Medicine in the age of " Ulysses ": James Joyce's portrait of life, medicine, and disease on a Dublin day a century ago.

abstract：:Shopping for genetic information has become popular, but consumers may not understand what exactly they are buying. The retail DNA industry is forcing laypersons, academics, and medical and legal professionals alike to face the crossroads of genetics, law, and society. How will we decipher the meanings of the tests, d...

journal_title：Perspectives in biology and medicine

authors： Wagner JK

更新日期：2010-04-01 00:00:00

abstract：:Kelly, Kelly, and Russo (2014) recently proposed to integrate biological, behavioral, and social mechanisms into "mixed mechanisms" situated in the individual's "lifeworld" when considering illness causation. This article suggests considering terminological discrepancies, replacing the pathogenetic with an etiological...

journal_title：Perspectives in biology and medicine

authors： Dammann O

更新日期：2017-01-01 00:00:00

abstract：:Human beings rely on metaphor as a primary cognitive device for interpreting the world around them. Metaphors figure especially strongly in discourse around health, illness, and medicine. It is not just that patients use metaphors to describe their personal experience of being unwell, or that medical professionals emp...

journal_title：Perspectives in biology and medicine

authors： Hanne M

更新日期：2015-01-01 00:00:00

abstract：:The general population is experiencing lifelong exposure to old and new hazardous substances. By using data collected from a subject's own teeth, accuracy in determining the effects of exposure is assured since extrapolation is excluded. The establishment of a common tooth bank can provide means to integrate data from...

journal_title：Perspectives in biology and medicine

authors： Sharon IM

更新日期：1988-10-01 00:00:00

abstract：:The advent of electronic health records (EHRs) to improve access and enable research in the everyday clinical world has simultaneously made medical information much more vulnerable to illicit, non-beneficent uses. This wealth of identified, aggregated data has and will attract attacks by domestic governments for surve...

journal_title：Perspectives in biology and medicine

authors： Graves S

更新日期：2013-01-01 00:00:00

abstract：:Marino Ortolani (1904-1983), a pediatrician from Ferrara, in northeastern Italy, was an outstanding pioneer in the early diagnosis and treatment of hip dysplasia. In 1935, while examining hip abduction-adduction in a six-month-old baby, Ortolani noted that a clearly audible and palpable "click" was sufficient to revea...

journal_title：Perspectives in biology and medicine

authors： Stecco C,Porzionato A,Macchi V,Fantoni I,Ortolani L,De Caro R

更新日期：2014-10-01 00:00:00

abstract：:Diverse and non-coherent sets of epistemological principles currently inform research in the general area of functional genomics. Here, from the personal point of view of a scientist with over half a century of immersion in hypothesis driven scientific discovery, I compare and deconstruct the ideological bases of prom...

journal_title：Perspectives in biology and medicine

authors： Davidson EH

更新日期：2015-04-01 00:00:00

abstract：:Iraqi detainees subjected to torture and mistreatment at Abu Ghraib prison may continue to suffer from significant physical and psychological consequences of their abuse. This article reports two cases of Iraqi individuals allegedly tortured at Abu Ghraib. Detailed forensic evaluations were conducted approximately one...

journal_title：Perspectives in biology and medicine

authors： Keller AS

更新日期：2006-10-01 00:00:00

abstract：:We argue that medical decisions on behalf of children should be made with the welfare of the child as the primary interest, that parents should generally be allowed to determine which options optimize the interests of their child, and that those decisions should be formally challenged only when the parental decision p...

journal_title：Perspectives in biology and medicine

authors： Diekema DS,Wilfond BS

更新日期：2016-01-01 00:00:00

abstract：:As health care has become of great importance to both individual citizens and to society, it has become more important to understand medicine's relationship to the society it serves in order to have a basis for meaningful dialogue. During the past decade, individuals in the medical, legal, social sciences, and health ...

journal_title：Perspectives in biology and medicine

authors： Cruess RL,Cruess SR

更新日期：2008-10-01 00:00:00

abstract：:Over recent years there has been a gratifying decrease in the incidence of recorded deaths from coronary artery disease in the Western world. The common view is that coronary artery disease is a recent phenomenon, that we have been subject to an epidemic in the mid-20th century that is now tailing off, and that with a...

journal_title：Perspectives in biology and medicine

authors： John LC

更新日期：2012-01-01 00:00:00

abstract：:Mary Shelley's Frankenstein is 200 years old and remains relevant to 21st-century scientific experimentation. Molecular biologists today have become especially bold in their attempts to cure diseases while remaining mindful of the real dangers of their research. Scientists presumably share an abiding concern about pro...

journal_title：Perspectives in biology and medicine

authors： Nowlin C

更新日期：2018-01-01 00:00:00

abstract：:Several studies suggest that clinical researchers are prone to overestimating the chance that scientific protocols will succeed, say, by confirming a treatment hypothesis or reaching recruitment targets. In this essay, we address the normative question of whether such "unrealistic optimism" is harmful in clinical rese...

journal_title：Perspectives in biology and medicine

authors： Benjamin D,Kimmelman J

更新日期：2016-01-01 00:00:00

abstract：:The treatment of broken bones has long adhered to principles of tight juxtaposition of fracture ends and of strict rest. Splinting and casting with plaster of Paris helped considerably. Attempts at internal splinting with pegs, bolts, or stabilizing contraptions usually failed. Foreign materials were either not biocom...

journal_title：Perspectives in biology and medicine

authors： Pierach CA

更新日期：2014-07-01 00:00:00

abstract：:How can we provide the best care for growing numbers of very frail, very sick, or very old people? The disciplines of geriatrics, palliative care, and clinical ethics each have a good deal to offer to improve care for elders, yet each field is saddled with heavy historical baggage. Using a case as a springboard, we ad...

