Fayad LE,Rodriguez MA,Pro B,Younes A,McLaughlin P,Goy A,Sarris AH,Dang NH,Samaniego F,Brown HM,Gagneja HK,Cabanillas F

更新日期：2003-02-01 00:00:00

abstract：:This paper discusses the imaging methods available for the detection and diagnosis of colon cancer, concentrating on endoscopy and barium radiology. Effective utilization of these two methods may be facilitated by using flexible sigmoidoscopy to direct further investigation. There is a need for educational efforts to ...

journal_title：Cancer

authors： Stevenson GW

更新日期：1993-06-15 00:00:00

abstract：BACKGROUND:We prospectively compared the proxy reporting of health-related quality of life (HRQL) by parents and nurses of children with Hodgkin disease to see how well they correlated with the children's report. METHODS:Children with all stages of Hodgkin disease, their parents, and the clinic nurse were all asked to...

journal_title：Cancer

authors： Klaassen RJ,Barr RD,Hughes J,Rogers P,Anderson R,Grundy P,Ali SK,Yanofsky R,Abla O,Silva M,Carret AS,Cappelli M

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Aprotinin has been used to decrease blood loss with complicated cardiac surgery but has not been investigated in extrapleural pneumonectomy, an operation that does not use cardiopulmonary bypass. In this prospective, randomized, placebo-controlled, double-blind trial, the authors investigated whether aprotin...

journal_title：Cancer

authors： Norman PH,Thall PF,Purugganan RV,Riedel BJ,Thakar DR,Rice DC,Huynh L,Qiao W,Wen S,Smythe WR

更新日期：2009-02-15 00:00:00

abstract：:A case-control study was conducted to assess the risk factors associated with the development of a contralateral primary breast cancer among women who had had a first primary breast cancer. Hospital records were reviewed for 292 women with an incident contralateral breast cancer, diagnosed in one of eight hospitals be...

journal_title：Cancer

authors： Horn PL,Thompson WD

更新日期：1988-07-15 00:00:00

abstract：BACKGROUND:The authors hypothesized that the outcomes for young patients who present with primary osteosarcoma of flat bones or secondary osteosarcoma after other primary malignancies are similar because the sites of these tumors rarely makes them amenable to complete surgical resection. METHODS:The authors reviewed t...

journal_title：Cancer

authors： Pratt CB,Meyer WH,Rao BN,Pappo AS,Fleming ID,Luo X,Cain A,Kaste SC,Shearer PD,Jenkins JJ 3rd

更新日期：1997-09-15 00:00:00

abstract：:Levels of glycoprotein:sialyltransferase activity (EC 2.4.99.1; CMP-acetyl-neuraminate:D-galactosyl-glycoprotein N-acetylneuraminyl-transferase) were measured in plasma of patients with neoplastic disease, and were found elevated above normal control values in 85% of patients examined. There was a correlation between ...

journal_title：Cancer

authors： Henderson M,Kessel D

更新日期：1977-03-01 00:00:00

abstract：BACKGROUND:Since endoscopic treatment was first evaluated and established as a treatment for patients with early stage gastric carcinoma, metachronous disease recurrence at other sites in the stomach after endoscopic treatment has become a major problem. METHODS:A retrospective case-control study was conducted on 10 p...

journal_title：Cancer

authors： Kawamura A,Adachi K,Ishihara S,Katsube T,Takashima T,Yuki M,Amano K,Fukuda R,Yamashita Y,Kinoshita Y

更新日期：2001-01-15 00:00:00

abstract：BACKGROUND:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) plays an important role in the process of lymphocyte-mediated cytotoxicity against malignant cells. Osteoprotegerin (OPG) is a soluble decoy receptor for TRAIL, and circulating OPG has been implicated in the protection of cells from TRAIL-mediat...

journal_title：Cancer

authors： Mizutani Y,Matsubara H,Yamamoto K,Nan Li Y,Mikami K,Okihara K,Kawauchi A,Bonavida B,Miki T

更新日期：2004-10-15 00:00:00

abstract：:Fifteen cases of pure supradiapragmatic lymphoma with initial prominent antero-superior mediastinal involvement displaying a B-cell pattern of reactivity were studied. These cases occurred in six men and nine women with a median age of 33 years at diagnosis (range, 23 to 75 years). Supradiapragmatic peripheral lymphad...

journal_title：Cancer

authors： Lavabre-Bertrand T,Donadio D,Fegueux N,Jessueld D,Taib J,Charlier D,Rousset T,Emberger JM,Baldet P,Navarro M

更新日期：1992-05-15 00:00:00

abstract：BACKGROUND:Previous studies have shown that matrix metalloproteinase-2 (MMP-2) (a 72-kilodalton Type IV collagenase/gelatinase A) is associated with breast carcinoma, but to the authors' knowledge there are no reports showing that it is prognostic for overall survival. METHODS:Expression of the immunoreactive protein ...

journal_title：Cancer

authors： Talvensaari-Mattila A,Pääkkö P,Höyhtyä M,Blanco-Sequeiros G,Turpeenniemi-Hujanen T

更新日期：1998-09-15 00:00:00

abstract：:Eight hundred sixty-five patients with a microscopically curative resection for carcinoma of the lung were accepted for study, none of whom were excluded from analysis. Adjuvant therapy was randomly assigned about the tenth to 14th postoperative day; 432 patients (treated) were to receive CCNU and hydroxyurea for one ...

journal_title：Cancer

authors： Shields TW,Higgins GA Jr,Humphrey EW,Matthews MJ,Keehn RJ

更新日期：1982-11-01 00:00:00

abstract：:The prognostic significance of the pretreatment growth characteristics of marrow blasts was examined in 37 patients with acute nonlymphocytic leukemia (ANLL) treated with a similar therapeutic regimen. Initial mitotic index (MI) and in vitro 3H-thymidine labeling index (LI) were broadly distributed showing no correlat...

journal_title：Cancer

authors： Amadori S,Petti MC,De Francesco A,Chierichini A,Mastrovincenzo C,Testa MG,Mandelli F

更新日期：1978-03-01 00:00:00

abstract：:The authors report a case of leiomyosarcoma in the mediastinum presenting with superior vena cava obstruction, and also demonstrate the aggressive nature of this tumor in spite of radiotherapy. Where technically feasible, surgery appears to be the treatment of choice. The pathologic and electron microscopic features o...

journal_title：Cancer

authors： Sunderrajan EV,Luger AM,Rosenholtz MJ,Maltby JD

更新日期：1984-06-01 00:00:00

abstract：:Thirty-eight metastatic breast cancer patients were treated with aminoglutethimide. All patients had progressive metastatic disease following initial response to Tamoxifen therapy. Thirty-two patients were evaluable for response, of these, two patients (6%) had complete remission, 13 patients (41%) had partial respons...

journal_title：Cancer

authors： Buzdar AU,Powell KC,Legha SS,Blumenschein GR

更新日期：1982-11-01 00:00:00

abstract：:The diagnosis of pulmonary candidiasis can only be made with certainty when tissue invasion by the organism is demonstrated histologically. In order to ascertain whether characteristic radiographic patterns are seen in patients with pulmonary candidiasis, antemortem radiographic abnormalities were correlated with auto...

journal_title：Cancer

authors： Dubois PJ,Myerowitz RL,Allen CM

更新日期：1977-09-01 00:00:00

abstract：:In the treatment of gynecologic malignancies, various combinations of surgery, drugs, and radiation therapy are used with increasing frequency. An examination is made of data dealing with combined modalities in the treatment of tumors of the cervix, endometrium, and ovary. Although the efficacy of such treatments has ...

journal_title：Cancer

authors： Brady LW

更新日期：1975-01-01 00:00:00

abstract：BACKGROUND:Optimal treatment of human immunodeficiency virus (HIV)-associated non-Hodgkin lymphoma (NHL) has yet to be defined, because chemotherapy could exacerbate immunodeficiency, with subsequent adverse effects for patients. METHODS:The authors investigated the feasibility of an intensive chemotherapy regimen for...

journal_title：Cancer

authors： Costello RT,Zerazhi H,Charbonnier A,de Colella JM,Alzieu C,Poizot-Martin I,Cohen R,Bardou VJ,Xerri L,Olive D,Nezri M,Lepeu G,Gastaut JA

更新日期：2004-02-15 00:00:00

abstract：:Exposure of tumor cells to reduced folates before or with the fluoropyrimidines, 5-fluorouracil or 5-fluoro-2'deoxyuridine, results in a substantial increase in the activity of these drugs. Available evidence suggests that the mechanism of this synergism is a kinetic stabilization of complex formed between thymidylate...

journal_title：Cancer

authors： Morgan RG

更新日期：1989-03-15 00:00:00

abstract：BACKGROUND:Although studies comparing conventional imaging modalities with (18)F-fluorodeoxyglucose positron emission tomography ((18)F-FDG-PET) for the detection of lymphoma and although the relations between (18)F-FDG-PET and histologic types were reported previously, most studies were not systematic and involved rel...

journal_title：Cancer

authors： Tsukamoto N,Kojima M,Hasegawa M,Oriuchi N,Matsushima T,Yokohama A,Saitoh T,Handa H,Endo K,Murakami H

更新日期：2007-08-01 00:00:00

abstract：BACKGROUND:A positive influence of anticoagulant treatment in small cell lung cancer (SCLC) has been suggested by experimental and clinical data. METHODS:In a multicenter clinical trial, 277 patients with SCLC were randomized either to receive or not to receive subcutaneous heparin injections for 5 weeks at effective ...

journal_title：Cancer

authors： Lebeau B,Chastang C,Brechot JM,Capron F,Dautzenberg B,Delaisements C,Mornet M,Brun J,Hurdebourcq JP,Lemarie E

更新日期：1994-07-01 00:00:00

abstract：:From November 1973 to May 1986, 50 patients with Stage I epithelial ovarian cancer were treated at the University of Kentucky Medical Center (Lexington, KY) with oral Alkeran (melphalan) chemotherapy after primary surgery. Twenty-two patients had Grade 1 tumors, 23 patients had Grade 2 tumors, and five patients had Gr...

journal_title：Cancer

authors： Gallion HH,van Nagell JR,Donaldson ES,Higgins RV,Powell DE,Kryscio RJ

更新日期：1989-03-15 00:00:00

abstract：:This report describes a patient referred at 14 years in 1971, after one year's surveillance by the family physician, for a persistently elevated erythrocyte sedimentation rate, leukopenia, and relative lymphocytosis. Despite the documented myeloproliferative syndrome of seven years, significant physiologic impairment ...

journal_title：Cancer

authors： Whaun JM,Lin CC,Biederman B,Cornish SJ,Dundas JB

更新日期：1981-09-01 00:00:00