journal_title：Perspectives in biology and medicine

authors： Smith AK,Micco G

更新日期：2017-01-01 00:00:00

abstract：:The reigning paradigm of rational drug discovery in translational medicine attempts to exploit biological theories and pathophysiological explanations to identify novel drug targets and therapeutic strategies. Yet because many theories in medicine are either incomplete (at best) or false (at worst), relying on theoret...

journal_title：Perspectives in biology and medicine

authors： Hey SP

更新日期：2019-01-01 00:00:00

abstract：:An intersex condition is one in which an individual is born with atypical male or female external genitalia, gonads, hormones, or chromosomes. Older terms, such as pseudohermaphroditism and hermaphroditism, are controversial, leading the Lawson Wilkins Pediatric Endocrine Society (LWPES) and the European Society for P...

journal_title：Perspectives in biology and medicine

authors： Reis E,McCarthy MW

更新日期：2016-01-01 00:00:00

abstract：:Randomized, controlled clinical trials (RCTs) may be possible, permissible, and practical in certain circumstances, but ethical or practical considerations often preclude their utilization. In many such cases, ethical objections will not apply to a similarly oriented, prospective, matched-pair observational study. Add...

journal_title：Perspectives in biology and medicine

authors： Kowalski CJ

更新日期：2013-04-01 00:00:00

abstract：:Charles Dickens's adult life parallels the period when the movement for sanitary reform took root in England. Although he was not one of its leaders, he became in time one of its most outspoken advocates. This essay describes Dickens's growing involvement in the sanitary movement and looks at one of the most important...

journal_title：Perspectives in biology and medicine

authors： Litsios S

更新日期：2003-04-01 00:00:00

abstract：:The recent death of a normal healthy volunteer, as well as the increased use of normal volunteers as research subjects, has heightened the attention given to the participation of normal volunteers in clinical research. An overlooked sub-population of normal healthy volunteers are repeat, veteran volunteers. This essay...

journal_title：Perspectives in biology and medicine

authors： Tishler CL,Bartholomae S

更新日期：2003-10-01 00:00:00

abstract：:The traditional forms of public health law were directed largely toward communicable diseases and other externalities, such as pollution, with negative health impacts. The more modern view treats any health issue that affects large numbers of individuals as one of public health, which would include such problems as ob...

journal_title：Perspectives in biology and medicine

authors： Epstein RA

更新日期：2003-07-01 00:00:00

abstract：:In retrospect, mortality from coronary heart disease (CHD) in the 20th century followed an epidemic pattern: mortality rates increased dramatically from 1920 until about 1960, remained roughly constant for almost a decade, and have been decreasing since the late 1960s. CHD has traditionally been conceived of as a sing...

journal_title：Perspectives in biology and medicine

authors： Azambuja MI,Levins R

更新日期：2007-04-01 00:00:00

abstract：:This paper constructs a brief history of the biochemical term agonist by exploring the multiple meanings of the root agôn in ancient Greek literature and describing how agonist first appeared in the scientific literature of the 20th century in the context of neurophysiologists' debates about the existence and properti...

journal_title：Perspectives in biology and medicine

authors： Russo R

更新日期：2002-07-01 00:00:00

abstract：:The clinical trial of the AbioCor artificial heart, initiated in July 2001 and still in process, has taken place within a matrix of social and cultural patterns that are both "old" and new. The old patterns--those that have accompanied previous clinical trials of other vital artificial organs and transplantation in th...

journal_title：Perspectives in biology and medicine

authors： Fox RC,Swazey JP

更新日期：2004-01-01 00:00:00

abstract：:There is a need in our society to raise the national consciousness about aging, health, and the prospects for longevity, so that many more persons take responsibility for their personal health and understand what we will need in an era of health-care reform to promote health across the life course. We address this imp...

journal_title：Perspectives in biology and medicine

authors： Hamerman D,Fried LP

更新日期：2013-04-01 00:00:00

abstract：:In 1900 William Osler established a friendship with Harvey Cushing that encompassed the personal and professional aspects of their lives for over two decades. Their shared participation in the covenant of medicine shaped an intense friendship and mentoring relationship that profited both individuals immeasurably. The ...

journal_title：Perspectives in biology and medicine

authors： Duffy TP

更新日期：2005-10-01 00:00:00

abstract：:Schneiderman, Jecker, and Jonsen (2017) correctly take issue with a recent multi-society statement that attempts to replace most uses of the term futility with "inappropriate treatment." However, they mistakenly categorize any treatment of permanent unconsciousness as futile. Futility can be readily defined as an inte...

journal_title：Perspectives in biology and medicine

authors： Brody H

更新日期：2018-01-01 00:00:00

abstract：:How we discovered that sea birds on the Great Barrier Reef are riddled with influenza viruses, and how one of these led to a new drug now being used in the battle against the flu. ...

journal_title：Perspectives in biology and medicine

authors： Laver WG

更新日期：2004-10-01 00:00:00

abstract：:The incidence of brain tumors is rising in children and the elderly, but little is known about the mechanisms underlying brain tumor initiation and progression. In the 1940s, Zimmerman and coworkers exploited the tumor-promoting potential of polycyclic hydrocarbons to produce brain tumor models in adult mice that simu...

journal_title：Perspectives in biology and medicine

authors： Seyfried TN

更新日期：2001-04-01 00:00:00

abstract：:This is a daunting time, not only in terms of our public health and our economic health but also in terms of the health of the republic. It is an old theme that any form of popular government needs virtuous citizens if it is to survive. It also needs citizens to agree on what counts as a virtue. I fear that the pandem...

journal_title：Perspectives in biology and medicine

authors： Brudney D

更新日期：2020-01-01 00:00:00